{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:33:44Z","timestamp":1787315624925,"version":"build-2736575974"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273115"],"award-info":[{"award-number":["82273115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972328"],"award-info":[{"award-number":["81972328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200601"],"award-info":[{"award-number":["82200601"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.lfs.2024.123090","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T13:04:40Z","timestamp":1728479080000},"page":"123090","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Zinc pyrithione ameliorates colitis in mice by interacting on intestinal epithelial TRPA1 and TRPV4 channels"],"prefix":"10.1016","volume":"358","author":[{"given":"Mengting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chensijin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guolong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxing","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2024.123090_bb0005","doi-asserted-by":"crossref","first-page":"113","DOI":"10.25122\/jml-2018-0075","article-title":"A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease","volume":"12","author":"Seyedian","year":"2019","journal-title":"J. Med. Life"},{"key":"10.1016\/j.lfs.2024.123090_bb0010","first-page":"17","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017, Lancet","volume":"5","author":"Alatab","year":"2020","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2024.123090_bb0015","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.3390\/ijms24021526","article-title":"Pathophysiology of inflammatory bowel disease: innate immune system","volume":"24","author":"Saez","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2024.123090_bb0020","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/MOG.0000000000000740","article-title":"New targets in inflammatory bowel disease therapy: 2021","volume":"37","author":"Cohen","year":"2021","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.lfs.2024.123090_bb0025","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.suc.2019.08.001","article-title":"Inflammatory bowel disease presentation and diagnosis","volume":"99","author":"Flynn","year":"2019","journal-title":"Surg. Clin. North Am."},{"key":"10.1016\/j.lfs.2024.123090_bb0030","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1096\/fj.201800535R","article-title":"Calcium\/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation","volume":"33","author":"Cunningham","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2024.123090_bb0035","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.3892\/or.2012.1969","article-title":"Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis","volume":"28","author":"Araki","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.lfs.2024.123090_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom12010001","article-title":"TRP channels as molecular targets to relieve cancer pain","volume":"12","author":"Duitama","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.lfs.2024.123090_bb0045","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.3389\/fimmu.2018.01273","article-title":"\u201cImmuno-transient receptor potential ion channels\u201d: the role in monocyte- and macrophage-mediated inflammatory responses","volume":"9","author":"Santoni","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2024.123090_bb0050","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/bph.12120","article-title":"The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis","volume":"169","author":"Romano","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2024.123090_bb0055","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/cells7060061","article-title":"Expression profiling of the transient receptor potential vanilloid (TRPV) channels 1, 2, 3 and 4 in mucosal epithelium of human ulcerative colitis","volume":"7","author":"Rizopoulos","year":"2018","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2024.123090_bb0060","doi-asserted-by":"crossref","unstructured":"D. Souza Monteiro de Araujo, R. Nassini, P. Geppetti, F. De Logu, TRPA1 as a therapeutic target for nociceptive pain, Expert Opin. Ther. Targets 24 (2020) 997\u20131008. doi:https:\/\/doi.org\/10.1080\/14728222.2020.1815191.","DOI":"10.1080\/14728222.2020.1815191"},{"key":"10.1016\/j.lfs.2024.123090_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111460","article-title":"TRPA1 expression and pathophysiology in immune cells","volume":"22","author":"Naert","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2024.123090_bb0070","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.pharmthera.2011.03.006","article-title":"Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system","volume":"131","author":"Holzer","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2024.123090_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102819","article-title":"Intracellular zinc protects Kv7 K+ channels from Ca2+\/calmodulin-mediated inhibition","volume":"299","author":"Yang","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2024.123090_bb0080","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1021\/ja00463a018","article-title":"Absence of metal interaction with sulfur in two metal complexes of a cysteine derivative. The structural characterization of bis(S-methyl-L-cysteinato)cadmium(II) and bis(S-methyl-L-cysteinato)zinc(II)","volume":"99","author":"De Meester","year":"1977","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.lfs.2024.123090_bb0085","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/00000372-200006000-00013","article-title":"Histopathology of psoriasis treated with zinc pyrithione","volume":"22","author":"Rowlands","year":"2000","journal-title":"Am. J. Dermatopathol."},{"key":"10.1016\/j.lfs.2024.123090_bb0090","first-page":"91","article-title":"Pyrithione-zinc prevents UVB-induced epidermal hyperplasia by inducing HIF-1alpha, Korean","volume":"14","author":"Cho","year":"2010","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2024.123090_bb0095","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/j.molonc.2015.05.005","article-title":"Anticancer activity of pyrithione zinc in oral cancer cells identified in small molecule screens and xenograft model: implications for oral cancer therapy","volume":"9","author":"Srivastava","year":"2015","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.lfs.2024.123090_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192699","article-title":"Zinc pyrithione activates K+ channels and hyperpolarizes the membrane of rat pulmonary artery smooth muscle cells","volume":"13","author":"Eid","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2024.123090_bb0105","article-title":"Understanding the mechanism of action of the anti-dandruff agent zinc pyrithione against Malassezia restricta","volume":"8","author":"Park","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2024.123090_bb0110","doi-asserted-by":"crossref","first-page":"5753","DOI":"10.1128\/AAC.00724-11","article-title":"Zinc pyrithione inhibits yeast growth through copper influx and inactivation of iron-sulfur proteins","volume":"55","author":"Reeder","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.lfs.2024.123090_bb0115","first-page":"C1088","article-title":"Zinc pyrithione activates the volume-regulated anion channel through an antioxidant-sensitive mechanism","volume":"320","author":"Figueroa","year":"2021","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.lfs.2024.123090_bb0120","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.toxlet.2018.03.007","article-title":"TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation","volume":"293","author":"Achanta","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.lfs.2024.123090_bb0125","doi-asserted-by":"crossref","first-page":"8374","DOI":"10.1073\/pnas.0812675106","article-title":"Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+","volume":"106","author":"Andersson","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.lfs.2024.123090_bb0130","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.lfs.2024.123090_bb0135","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1172\/JCI120261","article-title":"Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease","volume":"129","author":"Meir","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2024.123090_bb0140","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/0016-5085(90)90290-H","article-title":"A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice","volume":"98","author":"Okayasu","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2024.123090_bb0145","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nprot.2017.044","article-title":"Chemically induced mouse models of acute and chronic intestinal inflammation","volume":"12","author":"Wirtz","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.lfs.2024.123090_bb0150","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1021\/acs.molpharmaceut.2c00558","article-title":"Caffeic acid-conjugated budesonide-loaded nanomicelle attenuates inflammation in experimental colitis","volume":"20","author":"Mishra","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.lfs.2024.123090_bb0155","doi-asserted-by":"crossref","first-page":"5868","DOI":"10.1039\/D1BM00877C","article-title":"Aminocellulose - grafted polycaprolactone-coated core-shell nanoparticles alleviate the severity of ulcerative colitis: a novel adjuvant therapeutic approach","volume":"9","author":"Ahmad","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.lfs.2024.123090_bb0165","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2017762118","article-title":"Acetylcholine ameliorates colitis by promoting IL-10 secretion of monocytic myeloid-derived suppressor cells through the nAChR\/ERK pathway","volume":"118","author":"Zheng","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.lfs.2024.123090_bb0170","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1111\/bph.14640","article-title":"Molecular mechanisms of caffeine-mediated intestinal epithelial ion transports","volume":"176","author":"Zhang","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2024.123090_bb0175","first-page":"738","article-title":"GFP-Aequorin protein sensor for ex vivo and in vivo imaging of Ca(2+) dynamics in high-Ca(2+) organelles, cell","volume":"23","author":"Navas-Navarro","year":"2016","journal-title":"Chem. Biol."},{"key":"10.1016\/j.lfs.2024.123090_bb0180","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/7651_2019_259","article-title":"Scratch wound healing assay","volume":"2109","author":"Martinotti","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.lfs.2024.123090_bb0185","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1080\/14756366.2022.2108417","article-title":"Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication","volume":"37","author":"Kladnik","year":"2022","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.lfs.2024.123090_bb0190","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/rda.13245","article-title":"Intracellular calcium chelating agent (BAPTA-AM) aids stallion semen cooling and freezing-thawing","volume":"53","author":"Wu","year":"2018","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.lfs.2024.123090_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtherbio.2020.102779","article-title":"Ruthenium red attenuates brown adipose tissue thermogenesis in rats","volume":"95","author":"Vizin","year":"2021","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.lfs.2024.123090_bb0200","doi-asserted-by":"crossref","DOI":"10.1038\/srep37460","article-title":"Structural basis of TRPA1 inhibition by HC-030031 utilizing species-specific differences","volume":"6","author":"Gupta","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2024.123090_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172408","article-title":"The selective TRPV4 channel antagonist HC-067047 attenuates mechanical allodynia in diabetic mice","volume":"856","author":"Dias","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2024.123090_bb0210","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00424-017-1998-7","article-title":"Transient receptor potential vanilloid 4 (TRPV4) channel as a target of crotamiton and its bimodal effects","volume":"469","author":"Kittaka","year":"2017","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.lfs.2024.123090_bb0220","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/exd.14693","article-title":"TRPA1 promotes UVB-induced skin pigmentation by regulating melanosome luminal pH","volume":"32","author":"Wu","year":"2023","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.lfs.2024.123090_bb0225","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3390\/cells11091467","article-title":"P-cadherin regulates intestinal epithelial cell migration and mucosal repair, but is dispensable for colitis associated colon cancer","volume":"11","author":"Naydenov","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2024.123090_bb0230","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijbiomac.2022.02.109","article-title":"The role of Astragalus polysaccharides in promoting IEC-6 cell migration from polyamine-mediated Ca2+ regulation","volume":"207","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.lfs.2024.123090_bb0235","doi-asserted-by":"crossref","first-page":"G759","DOI":"10.1152\/ajpgi.00185.2015","article-title":"RhoA enhances store-operated Ca2+ entry and intestinal epithelial restitution by interacting with TRPC1 after wounding","volume":"309","author":"Chung","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2024.123090_bb0240","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108164","article-title":"Upregulation of the transient receptor potential ankyrin 1 ion channel in the inflamed human and mouse colon and its protective roles","volume":"9","author":"Kun","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2024.123090_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101847","article-title":"Capsaicin inhibits intestinal Cl- secretion and promotes Na+ absorption by blocking TRPV4 channels in healthy and colitic mice","volume":"298","author":"Wan","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2024.123090_bb0250","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s10571-022-01249-w","article-title":"Blockage of TRPV4 downregulates the nuclear factor-kappa B signaling pathway to inhibit inflammatory responses and neuronal death in mice with pilocarpine-induced status epilepticus","volume":"43","author":"An","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2024.123090_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108834","article-title":"TRPV4 inhibitor HC067047 produces antidepressant-like effect in LPS-induced depression mouse model","volume":"201","author":"Li","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2024.123090_bb0260","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.596314","article-title":"Lung epithelial TRPA1 mediates lipopolysaccharide-induced lung inflammation in bronchial epithelial cells and mice","volume":"11","author":"Ko","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2024.123090_bb0265","first-page":"451","article-title":"International consensus on methodological issues in standardization of fecal calprotectin measurement in inflammatory bowel diseases, United European","volume":"9","author":"D\u2019Amico","year":"2021","journal-title":"Gastroenterol. J."},{"key":"10.1016\/j.lfs.2024.123090_bb0270","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1111\/1462-2920.15269","article-title":"Unravelling lactate-acetate and sugar conversion into butyrate by intestinal Anaerobutyricum and Anaerostipes species by comparative proteogenomics","volume":"22","author":"Shetty","year":"2020","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.lfs.2024.123090_bb0275","article-title":"In vitro and in vivo approaches to determine intestinal epithelial cell permeability","author":"Li","year":"2018","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.lfs.2024.123090_bb0280","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ecoenv.2018.06.026","article-title":"Apoptosis in HepG2 cells induced by zinc pyrithione via mitochondrial dysfunction pathway: involvement of zinc accumulation and oxidative stress","volume":"161","author":"Mo","year":"2018","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.lfs.2024.123090_bb0285","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202112869","article-title":"Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2","volume":"154","author":"Kurebayashi","year":"2022","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.lfs.2024.123090_bb0290","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.258579","article-title":"S-acylation of Orai1 regulates store-operated Ca2+ entry","volume":"135","author":"West","year":"2022","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.lfs.2024.123090_bb0295","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.3390\/cancers12061459","article-title":"Eupatilin promotes cell death by calcium influx through ER-mitochondria axis with SERPINB11 inhibition in epithelial ovarian cancer","volume":"12","author":"Lee","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.lfs.2024.123090_bb0300","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fimmu.2018.00174","article-title":"Functional role of transient receptor potential channels in immune cells and epithelia","volume":"9","author":"Khalil","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2024.123090_bb0305","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nchembio.146","article-title":"Zinc activates damage-sensing TRPA1 ion channels","volume":"5","author":"Hu","year":"2009","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.lfs.2024.123090_bb0310","article-title":"Zinc homeostasis at the bacteria\/host Interface-from coordination chemistry to nutritional immunity","volume":"22","author":"J","year":"2016","journal-title":"Chemistry (Weinheim an Der Bergstrasse, Germany)"},{"key":"10.1016\/j.lfs.2024.123090_bb0315","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/08927010500044351","article-title":"Pyrithiones as antifoulants: environmental fate and loss of toxicity","volume":"21","author":"Turley","year":"2005","journal-title":"Biofouling"},{"key":"10.1016\/j.lfs.2024.123090_bb0320","doi-asserted-by":"crossref","first-page":"13942","DOI":"10.18632\/oncotarget.14572","article-title":"Repurposing an antidandruff agent to treating cancer: zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases","volume":"8","author":"Zhao","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2024.123090_bb0325","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1038\/s41467-022-32505-8","article-title":"Mannose ameliorates experimental colitis by protecting intestinal barrier integrity","volume":"13","author":"Dong","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2024.123090_bb0330","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1038\/s41467-024-47235-2","article-title":"DHX9 maintains epithelial homeostasis by restraining R-loop-mediated genomic instability in intestinal stem cells","volume":"15","author":"Ren","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2024.123090_bb0335","first-page":"248","article-title":"Epithelioid cell cultures from rat small intestine","volume":"80","author":"Quaroni","year":"1979","journal-title":"Characterization by morphologic and immunologic criteria, J Cell Biol"},{"key":"10.1016\/j.lfs.2024.123090_bb0340","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.3390\/foods12203800","article-title":"Inhibition of IEC-6 cell proliferation and the mechanism of ulcerative colitis in C57BL\/6 mice by dandelion root polysaccharides","volume":"12","author":"Yan","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.lfs.2024.123090_bb0345","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s13105-021-00854-5","article-title":"Procyanidin A1 alleviates DSS-induced ulcerative colitis via regulating AMPK\/mTOR\/p70S6K-mediated autophagy","volume":"78","author":"Zhang","year":"2022","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.lfs.2024.123090_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155116","article-title":"Astragaloside IV inhibits AOM\/DSS-induced colitis-associated tumorigenesis via activation of PPAR\u03b3 signaling in mice","volume":"121","author":"Liang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2024.123090_bb0355","doi-asserted-by":"crossref","first-page":"G33","DOI":"10.1152\/ajpgi.00105.2013","article-title":"Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage","volume":"307","author":"Yamawaki","year":"2014","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2024.123090_bb0360","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1136\/gutjnl-2015-310710","article-title":"The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1","volume":"66","author":"Bertin","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.lfs.2024.123090_bb0365","doi-asserted-by":"crossref","DOI":"10.1111\/bph.14072","article-title":"Transient receptor potential vanilloid 4 channel regulates vascular endothelial permeability during colonic inflammation in dextran sulphate sodium-induced murine colitis","volume":"175","author":"Matsumoto","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2024.123090_bb0370","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.biopha.2018.09.070","article-title":"The effect of serine phosphorylated claudin-7 on the epithelial barrier and the modulation by transient receptor potential vanilloid 4 in human colonic cells","volume":"108","author":"Huang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2024.123090_bb0375","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fphys.2017.00272","article-title":"TRPA1 channels modify TRPV1-mediated current responses in dorsal root ganglion neurons","volume":"8","author":"Masuoka","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2024.123090_bb0380","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ceca.2007.01.014","article-title":"Intracellular trafficking of TRP channels","volume":"42","author":"Cayouette","year":"2007","journal-title":"Cell Calcium"},{"key":"10.1016\/j.lfs.2024.123090_bb0385","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/ncb1150","article-title":"Rapid vesicular translocation and insertion of TRP channels","volume":"6","author":"Bezzerides","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.lfs.2024.123090_bb0390","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1159\/000093042","article-title":"Regulation of TRP channels by phosphorylation","volume":"14","author":"Yao","year":"2005","journal-title":"Neurosignals"},{"issue":"Suppl. 3","key":"10.1016\/j.lfs.2024.123090_bb0395","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.33549\/physiolres.931478","article-title":"Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin","volume":"57","author":"Vyklick\u00fd","year":"2008","journal-title":"Physiol. Res."},{"key":"10.1016\/j.lfs.2024.123090_bb0400","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jphs.2023.02.002","article-title":"Allyl isothiocyanate, an activator of TRPA1, increases gastric mucosal blood flow through calcitonin gene-related peptide and adrenomedullin in anesthetized rats","volume":"151","author":"Ohashi","year":"2023","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2024.123090_bb0405","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000171465","article-title":"The role of blood flow in gastric mucosal defence, damage and healing","volume":"12","author":"S\u00f8rbye","year":"1994","journal-title":"Dig. Dis."},{"key":"10.1016\/j.lfs.2024.123090_bb0410","first-page":"609","article-title":"Therapeutic effect of exogenous ghrelin in the healing of gingival ulcers is mediated by the release of endogenous growth hormone and insulin-like growth factor","volume":"68","author":"Cieszkowski","year":"2017","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2024.123090_bb0415","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/MPA.0000000000000517","article-title":"Therapeutic effect of obestatin in the course of cerulein-induced acute pancreatitis","volume":"45","author":"Bukowczan","year":"2016","journal-title":"Pancreas"},{"key":"10.1016\/j.lfs.2024.123090_bb0420","first-page":"87","article-title":"Treatment with ghrelin accelerates the healing of acetic acid-induced gastric and duodenal ulcers in rats","volume":"60","author":"Ceranowicz","year":"2009","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.lfs.2024.123090_bb0425","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3126280","article-title":"Synergic interaction of rifaximin and mutaflor (Escherichia coli Nissle 1917) in the treatment of acetic acid-induced colitis in rats","volume":"2016","author":"Dembi\u0144ski","year":"2016","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.lfs.2024.123090_bb0430","doi-asserted-by":"crossref","first-page":"G428","DOI":"10.1152\/ajpgi.00356.2012","article-title":"Epithelial transient receptor potential ankyrin 1 (TRPA1)-dependent adrenomedullin upregulates blood flow in rat small intestine","volume":"304","author":"Kono","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2024.123090_bb0435","doi-asserted-by":"crossref","first-page":"29794","DOI":"10.1021\/acsomega.3c04317","article-title":"\u03b1-Terpineol mitigates dextran sulfate sodium-induced colitis in rats by attenuating inflammation and apoptosis","volume":"8","author":"Khan","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.lfs.2024.123090_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111103","article-title":"Lipid-based nanocarrier-mediated targeted delivery of celecoxib attenuate severity of ulcerative colitis","volume":"116","author":"Mishra","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.lfs.2024.123090_bb0445","doi-asserted-by":"crossref","unstructured":"A. Kumar, null Kanika, V. Kumar, A. Ahmad, R.K. Mishra, A. Nadeem, N. Siddiqui, M.M. Ansari, S.S. Raza, K.K. Kondepudi, R. Khan, Colon-adhering delivery system with inflammation responsiveness for localized therapy of experimental colitis, ACS Biomater Sci. Eng. 9 (2023) 4781\u20134793. doi:https:\/\/doi.org\/10.1021\/acsbiomaterials.3c00480.","DOI":"10.1021\/acsbiomaterials.3c00480"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524006805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524006805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T12:37:14Z","timestamp":1736167034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524006805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":87,"alternative-id":["S0024320524006805"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.123090","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc pyrithione ameliorates colitis in mice by interacting on intestinal epithelial TRPA1 and TRPV4 channels","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.123090","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"123090"}}