{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:32:13Z","timestamp":1793233933803,"version":"4.5.0"},"reference-count":160,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FP009-2022"],"award-info":[{"award-number":["FP009-2022"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.lfs.2024.123112","type":"journal-article","created":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T09:47:07Z","timestamp":1728208027000},"page":"123112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Unravelling the interplay between ER stress, UPR and the cGAS-STING pathway: Implications for osteoarthritis pathogenesis and treatment strategy"],"prefix":"10.1016","volume":"357","author":[{"given":"Li-Jen","family":"Soh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siam-Yee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1193-5149","authenticated-orcid":false,"given":"Margaret M.","family":"Roebuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6705-2521","authenticated-orcid":false,"given":"Pooi-Fong","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2024.123112_bb0005","doi-asserted-by":"crossref","first-page":"16072","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"10182","key":"10.1016\/j.lfs.2024.123112_bb0010","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.lfs.2024.123112_bb0015","doi-asserted-by":"crossref","first-page":"105207","DOI":"10.1016\/j.jbspin.2021.105207","article-title":"Physical activity for osteoarthritis: efficiency and review of recommandations","volume":"88","author":"Daste","year":"2021","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.lfs.2024.123112_bb0020","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bmb\/lds038","article-title":"Epidemiology and burden of osteoarthritis","volume":"105","author":"Litwic","year":"2013","journal-title":"Br. Med. Bull."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0025","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.joca.2009.08.010","article-title":"Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis","volume":"18","author":"Blagojevic","year":"2010","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0030","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s12891-020-03367-2","article-title":"Risk factors and the natural history of accelerated knee osteoarthritis: a narrative review","volume":"21","author":"Driban","year":"2020","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.lfs.2024.123112_bb0035","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1186\/s12889-015-2529-0","article-title":"Osteoarthritis prevalence and modifiable factors: a population study","volume":"15","author":"Plotnikoff","year":"2015","journal-title":"BMC Public Health"},{"issue":"3","key":"10.1016\/j.lfs.2024.123112_bb0040","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1002\/acr.22952","article-title":"Dietary fat intake and radiographic progression of knee osteoarthritis: data from the osteoarthritis initiative","volume":"69","author":"Lu","year":"2017","journal-title":"Arthritis Care Res. (Hoboken)"},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0045","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/art.39842","article-title":"Review: metabolic regulation of inflammation in osteoarthritis","volume":"69","author":"Berenbaum","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.lfs.2024.123112_bb0050","doi-asserted-by":"crossref","first-page":"114118","DOI":"10.1016\/j.biopha.2022.114118","article-title":"Exercise induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K\/Akt\/NF-kappaB and NLRP3\/caspase-1\/GSDMD signaling","volume":"158","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.lfs.2024.123112_bb0055","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"8","key":"10.1016\/j.lfs.2024.123112_bb0060","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11926-019-0837-6","article-title":"The role of chondrocyte morphology and volume in controlling phenotype-implications for osteoarthritis, cartilage repair, and cartilage engineering","volume":"21","author":"Hall","year":"2019","journal-title":"Curr. Rheumatol. Rep."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0065","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/jor.23768","article-title":"Calcium signaling of in situ chondrocytes in articular cartilage under compressive loading: roles of calcium sources and cell membrane ion channels","volume":"36","author":"Lv","year":"2018","journal-title":"J. Orthop. Res."},{"issue":"6","key":"10.1016\/j.lfs.2024.123112_bb0070","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/1941738109350438","article-title":"The basic science of articular cartilage: structure, composition, and function","volume":"1","author":"Sophia Fox","year":"2009","journal-title":"Sports Health"},{"issue":"6","key":"10.1016\/j.lfs.2024.123112_bb0075","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1007\/s00167-016-4068-3","article-title":"Early osteoarthritis of the knee","volume":"24","author":"Madry","year":"2016","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"10.1016\/j.lfs.2024.123112_bb0080","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejr.2022.09.002","article-title":"Diagnostic value of matrix metalloproteinases-1, \u22123 and \u221213 in patients with primary knee osteoarthritis: relation to radiological severity","volume":"45","author":"Elamir","year":"2023","journal-title":"Egypt. Rheumatologist"},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0085","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13075-017-1229-9","article-title":"Synovitis in osteoarthritis: current understanding with therapeutic implications","volume":"19","author":"Mathiessen","year":"2017","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0090","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/jcp.30537","article-title":"IRE1 signaling regulates chondrocyte apoptosis and death fate in the osteoarthritis","volume":"237","author":"Huang","year":"2022","journal-title":"J. Cell. Physiol."},{"issue":"44","key":"10.1016\/j.lfs.2024.123112_bb0095","doi-asserted-by":"crossref","first-page":"45495","DOI":"10.1074\/jbc.M406933200","article-title":"CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells","volume":"279","author":"Yamaguchi","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.lfs.2024.123112_bb0100","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1016\/j.joca.2016.10.018","article-title":"Development and preliminary evaluation of the OsteoArthritis Questionnaire (OA-Quest): a psychometric study: methodological issues","volume":"25","author":"Safiri","year":"2017","journal-title":"Osteoarthr. Cartil."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0105","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molcel.2017.06.017","article-title":"The unfolded protein response and cell fate control","volume":"69","author":"Hetz","year":"2018","journal-title":"Mol. Cell"},{"issue":"7","key":"10.1016\/j.lfs.2024.123112_bb0110","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1111\/febs.12170","article-title":"Intracellular accumulation of advanced glycation end products induces apoptosis via endoplasmic reticulum stress in chondrocytes","volume":"280","author":"Yamabe","year":"2013","journal-title":"FEBS J."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0115","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41573-021-00320-3","article-title":"Pharmacological targeting of endoplasmic reticulum stress in disease","volume":"21","author":"Marciniak","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2\u20133","key":"10.1016\/j.lfs.2024.123112_bb0120","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s10237-006-0020-7","article-title":"Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields","volume":"5","author":"Knight","year":"2006","journal-title":"Biomech. Model. Mechanobiol."},{"issue":"3","key":"10.1016\/j.lfs.2024.123112_bb0125","doi-asserted-by":"crossref","first-page":"H634","DOI":"10.1152\/ajpheart.00717.2011","article-title":"Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling","volume":"302","author":"Bubolz","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0130","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s13075-016-1070-6","article-title":"The unfolded protein response genes in human osteoarthritic chondrocytes: PERK emerges as a potential therapeutic target","volume":"18","author":"Li","year":"2016","journal-title":"Arthritis Res. Ther."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0135","doi-asserted-by":"crossref","first-page":"75","DOI":"10.15430\/JCP.2014.19.2.75","article-title":"Endoplasmic reticulum stress and cancer","volume":"19","author":"Yadav","year":"2014","journal-title":"J. Cancer Prev."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010230","article-title":"The role of ER stress in diabetes: exploring pathological mechanisms using Wolfram syndrome","volume":"24","author":"Morikawa","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2024.123112_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18030665","article-title":"Endoplasmic reticulum stress and unfolded protein response in cartilage pathophysiology; contributing factors to apoptosis and osteoarthritis","volume":"18","author":"Hughes","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.lfs.2024.123112_bb0150","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/jbmr.2484","article-title":"ER stress during the pubertal growth spurt results in impaired long-bone growth in chondrocyte-specific ERp57 knockout mice","volume":"30","author":"Linz","year":"2015","journal-title":"J. Bone Miner. Res."},{"issue":"4","key":"10.1016\/j.lfs.2024.123112_bb0155","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2613.2010.00758.x","article-title":"Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage","volume":"92","author":"Takada","year":"2011","journal-title":"Int. J. Exp. Pathol."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0160","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13075-019-1988-6","article-title":"Cartilage endoplasmic reticulum stress may influence the onset but not the progression of experimental osteoarthritis","volume":"21","author":"Kung","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.lfs.2024.123112_bb0165","doi-asserted-by":"crossref","first-page":"101249","DOI":"10.1016\/j.arr.2020.101249","article-title":"The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis","volume":"66","author":"Zheng","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0170","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12964-023-01150-z","article-title":"Osteoarthritic chondrocytes undergo a glycolysis-related metabolic switch upon exposure to IL-1b or TNF","volume":"21","author":"Defois","year":"2023","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0175","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/13510002.2018.1445581","article-title":"Taurine alleviates endoplasmic reticulum stress in the chondrocytes from patients with osteoarthritis","volume":"23","author":"Bian","year":"2018","journal-title":"Redox Rep."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0180","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.cellsig.2013.11.018","article-title":"ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage","volume":"26","author":"Guo","year":"2014","journal-title":"Cell. Signal."},{"issue":"35","key":"10.1016\/j.lfs.2024.123112_bb0185","doi-asserted-by":"crossref","first-page":"31156","DOI":"10.1074\/jbc.M501069200","article-title":"Multiple signals induce endoplasmic reticulum stress in both primary and immortalized chondrocytes resulting in loss of differentiation, impaired cell growth, and apoptosis","volume":"280","author":"Yang","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.lfs.2024.123112_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041742","article-title":"Overview of MMP-13 as a promising target for the treatment of osteoarthritis","volume":"22","author":"Hu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"18","key":"10.1016\/j.lfs.2024.123112_bb0195","doi-asserted-by":"crossref","first-page":"11905","DOI":"10.1074\/jbc.M710557200","article-title":"AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response","volume":"283","author":"Luo","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2024.123112_bb0200","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.3389\/fimmu.2018.03083","article-title":"The C\/EBP homologous protein (CHOP) transcription factor functions in endoplasmic reticulum stress-induced apoptosis and microbial infection","volume":"9","author":"Hu","year":"2018","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.lfs.2024.123112_bb0205","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"18","author":"Sanchez-Lopez","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"issue":"Suppl 120(5)","key":"10.1016\/j.lfs.2024.123112_bb0210","first-page":"57","article-title":"Innate inflammation and synovial macrophages in osteoarthritis pathophysiology","volume":"37","author":"Griffin","year":"2019","journal-title":"Clin. Exp. Rheumatol."},{"issue":"11","key":"10.1016\/j.lfs.2024.123112_bb0215","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrrheum.2010.159","article-title":"The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis","volume":"6","author":"Sellam","year":"2010","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0220","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13075-019-1898-7","article-title":"Differential synovial tissue biomarkers among psoriatic arthritis and rheumatoid factor\/anti-citrulline antibody-negative rheumatoid arthritis","volume":"21","author":"Alivernini","year":"2019","journal-title":"Arthritis Res. Ther."},{"issue":"5","key":"10.1016\/j.lfs.2024.123112_bb0225","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.semarthrit.2013.10.005","article-title":"Importance of synovitis in osteoarthritis: evidence for the use of glycosaminoglycans against synovial inflammation","volume":"43","author":"Henrotin","year":"2014","journal-title":"Semin. Arthritis Rheum."},{"issue":"9","key":"10.1016\/j.lfs.2024.123112_bb0230","first-page":"1461","article-title":"What drives osteoarthritis?-synovial versus subchondral bone pathology","volume":"56","author":"H\u00fcgle","year":"2017","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0235","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","article-title":"The role of synovitis in osteoarthritis pathogenesis","volume":"51","author":"Scanzello","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.lfs.2024.123112_bb0240","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s13075-016-1083-1","article-title":"Suppression of the inflammatory response by disease-inducible interleukin-10 gene therapy in a three-dimensional micromass model of the human synovial membrane","volume":"18","author":"Broeren","year":"2016","journal-title":"Arthritis Res. Ther."},{"issue":"4","key":"10.1016\/j.lfs.2024.123112_bb0245","doi-asserted-by":"crossref","first-page":"R98","DOI":"10.1186\/ar2485","article-title":"Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane","volume":"10","author":"Huber","year":"2008","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.lfs.2024.123112_bb0250","doi-asserted-by":"crossref","first-page":"108082","DOI":"10.1016\/j.dib.2022.108082","article-title":"Histopathological dataset and demographic details of synovial tissues from patients with end-stage osteoarthritis, soft tissue and traumatic injuries of the knee","volume":"42","author":"Jamal","year":"2022","journal-title":"Data Brief"},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0255","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1074\/jbc.M208696200","article-title":"The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536","volume":"278","author":"Jiang","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"6059","key":"10.1016\/j.lfs.2024.123112_bb0260","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.lfs.2024.123112_bb0265","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/FJC.0000000000001465","article-title":"The STING-IRF3 signaling pathway, mediated by endoplasmic reticulum stress, contributes to impaired myocardial autophagic flux after ischemia\/reperfusion","volume":"82","author":"Li","year":"2023","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"8","key":"10.1016\/j.lfs.2024.123112_bb0270","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/ncb0805-758","article-title":"Ubiquitin signalling in the NF-kappaB pathway","volume":"7","author":"Chen","year":"2005","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.lfs.2024.123112_bb0275","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/molehr\/gaz002","article-title":"Involvement of endoplasmic reticulum stress in regulation of endometrial stromal cell invasiveness: possible role in pathogenesis of endometriosis","volume":"25","author":"Choi","year":"2019","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.lfs.2024.123112_bb0280","first-page":"8","article-title":"Obesity-related knee osteoarthritis-current concepts","volume":"13","author":"Shumnalieva","year":"2023","journal-title":"Life (Basel)"},{"issue":"10","key":"10.1016\/j.lfs.2024.123112_bb0285","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.molmed.2012.06.010","article-title":"ER stress-induced inflammation: does it aid or impede disease progression?","volume":"18","author":"Garg","year":"2012","journal-title":"Trends Mol. Med."},{"issue":"5","key":"10.1016\/j.lfs.2024.123112_bb0290","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/10799893.2017.1360353","article-title":"JNK pathway in osteoarthritis: pathological and therapeutic aspects","volume":"37","author":"Ge","year":"2017","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"10.1016\/j.lfs.2024.123112_bb0295","doi-asserted-by":"crossref","first-page":"109249","DOI":"10.1016\/j.biopha.2019.109249","article-title":"Cancer and ER stress: mutual crosstalk between autophagy, oxidative stress and inflammatory response","volume":"118","author":"Lin","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.lfs.2024.123112_bb0300","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.tips.2018.03.010","article-title":"ER stress: a therapeutic target in rheumatoid arthritis?","volume":"39","author":"Rahmati","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"issue":"9","key":"10.1016\/j.lfs.2024.123112_bb0305","doi-asserted-by":"crossref","first-page":"e1879","DOI":"10.1038\/cddis.2015.248","article-title":"ER stress induces NLRP3 inflammasome activation and hepatocyte death","volume":"6","author":"Lebeaupin","year":"2015","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0310","doi-asserted-by":"crossref","first-page":"e1247","DOI":"10.1002\/cti2.1247","article-title":"The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory disorders","volume":"10","author":"Chong","year":"2021","journal-title":"Clin. Transl. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0315","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cmet.2012.07.005","article-title":"Thioredoxin-interacting protein mediates ER stress-induced \u03b2 cell death through initiation of the inflammasome","volume":"16","author":"Oslowski","year":"2012","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.lfs.2024.123112_bb0320","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.immuni.2015.08.008","article-title":"Endoplasmic reticulum stress activates the inflammasome via NLRP3- and Caspase-2-driven mitochondrial damage","volume":"43","author":"Bronner","year":"2015","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.lfs.2024.123112_bb0325","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s41580-020-0244-x","article-title":"Molecular mechanisms and cellular functions of cGAS-STING signalling","volume":"21","author":"Hopfner","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0330","doi-asserted-by":"crossref","first-page":"183","DOI":"10.24272\/j.issn.2095-8137.2022.464","article-title":"Current understanding of the cGAS-STING signaling pathway: structure, regulatory mechanisms, and related diseases","volume":"44","author":"Pan","year":"2023","journal-title":"Zool. Res."},{"issue":"24","key":"10.1016\/j.lfs.2024.123112_bb0335","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.15252\/embj.201488726","article-title":"Cytosolic RNA:DNA hybrids activate the cGAS-STING axis","volume":"33","author":"Mankan","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.lfs.2024.123112_bb0340","doi-asserted-by":"crossref","first-page":"741599","DOI":"10.3389\/fimmu.2021.741599","article-title":"Roles of emerging RNA-binding activity of cGAS in innate antiviral response","volume":"12","author":"Ma","year":"2021","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0345","doi-asserted-by":"crossref","first-page":"e51800","DOI":"10.15252\/embr.202051800","article-title":"Regulation of cGAS activity by RNA-modulated phase separation","volume":"24","author":"Chen","year":"2023","journal-title":"EMBO Rep."},{"issue":"7676","key":"10.1016\/j.lfs.2024.123112_bb0350","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature24050","article-title":"Cytoplasmic chromatin triggers inflammation in senescence and cancer","volume":"550","author":"Dou","year":"2017","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.lfs.2024.123112_bb0355","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/ncb3586","article-title":"Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence","volume":"19","author":"Gl\u00fcck","year":"2017","journal-title":"Nat. Cell Biol."},{"issue":"9","key":"10.1016\/j.lfs.2024.123112_bb0360","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098151","article-title":"Role of cGAS-Sting signaling in Alzheimer\u2019s disease","volume":"24","author":"Govindarajulu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.lfs.2024.123112_bb0365","doi-asserted-by":"crossref","first-page":"E4612","DOI":"10.1073\/pnas.1705499114","article-title":"cGAS is essential for cellular senescence","volume":"114","author":"Yang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0370","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2019.05.036","article-title":"STING polymer structure reveals mechanisms for activation, Hyperactivation, and inhibition","volume":"178","author":"Ergun","year":"2019","journal-title":"Cell"},{"issue":"7748","key":"10.1016\/j.lfs.2024.123112_bb0375","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41586-019-0998-5","article-title":"Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP","volume":"567","author":"Shang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2024.123112_bb0380","doi-asserted-by":"crossref","first-page":"11932","DOI":"10.1038\/ncomms11932","article-title":"Activation of STING requires palmitoylation at the Golgi","volume":"7","author":"Mukai","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0385","doi-asserted-by":"crossref","first-page":"107492","DOI":"10.1016\/j.celrep.2020.03.056","article-title":"TBK1 and IKKepsilon act redundantly to mediate STING-induced NF-kappaB responses in myeloid cells","volume":"31","author":"Balka","year":"2020","journal-title":"Cell Rep."},{"issue":"7748","key":"10.1016\/j.lfs.2024.123112_bb0390","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41586-019-1000-2","article-title":"Structural basis of STING binding with and phosphorylation by TBK1","volume":"567","author":"Zhang","year":"2019","journal-title":"Nature"},{"issue":"6227","key":"10.1016\/j.lfs.2024.123112_bb0395","doi-asserted-by":"crossref","first-page":"aaa2630","DOI":"10.1126\/science.aaa2630","article-title":"Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation","volume":"347","author":"Liu","year":"2015","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.lfs.2024.123112_bb0400","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.1128\/JVI.00037-14","article-title":"Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-\u03baB activation through TBK1","volume":"88","author":"Abe","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.lfs.2024.123112_bb0405","doi-asserted-by":"crossref","first-page":"110022","DOI":"10.1016\/j.biopha.2020.110022","article-title":"STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress","volume":"125","author":"Zhang","year":"2020","journal-title":"Biomed. Pharmacother. Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.lfs.2024.123112_bb0410","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.joca.2009.09.008","article-title":"Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes","volume":"18","author":"Kim","year":"2010","journal-title":"Osteoarthr. Cartil."},{"issue":"4","key":"10.1016\/j.lfs.2024.123112_bb0415","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2019.02.038","article-title":"Interleukin-1beta induces mtDNA release to activate innate immune signaling via cGAS-STING","volume":"74","author":"Aarreberg","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.lfs.2024.123112_bb0420","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2018.08.038","article-title":"Reactive oxygen species, aging and articular cartilage homeostasis","volume":"132","author":"Bolduc","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.lfs.2024.123112_bb0425","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1177\/15353702221087966","article-title":"Identification in synovial fluid of a new potential pathogenic player in arthropathies","volume":"247","author":"Scanu","year":"2022","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0430","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41419-020-03341-9","article-title":"STING promotes senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the NF-kappaB signaling pathway","volume":"12","author":"Guo","year":"2021","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.lfs.2024.123112_bb0435","doi-asserted-by":"crossref","first-page":"336","DOI":"10.5483\/BMBRep.2019.52.5.072","article-title":"Induction of pro-inflammatory cytokines by 29-kDa FN-f via cGAS\/STING pathway","volume":"52","author":"Hwang","year":"2019","journal-title":"BMB Rep."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0440","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13075-023-03075-x","article-title":"STING mediates experimental osteoarthritis and mechanical allodynia in mouse","volume":"25","author":"Shin","year":"2023","journal-title":"Arthritis Res. Ther."},{"issue":"4","key":"10.1016\/j.lfs.2024.123112_bb0445","doi-asserted-by":"crossref","first-page":"e22867","DOI":"10.1096\/fj.202201600R","article-title":"The STING inhibitor C-176 attenuates osteoclast-related osteolytic diseases by inhibiting osteoclast differentiation","volume":"37","author":"Yu","year":"2023","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.lfs.2024.123112_bb0450","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s12276-020-0416-y","article-title":"The cGAS\/STING\/TBK1\/IRF3 innate immunity pathway maintains chromosomal stability through regulation of p21 levels","volume":"52","author":"Basit","year":"2020","journal-title":"Exp. Mol. Med."},{"issue":"9","key":"10.1016\/j.lfs.2024.123112_bb0455","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS-STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2024.123112_bb0460","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3389\/fimmu.2020.00615","article-title":"Research advances in how the cGAS-STING pathway controls the cellular inflammatory response","volume":"11","author":"Wan","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2024.123112_bb0465","doi-asserted-by":"crossref","first-page":"105800","DOI":"10.1016\/j.biocel.2020.105800","article-title":"Modulation of the mechanical responses of synovial fibroblasts by osteoarthritis-associated inflammatory stressors","volume":"126","author":"Jamal","year":"2020","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0470","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/acel.12562","article-title":"Cellular senescence in osteoarthritis pathology","volume":"16","author":"McCulloch","year":"2017","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0475","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/s41467-018-03555-8","article-title":"Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells","volume":"9","author":"Takahashi","year":"2018","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.lfs.2024.123112_bb0480","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1002\/jcb.23298","article-title":"ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis","volume":"112","author":"Verma","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.lfs.2024.123112_bb0485","doi-asserted-by":"crossref","first-page":"561459","DOI":"10.1155\/2014\/561459","article-title":"The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis","volume":"2014","author":"Wojdasiewicz","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.lfs.2024.123112_bb0490","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fcimb.2016.00182","article-title":"Mycobacterium bovis induces endoplasmic reticulum stress mediated-apoptosis by activating IRF3 in a murine macrophage cell line","volume":"6","author":"Cui","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"9","key":"10.1016\/j.lfs.2024.123112_bb0495","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.4049\/jimmunol.1102737","article-title":"Endoplasmic reticulum stress regulates the innate immunity critical transcription factor IRF3","volume":"189","author":"Liu","year":"2012","journal-title":"J. Immunol."},{"issue":"41","key":"10.1016\/j.lfs.2024.123112_bb0500","doi-asserted-by":"crossref","first-page":"16544","DOI":"10.1073\/pnas.1308331110","article-title":"STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease","volume":"110","author":"Petrasek","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0505","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1523\/JNEUROSCI.0718-19.2019","article-title":"Aberrant ER stress induced neuronal-IFN\u03b2 elicits white matter injury due to microglial activation and T-cell infiltration after TBI","volume":"40","author":"Sen","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2024.123112_bb0510","doi-asserted-by":"crossref","first-page":"611347","DOI":"10.3389\/fimmu.2020.611347","article-title":"STING, the endoplasmic reticulum, and mitochondria: is three a crowd or a conversation?","volume":"11","author":"Smith","year":"2020","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0515","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2012.07.007","article-title":"IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress","volume":"16","author":"Lerner","year":"2012","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0520","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4239\/wjd.v8.i2.56","article-title":"High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation: role of endoplasmic-reticulum-stress","volume":"8","author":"Coucha","year":"2017","journal-title":"World J. Diabetes"},{"issue":"10","key":"10.1016\/j.lfs.2024.123112_bb0525","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nchembio1006-509","article-title":"Flipping the safety catch of procaspase-3","volume":"2","author":"Porter","year":"2006","journal-title":"Nat. Chem. Biol."},{"issue":"7","key":"10.1016\/j.lfs.2024.123112_bb0530","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.cell.2014.11.036","article-title":"Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production","volume":"159","author":"White","year":"2014","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.lfs.2024.123112_bb0535","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1084\/jem.20182192","article-title":"STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death","volume":"216","author":"Wu","year":"2019","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.lfs.2024.123112_bb0540","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1158\/0008-5472.CAN-15-1885","article-title":"Agonist-mediated activation of STING induces apoptosis in malignant B cells","volume":"76","author":"Tang","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2024.123112_bb0545","doi-asserted-by":"crossref","first-page":"748485","DOI":"10.3389\/fcell.2021.748485","article-title":"Crosstalk between autophagy and the cGAS-STING signaling pathway in type I interferon production","volume":"9","author":"Zhang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.lfs.2024.123112_bb0550","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1038\/s41418-020-00624-8","article-title":"Crosstalk between cGAS-STING signaling and cell death","volume":"27","author":"Murthy","year":"2020","journal-title":"Cell Death Differ."},{"issue":"49","key":"10.1016\/j.lfs.2024.123112_bb0555","doi-asserted-by":"crossref","first-page":"20842","DOI":"10.1073\/pnas.0911267106","article-title":"Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response","volume":"106","author":"Saitoh","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7747","key":"10.1016\/j.lfs.2024.123112_bb0560","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41586-019-1006-9","article-title":"Autophagy induction via STING trafficking is a primordial function of the cGAS pathway","volume":"567","author":"Gui","year":"2019","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.lfs.2024.123112_bb0565","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41418-018-0251-z","article-title":"STING directly activates autophagy to tune the innate immune response","volume":"26","author":"Liu","year":"2019","journal-title":"Cell Death Differ."},{"issue":"8","key":"10.1016\/j.lfs.2024.123112_bb0570","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201797858","article-title":"Attenuation of cGAS-STING signaling is mediated by a p62\/SQSTM1-dependent autophagy pathway activated by TBK1","volume":"37","author":"Prabakaran","year":"2018","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0575","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.chom.2014.01.009","article-title":"Crosstalk between the cGAS DNA sensor and beclin-1 autophagy protein shapes innate antimicrobial immune responses","volume":"15","author":"Liang","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.lfs.2024.123112_bb0580","doi-asserted-by":"crossref","first-page":"116786","DOI":"10.1016\/j.lfs.2019.116786","article-title":"The role of matrix metalloproteinases in osteoarthritis pathogenesis: an updated review","volume":"234","author":"Mehana","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2024.123112_bb0585","doi-asserted-by":"crossref","DOI":"10.1177\/1076029620964864","article-title":"Interrelationship of osteopontin, MMP-9 and ADAMTS4 in patients with osteoarthritis undergoing total joint arthroplasty","volume":"26","author":"Slovacek","year":"2020","journal-title":"Clin. Appl. Thromb. Hemost."},{"issue":"2","key":"10.1016\/j.lfs.2024.123112_bb0590","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3892\/mmr.2016.6077","article-title":"Expression of MMPs is dependent on the activity of mitogen-activated protein kinase in chondrosarcoma","volume":"15","author":"Yao","year":"2017","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.lfs.2024.123112_bb0595","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/ar401","article-title":"Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors","volume":"4","author":"Vincenti","year":"2002","journal-title":"Arthritis Res."},{"issue":"11","key":"10.1016\/j.lfs.2024.123112_bb0600","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41576-019-0151-1","article-title":"DNA sensing by the cGAS-STING pathway in health and disease","volume":"20","author":"Motwani","year":"2019","journal-title":"Nat. Rev. Genet."},{"issue":"14","key":"10.1016\/j.lfs.2024.123112_bb0605","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1128\/MCB.23.14.4739-4752.2003","article-title":"NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity","volume":"23","author":"Beinke","year":"2003","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.lfs.2024.123112_bb0610","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1097-2765(03)00070-4","article-title":"NF-kappaB1\/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase","volume":"11","author":"Waterfield","year":"2003","journal-title":"Mol. Cell"},{"issue":"21","key":"10.1016\/j.lfs.2024.123112_bb0615","doi-asserted-by":"crossref","first-page":"9658","DOI":"10.1128\/MCB.24.21.9658-9667.2004","article-title":"Lipopolysaccharide activation of the TPL-2\/MEK\/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105","volume":"24","author":"Beinke","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"13","key":"10.1016\/j.lfs.2024.123112_bb0620","doi-asserted-by":"crossref","first-page":"6040","DOI":"10.1128\/MCB.24.13.6040-6048.2004","article-title":"IkappaB kinase is an essential component of the Tpl2 signaling pathway","volume":"24","author":"Waterfield","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.lfs.2024.123112_bb0625","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/j.apsb.2020.03.001","article-title":"Small molecules targeting the innate immune cGAS\u2013STING\u2013TBK1 signaling pathway","volume":"10","author":"Ding","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0630","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.apsb.2021.05.011","article-title":"The cGAS-STING signaling in cardiovascular and metabolic diseases: future novel target option for pharmacotherapy","volume":"12","author":"Oduro","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"7","key":"10.1016\/j.lfs.2024.123112_bb0635","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.celrep.2015.04.031","article-title":"Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity","volume":"11","author":"Corrales","year":"2015","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0640","doi-asserted-by":"crossref","first-page":"1777624","DOI":"10.1080\/2162402X.2020.1777624","article-title":"Trial watch: STING agonists in cancer therapy","volume":"9","author":"Le Naour","year":"2020","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.lfs.2024.123112_bb0645","doi-asserted-by":"crossref","first-page":"viii712","DOI":"10.1093\/annonc\/mdy424.015","article-title":"Preliminary results of the first-in-human (FIH) study of MK-1454, an agonist of stimulator of interferon genes (STING), as monotherapy or in combination with pembrolizumab (pembro) in patients with advanced solid tumors or lymphomas","volume":"29","author":"Harrington","year":"2018","journal-title":"Ann. Oncol."},{"issue":"4","key":"10.1016\/j.lfs.2024.123112_bb0650","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1158\/1078-0432.CCR-21-1963","article-title":"Phase I dose-escalation trial of MIW815 (ADU-S100), an intratumoral STING agonist, in patients with advanced\/metastatic solid tumors or lymphomas","volume":"28","author":"Meric-Bernstam","year":"2022","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0655","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1158\/1078-0432.CCR-22-2235","article-title":"Combination of the STING agonist MIW815 (ADU-S100) and PD-1 inhibitor spartalizumab in advanced\/metastatic solid tumors or lymphomas: An open-label, multicenter, phase Ib Study","volume":"29","author":"Meric-Bernstam","year":"2023","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.lfs.2024.123112_bb0660","doi-asserted-by":"crossref","first-page":"814709","DOI":"10.3389\/fimmu.2021.814709","article-title":"The cGAS-STING pathway in bacterial infection and bacterial immunity","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0665","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1038\/s41467-019-08620-4","article-title":"Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression","volume":"10","author":"Lama","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0670","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/s41467-017-00833-9","article-title":"Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice","volume":"8","author":"Vincent","year":"2017","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.lfs.2024.123112_bb0675","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1002\/art.40559","article-title":"Inhibition of cyclic GMP-AMP synthase using a novel antimalarial drug derivative in Trex1-deficient mice","volume":"70","author":"An","year":"2018","journal-title":"Arthritis Rheumatol."},{"issue":"9","key":"10.1016\/j.lfs.2024.123112_bb0680","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.4049\/jimmunol.1402793","article-title":"Cutting edge: antimalarial drugs inhibit IFN-\u03b2 production through blockade of cyclic GMP-AMP synthase-DNA interaction","volume":"194","author":"An","year":"2015","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.lfs.2024.123112_bb0685","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.4155\/fmc-2017-0322","article-title":"Suramin potently inhibits cGAMP synthase, cGAS, in THP1 cells to modulate IFN-beta levels","volume":"10","author":"Wang","year":"2018","journal-title":"Future Med. Chem."},{"issue":"4","key":"10.1016\/j.lfs.2024.123112_bb0690","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/eji.201747338","article-title":"Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes","volume":"48","author":"Steinhagen","year":"2018","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2024.123112_bb0695","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1021\/acs.joc.9b02666","article-title":"Discovery of small-molecule cyclic GMP-AMP synthase inhibitors","volume":"85","author":"Padilla-Salinas","year":"2020","journal-title":"J. Org. Chem."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0700","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1021\/acsmedchemlett.8b00466","article-title":"Discovery of a novel cGAMP competitive ligand of the inactive form of STING","volume":"10","author":"Siu","year":"2019","journal-title":"ACS Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0705","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10565-021-09692-z","article-title":"Lipotoxicity-induced mtDNA release promotes diabetic cardiomyopathy by activating the cGAS-STING pathway in obesity-related diabetes","volume":"39","author":"Ma","year":"2023","journal-title":"Cell Biol. Toxicol."},{"issue":"33","key":"10.1016\/j.lfs.2024.123112_bb0710","doi-asserted-by":"crossref","first-page":"E7768","DOI":"10.1073\/pnas.1806239115","article-title":"Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling","volume":"115","author":"Hansen","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7713","key":"10.1016\/j.lfs.2024.123112_bb0715","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41586-018-0287-8","article-title":"Targeting STING with covalent small-molecule inhibitors","volume":"559","author":"Haag","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0720","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12079-017-0438-y","article-title":"Assessment of TANK-binding kinase 1 as a therapeutic target in cancer","volume":"12","author":"Cruz","year":"2018","journal-title":"J. Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0725","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1021\/cb500908d","article-title":"Identification and further development of potent TBK1 inhibitors","volume":"10","author":"Richters","year":"2015","journal-title":"ACS Chem. Biol."},{"issue":"7699","key":"10.1016\/j.lfs.2024.123112_bb0730","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature25986","article-title":"Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1","volume":"556","author":"Mills","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2024.123112_bb0735","doi-asserted-by":"crossref","first-page":"114935","DOI":"10.1016\/j.bcp.2022.114935","article-title":"Itaconate attenuates osteoarthritis by inhibiting STING\/NF-kappaB axis in chondrocytes and promoting M2 polarization in macrophages","volume":"198","author":"Ni","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2024.123112_bb0740","doi-asserted-by":"crossref","first-page":"101309","DOI":"10.1016\/j.redox.2019.101309","article-title":"The Nrf2 activator RTA-408 attenuates osteoclastogenesis by inhibiting STING dependent NF-kappab signaling","volume":"28","author":"Sun","year":"2020","journal-title":"Redox Biol."},{"issue":"9","key":"10.1016\/j.lfs.2024.123112_bb0745","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1021\/np060156y","article-title":"Alkaloids from Gelsemium elegans","volume":"69","author":"Xu","year":"2006","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.lfs.2024.123112_bb0750","doi-asserted-by":"crossref","first-page":"114975","DOI":"10.1016\/j.bcp.2022.114975","article-title":"Gelsevirine improves age-related and surgically induced osteoarthritis in mice by reducing STING availability and local inflammation","volume":"198","author":"Feng","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"11","key":"10.1016\/j.lfs.2024.123112_bb0755","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrrheum.2012.130","article-title":"Bone remodelling in osteoarthritis","volume":"8","author":"Burr","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.lfs.2024.123112_bb0760","doi-asserted-by":"crossref","first-page":"109880","DOI":"10.1016\/j.cellsig.2020.109880","article-title":"Review: ER stress-induced cell death in osteoarthritic cartilage","volume":"78","author":"Rellmann","year":"2021","journal-title":"Cell. Signal."},{"issue":"5","key":"10.1016\/j.lfs.2024.123112_bb0765","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1302\/2046-3758.45.2000378","article-title":"Chondroprotective effects of Salubrinal in a mouse model of osteoarthritis","volume":"4","author":"Hamamura","year":"2015","journal-title":"Bone Joint Res."},{"issue":"6","key":"10.1016\/j.lfs.2024.123112_bb0770","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1093\/brain\/awx074","article-title":"Repurposed drugs targeting eIF2\u03b1-P-mediated translational repression prevent neurodegeneration in mice","volume":"140","author":"Halliday","year":"2017","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.lfs.2024.123112_bb0775","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/sj.embor.7400779","article-title":"Mediators of endoplasmic reticulum stress-induced apoptosis","volume":"7","author":"Szegezdi","year":"2006","journal-title":"EMBO Rep."},{"issue":"1","key":"10.1016\/j.lfs.2024.123112_bb0780","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10010108","article-title":"Targeting endoplasmic reticulum stress as an effective treatment for alcoholic pancreatitis","volume":"10","author":"Li","year":"2022","journal-title":"Biomedicines"},{"issue":"16","key":"10.1016\/j.lfs.2024.123112_bb0785","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1021\/jm300713s","article-title":"Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)","volume":"55","author":"Axten","year":"2012","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.lfs.2024.123112_bb0790","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1021\/ml400228e","article-title":"Discovery of GSK2656157: an optimized PERK inhibitor selected for preclinical development","volume":"4","author":"Axten","year":"2013","journal-title":"ACS Med. Chem. Lett."},{"issue":"3","key":"10.1016\/j.lfs.2024.123112_bb0795","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/febs.15372","article-title":"Peptidomimetic-based identification of FDA-approved compounds inhibiting IRE1 activity","volume":"288","author":"Doultsinos","year":"2021","journal-title":"FEBS J."},{"issue":"8","key":"10.1016\/j.lfs.2024.123112_bb0800","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/ard.60.8.729","article-title":"Anti-inflammatory mechanisms of methotrexate in rheumatoid arthritis","volume":"60","author":"Cutolo","year":"2001","journal-title":"Ann. Rheum. Dis."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524007021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524007021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:22:28Z","timestamp":1778642548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524007021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":160,"alternative-id":["S0024320524007021"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.123112","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unravelling the interplay between ER stress, UPR and the cGAS-STING pathway: Implications for osteoarthritis pathogenesis and treatment strategy","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.123112","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123112"}}