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Sci."},{"key":"10.1016\/j.lfs.2024.123155_bb0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122167","article-title":"Transferrin-functionalized liposomes loaded with vitamin VB12 for Alzheimer\u2019s disease therapy","volume":"626","author":"Andrade","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.lfs.2024.123155_bb0505","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1018336","article-title":"Lactoferrin: A glycoprotein that plays an active role in human health","volume":"9","author":"Cao","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.lfs.2024.123155_bb0510","doi-asserted-by":"crossref","DOI":"10.3390\/app11094305","article-title":"Surface functionalization of plga nanoparticles to increase transport across the bbb for alzheimer\u2019s disease","volume":"11","author":"Del Amo","year":"2021","journal-title":"Appl. Sci."},{"key":"10.1016\/j.lfs.2024.123155_bb0515","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4103\/1673-5374.344841","article-title":"Lactoferrin modification of berberine nanoliposomes enhances the neuroprotective effects in a mouse model of Alzheimer\u2019s disease","volume":"18","author":"Wang","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.lfs.2024.123155_bb0520","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1021\/acs.bioconjchem.9b00505","article-title":"Lactoferrin Coupled Lower Generation PAMAM Dendrimers for Brain Targeted Delivery of Memantine in Aluminum-Chloride-Induced Alzheimer\u2019s Disease in Mice","volume":"30","author":"Gothwal","year":"2019","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.lfs.2024.123155_bb0525","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22095010","article-title":"Glutathione in the brain","volume":"22","author":"Aoyama","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2024.123155_bb0530","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.brainres.2015.03.018","article-title":"Targeting transporters: Promoting blood-brain barrier repair in response to oxidative stress injury","volume":"1623","author":"Ronaldson","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.lfs.2024.123155_bb0535","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1021\/acs.molpharmaceut.6b00738","article-title":"Optimization of Curcumin-Loaded PEG-PLGA Nanoparticles by GSH Functionalization: Investigation of the Internalization Pathway in Neuronal Cells","volume":"14","author":"Paka","year":"2017","journal-title":"Mol. 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Nanomedicine"},{"key":"10.1016\/j.lfs.2024.123155_bb0620","article-title":"Transferrin functionalized nanostructured lipid carriers for targeting Rivastigmine and Resveratrol to Alzheimer\u2019s disease: Synthesis, in vitro characterization and brain uptake analysis","volume":"86","author":"Jain","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.lfs.2024.123155_bb0625","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2147\/IJN.S151474","article-title":"Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of alzheimer\u2019s disease","volume":"13","author":"Meng","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.lfs.2024.123155_bb0630","first-page":"205","article-title":"Preparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil, Drug Des","volume":"10","author":"Al Asmari","year":"2016","journal-title":"Devel. Ther."},{"key":"10.1016\/j.lfs.2024.123155_bb0635","first-page":"1","article-title":"ApoE-targeting increases the transfer of solid lipid nanoparticles with donepezil cargo across a culture model of the blood\u2013brain barrier","volume":"13","author":"Topal","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.lfs.2024.123155_bb0640","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1021\/acs.molpharmaceut.6b00781","article-title":"Biomimetic ApoE-Reconstituted High Density Lipoprotein Nanocarrier for Blood-Brain Barrier Penetration and Amyloid Beta-Targeting Drug Delivery","volume":"13","author":"S. Q., S. H., X. J., H. J., H. M., G.G.G. X., C. J., Z. G., C. H., G.G.G. 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Neurosci."},{"key":"10.1016\/j.lfs.2024.123155_bb0685","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/9781119769897.ch7","article-title":"Safety and toxicity issues of polymeric nanoparticles a serious concern","author":"Patel","year":"2021","journal-title":"Nanotechnol. Med. Toxic. Saf."},{"key":"10.1016\/j.lfs.2024.123155_bb0690","first-page":"1673","article-title":"Effect of particle size on the biodistribution, toxicity, and efficacy of drug-loaded polymeric nanoparticles in chemoradiotherapy, Nanomedicine Nanotechnology","volume":"13","author":"Caster","year":"2017","journal-title":"Biol. 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