{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:56:45Z","timestamp":1773093405135,"version":"3.50.1"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.lfs.2024.123229","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T11:49:16Z","timestamp":1731412156000},"page":"123229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Hepatoprotective and neuroprotective effects of quinacrine against bile duct ligation-induced hepatic encephalopathy in rats: Role of bone morphogenetic proteins signaling"],"prefix":"10.1016","volume":"359","author":[{"given":"Manar M.","family":"Esmail","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha M.","family":"Saeed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana M.F.","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haidy E.","family":"Michel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem N.","family":"El-Naga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0253-8280","authenticated-orcid":false,"given":"Samar S.","family":"Azab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.lfs.2024.123229_bb0005","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.jhep.2020.07.013","article-title":"Hepatic encephalopathy: novel insights into classification, pathophysiology and therapy","volume":"73","author":"Rose","year":"2020","journal-title":"J. Hepatol."},{"issue":"12","key":"10.1016\/j.lfs.2024.123229_bb0010","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1007\/s00213-020-05633-6","article-title":"Curcumin prevents cognitive deficits in the bile duct ligated rats","volume":"237","author":"Baghbaderani","year":"2020","journal-title":"Psychopharmacology"},{"issue":"10","key":"10.1016\/j.lfs.2024.123229_bb0015","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1007\/s11064-021-03372-4","article-title":"Hepatic encephalopathy: from metabolic to neurodegenerative","volume":"46","author":"Ochoa-Sanchez","year":"2021","journal-title":"Neurochem. Res."},{"issue":"2","key":"10.1016\/j.lfs.2024.123229_bb0020","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.abb.2013.03.016","article-title":"Inflammation and hepatic encephalopathy","volume":"536","author":"Coltart","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"issue":"5","key":"10.1016\/j.lfs.2024.123229_bb0025","doi-asserted-by":"crossref","first-page":"G749","DOI":"10.1152\/ajpgi.00184.2011","article-title":"Liver-brain inflammation axis","volume":"301","author":"D\u2019Mello","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2024.123229_bb0030","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bbi.2018.03.002","article-title":"Systemic inflammation without gliosis mediates cognitive deficits through impaired BDNF expression in bile duct ligation model of hepatic encephalopathy","volume":"70","author":"Dhanda","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.lfs.2024.123229_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115548","article-title":"Discovery of bone morphogenetic proteins - A historical perspective","volume":"140","author":"Sampath","year":"2020","journal-title":"Bone"},{"issue":"8","key":"10.1016\/j.lfs.2024.123229_bb0040","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/s41374-018-0069-9","article-title":"BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-\u03b21 signaling","volume":"98","author":"Chung","year":"2018","journal-title":"Lab. Investig."},{"issue":"1","key":"10.1016\/j.lfs.2024.123229_bb0045","doi-asserted-by":"crossref","first-page":"9241","DOI":"10.1038\/s41598-018-27581-0","article-title":"BMP and WNT signalling cooperate through LEF1 in the neuronal specification of adult hippocampal neural stem and progenitor cells","volume":"8","author":"Armenteros","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2024.123229_bb0050","article-title":"BuMPing into neurogenesis: how the canonical BMP pathway regulates neural stem cell divisions throughout space and time","volume":"15","author":"Le Dr\u00e9au","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.lfs.2024.123229_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105760","article-title":"Wnt-3a alleviates neuroinflammation after ischemic stroke by modulating the responses of microglia\/macrophages and astrocytes","volume":"75","author":"Zhang","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"19","key":"10.1016\/j.lfs.2024.123229_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910660","article-title":"Quinacrine ameliorates cisplatin-induced renal toxicity via modulation of Sirtuin-1 pathway","volume":"22","author":"Abo El-Magd","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2024.123229_bb0065","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/630509","article-title":"The effects of quinacrine, proglumide, and pentoxifylline on seizure activity, cognitive deficit, and oxidative stress in rat lithium-pilocarpine model of status epilepticus","volume":"2014","author":"Ahmad","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.lfs.2024.123229_bb0070","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12882-017-0450-8","article-title":"Protective effect of quinacrine against glycerol-induced acute kidney injury in rats","volume":"18","author":"Al Asmari","year":"2017","journal-title":"BMC Nephrol."},{"issue":"7","key":"10.1016\/j.lfs.2024.123229_bb0075","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1007\/s12035-021-02351-8","article-title":"Quinacrine and Niclosamide promote neurite growth in midbrain dopaminergic neurons through the canonical BMP-Smad pathway and protect against neurotoxin and \u03b1-Synuclein-induced neurodegeneration","volume":"58","author":"Goulding","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.lfs.2024.123229_bb0080","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1478-3231.2009.02034.x","article-title":"Experimental models of hepatic encephalopathy: ISHEN guidelines","volume":"29","author":"Butterworth","year":"2009","journal-title":"Liver Int."},{"key":"10.1016\/j.lfs.2024.123229_bb0085","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.fct.2012.11.015","article-title":"Merit of quinacrine in the decrease of ingested sulfite-induced toxic action in rat brain","volume":"52","author":"Kencebay","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2024.123229_bb0090","doi-asserted-by":"crossref","unstructured":"Khader, A. A., Sulaiman, M. A., Kishore, P. N., Morais, C., & Tariq, M. (1996). QUINACRINE ATTENUATES CYCLOSPORINE-INDUCED NEPHROTOXICITY IN RATS1. 62(4), 427-435. https:\/\/journals.lww.com\/transplantjournal\/Fulltext\/1996\/08270\/QUINACRINE_ATTENUATES_CYCLOSPORINE_INDUCED.1.aspx.","DOI":"10.1097\/00007890-199608270-00001"},{"issue":"12","key":"10.1016\/j.lfs.2024.123229_bb0095","first-page":"158","volume":"11","author":"Fayez","year":"2021","journal-title":"Progression of hepatic encephalopathy induced by bile duct ligation versus thioacetamide in rats: Regulatory role of apigenin."},{"key":"10.1016\/j.lfs.2024.123229_bb0100","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.lfs.2018.09.037","article-title":"Paclitaxel alleviates liver fibrosis induced by bile duct ligation in rats: role of TGF-\u03b21, IL-10 and c-Myc","volume":"211","author":"Sharawy","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2024.123229_bb0105","doi-asserted-by":"crossref","DOI":"10.3791\/52438-v","article-title":"Bile duct ligation in mice: induction of inflammatory liver injury and fibrosis by obstructive cholestasis","author":"Tag","year":"2015","journal-title":"J Vis Exp(96)."},{"issue":"1","key":"10.1016\/j.lfs.2024.123229_bb0110","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11011-014-9600-x","article-title":"Erythropoietin ameliorates the motor and cognitive function impairments in a rat model of hepatic cirrhosis","volume":"30","author":"Aghaei","year":"2015","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.lfs.2024.123229_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175204","article-title":"Neuroprotective repositioning and anti-tau effect of carvedilol on rotenone induced neurotoxicity in rats: insights from an insilico& in vivo anti-Parkinson\u2019s disease study","volume":"932","author":"Kamal","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2024.123229_bb0120","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bcp.2018.09.004","article-title":"Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: impact on oxidative, inflammatory and apoptotic machineries","volume":"156","author":"Ali","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.lfs.2024.123229_bb0125","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s11011-016-9929-4","article-title":"Effect of rutin against a mitochondrial toxin, 3-nitropropionicacid induced biochemical, behavioral and histological alterations-a pilot study on Huntington\u2019s disease model in rats","volume":"32","author":"Suganya","year":"2017","journal-title":"Metab. Brain Dis."},{"issue":"2","key":"10.1016\/j.lfs.2024.123229_bb0130","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process."},{"key":"10.1016\/j.lfs.2024.123229_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jim.2018.03.004","article-title":"A new background subtraction method for Western blot densitometry band quantification through image analysis software","volume":"457","author":"Gallo-Oller","year":"2018","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.lfs.2024.123229_bb0140","series-title":"Handbook of Histopathological and Histochemical Techniques: Including Museum Techniques","author":"Culling","year":"2013"},{"key":"10.1016\/j.lfs.2024.123229_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2022.103940","article-title":"Aprepitant exerts anti-fibrotic effect via inhibition of TGF-\u03b2\/Smad3 pathway in bleomycin-induced pulmonary fibrosis in rats","volume":"95","author":"Mohamed","year":"2022","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2024.123229_bb0150","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/17474124.2023.2183386","article-title":"Hepatic encephalopathy - recent advances in treatment and diagnosis","volume":"17","author":"Nardelli","year":"2023","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2024.123229_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2022.114795","article-title":"Overview of oxidative stress findings in hepatic encephalopathy: from cellular and ammonium-based animal models to human data","volume":"654","author":"Simicic","year":"2022","journal-title":"Anal. Biochem."},{"issue":"7","key":"10.1016\/j.lfs.2024.123229_bb0160","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.4103\/1673-5374.386398","article-title":"Activation of the Wnt\/\u03b2-catenin\/CYP1B1 pathway alleviates oxidative stress and protects the blood-brain barrier under cerebral ischemia\/reperfusion conditions","volume":"19","author":"Chen","year":"2024","journal-title":"Neural Regen. Res."},{"issue":"3","key":"10.1016\/j.lfs.2024.123229_bb0165","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1089\/scd.2013.0345","article-title":"LPS-stimulated inflammatory environment inhibits BMP-2-induced osteoblastic differentiation through crosstalk between TLR4\/MyD88\/NF-\u03baB and BMP\/Smad signaling","volume":"23","author":"Huang","year":"2014","journal-title":"Stem Cells Dev."},{"issue":"6","key":"10.1016\/j.lfs.2024.123229_bb0170","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/BF01977399","article-title":"Late preventive effects of quinacrine on carbon tetrachloride induced liver necrosis","volume":"67","author":"Gonz\u00e1lez Padr\u00f3n","year":"1993","journal-title":"Arch. Toxicol."},{"issue":"6","key":"10.1016\/j.lfs.2024.123229_bb0175","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.dld.2014.01.159","article-title":"Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms","volume":"46","author":"Quinn","year":"2014","journal-title":"Dig. Liver Dis."},{"issue":"2","key":"10.1016\/j.lfs.2024.123229_bb0180","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ajpath.2015.10.005","article-title":"Bile acid signaling is involved in the neurological decline in a murine model of acute liver failure","volume":"186","author":"McMillin","year":"2016","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.lfs.2024.123229_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/foods7060088","article-title":"Protection by the Total flavonoids from Rosa laevigata Michx fruit against lipopolysaccharide-induced liver injury in mice via modulation of FXR signaling","volume":"7","author":"Dong","year":"2018","journal-title":"Foods"},{"key":"10.1016\/j.lfs.2024.123229_bb0190","article-title":"The role of intestinal Bacteria and gut-brain Axis in hepatic encephalopathy","volume":"10","author":"Chen","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"2","key":"10.1016\/j.lfs.2024.123229_bb0195","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/aps.2017.98","article-title":"D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acid secretion and attenuating oxidative stress","volume":"39","author":"Zhao","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"issue":"7","key":"10.1016\/j.lfs.2024.123229_bb0200","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1080\/10715760410001705131","article-title":"Melatonin prevents oxidative stress and hepatocyte cell death induced by experimental cholestasis","volume":"38","author":"Padillo","year":"2004","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.lfs.2024.123229_bb0205","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/948376","article-title":"Swertianlarin, an herbal agent derived from Swertia mussotii Franch, attenuates liver injury, inflammation, and cholestasis in common bile duct-ligated rats","volume":"2015","author":"Zhang","year":"2015","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"12","key":"10.1016\/j.lfs.2024.123229_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18122603","article-title":"Quinacrine inhibits ICAM-1 transcription by blocking DNA binding of the NF-\u03baB subunit p65 and sensitizes human lung adenocarcinoma A549 cells to TNF-\u03b1 and the Fas ligand","volume":"18","author":"Harada","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2024.123229_bb0215","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.00042.2016","article-title":"Physiology of Astroglia","volume":"98","author":"Verkhratsky","year":"2018","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.lfs.2024.123229_bb0220","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1042\/BST20130237","article-title":"Astrocyte glutamine synthetase: pivotal in health and disease","volume":"41","author":"Rose","year":"2013","journal-title":"Biochem. Soc. Trans."},{"issue":"4","key":"10.1016\/j.lfs.2024.123229_bb0225","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s11011-020-00549-8","article-title":"Astrocyte swelling in hepatic encephalopathy: molecular perspective of cytotoxic edema","volume":"35","author":"Sepehrinezhad","year":"2020","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.lfs.2024.123229_bb0230","series-title":"Inflammation in Parkinson\u2019s Disease: Scientific and Clinical Aspects","first-page":"127","article-title":"The role of astrocytes in Parkinson\u2019s disease","author":"Stevens","year":"2014"},{"key":"10.1016\/j.lfs.2024.123229_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.896172","article-title":"Astrocytes profiling in acute hepatic encephalopathy: possible enrolling of glial fibrillary acidic protein, tumor necrosis factor-alpha, inwardly rectifying potassium channel (Kir 4.1) and aquaporin-4 in rat cerebral cortex","volume":"16","author":"Elsherbini","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.lfs.2024.123229_bb0240","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.neuroscience.2012.05.006","article-title":"Role of cerebral endothelial cells in the astrocyte swelling and brain edema associated with acute hepatic encephalopathy","volume":"218","author":"Jayakumar","year":"2012","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.lfs.2024.123229_bb0245","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12035-020-02093-z","article-title":"Effects of antimalarial drugs on Neuroinflammation-potential use for treatment of COVID-19-related neurologic complications","volume":"58","author":"Ong","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"11","key":"10.1016\/j.lfs.2024.123229_bb0250","doi-asserted-by":"crossref","DOI":"10.3390\/cells8111419","article-title":"TGF-\u03b2 in hepatic stellate cell activation and liver Fibrogenesis-updated 2019","volume":"8","author":"Dewidar","year":"2019","journal-title":"Cells"},{"issue":"9","key":"10.1016\/j.lfs.2024.123229_bb0255","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1002\/jcb.23180","article-title":"BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition","volume":"112","author":"Yang","year":"2011","journal-title":"J. Cell. Biochem."},{"issue":"2","key":"10.1016\/j.lfs.2024.123229_bb0260","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1210\/en.2008-0090","article-title":"Bone morphogenetic protein-2 antagonizes renal interstitial fibrosis by promoting catabolism of type I transforming growth factor-beta receptors","volume":"150","author":"Yang","year":"2009","journal-title":"Endocrinology"},{"issue":"21","key":"10.1016\/j.lfs.2024.123229_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13215279","article-title":"Sulfatase-2 regulates liver fibrosis through the TGF-\u03b2 signaling pathway","volume":"13","author":"Nakamura","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.lfs.2024.123229_bb0270","first-page":"17","volume":"12","author":"Yang","year":"2021","journal-title":"The role of bone morphogenetic proteins in liver fibrosis."},{"issue":"7\u20138","key":"10.1016\/j.lfs.2024.123229_bb0275","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1089\/ten.tea.2017.0232","article-title":"The immunomodulatory role of BMP-2 on macrophages to accelerate osteogenesis","volume":"24","author":"Wei","year":"2018","journal-title":"Tissue Eng. Part A"},{"issue":"4","key":"10.1016\/j.lfs.2024.123229_bb0280","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/hipo.10035","article-title":"BDNF-triggered events in the rat hippocampus are required for both short- and long-term memory formation","volume":"12","author":"Alonso","year":"2002","journal-title":"Hippocampus"},{"issue":"4","key":"10.1016\/j.lfs.2024.123229_bb0285","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1254\/jphs.91.267","article-title":"Brain-derived neurotrophic factor\/TrkB signaling in memory processes","volume":"91","author":"Yamada","year":"2003","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2024.123229_bb0290","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuro.2017.05.006","article-title":"Hyperammonemia compromises glutamate metabolism and reduces BDNF in the rat hippocampus","volume":"62","author":"Galland","year":"2017","journal-title":"Neurotoxicology"},{"issue":"4","key":"10.1016\/j.lfs.2024.123229_bb0295","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1046\/j.1471-4159.2001.00570.x","article-title":"Brain-derived neurotrophic factor (BDNF) mediates bone morphogenetic protein-2 (BMP-2) effects on cultured striatal neurones","volume":"79","author":"Gratac\u00f2s","year":"2001","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.lfs.2024.123229_bb0300","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/FBP.0b013e3283618a8c","article-title":"Nitric oxide mediates the beneficial effect of chronic naltrexone on cholestasis-induced memory impairment in male rats","volume":"24","author":"Javadi-Paydar","year":"2013","journal-title":"Behav. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2024.123229_bb0305","first-page":"425","article-title":"The effect of gallic acid on memory and anxiety-like behaviors in rats with bile duct ligation-induced hepatic encephalopathy: role of AMPK pathway","volume":"12","author":"Jafaripour","year":"2022","journal-title":"Avicenna J Phytomed"},{"issue":"1","key":"10.1016\/j.lfs.2024.123229_bb0310","doi-asserted-by":"crossref","first-page":"19","DOI":"10.17085\/apm.2020.15.1.19","article-title":"Bile duct ligation of C57BL\/6 mice as a model of hepatic encephalopathy","volume":"15","author":"Cho","year":"2020","journal-title":"Anesth Pain Med (Seoul)"},{"issue":"1","key":"10.1016\/j.lfs.2024.123229_bb0315","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1684\/mrh.2015.0380","article-title":"Magnesium protects against bile duct ligation-induced liver injury in male Wistar rats","volume":"28","author":"Eshraghi","year":"2015","journal-title":"Magnes. Res."}],"updated-by":[{"DOI":"10.1016\/j.lfs.2025.123414","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000}}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524008191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524008191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T12:05:47Z","timestamp":1738152347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524008191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":63,"alternative-id":["S0024320524008191"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.123229","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatoprotective and neuroprotective effects of quinacrine against bile duct ligation-induced hepatic encephalopathy in rats: Role of bone morphogenetic proteins signaling","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.123229","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"123229"}}