{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:30:30Z","timestamp":1791995430898,"version":"4.4.0"},"reference-count":104,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.lfs.2024.123360","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T17:19:55Z","timestamp":1735665595000},"page":"123360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Research progress on pathogenesis and treatment of febrile seizures"],"prefix":"10.1016","volume":"362","author":[{"given":"Chang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenmi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxuan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.lfs.2024.123360_bb0005","first-page":"445","article-title":"Febrile seizures: risks, evaluation, and prognosis","volume":"99","author":"Smith","year":"2019","journal-title":"Am. Fam. Physician"},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0010","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.pedhc.2006.10.006","article-title":"Febrile seizures","volume":"21","author":"Leung","year":"2007","journal-title":"J. Pediatr. Health Care"},{"issue":"2","key":"10.1016\/j.lfs.2024.123360_bb0015","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1542\/peds.2010-3318","article-title":"Neurodiagnostic evaluation of the child with a simple febrile seizure","volume":"127","year":"2011","journal-title":"Pediatrics"},{"issue":"10","key":"10.1016\/j.lfs.2024.123360_bb0020","first-page":"723","article-title":"Expert consensus on the diagnosis and management of febrile seizures (2016)","volume":"54","author":"Subspecialty Group of Neurology T S O P, Chinese Medical Association","year":"2016","journal-title":"Zhonghua er ke za zhi = Chinese journal of pediatrics"},{"key":"10.1016\/j.lfs.2024.123360_bb0025","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pediatrneurol.2017.05.027","article-title":"Febrile seizures and epilepsy: association with autism and other neurodevelopmental disorders in the child and adolescent twin study in Sweden","volume":"74","author":"Gillberg","year":"2017","journal-title":"Pediatr. Neurol."},{"issue":"11","key":"10.1016\/j.lfs.2024.123360_bb0030","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/dmcn.14642","article-title":"Current understanding of febrile seizures and their long-term outcomes","volume":"62","author":"Mewasingh","year":"2020","journal-title":"Dev. Med. Child Neurol."},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0035","article-title":"Febrile seizures: a review","volume":"3","author":"Eilbert","year":"2022","journal-title":"J Am Coll Emerg Physicians Open"},{"issue":"3","key":"10.1016\/j.lfs.2024.123360_bb0040","article-title":"Seasonal trend of viral prevalence and incidence of febrile convulsion: a Korea public health data analysis","volume":"10","author":"Keum","year":"2023","journal-title":"Children (Basel)"},{"issue":"7","key":"10.1016\/j.lfs.2024.123360_bb0045","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1111\/epi.17639","article-title":"Twenty-four hour pattern of childhood febrile seizures substantiated by time series meta-analysis: circadian medicine perspectives","volume":"64","author":"Smolensky","year":"2023","journal-title":"Epilepsia"},{"issue":"11","key":"10.1016\/j.lfs.2024.123360_bb0050","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1007\/s00381-013-2224-3","article-title":"Febrile seizures: recent developments and unanswered questions","volume":"29","author":"Pavlidou","year":"2013","journal-title":"Childs Nerv. Syst."},{"issue":"3","key":"10.1016\/j.lfs.2024.123360_bb0055","doi-asserted-by":"crossref","first-page":"129","DOI":"10.62438\/tunismed.v102i3.4474","article-title":"An overview of risk factors in children with febrile seizures","volume":"102","author":"Abbari","year":"2024","journal-title":"Tunis. Med."},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0060","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13052-018-0491-z","article-title":"Benign and severe early-life seizures: a round in the first year of life","volume":"44","author":"Pavone","year":"2018","journal-title":"Ital. J. Pediatr."},{"issue":"11","key":"10.1016\/j.lfs.2024.123360_bb0065","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s13312-022-2646-7","article-title":"Risk factors of first episode simple febrile seizures in children aged 6 month to 5 year: a case control study","volume":"59","author":"Kumari","year":"2022","journal-title":"Indian Pediatr."},{"key":"10.1016\/j.lfs.2024.123360_bb0070","series-title":"StatPearls","article-title":"Febrile seizure","author":"Xixis","year":"2024"},{"key":"10.1016\/j.lfs.2024.123360_bb0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.brainres.2011.08.027","article-title":"Hyperthermia induces epileptiform discharges in cultured rat cortical neurons","volume":"1417","author":"Wang","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.lfs.2024.123360_bb0080","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.seizure.2020.11.007","article-title":"Respiratory viruses and febrile response in children with febrile seizures: a cohort study and embedded case-control study","volume":"84","author":"Hautala","year":"2021","journal-title":"Seizure"},{"issue":"2","key":"10.1016\/j.lfs.2024.123360_bb0085","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3345\/cep.2021.01039","article-title":"Pathogenetic and etiologic considerations of febrile seizures","volume":"66","author":"Han","year":"2023","journal-title":"Clin Exp Pediatr"},{"issue":"2","key":"10.1016\/j.lfs.2024.123360_bb0090","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1542\/peds.2007-2290","article-title":"Analysis of rotavirus antigenemia and extraintestinal manifestations in children with rotavirus gastroenteritis","volume":"122","author":"Sugata","year":"2008","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0095","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1542\/peds.2008-2915","article-title":"Influenza virus infection and the risk of serious bacterial infections in young febrile infants","volume":"124","author":"Krief","year":"2009","journal-title":"Pediatrics"},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0100","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1515\/revneuro-2013-0053","article-title":"Genetic background of febrile seizures","volume":"25","author":"Saghazadeh","year":"2014","journal-title":"Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0105","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1080\/14760584.2023.2252065","article-title":"Combined measles-mumps-rubella-varicella vaccine and febrile convulsions: the risk considered in the broad context","volume":"22","author":"Casabona","year":"2023","journal-title":"Expert Rev. Vaccines"},{"issue":"3","key":"10.1016\/j.lfs.2024.123360_bb0110","doi-asserted-by":"crossref","first-page":"e226","DOI":"10.1212\/WNL.0000000000009876","article-title":"Developmental outcomes following vaccine-proximate febrile seizures in children","volume":"95","author":"Deng","year":"2020","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.lfs.2024.123360_bb0115","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1001\/jamapediatrics.2013.2745","article-title":"Effect of age on the risk of fever and seizures following immunization with measles-containing vaccines in children","volume":"167","author":"Rowhani-Rahbar","year":"2013","journal-title":"JAMA Pediatr."},{"issue":"10","key":"10.1016\/j.lfs.2024.123360_bb0120","doi-asserted-by":"crossref","first-page":"e388","DOI":"10.3928\/19382359-20230829-03","article-title":"Febrile seizures","volume":"52","author":"Biltz","year":"2023","journal-title":"Pediatr. Ann."},{"issue":"50","key":"10.1016\/j.lfs.2024.123360_bb0125","doi-asserted-by":"crossref","first-page":"18177","DOI":"10.1073\/pnas.0506818102","article-title":"Identification of an Nav1.1 sodium channel (SCN1A) loss-of-function mutation associated with familial simple febrile seizures","volume":"102","author":"Mantegazza","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.lfs.2024.123360_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000649","article-title":"A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome","volume":"5","author":"Singh","year":"2009","journal-title":"PLoS Genet."},{"issue":"17","key":"10.1016\/j.lfs.2024.123360_bb0135","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1212\/01.wnl.0000260062.02829.e3","article-title":"New locus for febrile seizures with absence epilepsy on 3p and a possible modifier gene on 18p","volume":"68","author":"Nabbout","year":"2007","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/hmg\/9.1.87","article-title":"Significant evidence for linkage of febrile seizures to chromosome 5q14-q15","volume":"9","author":"Nakayama","year":"2000","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0145","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1212\/01.wnl.0000230145.73496.a2","article-title":"A novel GABRG2 mutation associated with febrile seizures","volume":"67","author":"Audenaert","year":"2006","journal-title":"Neurology"},{"issue":"Pt 12","key":"10.1016\/j.lfs.2024.123360_bb0150","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1093\/brain\/awf281","article-title":"A locus for simple pure febrile seizures maps to chromosome 6q22-q24","volume":"125","author":"Nabbout","year":"2002","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0155","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1136\/jmg.33.4.308","article-title":"Suggestion of a major gene for familial febrile convulsions mapping to 8q13-21","volume":"33","author":"Wallace","year":"1996","journal-title":"J. Med. Genet."},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0160","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/humu.21613","article-title":"Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy","volume":"33","author":"Salzmann","year":"2012","journal-title":"Hum. Mutat."},{"issue":"10","key":"10.1016\/j.lfs.2024.123360_bb0165","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1212\/01.WNL.0000144499.34164.E0","article-title":"Linkage and association of febrile seizures to the IMPA2 gene on human chromosome 18","volume":"63","author":"Nakayama","year":"2004","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0170","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/hmg\/7.1.63","article-title":"Evidence for a novel gene for familial febrile convulsions, FEB2, linked to chromosome 19p in an extended family from the Midwest","volume":"7","author":"Johnson","year":"1998","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0175","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00439-008-0566-9","article-title":"A novel genetic locus for familial febrile seizures and epilepsy on chromosome 3q26.2-q26.33","volume":"124","author":"Dai","year":"2008","journal-title":"Hum. Genet."},{"issue":"10","key":"10.1016\/j.lfs.2024.123360_bb0180","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1111\/j.1528-1167.2006.00637.x","article-title":"Identification of a novel locus for febrile seizures and epilepsy on chromosome 21q22","volume":"47","author":"Hedera","year":"2006","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.lfs.2024.123360_bb0185","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/brain\/awab260","article-title":"Genome-wide association study of febrile seizures implicates fever response and neuronal excitability genes","volume":"145","author":"Skotte","year":"2022","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0190","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/acn3.48","article-title":"Identification of Srp9 as a febrile seizure susceptibility gene","volume":"1","author":"Hessel","year":"2014","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"5","key":"10.1016\/j.lfs.2024.123360_bb0195","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1212\/WNL.0000000000003565","article-title":"Mutations in GABRB3: from febrile seizures to epileptic encephalopathies","volume":"88","author":"M\u00f8ller","year":"2017","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.lfs.2024.123360_bb0200","doi-asserted-by":"crossref","first-page":"23408","DOI":"10.3390\/ijms151223408","article-title":"PRRT2 mutations are related to febrile seizures in epileptic patients","volume":"15","author":"He","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.lfs.2024.123360_bb0205","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s12035-014-9047-4","article-title":"Identification of a premature termination mutation in the proline-rich transmembrane protein 2 gene in a Chinese family with febrile seizures","volume":"53","author":"Zheng","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"30","key":"10.1016\/j.lfs.2024.123360_bb0210","doi-asserted-by":"crossref","first-page":"7911","DOI":"10.1523\/JNEUROSCI.1314-16.2016","article-title":"Distinct functions of syntaxin-1 in neuronal maintenance, synaptic vesicle docking, and fusion in mouse neurons","volume":"36","author":"Vardar","year":"2016","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0215","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/ana.21909","article-title":"Augmented currents of an HCN2 variant in patients with febrile seizure syndromes","volume":"67","author":"Dibbens","year":"2010","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.lfs.2024.123360_bb0220","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/embr.201438749","article-title":"A variant of KCC2 from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation","volume":"15","author":"Puskarjov","year":"2014","journal-title":"EMBO Rep."},{"issue":"24","key":"10.1016\/j.lfs.2024.123360_bb0225","doi-asserted-by":"crossref","first-page":"9920","DOI":"10.1523\/JNEUROSCI.5482-12.2013","article-title":"Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures","volume":"33","author":"Radzicki","year":"2013","journal-title":"J. Neurosci."},{"issue":"23","key":"10.1016\/j.lfs.2024.123360_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232314638","article-title":"Na(+)\/K(+)- and Mg(2+)-ATPases and their interaction with AMPA, NMDA and D(2) dopamine receptors in an animal model of febrile seizures","volume":"23","author":"Crespo","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2024.123360_bb0235","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/ana.10285","article-title":"Hyperthermia induces age-dependent changes in rat hippocampal excitability","volume":"52","author":"Liebregts","year":"2002","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0240","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41420-024-01837-3","article-title":"Increased thrombospondin-1 levels contribute to epileptic susceptibility in neonatal hyperthermia without seizures via altered synaptogenesis","volume":"10","author":"Zhai","year":"2024","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.lfs.2024.123360_bb0245","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s11571-021-09706-w","article-title":"A dynamics model of neuron-astrocyte network accounting for febrile seizures","volume":"16","author":"Du","year":"2022","journal-title":"Cogn. Neurodyn."},{"issue":"20","key":"10.1016\/j.lfs.2024.123360_bb0250","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023342118","article-title":"TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures","volume":"118","author":"Wang","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.lfs.2024.123360_bb0255","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1165\/rcmb.2023-0451OC","article-title":"The impact of inflammation on thermal hyperpnea: relevance for heat stress and febrile seizures","volume":"71","author":"Barrett","year":"2024","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"8","key":"10.1016\/j.lfs.2024.123360_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci11081077","article-title":"Inflammatory biomarkers in febrile seizure: a comprehensive bibliometric, review and visualization analysis","volume":"11","author":"Maniu","year":"2021","journal-title":"Brain Sci"},{"issue":"5","key":"10.1016\/j.lfs.2024.123360_bb0265","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s12264-023-01170-2","article-title":"Interleukins in epilepsy: friend or foe","volume":"40","author":"Dong","year":"2024","journal-title":"Neurosci. Bull."},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0270","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.braindev.2019.12.013","article-title":"Increased levels of NLRP3 in children with febrile seizures","volume":"42","author":"Liu","year":"2020","journal-title":"Brain and Development"},{"issue":"6","key":"10.1016\/j.lfs.2024.123360_bb0275","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/s41390-022-02282-7","article-title":"Recurrent febrile seizures and serum cytokines: a controlled follow-up study","volume":"93","author":"Hautala","year":"2023","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.lfs.2024.123360_bb0280","doi-asserted-by":"crossref","DOI":"10.1177\/2633105520956973","article-title":"The pathogenesis of fever-induced febrile seizures and its current state","volume":"15","author":"Mosili","year":"2020","journal-title":"Neurosci Insights"},{"issue":"7","key":"10.1016\/j.lfs.2024.123360_bb0285","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/s41401-024-01257-0","article-title":"Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission","volume":"45","author":"Wang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"issue":"Pt A","key":"10.1016\/j.lfs.2024.123360_bb0290","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuropharm.2014.10.027","article-title":"Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability","volume":"96","author":"Vezzani","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lfs.2024.123360_bb0295","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13052-016-0250-y","article-title":"Serum and CSF adiponectin, leptin, and interleukin 6 levels as adipocytokines in Egyptian children with febrile seizures: a cross-sectional study","volume":"42","author":"Azab","year":"2016","journal-title":"Ital. J. Pediatr."},{"issue":"2","key":"10.1016\/j.lfs.2024.123360_bb0300","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neulet.2004.04.061","article-title":"Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats","volume":"365","author":"Kalueff","year":"2004","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0305","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.pbb.2004.01.012","article-title":"Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice","volume":"77","author":"De Sarro","year":"2004","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0310","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1152\/jn.00188.2020","article-title":"IL-6 induced upregulation of T-type Ca(2+) currents and sensitization of DRG nociceptors is attenuated by MNK inhibition","volume":"124","author":"Jeevakumar","year":"2020","journal-title":"J. Neurophysiol."},{"issue":"20","key":"10.1016\/j.lfs.2024.123360_bb0315","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1523\/JNEUROSCI.3338-07.2008","article-title":"Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord","volume":"28","author":"Kawasaki","year":"2008","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0320","first-page":"55","article-title":"Tumor necrosis factor alpha (TNF\u03b1) gene promoter polymorphisms and haplotypes are associated with the febrile seizure (FS) and TNF\u03b1 serum levels","volume":"17","author":"Ghanbarzadeh","year":"2023","journal-title":"Iran J. Child Neurol."},{"issue":"3","key":"10.1016\/j.lfs.2024.123360_bb0325","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1007\/s12035-022-02725-6","article-title":"Neuroinflammation and proinflammatory cytokines in epileptogenesis","volume":"59","author":"Soltani Khaboushan","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0330","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1038\/s41598-022-07173-9","article-title":"Functional network connectivity imprint in febrile seizures","volume":"12","author":"Acharya","year":"2022","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0335","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1152\/physrev.00025.2020","article-title":"Sodium channelopathies of skeletal muscle and brain","volume":"101","author":"Mantegazza","year":"2021","journal-title":"Physiol. Rev."},{"issue":"11","key":"10.1016\/j.lfs.2024.123360_bb0340","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1093\/brain\/awac210","article-title":"The gain of function SCN1A disorder spectrum: novel epilepsy phenotypes and therapeutic implications","volume":"145","author":"Brunklaus","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.lfs.2024.123360_bb0345","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.seizure.2021.04.006","article-title":"Mutations in the sodium channel genes SCN1A, SCN3A, and SCN9A in children with epilepsy with febrile seizures plus(EFS+)","volume":"88","author":"Ma","year":"2021","journal-title":"Seizure"},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0350","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00401-022-02429-0","article-title":"SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility","volume":"144","author":"Silvennoinen","year":"2022","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.lfs.2024.123360_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2020.102083","article-title":"Generation of iPSC lines from two patients affected by febrile seizure due to inherited missense mutation in SCN1A gene","volume":"49","author":"Scalise","year":"2020","journal-title":"Stem Cell Res."},{"issue":"10","key":"10.1016\/j.lfs.2024.123360_bb0360","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1093\/hmg\/ddad015","article-title":"SCN1A: bioinformatically informed revised boundaries for promoter and enhancer regions","volume":"32","author":"Pagni","year":"2023","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.lfs.2024.123360_bb0365","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.809951","article-title":"SCN2A-related epilepsy: the phenotypic spectrum, treatment and prognosis","volume":"15","author":"Zeng","year":"2022","journal-title":"Front. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.lfs.2024.123360_bb0370","doi-asserted-by":"crossref","DOI":"10.3390\/biom13030414","article-title":"GABRG2 variants associated with febrile seizures","volume":"13","author":"Hernandez","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.lfs.2024.123360_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105296","article-title":"The K328M substitution in the human GABA(A) receptor gamma2 subunit causes GEFS+ and premature sudden death in knock-in mice","volume":"152","author":"Qu","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.lfs.2024.123360_bb0380","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.809163","article-title":"Phenotypic Spectrum and prognosis of epilepsy patients with GABRG2 variants","volume":"15","author":"Yang","year":"2022","journal-title":"Front. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0385","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4161\/chan.25956","article-title":"Turning up the heat on L-type Ca2+ channels promotes neuronal firing and seizure activity","volume":"7","author":"Braun","year":"2013","journal-title":"Channels (Austin)"},{"issue":"29","key":"10.1016\/j.lfs.2024.123360_bb0390","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo3625","article-title":"Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine","volume":"8","author":"Yang","year":"2022","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.01.023","article-title":"Immunohistochemical analysis of KCNQ2 potassium channels in adult and developing mouse brain","volume":"1077","author":"Weber","year":"2006","journal-title":"Brain Res."},{"issue":"15","key":"10.1016\/j.lfs.2024.123360_bb0400","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1097\/00001756-200210280-00028","article-title":"The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions","volume":"13","author":"Chou","year":"2002","journal-title":"Neuroreport"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2024.123360_bb0405","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0920-1211(02)00249-8","article-title":"Age-dependent modulation of hippocampal excitability by KCNQ-channels","volume":"53","author":"Okada","year":"2003","journal-title":"Epilepsy Res."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2024.123360_bb0410","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.eplepsyres.2011.07.005","article-title":"Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures","volume":"97","author":"Yu","year":"2011","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.lfs.2024.123360_bb0415","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.pediatrneurol.2024.09.026","article-title":"Febrile seizures, ongoing epileptiform activity, and the resulting long-term consequences: lessons from animal models","volume":"161","author":"Harris","year":"2024","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.lfs.2024.123360_bb0420","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2024.110051","article-title":"Risk factors for secondary epilepsy following febrile seizures in children: a meta-analysis","volume":"161","author":"Zhang","year":"2024","journal-title":"Epilepsy Behav."},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0425","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/epi.17882","article-title":"Genotype-phenotype associations in 1018 individuals with SCN1A-related epilepsies","volume":"65","author":"Gallagher","year":"2024","journal-title":"Epilepsia"},{"key":"10.1016\/j.lfs.2024.123360_bb0430","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.889534","article-title":"ATP6V0C is associated with febrile seizures and epilepsy with febrile seizures plus","volume":"15","author":"Tian","year":"2022","journal-title":"Front. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.lfs.2024.123360_bb0435","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/1252","article-title":"Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B","volume":"19","author":"Wallace","year":"1998","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.lfs.2024.123360_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmg.2022.104577","article-title":"De novo SCN3A missense variant associated with self-limiting generalized epilepsy with fever sensitivity","volume":"65","author":"Johannesen","year":"2022","journal-title":"Eur. J. Med. Genet."},{"issue":"11","key":"10.1016\/j.lfs.2024.123360_bb0445","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1212\/WNL.0000000000003087","article-title":"Phenotypic spectrum of GABRA1: from generalized epilepsies to severe epileptic encephalopathies","volume":"87","author":"Johannesen","year":"2016","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.lfs.2024.123360_bb0450","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1523\/JNEUROSCI.2977-05.2006","article-title":"An epilepsy mutation in the sodium channel SCN1A that decreases channel excitability","volume":"26","author":"Barela","year":"2006","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.lfs.2024.123360_bb0455","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.nbd.2008.07.017","article-title":"A CACNB4 mutation shows that altered Ca(v)2.1 function may be a genetic modifier of severe myoclonic epilepsy in infancy","volume":"32","author":"Ohmori","year":"2008","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.lfs.2024.123360_bb0460","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/ajmg.1582","article-title":"Ion channels and epilepsy","volume":"106","author":"Holger","year":"2001","journal-title":"Am. J. Med. Genet."},{"issue":"11","key":"10.1016\/j.lfs.2024.123360_bb0465","first-page":"12030","article-title":"Novel KCNQ(4) gene mutations contribute to susceptibility of genetic febrile seizures","volume":"9","author":"Zou","year":"2016","journal-title":"Int. J. Clin. Exp. Pathol."},{"issue":"20","key":"10.1016\/j.lfs.2024.123360_bb0470","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000033730","article-title":"Changes of intestinal flora in children with febrile seizure","volume":"102","author":"Yang","year":"2023","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.lfs.2024.123360_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104576","article-title":"Emerging roles for the intestinal microbiome in epilepsy","volume":"135","author":"Lum","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"11","key":"10.1016\/j.lfs.2024.123360_bb0480","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1111\/ene.15275","article-title":"Changes of serum metabolomics and gut microbiota reveal specific characteristics of children with febrile seizures","volume":"30","author":"Hu","year":"2023","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.lfs.2024.123360_bb0485","article-title":"Altered intestinal microbiota composition with epilepsy and concomitant diarrhea and potential indicator biomarkers in infants","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.lfs.2024.123360_bb0490","doi-asserted-by":"crossref","first-page":"11","DOI":"10.47936\/encephalitis.2023.00206","article-title":"Gut microbiome diversity in a febrile seizure mouse model","volume":"4","author":"Kim","year":"2024","journal-title":"Encephalitis"},{"issue":"9","key":"10.1016\/j.lfs.2024.123360_bb0495","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/j.1528-1167.2012.03567.x","article-title":"Design and phenomenology of the FEBSTAT study","volume":"53","author":"Hesdorffer","year":"2012","journal-title":"Epilepsia"},{"issue":"3","key":"10.1016\/j.lfs.2024.123360_bb0500","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/MOP.0000000000000220","article-title":"Febrile seizures: emergency medicine perspective","volume":"27","author":"Kimia","year":"2015","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.lfs.2024.123360_bb0505","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1186050","article-title":"The long-term neurodevelopmental outcomes of febrile seizures and underlying mechanisms","volume":"11","author":"Yi","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"12","key":"10.1016\/j.lfs.2024.123360_bb0510","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3928\/00904481-20131122-09","article-title":"Febrile seizures","volume":"42","author":"Patterson","year":"2013","journal-title":"Pediatr. Ann."},{"key":"10.1016\/j.lfs.2024.123360_bb0515","first-page":"38","article-title":"Comparing the effect of intermittent diazepam and continuous phenobarbital in preventing recurrent febrile seizures among children under 6 years old: a systematic review and meta-analysis","volume":"28","author":"Faraji Gavgani","year":"2023","journal-title":"J. Res. Med. Sci."},{"issue":"6","key":"10.1016\/j.lfs.2024.123360_bb0520","article-title":"Prophylactic drug management for febrile seizures in children","volume":"6","author":"Offringa","year":"2021","journal-title":"Cochrane Database Syst. Rev."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524009500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320524009500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T17:36:29Z","timestamp":1740332189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320524009500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":104,"alternative-id":["S0024320524009500"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2024.123360","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Research progress on pathogenesis and treatment of febrile seizures","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2024.123360","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123360"}}