{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:24:01Z","timestamp":1791235441592,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002729","name":"Anhui University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002729","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.lfs.2025.123430","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T11:47:09Z","timestamp":1738064829000},"page":"123430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Arginine-derived carbon dots with antioxidant activity for treating aflatoxin B1-induced liver injury via Nrf2\/Keap1 and NLRP3 pathways in mice"],"prefix":"10.1016","volume":"364","author":[{"given":"Xuejing","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuxiang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongshou","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2025.123430_bb0005","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.3389\/fmicb.2019.02861","article-title":"Adverse effects, transformation and channeling of aflatoxins into food raw materials in livestock","volume":"10","author":"Peles","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.lfs.2025.123430_bb0010","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.3389\/fmicb.2019.02908","article-title":"Toxicological and medical aspects of Aspergillus-derived mycotoxins entering the feed and food chain","volume":"10","author":"R\u00e1duly","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.lfs.2025.123430_bb0015","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.fct.2018.11.047","article-title":"Aflatoxin B1: a review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods","volume":"124","author":"Rushing","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2025.123430_bb0020","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/15376516.2021.2021339","article-title":"Aflatoxin B1: metabolism, toxicology, and its involvement in oxidative stress and cancer development","volume":"32","author":"Cao","year":"2022","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.lfs.2025.123430_bb0025","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.tifs.2018.08.009","article-title":"Current major degradation methods for aflatoxins: a review","volume":"80","author":"Peng","year":"2018","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.lfs.2025.123430_bb0030","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1007\/s11427-023-2512-6","article-title":"AP-1 and SP1 trans-activate the expression of hepatic CYP1A1 and CYP2A6 in the bioactivation of AFB1 in chicken","volume":"67","author":"Deng","year":"2024","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.lfs.2025.123430_bb0035","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1007\/s00204-014-1312-9","article-title":"Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences","volume":"88","author":"Dohnal","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.lfs.2025.123430_bb0040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3109\/15569543.2012.730092","article-title":"Overview on aflatoxins and oxidative stress","volume":"31","author":"Marin","year":"2012","journal-title":"Toxin Rev."},{"key":"10.1016\/j.lfs.2025.123430_bb0045","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12272-019-01192-3","article-title":"Nrf2 in liver toxicology","volume":"43","author":"Taguchi","year":"2020","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.lfs.2025.123430_bb0050","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.3390\/antiox12081491","article-title":"Advances in understanding the role of NRF2 in liver pathophysiology and its relationship with hepatic-specific cyclooxygenase-2 expression","volume":"12","author":"Fuertes-Agudo","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.lfs.2025.123430_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112624","article-title":"Ferulic acid prevents aflatoxin B1-induced liver injury in rats via inhibiting cytochrome P450 enzyme, activating Nrf2\/GST pathway and regulating mitochondrial pathway","volume":"224","author":"Wang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.lfs.2025.123430_bb0060","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41580-023-00645-4","article-title":"Understanding mechanisms of antioxidant action in health and disease","volume":"25","author":"Halliwell","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.lfs.2025.123430_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202211210","article-title":"Multienzyme-like nanozymes: regulation, rational design, and application","volume":"36","author":"Sheng","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.lfs.2025.123430_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.100925","article-title":"Dual detoxification and inflammatory regulation by ceria nanozymes for drug-induced liver injury therapy","volume":"35","author":"Li","year":"2020","journal-title":"Nano Today"},{"key":"10.1016\/j.lfs.2025.123430_bb0075","article-title":"Polyacrylic acid-coated selenium-doped carbon dots inhibit ferroptosis to alleviate chemotherapy-associated acute kidney injury","volume":"11","author":"Li","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.lfs.2025.123430_bb0080","doi-asserted-by":"crossref","first-page":"5182","DOI":"10.1021\/acs.jpclett.9b01384","article-title":"Carbonized polymer dots: a brand new perspective to recognize luminescent carbon-based nanomaterials","volume":"10","author":"Tao","year":"2019","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.lfs.2025.123430_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.214010","article-title":"Carbon dots as a new class of nanomedicines: opportunities and challenges","volume":"442","author":"Wang","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.lfs.2025.123430_bb0090","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.carbon.2020.06.024","article-title":"Carbon dots with red\/near-infrared emissions and their intrinsic merits for biomedical applications","volume":"167","author":"Ding","year":"2020","journal-title":"Carbon"},{"key":"10.1016\/j.lfs.2025.123430_bb0095","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.carbon.2023.01.006","article-title":"Versatile carbon dots with superoxide dismutase-like nanozyme activity and red fluorescence for inflammatory bowel disease therapeutics","volume":"204","author":"Ma","year":"2023","journal-title":"Carbon"},{"key":"10.1016\/j.lfs.2025.123430_bb0100","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1021\/acsbiomaterials.2c01537","article-title":"Hydrothermally derived green carbon dots from broccoli water extracts: decreased toxicity, enhanced free-radical scavenging, and anti-inflammatory performance","volume":"9","author":"Deng","year":"2023","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.lfs.2025.123430_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1253195","article-title":"Protective effect of carbon dots derived from scrambled Coptidis Rhizoma against ulcerative colitis in mice","volume":"10","author":"Mou","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.lfs.2025.123430_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101768","article-title":"Integrating Pt nanoparticles with carbon nanodots to achieve robust cascade superoxide dismutase-catalase nanozyme for antioxidant therapy","volume":"49","author":"Zhang","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.lfs.2025.123430_bb0115","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/jfbc.12160","article-title":"Phenolic extract from propolis and bee pollen: composition, antioxidant and antibacterial activities","volume":"39","author":"Mohdaly","year":"2015","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.lfs.2025.123430_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.496","article-title":"Neurotoxicity evaluation of nanomaterials using C. elegans: survival, locomotion behaviors, and oxidative stress","volume":"2","author":"Zheng","year":"2022","journal-title":"Curr Protoc."},{"key":"10.1016\/j.lfs.2025.123430_bb0125","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.actbio.2021.11.010","article-title":"Quaternized carbon quantum dots with broad-spectrum antibacterial activity for the treatment of wounds infected with mixed bacteria","volume":"138","author":"Zhao","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.lfs.2025.123430_bb0130","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1038\/s41467-020-19277-9","article-title":"Fast site-to-site electron transfer of high-entropy alloy nanocatalyst driving redox electrocatalysis","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2025.123430_bb0135","doi-asserted-by":"crossref","first-page":"9479","DOI":"10.1021\/acsnano.2c02518","article-title":"Copper doped carbon dots for addressing bacterial biofilm formation, wound infection, and tooth staining","volume":"16","author":"Liu","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.lfs.2025.123430_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.142338","article-title":"Carbon dots as potential antioxidants for the scavenging of multi-reactive oxygen and nitrogen species","volume":"462","author":"Gao","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.lfs.2025.123430_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2023.1158198","article-title":"Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases","volume":"11","author":"Chaudhary","year":"2023","journal-title":"Front. Chem."},{"key":"10.1016\/j.lfs.2025.123430_bb0150","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3892\/ol.2013.1169","article-title":"Aflatoxin B1-induced hepatocellular carcinoma in developing countries: geographical distribution, mechanism of action and prevention","volume":"5","author":"Hamid","year":"2013","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.lfs.2025.123430_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112124","article-title":"Bacillus amyloliquefaciens B10 can alleviate liver apoptosis and oxidative stress induced by aflatoxin B1","volume":"151","author":"Li","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2025.123430_bb0160","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.toxicon.2021.01.020","article-title":"The effects of Nigella sativa seeds and thymoquinone on aflatoxin phase-2 detoxification through glutathione and glutathione-S-transferase alpha-3, and the relationship between aflatoxin B1-DNA adducts in broilers","volume":"193","author":"Ates","year":"2021","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2025.123430_bb0165","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/bj2540567","article-title":"Positive correlation exists between glutathione S-transferase activity and aflatoxin formation in Aspergillus flavus","volume":"254","author":"Saxena","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.lfs.2025.123430_bb0170","doi-asserted-by":"crossref","first-page":"7953","DOI":"10.1021\/acs.jafc.2c02015","article-title":"Orientin attenuated d-GalN\/LPS-induced liver injury through the inhibition of oxidative stress via Nrf2\/Keap1 pathway","volume":"70","author":"Li","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.lfs.2025.123430_bb0175","doi-asserted-by":"crossref","first-page":"907","DOI":"10.17219\/acem\/66347","article-title":"Vitamin E (\u03b1 tocopherol) attenuates toxicity and oxidative stress induced by aflatoxin in rats","volume":"26","author":"Y\u0131lmaz","year":"2017","journal-title":"Adv. Clin. Exp. Med."},{"key":"10.1016\/j.lfs.2025.123430_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105388","article-title":"Regulation of the NLRP3 inflammasome with natural products against chemical-induced liver injury","volume":"164","author":"Zou","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2025.123430_bb0185","doi-asserted-by":"crossref","DOI":"10.1515\/jcim-2018-0218","article-title":"Role of antioxidant supplementation in oxidant\/antioxidant status and hepatotoxic effects due to aflatoxin B1 in wheat miller workers","volume":"16","author":"Saad-Hussein","year":"2019","journal-title":"J Complement Integr Med."},{"key":"10.1016\/j.lfs.2025.123430_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113417","article-title":"Progress on the detoxification of aflatoxin B1 using natural anti-oxidants","volume":"169","author":"Wang","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.lfs.2025.123430_bb0195","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.toxicon.2021.03.007","article-title":"Research progress on the protection and detoxification of phytochemicals against aflatoxin B(1)-induced liver toxicity","volume":"195","author":"Fan","year":"2021","journal-title":"Toxicon"},{"key":"10.1016\/j.lfs.2025.123430_bb0200","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3390\/molecules21040443","article-title":"Silymarin prevents restraint stress-induced acute liver injury by ameliorating oxidative stress and reducing inflammatory response","volume":"21","author":"Kim","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2025.123430_bb0205","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1021\/acs.jafc.3c05776","article-title":"The ameliorative role of Lico A on aflatoxin B(1)-triggered hepatotoxicity partially by activating Nrf2 signal pathway","volume":"72","author":"Lv","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.lfs.2025.123430_bb0210","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1186\/s12951-023-02234-1","article-title":"Carbon dot nanozymes as free radicals scavengers for the management of hepatic ischemia-reperfusion injury by regulating the liver inflammatory network and inhibiting apoptosis","volume":"21","author":"Geng","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.lfs.2025.123430_bb0215","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1186\/s12951-024-02702-2","article-title":"Natural medicines-derived carbon dots as novel oral antioxidant administration strategy for ulcerative colitis therapy","volume":"22","author":"Wu","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.lfs.2025.123430_bb0220","article-title":"The Nrf2 pathway in liver diseases","volume":"10","author":"Zhou","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2025.123430_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152999","article-title":"Persistent activation of Nrf2 promotes a vicious cycle of oxidative stress and autophagy inhibition in cadmium-induced kidney injury","volume":"464","author":"Fan","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.lfs.2025.123430_bb0230","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jare.2022.04.016","article-title":"Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy","volume":"46","author":"Lian","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.lfs.2025.123430_bb0235","article-title":"Contamination of aflatoxins induces severe hepatotoxicity through multiple mechanisms","volume":"11","author":"Hua","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123430_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquaculture.2022.738255","article-title":"Condensed tannins protect against aflatoxin B1-induced toxicity in Lateolabrax maculatus by restoring intestinal integrity and regulating bacterial microbiota","volume":"555","author":"Peng","year":"2022","journal-title":"Aquaculture"},{"key":"10.1016\/j.lfs.2025.123430_bb0245","doi-asserted-by":"crossref","first-page":"526","DOI":"10.3945\/an.112.002188","article-title":"Food chain mycotoxin exposure, gut health, and impaired growth: a conceptual framework","volume":"3","author":"Smith","year":"2012","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.lfs.2025.123430_bb0250","doi-asserted-by":"crossref","first-page":"10787","DOI":"10.1021\/acs.jafc.3c02617","article-title":"Aflatoxin B(1) induces inflammatory liver injury via gut microbiota in mice","volume":"71","author":"Ye","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.lfs.2025.123430_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2020.104920","article-title":"Host microbiota dictates the proinflammatory impact of LPS in the murine liver","volume":"67","author":"Suriguga","year":"2020","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.lfs.2025.123430_bb0260","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1021\/acs.jafc.0c06815","article-title":"Gut microbiota modulation by polyphenols from Aronia melanocarpa of LPS-induced liver diseases in rats","volume":"69","author":"Kong","year":"2021","journal-title":"J. Agric. Food Chem."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525000633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525000633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T01:53:50Z","timestamp":1741312430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525000633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":52,"alternative-id":["S0024320525000633"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123430","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arginine-derived carbon dots with antioxidant activity for treating aflatoxin B1-induced liver injury via Nrf2\/Keap1 and NLRP3 pathways in mice","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123430"}}