{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T04:03:10Z","timestamp":1793678590274,"version":"4.5.1"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Heilongjiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.lfs.2025.123449","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T11:54:09Z","timestamp":1738756449000},"page":"123449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The effect of modulation Piezo2 by IGF-1 on tactile hypersensitivity in BTBR model mice"],"prefix":"10.1016","volume":"364","author":[{"given":"Jinhe","family":"Zhai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Tomoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueke","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.lfs.2025.123449_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss7011a1","article-title":"Prevalence and charac-teristics of autism spectrum disorder among children aged 8 years\u2013autism and developmental disabilities monitoring network, 11 sites, United States, 2018","volume":"70","author":"Maenner","year":"2021","journal-title":"MMWR Surveill. Summ."},{"issue":"2","key":"10.1016\/j.lfs.2025.123449_bb0010","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s12264-017-0100-y","article-title":"An overview of autism Spectrum disorder, heterogeneity and treatment options","volume":"33","author":"Masi","year":"2017","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.lfs.2025.123449_bb0015","doi-asserted-by":"crossref","unstructured":"Zhang M,Zhou Y,Jiang Y, et al. Profiling of Sexually Dimorphic Genes in Neural Cells to Identify Eif2s3y, Whose Overexpression Causes Autism-Like Behaviors in Male Mice. Front. Cell Dev. Biol. 2021;9:669798.","DOI":"10.3389\/fcell.2021.669798"},{"issue":"2","key":"10.1016\/j.lfs.2025.123449_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss7202a1","article-title":"Prevalence and characteristics of autism Spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2020","volume":"72","author":"Maenner","year":"2023","journal-title":"MMWR Surveill. Summ."},{"key":"10.1016\/j.lfs.2025.123449_bb0025","doi-asserted-by":"crossref","DOI":"10.1017\/S2045796022000178","article-title":"Global, regional and national burden of autism spectrum disorder from 1990 to 2019: results from the global burden of disease study 2019","volume":"31","author":"Li","year":"2022","journal-title":"Epidemiol. Psychiatr. Sci."},{"issue":"12","key":"10.1016\/j.lfs.2025.123449_bb0030","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.1007\/s10803-022-05763-0","article-title":"Sensory phenotypes in autism: making a case for the inclusion of sensory integration functions","volume":"53","author":"Schaaf","year":"2023","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.lfs.2025.123449_bb0035","series-title":"The Diagnostic and Statistical Manual of Mental Disorders: DSM 5","first-page":"991","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.lfs.2025.123449_bb0040","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.dcn.2018.06.002","article-title":"Hand or spoon? Exploring the neural basis of affective touch in 5-month-old infants","volume":"35","author":"Pirazzoli","year":"2019","journal-title":"Dev. Cogn. Neurosci."},{"issue":"2","key":"10.1016\/j.lfs.2025.123449_bb0045","doi-asserted-by":"crossref","first-page":"190","DOI":"10.5014\/ajot.61.2.190","article-title":"Sensory processing in children with and without autism: a comparative study using the short sensory profile","volume":"61","author":"Tomchek","year":"2007","journal-title":"Am. J. Occup. Ther."},{"issue":"8","key":"10.1016\/j.lfs.2025.123449_bb0050","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1007\/s10803-017-3163-8","article-title":"Touch processing and social behavior in ASD","volume":"47","author":"Miguel","year":"2017","journal-title":"J. Autism Dev. Disord."},{"issue":"1","key":"10.1016\/j.lfs.2025.123449_bb0055","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13229-023-00567-0","article-title":"Cortex-restricted deletion of Foxp1 impairs barrel formation and induces aberrant tactile responses in a mouse model of autism","volume":"14","author":"Li","year":"2023","journal-title":"Mol. Autism."},{"issue":"9","key":"10.1016\/j.lfs.2025.123449_bb0060","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s11920-022-01345-0","article-title":"Correction to: mechanisms of tactile sensory phenotypes in autism: current understanding and future directions for research","volume":"26","author":"Schaffler","year":"2024","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.lfs.2025.123449_bb0065","article-title":"Correlation and predictive ability of sensory characteristics and social interaction in children with autism spectrum disorder","volume":"14","author":"Zhai","year":"2023","journal-title":"Front. Psych."},{"key":"10.1016\/j.lfs.2025.123449_bb0070","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fnins.2020.00020","article-title":"Insulin-like growth Factor-1 Down-regulates the phosphorylation of FXYD1 and rescues behavioral deficits in a mouse model of Rett syndrome","volume":"14","author":"Yuan","year":"2020","journal-title":"Front. Neurosci."},{"issue":"Pt B","key":"10.1016\/j.lfs.2025.123449_bb0075","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nbd.2016.04.007","article-title":"Insulin-like growth factor 1 in diabetic neuropathy and amyotrophic lateral sclerosis","volume":"97","author":"Rauskolb","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.lfs.2025.123449_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2021.102467","article-title":"Insulin-like growth factor-1 regulates the mechanosensitivity of chondrocytes by modulating TRPV4","volume":"99","author":"Trompeter","year":"2021","journal-title":"Cell Calcium"},{"issue":"3","key":"10.1016\/j.lfs.2025.123449_bb0085","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/jcp.21065","article-title":"IGF-1 activates hEAG K(+) channels through an Akt-dependent signaling pathway in breast cancer cells: role in cell proliferation","volume":"212","author":"Borowiec","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2025.123449_bb0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2051-5960-1-15","article-title":"Peripheral nervous system insulin resistance in Ob\/Ob mice","volume":"1","author":"Grote","year":"2013","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.lfs.2025.123449_bb0095","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neubiorev.2016.01.001","article-title":"The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders","volume":"63","author":"Costales","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"11","key":"10.1016\/j.lfs.2025.123449_bb0100","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/nn.4420","article-title":"Lessons learned from studying syndromic autism spectrum disorders","volume":"19","author":"Sztainberg","year":"2016","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.lfs.2025.123449_bb0105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/gbb.12340","article-title":"Changes in insulin-like growth factor signaling alter phenotypes in fragile X mice","volume":"16","year":"2017","journal-title":"Genes Brain Behav."},{"issue":"27","key":"10.1016\/j.lfs.2025.123449_bb0110","doi-asserted-by":"crossref","first-page":"9941","DOI":"10.1073\/pnas.1311685111","article-title":"Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett syndrome","volume":"111","author":"Castro","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.lfs.2025.123449_bb0115","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/mp.2016.95","article-title":"Altered proliferation and networks in neural cells derived from idiopathic autistic individuals","volume":"22","author":"Marchetto","year":"2017","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.lfs.2025.123449_bb0120","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13229-020-00359-w","article-title":"IGF-1 treatment causes unique transcriptional response in neurons from individuals with idiopathic autism","volume":"11","author":"Linker","year":"2020","journal-title":"Mol. Autism."},{"issue":"1","key":"10.1016\/j.lfs.2025.123449_bb0125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12017-015-8341-2","article-title":"NNZ-2566, a novel analog of (1-3) IGF-1, as a potential therapeutic agent for fragile X syndrome","volume":"17","author":"Deacon","year":"2015","journal-title":"Neuromolecular Med."},{"issue":"10","key":"10.1016\/j.lfs.2025.123449_bb0130","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1093\/brain\/awae227","article-title":"Piezo2 voltage-block regulates mechanical pain sensitivity","volume":"147","author":"S\u00e1nchez-Carranza","year":"2024","journal-title":"Brain"},{"issue":"47","key":"10.1016\/j.lfs.2025.123449_bb0135","doi-asserted-by":"crossref","first-page":"E5114","DOI":"10.1073\/pnas.1414298111","article-title":"Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage","volume":"111","author":"Lee","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.lfs.2025.123449_bb0140","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1038\/s41580-024-00773-5","article-title":"Mechanisms of mechanotransduction and physiological roles of PIEZO channels","volume":"25","author":"Xiao","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"7773","key":"10.1016\/j.lfs.2025.123449_bb0145","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41586-019-1505-8","article-title":"Structure and mechanogating of the mammalian tactile channel PIEZO2","volume":"573","author":"Wang","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.lfs.2025.123449_bb0150","doi-asserted-by":"crossref","first-page":"6446","DOI":"10.1038\/s41598-019-42492-4","article-title":"The Piezo2 ion channel is mechanically activated by low-threshold positive pressure","volume":"9","author":"Shin","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2025.123449_bb0155","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev-biochem-081720-023244","article-title":"The form and function of PIEZO2","volume":"90","author":"Szczot","year":"2021","journal-title":"Annu. Rev. Biochem."},{"issue":"7529","key":"10.1016\/j.lfs.2025.123449_bb0160","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature13980","article-title":"Piezo2 is the major transducer of mechanical forces for touch sensation in mice","volume":"516","author":"Ranade","year":"2014","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.lfs.2025.123449_bb0165","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuron.2020.10.028","article-title":"Decoding cellular mechanisms for Mechanosensory discrimination","volume":"109","author":"Buchholtz","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.lfs.2025.123449_bb0170","article-title":"PIEZO2 mediates injury-induced tactile pain in mice and humans","volume":"10(462):eaat9892","author":"Szczot","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"6660","key":"10.1016\/j.lfs.2025.123449_bb0175","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1126\/science.adg0144","article-title":"PIEZO2 and perineal mechanosensation are essential for sexual function","volume":"381","author":"Lam","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.lfs.2025.123449_bb0180","article-title":"The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice","volume":"10(462):eaat9897","author":"Murthy","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.lfs.2025.123449_bb0185","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201949124","article-title":"Gi-coupled receptor activation potentiates Piezo2 currents via G\u03b2\u03b3","volume":"21","author":"Del Rosario","year":"2020","journal-title":"EMBO Rep."},{"issue":"3","key":"10.1016\/j.lfs.2025.123449_bb0190","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.celrep.2012.07.014","article-title":"Inflammatory signals enhance piezo2-mediated mechanosensitive currents","volume":"2","author":"Dubin","year":"2012","journal-title":"Cell Rep."},{"issue":"12","key":"10.1016\/j.lfs.2025.123449_bb0195","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1093\/scan\/nsab069","article-title":"Maternal sensitivity and infant neural response to touch: an fNIRS study","volume":"16","author":"Mateus","year":"2021","journal-title":"Soc. Cogn. Affect. Neurosci."},{"issue":"2","key":"10.1016\/j.lfs.2025.123449_bb0200","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000511604","article-title":"Affectionate touch in the context of breastfeeding and maternal depression influences infant neurodevelopmental and temperamental substrates","volume":"80","author":"Hardin","year":"2021","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.lfs.2025.123449_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2024.114479","article-title":"The impact of daily affective touch on cortisol levels in institutionalized & fostered children","volume":"277","author":"Nikolaeva","year":"2024","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.lfs.2025.123449_bb0210","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3389\/fnins.2020.00393","article-title":"The repetitive mechanical tactile stimulus intervention effects depend on input methods","volume":"14","author":"Watanabe","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.lfs.2025.123449_bb0215","article-title":"Effect of tactile experience during preterm infant feeding on clinical outcomes","volume":"69(5S Suppl 1):S21-S28","author":"Pickler","year":"2020","journal-title":"Nurs. Res."},{"issue":"6","key":"10.1016\/j.lfs.2025.123449_bb0220","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.neuron.2021.12.022","article-title":"Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions","volume":"110","author":"Yu","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.lfs.2025.123449_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2022.102527","article-title":"Bridging skin, brain, and behavior to understand pleasurable social touch","volume":"73","author":"Elias","year":"2022","journal-title":"Curr. Opin. Neurobiol."},{"issue":"3","key":"10.1016\/j.lfs.2025.123449_bb0230","doi-asserted-by":"crossref","first-page":"406","DOI":"10.4088\/JCP.09r05848whi","article-title":"Massage therapy for children with autism spectrum disorders: a systematic review","volume":"72","author":"Lee","year":"2011","journal-title":"J. Clin. Psychiatry"},{"issue":"5","key":"10.1016\/j.lfs.2025.123449_bb0235","doi-asserted-by":"crossref","first-page":"550","DOI":"10.5014\/ajot.2011.000661","article-title":"Early intervention for autism with a parent-delivered Qigong massage program: a randomized controlled trial","volume":"65","author":"Silva","year":"2011","journal-title":"Am. J. Occup. Ther."},{"key":"10.1016\/j.lfs.2025.123449_bb0240","doi-asserted-by":"crossref","DOI":"10.2196\/41839","article-title":"Physiological and psychological effects of parent-delivered traditional Thai massage in children with autism: protocol for a randomized controlled trial","volume":"12","author":"Ruan","year":"2023","journal-title":"JMIR Res Protoc."},{"issue":"8","key":"10.1016\/j.lfs.2025.123449_bb0245","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1007\/s10802-017-0390-6","article-title":"Reduction of pain sensitivity after somatosensory therapy in children with autism spectrum disorders","volume":"46","author":"Riquelme","year":"2018","journal-title":"J. Abnorm. Child Psychol."},{"issue":"2","key":"10.1016\/j.lfs.2025.123449_bb0250","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.infbeh.2009.12.004","article-title":"Preterm infant massage therapy research: a review","volume":"33","author":"Field","year":"2010","journal-title":"Infant Behav. Dev."},{"issue":"6","key":"10.1016\/j.lfs.2025.123449_bb0255","first-page":"4653","article-title":"Reduced environmental stimuli is associated with improved insulin-like growth factor-1 levels and physical growth in very low birth weight premature infants","volume":"17","author":"Chen","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.lfs.2025.123449_bb0260","article-title":"Xenopus gpx3 mediates posterior development by regulating cell death during embryogenesis","volume":"9 (12):null","author":"Lee","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.lfs.2025.123449_bb0265","article-title":"ZNF384: a potential therapeutic target for psoriasis and Alzheimer\u2019s disease through inflammation and metabolism","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2025.123449_bb0270","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1038\/s41467-019-10993-5","article-title":"Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma","volume":"10","author":"Ning","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2025.123449_bb0275","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13073-020-00823-5","article-title":"Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients","volume":"13","author":"Aschenbrenner","year":"2021","journal-title":"Genome Med."},{"issue":"12","key":"10.1016\/j.lfs.2025.123449_bb0280","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/j.celrep.2015.05.045","article-title":"Integrated genomics of Crohn\u2019s disease risk variant identifies a role for CLEC12A in antibacterial autophagy","volume":"11","author":"Begun","year":"2015","journal-title":"Cell Rep."},{"issue":"15","key":"10.1016\/j.lfs.2025.123449_bb0285","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1038\/s41388-020-1210-y","article-title":"Phosphorylation independent eIF4E translational reprogramming of selective mRNAs determines tamoxifen resistance in breast cancer","volume":"39","author":"Gong","year":"2020","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.lfs.2025.123449_bb0290","doi-asserted-by":"crossref","first-page":"257","DOI":"10.7150\/ijbs.7629","article-title":"Gene expression profiling in winged and wingless cotton aphids, Aphis gossypii (Hemiptera: Aphididae)","volume":"10","author":"Yang","year":"2014","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.lfs.2025.123449_bb0295","article-title":"Global crotonylome reveals CDYL-regulated RPA1 crotonylation in homologous recombination-mediated DNA repair","volume":"6 (11):eaay4697","author":"Yu","year":"2020","journal-title":"Sci. Adv."},{"issue":"13","key":"10.1016\/j.lfs.2025.123449_bb0300","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144201","article-title":"Passive transfer of fibromyalgia symptoms from patients to mice","volume":"131","author":"Goebel","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.lfs.2025.123449_bb0305","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.neuron.2019.10.035","article-title":"CUL3 deficiency causes social deficits and anxiety-like behaviors by impairing excitation-inhibition balance through the promotion of cap-dependent translation","volume":"105","author":"Dong","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.lfs.2025.123449_bb0310","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.bbi.2020.04.061","article-title":"Baseline immunoreactivity before pregnancy and poly(I:C) dose combine to dictate susceptibility and resilience of offspring to maternal immune activation","volume":"88","author":"Estes","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.lfs.2025.123449_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119308","article-title":"The implication of transient receptor potential canonical 6 in BDNF-induced mechanical allodynia in rat model of diabetic neuropathic pain","volume":"273","author":"Miao","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2025.123449_bb0320","article-title":"Painful diabetic neu-ropathy is associated with compromised microglial IGF-1 signaling which can be rescued by green tea poly-phenol EGCG in mice","volume":"2022","author":"Chen","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"11","key":"10.1016\/j.lfs.2025.123449_bb0325","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.3390\/ijms21113834","article-title":"Functional expression of Piezo1 in dorsal root ganglion (DRG) neurons","volume":"21","author":"Roh","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2025.123449_bb0330","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1038\/s41467-018-04194-9","article-title":"Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis","volume":"9","author":"Romac","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2025.123449_bb0335","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12931-023-02328-2","article-title":"Intraluminal chloride regulates lung branching morphogenesis: involvement of PIEZO1\/PIEZO2","volume":"24","author":"Gon\u00e7alves","year":"2023","journal-title":"Respir. Res."},{"key":"10.1016\/j.lfs.2025.123449_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2024.105963","article-title":"The role of the Piezo1 channel in osteoblasts under cyclic stretching: a study on osteogenic and osteoclast factors","volume":"163","author":"Kang","year":"2024","journal-title":"Arch. Oral Biol."},{"issue":"1","key":"10.1016\/j.lfs.2025.123449_bb0350","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13229-020-00393-8","article-title":"Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats","volume":"11","author":"Jacot-Descombes","year":"2020","journal-title":"Mol. Autism."},{"key":"10.1016\/j.lfs.2025.123449_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.110101","article-title":"Medial prefrontal cortex circuitry and social behaviour in autism","volume":"260","author":"Mediane","year":"2024","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.lfs.2025.123449_bb0360","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/aur.2073","article-title":"Tactile hypersensitivity and GABA concentration in the sensorimotor cortex of adults with autism","volume":"12","author":"Sapey-Triomphe","year":"2019","journal-title":"Autism Res."},{"issue":"1","key":"10.1016\/j.lfs.2025.123449_bb0365","volume":"7","author":"Fukuyama","year":"2017","journal-title":"Autonomic versus perceptual accounts for tactile hypersensitivity in autism spectrum disorder [published correction appears in Sci. Rep.]"},{"issue":"4","key":"10.1016\/j.lfs.2025.123449_bb0370","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.cell.2019.07.024","article-title":"Targeting peripheral somatosensory neurons to improve tactile-related phenotypes in ASD models","volume":"178","author":"Orefice","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.lfs.2025.123449_bb0375","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bbr.2010.06.032","article-title":"Somatosensory and sensorimotor consequences associated with the heterozygous disruption of the autism candidate gene, Gabrb3","volume":"216","author":"DeLorey","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"14","key":"10.1016\/j.lfs.2025.123449_bb0380","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1093\/cercor\/bhab399","article-title":"Abnormal whisker-dependent behaviors and altered Cortico-hippocampal connectivity in Shank3b\u2212\/\u2212 mice","volume":"32","author":"Balasco","year":"2022","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.lfs.2025.123449_bb0385","article-title":"Astrocytes contribute to pain gating in the spinal cord","volume":"7 (45):eabi6287","author":"Xu","year":"2021","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.lfs.2025.123449_bb0390","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/j.pain.0000000000001416","article-title":"Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury","volume":"160","author":"Baskozos","year":"2019","journal-title":"Pain"},{"issue":"6","key":"10.1016\/j.lfs.2025.123449_bb0395","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.neuron.2016.11.007","article-title":"SHANK3 deficiency impairs heat hyperalgesia and TRPV1 signaling in primary sensory neurons","volume":"92","author":"Han","year":"2016","journal-title":"Neuron"},{"issue":"33","key":"10.1016\/j.lfs.2025.123449_bb0400","doi-asserted-by":"crossref","first-page":"E6952","DOI":"10.1073\/pnas.1618210114","article-title":"Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in a rat model of Rett syndrome","volume":"114","author":"Bhattacherjee","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.lfs.2025.123449_bb0405","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-17503-6","article-title":"BDNF, proBDNF and IGF-1 serum levels in na\u00efve and medicated subjects with autism","volume":"12","author":"Robinson-Agramonte","year":"2022","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.lfs.2025.123449_bb0410","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1017\/S0012162206001605","article-title":"Cerebrospinal fluid insulin-like growth factors IGF-1 and IGF-2 in infantile autism","volume":"48","author":"Riikonen","year":"2006","journal-title":"Dev. Med. Child Neurol."},{"issue":"4","key":"10.1016\/j.lfs.2025.123449_bb0415","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.pain.2011.01.004","article-title":"Peripheral sensitization caused by insulin-like growth factor 1 contributes to pain hypersensitivity after tissue injury","volume":"152","author":"Miura","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2025.123449_bb0420","article-title":"Peripheral pain is enhanced by insulin-like growth factor 1 through a G protein-mediated stimulation of T-type calcium channels","volume":"7(346):ra94","author":"Zhang","year":"2014","journal-title":"Sci. Signal."},{"issue":"6","key":"10.1016\/j.lfs.2025.123449_bb0425","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/j.1532-2149.2013.00420.x","article-title":"Enhanced function of TRPV1 via up-regulation by insulin-like growth factor-1 in a rat model of bone cancer pain","volume":"18","author":"Li","year":"2014","journal-title":"Eur. J. Pain"},{"issue":"20","key":"10.1016\/j.lfs.2025.123449_bb0430","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1016\/j.neuron.2023.08.023","article-title":"Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch","volume":"111","author":"Handler","year":"2023","journal-title":"Neuron"},{"issue":"28","key":"10.1016\/j.lfs.2025.123449_bb0435","doi-asserted-by":"crossref","first-page":"11715","DOI":"10.1523\/JNEUROSCI.3541-12.2013","article-title":"Enriched early life experiences reduce adult anxiety-like behavior in rats: a role for insulin-like growth factor 1","volume":"33","author":"Baldini","year":"2013","journal-title":"J. Neurosci."},{"issue":"18","key":"10.1016\/j.lfs.2025.123449_bb0440","doi-asserted-by":"crossref","first-page":"6042","DOI":"10.1523\/JNEUROSCI.5548-08.2009","article-title":"Massage accelerates brain development and the maturation of visual function","volume":"29","author":"Guzzetta","year":"2009","journal-title":"J. Neurosci."},{"issue":"4\u20135","key":"10.1016\/j.lfs.2025.123449_bb0445","first-page":"225","article-title":"Massage efficacy in the treatment of autistic children - a literature review","volume":"64","author":"Walaszek","year":"2017","journal-title":"Int J Dev Disabil."},{"issue":"2","key":"10.1016\/j.lfs.2025.123449_bb0455","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2016.05.033","article-title":"Peripheral mechanosensory neuron dysfunction underlies tactile and behavioral deficits in mouse models of ASDs","volume":"166","author":"Orefice","year":"2016","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.lfs.2025.123449_bb0460","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.biopsych.2020.08.023","article-title":"A subpopulation of prefrontal cortical neurons is required for social memory","volume":"89","author":"Xing","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.lfs.2025.123449_bb0465","article-title":"Prenatal GABAB receptor agonist administration corrects the inheritance of autism-like core behaviors in offspring of mice prenatally exposed to valproic acid","volume":"13","author":"Jiang","year":"2022","journal-title":"Front. Psych."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525000827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525000827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T01:55:03Z","timestamp":1741312503000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525000827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":91,"alternative-id":["S0024320525000827"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123449","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of modulation Piezo2 by IGF-1 on tactile hypersensitivity in BTBR model mice","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123449","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123449"}}