{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:51:51Z","timestamp":1790682711481,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.lfs.2025.123471","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T20:59:03Z","timestamp":1739566743000},"page":"123471","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["MiRNA-21-loaded chitosan nanoparticles ameliorate pancreatic apoptosis and oxidative stress in diabetic rats"],"prefix":"10.1016","volume":"366-367","author":[{"given":"Eman H.","family":"Thabet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehal A.","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M.","family":"Essawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar A.","family":"Harby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany A.","family":"Solaiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanaa M.","family":"El Gazaerly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yassmin H.","family":"Khalifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.lfs.2025.123471_bb0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"2","key":"10.1016\/j.lfs.2025.123471_bb0010","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nrg2290","article-title":"Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?","volume":"9","author":"Filipowicz","year":"2008","journal-title":"Nat. Rev. Genet."},{"issue":"3","key":"10.1016\/j.lfs.2025.123471_bb0015","doi-asserted-by":"crossref","first-page":"8810","DOI":"10.4238\/2015.August.3.4","article-title":"Characterization and effects of miR-21 expression in esophageal cancer","volume":"14","author":"Wen","year":"2015","journal-title":"Genet. Mol. Res."},{"issue":"12","key":"10.1016\/j.lfs.2025.123471_bb0020","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1093\/molehr\/gaaa068","article-title":"Extracellular vesicles miRNA-21: a potential therapeutic tool in premature ovarian dysfunction","volume":"26","author":"Thabet","year":"2020","journal-title":"Mol. Hum. Reprod."},{"issue":"23","key":"10.1016\/j.lfs.2025.123471_bb0025","first-page":"108","article-title":"Microrna-21 as novel biomarker for pancreatic Beta cells stress and\/or death in patients with diabetes mellitus type","volume":"18","author":"Awad","year":"2023","journal-title":"Euromediterr Biomed J"},{"issue":"2","key":"10.1016\/j.lfs.2025.123471_bb0030","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1053\/j.ajkd.2013.10.047","article-title":"New insights into molecular mechanisms of diabetic kidney disease","volume":"63","author":"Badal","year":"2014","journal-title":"Am. J. Kidney Dis."},{"issue":"29","key":"10.1016\/j.lfs.2025.123471_bb0035","doi-asserted-by":"crossref","first-page":"25586","DOI":"10.1074\/jbc.M110.208066","article-title":"MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes","volume":"286","author":"Dey","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.lfs.2025.123471_bb0040","first-page":"180","article-title":"Distribution of systemically administered nanoparticles during acute pancreatitis: effects of particle size and disease severity","volume":"76","author":"Qiang","year":"2021","journal-title":"Pharmazie"},{"issue":"1","key":"10.1016\/j.lfs.2025.123471_bb0045","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1080\/10717544.2022.2058648","article-title":"Chitosan-coated bovine serum albumin nanoparticles for topical tetrandrine delivery in glaucoma: in vitro and in vivo assessment","volume":"29","author":"Radwan","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.lfs.2025.123471_bb0050","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-4939-2272-7_3","article-title":"Getting across the cell membrane: an overview for small molecules, peptides, and proteins","volume":"1266","author":"Yang","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.lfs.2025.123471_bb0055","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.ijbiomac.2019.10.113","article-title":"Chitosan as an environment friendly biomaterial\u2013a review on recent modifications and applications","volume":"150","author":"Bakshi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.lfs.2025.123471_bb0060","article-title":"A review on potential anti-diabetic mechanisms of chitosan and its derivatives","volume":"3","author":"Priyanka","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.lfs.2025.123471_bb0065","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1080\/21691401.2022.2092123","article-title":"MicroRNA-219 loaded chitosan nanoparticles for treatment of glioblastoma","volume":"50","author":"Alswailem","year":"2022","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"2","key":"10.1016\/j.lfs.2025.123471_bb0070","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/jcmm.14007","article-title":"Pancreatic fibroblast growth factor 21 protects against type 2 diabetes in mice by promoting insulin expression and secretion in a PI3K\/Akt signaling-dependent manner","volume":"23","author":"Pan","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2025.123471_bb0075","doi-asserted-by":"crossref","unstructured":"Furman B. Streptozotocin-induced diabetic models in mice and rats. Curr. Protoc. Pharmacol. 2015; 70:5.47.1\u201320.","DOI":"10.1002\/0471141755.ph0547s70"},{"issue":"1","key":"10.1016\/j.lfs.2025.123471_bb0080","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ijmmb.2021.01.004","article-title":"Evaluation of combined ciprofloxacin and azithromycin free and nano formulations to control biofilm producing Pseudomonas aeruginosa isolated from burn wounds","volume":"39","author":"Raouf","year":"2021","journal-title":"Indian J. Med. Microbiol."},{"issue":"9","key":"10.1016\/j.lfs.2025.123471_bb0085","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.1021\/acs.nanolett.8b02578","article-title":"Nanoparticle delivery of miRNA-21 mimic to cardiac macrophages improves myocardial remodeling after myocardial infarction","volume":"18","author":"Bejerano","year":"2018","journal-title":"Nano Lett."},{"issue":"12","key":"10.1016\/j.lfs.2025.123471_bb0090","first-page":"1000","article-title":"Biocompatible luminescent nanosized curcumin: verified parameters affecting stability and bioavailability","volume":"7","author":"Mohamed","year":"2020","journal-title":"Int J Dentistry Oral Sci"},{"key":"10.1016\/j.lfs.2025.123471_bb0095","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/146320","article-title":"Development of chitosan nanoparticles as a stable drug delivery system for protein\/siRNA","volume":"2013","author":"Katas","year":"2013","journal-title":"Int J Biomater"},{"key":"10.1016\/j.lfs.2025.123471_bb0100","doi-asserted-by":"crossref","unstructured":"Abou-Elnour FS, El-Habashy SE, Essawy MM, Abdallah OY. Alendronate\/lactoferrin-dual decorated lipid nanocarriers for bone-homing and active targeting of ivermectin and methyl dihydrojasmonate for leukemia. Biomaterials Advances. 2024 Jun 9:213924.","DOI":"10.1016\/j.bioadv.2024.213924"},{"issue":"6","key":"10.1016\/j.lfs.2025.123471_bb0105","doi-asserted-by":"crossref","first-page":"E1323","DOI":"10.1152\/ajpendo.90617.2008","article-title":"Evaluating the glucose tolerance test in mice","volume":"295","author":"Andrikopoulos","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2025.123471_bb0110","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/378790","article-title":"Markers of oxidative stress during diabetes mellitus","volume":"2013","author":"Tiwari","year":"2013","journal-title":"J Biomark"},{"issue":"2","key":"10.1016\/j.lfs.2025.123471_bb0115","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"issue":"1","key":"10.1016\/j.lfs.2025.123471_bb0120","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia","year":"1967","journal-title":"J. Lab. Clin. Med."},{"issue":"5","key":"10.1016\/j.lfs.2025.123471_bb0125","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1136\/jcp.54.5.356","article-title":"Method for the measurement of antioxidant activity in human fluids","volume":"54","author":"Koracevic","year":"2001","journal-title":"J. Clin. Pathol."},{"issue":"4","key":"10.1016\/j.lfs.2025.123471_bb0130","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.lfs.2025.123471_bb0135","series-title":"Bancroft\u2019s Theory and Practice of Histological Techniques","first-page":"25","article-title":"Light microscopy","author":"Bancroft","year":"2019"},{"issue":"1","key":"10.1016\/j.lfs.2025.123471_bb0140","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4161\/isl.2.1.10041","article-title":"Immunocytochemical localization of cleaved caspase-3 in pancreatic islets from type 1 diabetic subjects","volume":"2","author":"Tomita","year":"2010","journal-title":"Islets"},{"issue":"7\u20138","key":"10.1016\/j.lfs.2025.123471_bb0145","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/mrd.22489","article-title":"The ImageJ ecosystem: an open platform for biomedical image analysis","volume":"82","author":"Schindelin","year":"2015","journal-title":"Mol. Reprod. Dev."},{"issue":"6","key":"10.1016\/j.lfs.2025.123471_bb0150","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.cell.2012.02.010","article-title":"Diabetes mellitus and the \u03b2 cell: the last ten years","volume":"148","author":"Ashcroft","year":"2012","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.lfs.2025.123471_bb0155","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/MED.0000000000000548","article-title":"The role of Beta cell dysfunction in early type 1 diabetes","volume":"27","author":"Sims","year":"2020","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.lfs.2025.123471_bb0160","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00592-012-0446-6","article-title":"Ultrastructural morphometric analysis of insulin secretory granules in human type 2 diabetes","volume":"49","author":"Masini","year":"2012","journal-title":"Acta Diabetol."},{"issue":"3","key":"10.1016\/j.lfs.2025.123471_bb0165","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jmau.2015.03.005","article-title":"Effect of genistein, a natural soy isoflavone, on pancreatic \u03b2-cells of streptozotocin-induced diabetic rats: histological and immunohistochemical study","volume":"3","author":"El-Kordy","year":"2015","journal-title":"J Microsc Ultrastruct"},{"issue":"1","key":"10.1016\/j.lfs.2025.123471_bb0170","article-title":"Determination of secretory granule maturation times in pancreatic islet \u03b2-cells by serial block-face electron microscopy","volume":"212","author":"Rao","year":"2020","journal-title":"J StrBiol"},{"key":"10.1016\/j.lfs.2025.123471_bb0175","series-title":"Electron Microscopy","article-title":"Application of transmission Electron microscopy to detect changes in pancreas physiology","author":"Ma\u0161a Skelin","year":"2022"},{"issue":"2","key":"10.1016\/j.lfs.2025.123471_bb0180","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan-and streptozotocin-induced diabetes","volume":"51","author":"Lenzen","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.lfs.2025.123471_bb0185","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fcell.2017.00055","article-title":"Pancreatic beta cell identity in humans and the role of type 2 diabetes","volume":"5","author":"Marchetti","year":"2017","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2025.123471_bb0190","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.mito.2019.06.002","article-title":"Mitochondrial dynamics and their potential as a therapeutic target","volume":"49","author":"Whitley","year":"2019","journal-title":"Mitochondrion"},{"issue":"6","key":"10.1016\/j.lfs.2025.123471_bb0195","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.beem.2012.05.004","article-title":"Mitochondrial dynamics and morphology in beta-cells","volume":"26","author":"Stiles","year":"2012","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.lfs.2025.123471_bb0200","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/antiox6020033","article-title":"The interplay between oncogenic signaling networks and mitochondrial dynamics","volume":"6","author":"Nagdas","year":"2017","journal-title":"Antioxidants"},{"issue":"3","key":"10.1016\/j.lfs.2025.123471_bb0205","doi-asserted-by":"crossref","first-page":"399","DOI":"10.5534\/wjmh.210146","article-title":"The role of mitochondrial dynamic dysfunction in age-associated type 2 diabetes","volume":"40","author":"Vezza","year":"2022","journal-title":"World J Mens Health"},{"issue":"6","key":"10.1016\/j.lfs.2025.123471_bb0210","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.54.6.1615","article-title":"The pathobiology of diabetic complications: a unifying mechanism","volume":"54","author":"Brownlee","year":"2005","journal-title":"Diabetes"},{"issue":"11","key":"10.1016\/j.lfs.2025.123471_bb0215","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.7150\/ijbs.27173","article-title":"The PI3K\/AKT pathway in obesity and type 2 diabetes","volume":"14","author":"Huang","year":"2018","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2025.123471_bb0220","doi-asserted-by":"crossref","first-page":"256","DOI":"10.23736\/S0031-0808.20.03974-9","article-title":"MiR-21-5p reduces apoptosis and inflammation in rats with spinal cord injury through PI3K\/AKT pathway","volume":"66","author":"Lv","year":"2024","journal-title":"Panminerva Med."},{"issue":"9","key":"10.1016\/j.lfs.2025.123471_bb0230","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fendo.2018.00338","article-title":"PTEN: tumor suppressor and metabolic regulator","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.lfs.2025.123471_bb0235","doi-asserted-by":"crossref","unstructured":"Wang L, Liu Y, Yan Lu S, Nguyen KT, Schroer SA, Suzuki A, Mak TW, Gaisano H, Woo M. Deletion of Pten in pancreatic \u03b2-cells protects against deficient \u03b2-cell mass and function in mouse models of type 2 diabetes. Diabetes. 2010 Dec 1;59(12):3117\u201326.","DOI":"10.2337\/db09-1805"},{"issue":"1","key":"10.1016\/j.lfs.2025.123471_bb0240","doi-asserted-by":"crossref","first-page":"109","DOI":"10.51967\/tanesa.v24i1.2004","article-title":"PTEN: the potential therapeutic target of diabetes mellitus","volume":"24","author":"Sukanty","year":"2023","journal-title":"Buletin Poltanesa"},{"issue":"8","key":"10.1016\/j.lfs.2025.123471_bb0245","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a036137","article-title":"Metabolic role of PTEN in insulin signaling and resistance","volume":"10","author":"Li","year":"2020","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"2","key":"10.1016\/j.lfs.2025.123471_bb0250","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.2217\/rme-2019-0065","article-title":"Pharmacological PTEN inhibition: potential clinical applications and effects in tissue regeneration","volume":"15","author":"Borges","year":"2020","journal-title":"Regen. Med."},{"issue":"6","key":"10.1016\/j.lfs.2025.123471_bb0255","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/cr.2009.42","article-title":"Pancreas-specific Pten deficiency causes partial resistance to diabetes and elevated hepatic AKT signaling","volume":"19","author":"Tong","year":"2009","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.lfs.2025.123471_bb0260","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.2337\/diabetes.51.4.1028","article-title":"Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice","volume":"51","author":"Butler","year":"2002","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.lfs.2025.123471_bb0265","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/molecules25010112","article-title":"The history of nanoscience and nanotechnology: from chemical\u2013physical applications to nanomedicine","volume":"25","author":"Bayda","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.lfs.2025.123471_bb0270","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.2147\/IJN.S385590","article-title":"A mini-review of diagnostic and therapeutic nano-tools for pancreatitis","volume":"17","author":"Zhang","year":"2022","journal-title":"Int. J. Nanomedicine"},{"issue":"3","key":"10.1016\/j.lfs.2025.123471_bb0275","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1021\/acsnano.6b06040","article-title":"Diverse applications of nanomedicine","volume":"11","author":"Pelaz","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.lfs.2025.123471_bb0280","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-12-800268-1.00003-2","article-title":"Antidiabetic activities of chitosan and its derivatives: a mini review","volume":"73","author":"Karadeniz","year":"2014","journal-title":"Adv. Food Nutr. Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525001043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525001043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T12:31:36Z","timestamp":1741264296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525001043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":55,"alternative-id":["S0024320525001043"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123471","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MiRNA-21-loaded chitosan nanoparticles ameliorate pancreatic apoptosis and oxidative stress in diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123471","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123471"}}