{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T20:04:20Z","timestamp":1789589060389,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA1802300"],"award-info":[{"award-number":["2024YFA1802300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20270"],"award-info":[{"award-number":["U22A20270"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360056"],"award-info":[{"award-number":["82360056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170440"],"award-info":[{"award-number":["82170440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010834","name":"Education Department of Hainan Province","doi-asserted-by":"publisher","award":["Hnky2023ZD-10"],"award-info":[{"award-number":["Hnky2023ZD-10"]}],"id":[{"id":"10.13039\/501100010834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.lfs.2025.123570","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T20:15:46Z","timestamp":1742328946000},"page":"123570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["MMP3 as a new target of Danshensu\/tetramethylpyrazine derivative for attenuating cardiac fibrosis post-myocardial infarction"],"prefix":"10.1016","volume":"370","author":[{"given":"Wei","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo","family":"In Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyue","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2025.123570_bb0005","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ehf2.13144","article-title":"Heart failure after myocardial infarction: incidence and predictors","volume":"8","author":"Jen\u010da","year":"2021","journal-title":"ESC. Heart. Fail."},{"key":"10.1016\/j.lfs.2025.123570_bb0010","article-title":"Fibrosis after myocardial infarction: an overview on cellular processes, molecular pathways, clinical evaluation and prognostic value","volume":"9","author":"Scalise","year":"2021","journal-title":"Med. Sci (Basel)"},{"key":"10.1016\/j.lfs.2025.123570_bb0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1074248420952233","article-title":"Endothelial-to-mesenchymal transition: role in cardiac fibrosis","volume":"26","author":"Cheng","year":"2021","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2025.123570_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/cells11111834","article-title":"The role of endothelial-to-mesenchymal transition in cardiovascular disease","volume":"11","author":"Peng","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2025.123570_bb0025","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.7150\/thno.85361","article-title":"Lactoferrin attenuates cardiac fibrosis and cardiac remodeling after myocardial infarction via inhibiting mTORC1\/S6K signaling pathway","volume":"13","author":"Ye","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.lfs.2025.123570_bb0030","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/s12933-023-02040-x","article-title":"SIRT1 mediates the inhibitory effect of Dapagliflozin on EndMT by inhibiting the acetylation of endothelium Notch1","volume":"22","author":"Wang","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.lfs.2025.123570_bb0035","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adc9465","article-title":"Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction","volume":"9","author":"Fan","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.lfs.2025.123570_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.688396","article-title":"Integration of functional imaging, cytometry, and unbiased proteomics reveals new features of endothelial-to-mesenchymal transition in ischemic mitral valve regurgitation in human patients","volume":"8","author":"Lupieri","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.lfs.2025.123570_bb0045","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6595437","article-title":"Tongxinluo attenuates myocardiac fibrosis after acute myocardial infarction in rats via inhibition of endothelial-to-mesenchymal transition","volume":"2019","author":"Yin","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.lfs.2025.123570_bb0050","doi-asserted-by":"crossref","DOI":"10.1063\/5.0033710","article-title":"Bioengineering strategies to control epithelial-to-mesenchymal transition for studies of cardiac development and disease","volume":"5","author":"Bannerman","year":"2021","journal-title":"APL. Bioeng."},{"key":"10.1016\/j.lfs.2025.123570_bb0055","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1093\/chromsci\/bmu133","article-title":"Pharmacokinetic and metabolic studies of ADTM: a novel Danshensu derivative confers cardioprotection by HPLC-UV and LC-MS\/MS","volume":"53","author":"Li","year":"2015","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.lfs.2025.123570_bb0060","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ejphar.2017.10.034","article-title":"A novel Danshensu\/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs","volume":"818","author":"Xu","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123570_bb0065","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.ijcard.2012.12.012","article-title":"A novel Danshensu derivative confers cardioprotection via PI3K\/Akt and Nrf2 pathways","volume":"168","author":"Cui","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.lfs.2025.123570_bb0070","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.phrs.2018.06.005","article-title":"A novel Ca(2+) current blocker promotes angiogenesis and cardiac healing after experimental myocardial infarction in mice","volume":"134","author":"Cui","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2025.123570_bb0075","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.7150\/ijms.59411","article-title":"A novel Danshensu\/tetramethylpyrazine protects against myocardial ischemia reperfusion injury in rats","volume":"18","author":"Wang","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.lfs.2025.123570_bb0080","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.3389\/fphar.2019.01268","article-title":"Deletion of neuropeptide Y attenuates cardiac dysfunction and apoptosis during acute myocardial infarction","volume":"10","author":"Huang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123570_bb0085","doi-asserted-by":"crossref","first-page":"1074837","DOI":"10.3389\/fphar.2023.1074837","article-title":"Linggui Zhugan decoction activates the SIRT1-AMPK-PGC1\u03b1 signaling pathway to improve mitochondrial and oxidative damage in rats with chronic heart failure caused by myocardial infarction","volume":"14","author":"Yu","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123570_bb0090","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00210-017-1443-7","article-title":"Transient receptor potential vanilloid-3 (TRPV3) activation plays a central role in cardiac fibrosis induced by pressure overload in rats via TGF-\u03b2(1) pathway","volume":"391","author":"Liu","year":"2018","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123570_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109824","article-title":"Fibroblast contributions to ischemic cardiac remodeling","volume":"77","author":"Burke","year":"2021","journal-title":"Cell. Signal."},{"key":"10.1016\/j.lfs.2025.123570_bb0100","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/6018375","article-title":"The Carthamus tinctorius L. and Lepidium apetalum Willd. drug pair inhibits EndMT through the TGF\u03b21\/snail signaling pathway in the treatment of myocardial fibrosis","volume":"2023","author":"Zhou","year":"2023","journal-title":"Evid. Based. Complement. Alternat. Med."},{"key":"10.1016\/j.lfs.2025.123570_bb0105","article-title":"Epigallocatechin-3-Gallate attenuates myocardial dysfunction via inhibition of endothelial-to-mesenchymal transition","volume":"12","author":"Kim","year":"2023","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.lfs.2025.123570_bb0110","doi-asserted-by":"crossref","first-page":"12799","DOI":"10.1111\/jcmm.15871","article-title":"MFGE8 is down-regulated in cardiac fibrosis and attenuates endothelial-mesenchymal transition through Smad2\/3-Snail signalling pathway","volume":"24","author":"Wang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2025.123570_bb0115","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/cvr\/cvv015","article-title":"Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis","volume":"105","author":"Xu","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2025.123570_bb0120","article-title":"Kanglexin protects against cardiac fibrosis and dysfunction in mice by TGF-\u03b21\/ERK1\/2 noncanonical pathway","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123570_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2024.1336551","article-title":"Cardiac fibrogenesis: an immuno-metabolic perspective","volume":"15","author":"Hoque","year":"2024","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2025.123570_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106682","article-title":"Integrating network analysis and experimental validation to reveal the mitophagy-associated mechanism of Yiqi Huoxue (YQHX) prescription in the treatment of myocardial ischemia\/reperfusion injury","volume":"189","author":"Chen","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2025.123570_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154500","article-title":"Network pharmacology and pharmacological evaluation for deciphering novel indication of Sishen Wan in insomnia treatment","volume":"108","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2025.123570_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154268","article-title":"Network pharmacology provides a systematic approach to understanding the treatment of ischemic heart diseases with traditional Chinese medicine","volume":"104","author":"Yang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2025.123570_bb0145","doi-asserted-by":"crossref","first-page":"198","DOI":"10.4161\/cbt.10.2.12193","article-title":"Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT)","volume":"10","author":"Blavier","year":"2010","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.lfs.2025.123570_bb0150","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ijc.28662","article-title":"Filamin A interacting protein 1-like inhibits WNT signaling and MMP expression to suppress cancer cell invasion and metastasis","volume":"135","author":"Kwon","year":"2014","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.lfs.2025.123570_bb0155","first-page":"1413","article-title":"Transforming growth factor-\u03b2-dependent Wnt secretion controls myofibroblast formation and myocardial fibrosis progression in experimental autoimmune myocarditis","volume":"38","author":"Blyszczuk","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2025.123570_bb0160","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.7150\/thno.38640","article-title":"Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1","volume":"10","author":"Wilhelmi","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.lfs.2025.123570_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e24010","article-title":"Triptolide attenuates cardiac remodeling by inhibiting pyroptosis and EndMT via modulating USP14\/Keap1\/Nrf2 pathway","volume":"10","author":"Ba","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.lfs.2025.123570_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10194430","article-title":"A review of the molecular mechanisms underlying cardiac fibrosis and atrial fibrillation","volume":"10","author":"Sygitowicz","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.lfs.2025.123570_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110132","article-title":"Si-Miao-Yong-An decoction attenuates cardiac fibrosis via suppressing TGF-\u03b21 pathway and interfering with MMP-TIMPs expression","volume":"127","author":"Su","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2025.123570_bb0180","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/1354750X.2015.1118539","article-title":"Circulating multimarker profile of patients with symptomatic heart failure supports enhanced fibrotic degradation and decreased angiogenesis","volume":"21","author":"Morine","year":"2016","journal-title":"Biomarkers"},{"key":"10.1016\/j.lfs.2025.123570_bb0185","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.cardiores.2005.08.009","article-title":"Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: the role of MAP kinases and NAD(P)H oxidase","volume":"69","author":"Spallarossa","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2025.123570_bb0190","first-page":"143","article-title":"Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts, IUBMB","volume":"64","author":"Turner","year":"2012","journal-title":"Life"},{"key":"10.1016\/j.lfs.2025.123570_bb0195","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0022-2828(03)00113-5","article-title":"Targeted deletion of caspase-1 reduces early mortality and left ventricular dilatation following myocardial infarction","volume":"35","author":"Frantz","year":"2003","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2025.123570_bb0200","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ejheart.2007.12.009","article-title":"Circulating stromelysin-1 (MMP-3): a novel predictor of LV dysfunction, remodelling and all-cause mortality after acute myocardial infarction","volume":"10","author":"Kelly","year":"2008","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.lfs.2025.123570_bb0205","article-title":"Matrix metalloproteinase 3 regulates angiotensin II-induced myocardial fibrosis cell viability, migration and apoptosis","volume":"23","author":"Shu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2025.123570_bb0210","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.yjmcc.2017.07.011","article-title":"Entanglement of GSK-3\u03b2, \u03b2-catenin and TGF-\u03b21 signaling network to regulate myocardial fibrosis","volume":"110","author":"Guo","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2025.123570_bb0215","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1242\/dmm.006510","article-title":"Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition","volume":"4","author":"Aisagbonhi","year":"2011","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.lfs.2025.123570_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810072","article-title":"WNT\/\u03b2-catenin signaling promotes TGF-\u03b2-mediated activation of human cardiac fibroblasts by enhancing IL-11 production","volume":"22","author":"Dzia\u0142o","year":"2021","journal-title":"Int. J. Mol. Sci."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525002048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525002048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:09:49Z","timestamp":1762211389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525002048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":44,"alternative-id":["S0024320525002048"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123570","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MMP3 as a new target of Danshensu\/tetramethylpyrazine derivative for attenuating cardiac fibrosis post-myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123570","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123570"}}