{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:58:58Z","timestamp":1793278738239,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100668"],"award-info":[{"award-number":["82100668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20190138"],"award-info":[{"award-number":["BK20190138"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017964","name":"Tianjin Municipal Health Commission","doi-asserted-by":"publisher","award":["ZKX22048"],"award-info":[{"award-number":["ZKX22048"]}],"id":[{"id":"10.13039\/100017964","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017964","name":"Tianjin Municipal Health Commission","doi-asserted-by":"publisher","award":["ZKX17036"],"award-info":[{"award-number":["ZKX17036"]}],"id":[{"id":"10.13039\/100017964","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.lfs.2025.123575","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T22:48:12Z","timestamp":1742770092000},"page":"123575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Interferon regulatory factor 1 contributes to metabolic dysfunction associated steatotic liver disease"],"prefix":"10.1016","volume":"370","author":[{"given":"Xinyue","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanwen","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulian","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocen","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2025.123575_bb0005","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0025-6196(24)00530-5","article-title":"Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease","volume":"55","author":"Ludwig","year":"1980","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.lfs.2025.123575_bb0010","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2025.123575_bb0015","doi-asserted-by":"crossref","first-page":"e249","DOI":"10.1016\/j.jhep.2024.02.010","article-title":"Changing from NAFLD to MASLD: the implications for health-related quality of life data","volume":"80","author":"Hashida","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2025.123575_bb0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(21)01701-3","article-title":"The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality","volume":"399","author":"Karlsen","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2025.123575_bb0025","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"A phase 3, randomized, controlled trial of Resmetirom in NASH with liver fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2025.123575_bb0030","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1038\/s41467-024-50660-y","article-title":"A male mouse model for metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma","volume":"15","author":"Jeong","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2025.123575_bb0035","doi-asserted-by":"crossref","first-page":"G462","DOI":"10.1152\/ajpgi.00358.2018","article-title":"Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals","volume":"316","author":"Suppli","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2025.123575_bb0040","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s43856-024-00465-3","article-title":"Transcriptomics-driven metabolic pathway analysis reveals similar alterations in lipid metabolism in mouse MASH model and human","volume":"4","author":"Tsouka","year":"2024","journal-title":"Commun. Med."},{"key":"10.1016\/j.lfs.2025.123575_bb0045","article-title":"C-C motif chemokine CCL11 is a novel regulator and a potential therapeutic target in non-alcoholic fatty liver disease","volume":"5","author":"Fan","year":"2023","journal-title":"JHEP Rep."},{"key":"10.1016\/j.lfs.2025.123575_bb0050","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1631\/jzus.B2300159","article-title":"Key role of interferon regulatory factor 1 (IRF-1) in regulating liver disease: progress and outlook","volume":"25","author":"Chen","year":"2024","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.lfs.2025.123575_bb0055","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/hep.26751","article-title":"Interferon regulatory factor 3 constrains IKKbeta\/NF-kappaB signaling to alleviate hepatic steatosis and insulin resistance","volume":"59","author":"Wang","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2025.123575_bb0060","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1002\/hep.30559","article-title":"Hepatic interferon regulatory factor 6 alleviates liver steatosis and metabolic disorder by transcriptionally suppressing peroxisome proliferator-activated receptor gamma in mice","volume":"69","author":"Tong","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2025.123575_bb0065","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/hep.26368","article-title":"Interferon regulatory factor 9 protects against hepatic insulin resistance and steatosis in male mice","volume":"58","author":"Wang","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2025.123575_bb0070","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00184.2004","article-title":"IFN-gamma\/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1","volume":"287","author":"Jaruga","year":"2004","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2025.123575_bb0075","doi-asserted-by":"crossref","first-page":"G1261","DOI":"10.1152\/ajpgi.00460.2005","article-title":"The transcription factor interferon regulatory factor-1 mediates liver damage during ischemia-reperfusion injury","volume":"290","author":"Tsung","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2025.123575_bb0080","doi-asserted-by":"crossref","first-page":"6045","DOI":"10.4049\/jimmunol.1402505","article-title":"IRF-1 promotes liver transplant ischemia\/reperfusion injury via hepatocyte IL-15\/IL-15Ralpha production","volume":"194","author":"Yokota","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2025.123575_bb0085","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.canlet.2011.09.031","article-title":"Interferon-gamma induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1)","volume":"314","author":"Li","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lfs.2025.123575_bb0090","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.canlet.2021.03.002","article-title":"Interferon regulatory factor 1(IRF-1) activates anti-tumor immunity via CXCL10\/CXCR3 axis in hepatocellular carcinoma (HCC)","volume":"506","author":"Yan","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lfs.2025.123575_bb0095","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abq3362","article-title":"SUMOylated IL-33 in the nucleus stabilizes the transcription factor IRF1 in hepatocellular carcinoma cells to promote immune escape","volume":"16","author":"Wang","year":"2023","journal-title":"Sci. Signal."},{"key":"10.1016\/j.lfs.2025.123575_bb0100","doi-asserted-by":"crossref","first-page":"12359","DOI":"10.1074\/jbc.RA119.007409","article-title":"Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria","volume":"294","author":"Liang","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2025.123575_bb0105","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.molimm.2021.03.005","article-title":"IFN-gamma contributes to the hepatic inflammation in HFD-induced nonalcoholic steatohepatitis by STAT1beta\/TLR2 signaling pathway","volume":"134","author":"Li","year":"2021","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.lfs.2025.123575_bb0110","article-title":"Zinc finger transcription factor Egf1 promotes non-alcoholic fatty liver disease","volume":"5","author":"Guo","year":"2023","journal-title":"JHEP Rep."},{"key":"10.1016\/j.lfs.2025.123575_bb0115","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.622866","article-title":"The chromatin remodeling protein BRG1 regulates SREBP maturation by activating SCAP transcription in hepatocytes","volume":"9","author":"Kong","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2025.123575_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.705302","article-title":"Choline kinase alpha is a novel transcriptional target of the Brg1 in hepatocyte: implication in liver regeneration","volume":"9","author":"Kong","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2025.123575_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102079","article-title":"Redox-sensitive activation of CCL7 by BRG1 in hepatocytes during liver injury","volume":"46","author":"Kong","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2025.123575_bb0130","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.688","article-title":"Myocardin-related transcription factor a drives ROS-fueled expansion of hepatic stellate cells by regulating p38-MAPK signalling","volume":"12","author":"Dong","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.lfs.2025.123575_bb0135","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2025.123575_bb0140","doi-asserted-by":"crossref","first-page":"18466","DOI":"10.1074\/jbc.RA118.005583","article-title":"Mechanisms of concanavalin A-induced cytokine synthesis by hepatic stellate cells: distinct roles of interferon regulatory factor-1 in liver injury","volume":"293","author":"Rani","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"1728\u201344","key":"10.1016\/j.lfs.2025.123575_bb0145","article-title":"Identification of lineage-specific transcription factors that prevent activation of hepatic stellate cells and promote fibrosis resolution","volume":"158","author":"Liu","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2025.123575_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154950","article-title":"Ginsenoside Rh2 promotes hepatic stellate cell ferroptosis and inactivation via regulation of IRF1-inhibited SLC7A11","volume":"118","author":"Lang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2025.123575_bb0155","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1159\/000477211","article-title":"Endothelial interferon regulatory factor 1 regulates lipopolysaccharide-induced VCAM-1 expression independent of NFkappaB","volume":"9","author":"Yan","year":"2017","journal-title":"J. Innate Immun."},{"key":"10.1016\/j.lfs.2025.123575_bb0160","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/CS20220876","article-title":"Interferon regulatory factor 1 (IRF1) inhibits lung endothelial regeneration following inflammation-induced acute lung injury","volume":"137","author":"Chen","year":"2023","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.lfs.2025.123575_bb0165","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.yjmcc.2020.02.006","article-title":"IRF-1 mediates the suppressive effects of mTOR inhibition on arterial endothelium","volume":"140","author":"Peng","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2025.123575_bb0170","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1161\/ATVBAHA.106.138545","article-title":"Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis","volume":"27","author":"Yan","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2025.123575_bb0175","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1172\/JCI85499","article-title":"Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease","volume":"127","author":"Stein","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2025.123575_bb0180","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1096\/fj.201901799RR","article-title":"REDD1 deficiency protects against nonalcoholic hepatic steatosis induced by high-fat diet","volume":"34","author":"Dumas","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2025.123575_bb0185","article-title":"DDIT4 S-nitrosylation aids p38-MAPK signaling complex assembly to promote hepatic reactive oxygen species production","volume":"8","author":"Li","year":"2021","journal-title":"Adv Sci (Weinh)."},{"key":"10.1016\/j.lfs.2025.123575_bb0190","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1042\/CS20110515","article-title":"Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis","volume":"123","author":"Galastri","year":"2012","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.lfs.2025.123575_bb0195","first-page":"8","article-title":"Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis","author":"Kang","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.lfs.2025.123575_bb0200","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.semcancer.2020.07.005","article-title":"Targeting p53 for the treatment of cancer","volume":"79","author":"Duffy","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.lfs.2025.123575_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103756","article-title":"Therapeutic targeting of \u201cundruggable\u201d MYC","volume":"75","author":"Llombart","year":"2022","journal-title":"EBioMedicine"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525002097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525002097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T09:23:27Z","timestamp":1744277007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525002097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":41,"alternative-id":["S0024320525002097"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123575","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interferon regulatory factor 1 contributes to metabolic dysfunction associated steatotic liver disease","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123575","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123575"}}