{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:17:15Z","timestamp":1762211835725,"version":"build-2065373602"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2242021K10004","2242018K3DN05"],"award-info":[{"award-number":["2242021K10004","2242018K3DN05"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2020777"],"award-info":[{"award-number":["BE2020777"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671807"],"award-info":[{"award-number":["81671807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010023","name":"Natural Science Research of Jiangsu Higher Education Institutions of China","doi-asserted-by":"publisher","award":["24KJB310002"],"award-info":[{"award-number":["24KJB310002"]}],"id":[{"id":"10.13039\/501100010023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.lfs.2025.123587","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T02:04:41Z","timestamp":1743041081000},"page":"123587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Engineered promoter-free insulin-secreting cells provide closed-loop glycemic control"],"prefix":"10.1016","volume":"371","author":[{"given":"Yumin","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doulathunnisa","family":"Ahamed Younis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengming","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongdang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2025.123587_bb0005","doi-asserted-by":"crossref","unstructured":"Saeedi, P. et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes atlas, 9th edition. Diabetes Res. Clin. Pract. 157, (2019).","DOI":"10.1016\/j.diabres.2019.107843"},{"year":"2021","series-title":"IDF Diabetes Atlas","author":"Magliano","key":"10.1016\/j.lfs.2025.123587_bb0010"},{"key":"10.1016\/j.lfs.2025.123587_bb0015","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.cell.2012.02.010","article-title":"Diabetes mellitus and the \u03b2 cell: the last ten years","volume":"148","author":"Ashcroft","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2025.123587_bb0020","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1055\/a-1018-9078","article-title":"Definition, classification and diagnosis of diabetes mellitus","volume":"127","author":"Petersmann","year":"2019","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.lfs.2025.123587_bb0025","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nrendo.2012.47","article-title":"Cardiovascular risk in double diabetes mellitus\u2014when two worlds collide","volume":"8","author":"Cleland","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.lfs.2025.123587_bb0030","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1056\/NEJMra1011035","article-title":"Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease","volume":"371","author":"Shulman","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2025.123587_bb0035","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1530\/JOE-12-0455","article-title":"Testosterone: a metabolic hormone in health and disease","volume":"217","author":"Kelly","year":"2013","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2025.123587_bb0040","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.stemcr.2015.02.011","article-title":"Treating diet-induced diabetes and obesity with human embryonic stem cell-derived pancreatic progenitor cells and antidiabetic drugs","volume":"4","author":"Bruin","year":"2015","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.lfs.2025.123587_bb0045","doi-asserted-by":"crossref","first-page":"eabn0071","DOI":"10.1126\/sciadv.abn0071","article-title":"Engineered immunomodulatory accessory cells improve experimental allogeneic islet transplantation without immunosuppression","volume":"8","author":"Wang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.lfs.2025.123587_bb0050","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/nbt.3033","article-title":"Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells","volume":"32","author":"Rezania","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.lfs.2025.123587_bb0055","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1056\/NEJMct1113948","article-title":"Insulin-pump therapy for type 1 diabetes mellitus","volume":"366","author":"Pickup","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2025.123587_bb0060","article-title":"Malaria: Global progress 2000\u20132015 and future challenges","volume":"5, 61","author":"Cibulskis","year":"2016","journal-title":"Infect. Dis. Poverty"},{"key":"10.1016\/j.lfs.2025.123587_bb0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0168-8227(01)00220-0","article-title":"Hepatic insulin expression improves glycemic control in type 1 diabetic rats","volume":"52","author":"Dong","year":"2001","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.lfs.2025.123587_bb0070","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1677\/joe.0.1720653","article-title":"Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo","volume":"172","author":"Shaw","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2025.123587_bb0075","unstructured":"ViaCyte. A Prospective, Multicenter, Open-Label, First-in-Human Phase 1\/2 Study With Two Cohorts to Evaluate the Safety, Tolerability, and Efficacy of Various Doses of VC-01\u2122 Combination Product in Subjects With Type 1 Diabetes Mellitus. https:\/\/clinicaltrials.gov\/study\/NCT02239354 (2022)."},{"key":"10.1016\/j.lfs.2025.123587_bb0080","unstructured":"ViaCyte. A One-Year, Multicenter, Observational, Follow-up Safety Study in Subjects Previously Implanted With VC-01\u2122 Combination Product. https:\/\/clinicaltrials.gov\/study\/NCT02939118 (2023)."},{"key":"10.1016\/j.lfs.2025.123587_bb0085","unstructured":"ViaCyte. An Open-Label Study Evaluating the Safety and Tolerability of VC-02\u2122 Combination Product in Subjects With Type 1 Diabetes Mellitus. https:\/\/clinicaltrials.gov\/study\/NCT03162926 (2018)."},{"key":"10.1016\/j.lfs.2025.123587_bb0090","unstructured":"ViaCyte. An Open-Label, First-In-Human Study Evaluating the Safety, Tolerability, and Efficacy of VC-02\u2122 Combination Product in Subjects With Type 1 Diabetes Mellitus and Hypoglycemia Unawareness. https:\/\/clinicaltrials.gov\/study\/NCT03163511 (2023)."},{"key":"10.1016\/j.lfs.2025.123587_bb0095","unstructured":"A Study to Evaluate Safety, Engraftment, and Efficacy of VC-01 in Subjects With T1 Diabetes Mellitus. ctv.veeva.com https:\/\/ctv.veeva.com\/study\/a-study-to-evaluate-safety-engraftment-and-efficacy-of-vc-01-in-subjects-with-t1-diabetes-mellitus."},{"key":"10.1016\/j.lfs.2025.123587_bb0100","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/1566523216666160122113958","article-title":"Correction of murine diabetic hyperglycaemia with a single systemic administration of an AAV2\/8 vector containing a novel codon optimized human insulin gene","volume":"16","author":"Gan","year":"2016","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.lfs.2025.123587_bb0105","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/labinvest.3700368","article-title":"Reprogramming liver-stem WB cells into functional insulin-producing cells by persistent expression of Pdx1- and Pdx1-VP16 mediated by lentiviral vectors","volume":"86","author":"Tang","year":"2006","journal-title":"Lab. Investig. J. Tech. Methods Pathol."},{"key":"10.1016\/j.lfs.2025.123587_bb0110","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/jgm.2692","article-title":"Long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy","volume":"15","author":"Ren","year":"2013","journal-title":"J. Gene Med."},{"key":"10.1016\/j.lfs.2025.123587_bb0115","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.3390\/cells9112474","article-title":"Modification of a constitutive to glucose-responsive liver-specific promoter resulted in increased efficacy of adeno-associated virus serotype 8-insulin gene therapy of diabetic mice","volume":"9","author":"Sia","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2025.123587_bb0120","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1126\/science.aaf4006","article-title":"\u03b2-cell-mimetic designer cells provide closed-loop glycemic control","volume":"354","author":"Xie","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.lfs.2025.123587_bb0125","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1126\/science.1142658","article-title":"AAV vector integration sites in mouse hepatocellular carcinoma","volume":"317","author":"Donsante","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.lfs.2025.123587_bb0130","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1172\/JCI35700","article-title":"Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1","volume":"118","author":"Hacein-Bey-Abina","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2025.123587_bb0135","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.bbagrm.2015.09.006","article-title":"Cap-dependent, scanning-free translation initiation mechanisms","volume":"1849","author":"Haimov","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2025.123587_bb0140","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1101\/gad.891101","article-title":"Internal ribosome entry sites in eukaryotic mRNA molecules","volume":"15","author":"Hellen","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.lfs.2025.123587_bb0145","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.bbagrm.2009.07.005","article-title":"Structural and functional diversity of viral IRESes","volume":"1789","author":"Balvay","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2025.123587_bb0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/BC20070098","article-title":"Re-programming of translation following cell stress allows IRES-mediated translation to predominate","volume":"100","author":"Spriggs","year":"2008","journal-title":"Biol. Cell."},{"key":"10.1016\/j.lfs.2025.123587_bb0155","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/sj.onc.1210777","article-title":"For IRES trans-acting factors, it is all about location","volume":"27","author":"Lewis","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2025.123587_bb0160","first-page":"1583","article-title":"Hyperglycemia upregulates translation of the fibroblast growth factor 2 mRNA in mouse aorta via internal ribosome entry site","volume":"18","author":"Teshima-Kondo","year":"2004","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/j.lfs.2025.123587_bb0165","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/BST0340017","article-title":"IRES-dependent regulation of FGF-2 mRNA translation in pathophysiological conditions in the mouse","volume":"34","author":"Gonzalez-Herrera","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.lfs.2025.123587_bb0170","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12951-022-01462-1","article-title":"Engineering a HEK-293T exosome-based delivery platform for efficient tumor-targeting chemotherapy\/internal irradiation combination therapy","volume":"20","author":"Wang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.lfs.2025.123587_bb0175","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/s41401-021-00758-6","article-title":"Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors","volume":"43","author":"Wang","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.lfs.2025.123587_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0249117","article-title":"Generation and utilization of a HEK-293T murine GM-CSF expressing cell line","volume":"16","author":"Robinson","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2025.123587_bb0185","first-page":"R870","article-title":"Activation of adenylyl cyclases, regulation of insulin status, and cell survival by G(alpha)olf in pancreatic beta-cells","volume":"282","author":"R\u00e9gnauld","year":"2002","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.lfs.2025.123587_bb0190","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3389\/fphys.2019.01621","article-title":"MicroRNA-29b-3p promotes human retinal microvascular endothelial cell apoptosis via blocking SIRT1 in diabetic retinopathy","volume":"10","author":"Zeng","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2025.123587_bb0195","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13287-017-0511-8","article-title":"CRISPR-targeted genome editing of mesenchymal stem cell-derived therapies for type 1 diabetes: a path to clinical success?","volume":"8","author":"Gerace","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.lfs.2025.123587_bb0200","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature13589","article-title":"CRISPR-mediated direct mutation of cancer genes in the mouse liver","volume":"514","author":"Xue","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2025.123587_bb0205","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1089\/10430349950017437","article-title":"Reversal of diabetes in mice by implantation of human fibroblasts genetically engineered to release mature human insulin","volume":"10","author":"Falqui","year":"1999","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.lfs.2025.123587_bb0210","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123587_bb0215","doi-asserted-by":"crossref","first-page":"1439351","DOI":"10.3389\/fendo.2024.1439351","article-title":"Engineered IRES-mediated promoter-free insulin-producing cells reverse hyperglycemia","volume":"15","author":"Li","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.lfs.2025.123587_bb0220","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.tibtech.2003.11.004","article-title":"History, challenges and perspectives of cell microencapsulation","volume":"22","author":"Orive","year":"2004","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.lfs.2025.123587_bb0225","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13287-019-1135-y","article-title":"Adipocyte-derived stem cell-based gene therapy upon adipogenic differentiation on microcarriers attenuates type 1 diabetes in mice","volume":"10","author":"Fang","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.lfs.2025.123587_bb0230","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.addr.2018.04.018","article-title":"Cell encapsulation: overcoming barriers in cell transplantation in diabetes and beyond","volume":"139","author":"Farina","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.lfs.2025.123587_bb0235","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","article-title":"Type 1 diabetes","volume":"383","author":"Atkinson","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2025.123587_bb0240","unstructured":"tresiba.pdf."},{"key":"10.1016\/j.lfs.2025.123587_bb0245","first-page":"110","article-title":"Diagnosis and assessment of hypoglycemia in patients with diabetes mellitus","volume":"69","author":"Scheen","year":"2014","journal-title":"Rev. Med. Liege"},{"key":"10.1016\/j.lfs.2025.123587_bb0250","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/dmrr.912","article-title":"Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells","volume":"25","author":"Weinstein","year":"2009","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.lfs.2025.123587_bb0255","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1007\/s00125-010-1760-6","article-title":"Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling","volume":"53","author":"Sciacca","year":"2010","journal-title":"Diabetologia"},{"key":"10.1016\/j.lfs.2025.123587_bb0260","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1056\/NEJMoa1314474","article-title":"Outpatient glycemic control with a bionic pancreas in type 1 diabetes","volume":"371","author":"Russell","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2025.123587_bb0265","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.2337\/diabetes.51.12.3428","article-title":"Intrahepatic islet transplantation in type 1 diabetic patients does not restore hypoglycemic hormonal counterregulation or symptom recognition after insulin independence","volume":"51","author":"Paty","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2025.123587_bb0270","doi-asserted-by":"crossref","first-page":"11247","DOI":"10.1038\/ncomms11247","article-title":"A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells","volume":"7","author":"Saxena","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2025.123587_bb0275","doi-asserted-by":"crossref","first-page":"21982","DOI":"10.1074\/jbc.M111.226795","article-title":"Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion","volume":"286","author":"McCluskey","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2025.123587_bb0280","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00002480-198804000-00005","article-title":"Inflammatory response to implants","volume":"34","author":"Anderson","year":"1988","journal-title":"ASAIO Trans."},{"key":"10.1016\/j.lfs.2025.123587_bb0285","doi-asserted-by":"crossref","first-page":"15884","DOI":"10.1074\/jbc.270.26.15884","article-title":"Identification of heterogeneous ribonucleoprotein A1 as a novel substrate for protein kinase C zeta","volume":"270","author":"Municio","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2025.123587_bb0290","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1046\/j.1523-1755.2001.059002463.x","article-title":"High glucose-induced PKC activation mediates TGF-beta 1 and fibronectin synthesis by peritoneal mesothelial cells","volume":"59","author":"Ha","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2025.123587_bb0295","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1242\/jcs.034355","article-title":"Mechanisms of biphasic insulin-granule exocytosis \u2013 roles of the cytoskeleton, small GTPases and SNARE proteins","volume":"122","author":"Wang","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.lfs.2025.123587_bb0300","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0167-7799(99)01356-6","article-title":"Rationalizing the design of polymeric biomaterials","volume":"17","author":"Angelova","year":"1999","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.lfs.2025.123587_bb0305","doi-asserted-by":"crossref","first-page":"12764","DOI":"10.1021\/acs.chemrev.7b00094","article-title":"Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment","volume":"117","author":"Huang","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.lfs.2025.123587_bb0310","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrd.2016.232","article-title":"Advances in islet encapsulation technologies","volume":"16","author":"Desai","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.lfs.2025.123587_bb0315","doi-asserted-by":"crossref","first-page":"984","DOI":"10.2174\/1573399816666200324152517","article-title":"Diabetes mellitus and osteoporosis correlation: challenges and hopes","volume":"16","author":"Ala","year":"2020","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.lfs.2025.123587_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2022.101779","article-title":"Diabetes and osteoporosis - treating two entities: a challenge or cause for concern?","volume":"36","author":"Rasmussen","year":"2022","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.lfs.2025.123587_bb0325","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJM199309303291401","article-title":"The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus","volume":"329","author":"Diabetes Control and Complications Trial Research Group","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2025.123587_bb0330","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1056\/NEJMoa052187","article-title":"Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes","volume":"353","author":"Nathan","year":"2005","journal-title":"N. Engl. J. Med."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525002218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525002218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:13:04Z","timestamp":1762211584000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525002218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":66,"alternative-id":["S0024320525002218"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123587","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered promoter-free insulin-secreting cells provide closed-loop glycemic control","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123587","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"123587"}}