{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:26:06Z","timestamp":1781335566940,"version":"3.54.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471727"],"award-info":[{"award-number":["82471727"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071679"],"award-info":[{"award-number":["82071679"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271721"],"award-info":[{"award-number":["82271721"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["JKS2022010"],"award-info":[{"award-number":["JKS2022010"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705900"],"award-info":[{"award-number":["2023YFC2705900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.lfs.2025.123603","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T23:26:45Z","timestamp":1743722805000},"page":"123603","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Regional uterine contractility differences during pregnancy: The role of hypoxia and ferroptosis in vitro"],"prefix":"10.1016","volume":"371","author":[{"given":"Ruixian","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8715-0874","authenticated-orcid":false,"given":"Yunxia","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5968-6332","authenticated-orcid":false,"given":"Zongzhi","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2025.123603_bb0005","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/s41467-023-36440-0","article-title":"Noninvasive electromyometrial imaging of human uterine maturation during term labor","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2025.123603_bb0010","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3389\/fphys.2018.01091","article-title":"The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation","volume":"9","author":"Napso","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2025.123603_bb0015","first-page":"146","article-title":"Development of the human placenta","author":"Turco","year":"2019","journal-title":"DEVELOPMENT"},{"key":"10.1016\/j.lfs.2025.123603_bb0020","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nrd.2018.174","article-title":"Mitochondria as a therapeutic target for common pathologies","volume":"17","author":"Murphy","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.lfs.2025.123603_bb0025","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fcell.2020.00532","article-title":"Sarcoplasmic reticulum-mitochondria kissing in cardiomyocytes: Ca(2+), ATP, and undisclosed secrets","volume":"8","author":"Rossini","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2025.123603_bb0030","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.tibs.2016.01.001","article-title":"Mitochondrial cristae: where beauty meets functionality","volume":"41","author":"Cogliati","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.lfs.2025.123603_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101674","article-title":"Mitochondrial electron transport chain: oxidative phosphorylation, oxidant production, and methods of measurement","volume":"37","author":"Nolfi-Donegan","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2025.123603_bb0040","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1038\/s41467-023-39811-9","article-title":"Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion","volume":"14","author":"Hao","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2025.123603_bb0045","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12915-024-02048-z","article-title":"SETDB1 targeting SESN2 regulates mitochondrial damage and oxidative stress in renal ischemia-reperfusion injury","volume":"22","author":"Xia","year":"2024","journal-title":"BMC Biol."},{"key":"10.1016\/j.lfs.2025.123603_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121608","article-title":"TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia\/reperfusion-induced acute kidney injury","volume":"321","author":"Sun","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2025.123603_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113572","article-title":"Dexmedetomidine attenuates myocardial ischemia\/reperfusion-induced ferroptosis via AMPK\/GSK-3\u03b2\/Nrf2 axis","volume":"154","author":"Wang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2025.123603_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112945","article-title":"HIF-1\u03b1 drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1","volume":"42","author":"Yang","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.lfs.2025.123603_bb0065","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"CELL"},{"key":"10.1016\/j.lfs.2025.123603_bb0070","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"CELL"},{"key":"10.1016\/j.lfs.2025.123603_bb0075","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.lfs.2025.123603_bb0080","doi-asserted-by":"crossref","first-page":"C1106","DOI":"10.1152\/ajpcell.00598.2023","article-title":"Myometrium infection decreases TREK1 through NHE1 and increases contraction in pregnant mice","volume":"326","author":"Yu","year":"2024","journal-title":"AM J PHYSIOL-CELL PH."},{"key":"10.1016\/j.lfs.2025.123603_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101706","article-title":"Mdivi-1 attenuates oxidative stress and exerts vascular protection in ischemic\/hypoxic injury by a mechanism independent of Drp1 GTPase activity","volume":"37","author":"Duan","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2025.123603_bb0090","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.bcp.2018.03.021","article-title":"Adaptive reduction of human myometrium contractile activity in response to prolonged uterine stretch during term and twin pregnancy. Role of TREK-1 channel","volume":"152","author":"Yin","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123603_bb0095","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1007\/s10571-023-01388-8","article-title":"The mechanisms of ferroptosis under hypoxia","volume":"43","author":"Gao","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2025.123603_bb0100","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.redox.2015.09.005","article-title":"Reactive oxygen species and mitochondria: a nexus of cellular homeostasis","volume":"6","author":"Dan","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2025.123603_bb0105","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/FM9.0000000000000210","article-title":"Basic research advances in China on embryo implantation, placentation, and parturition","volume":"6","author":"Bao","year":"2024","journal-title":"MATERN-FETAL MED."},{"key":"10.1016\/j.lfs.2025.123603_bb0110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/FM9.0000000000000256","article-title":"Recognition and management of postpartum hemorrhage","volume":"7","author":"Mohamed","year":"2025","journal-title":"MATERN-FETAL MED."},{"key":"10.1016\/j.lfs.2025.123603_bb0115","doi-asserted-by":"crossref","first-page":"S1209","DOI":"10.1016\/j.ajog.2022.09.003","article-title":"Assessment of uterine contractions in labor and delivery","volume":"228","author":"Rosen","year":"2023","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2025.123603_bb0120","first-page":"C1","article-title":"Uterine contraction and physiological mechanisms of modulation","volume":"264","author":"Wray","year":"1993","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.lfs.2025.123603_bb0125","doi-asserted-by":"crossref","first-page":"R51","DOI":"10.1530\/REP-16-0156","article-title":"Mechanotransduction mechanisms for coordinating uterine contractions in human labor","volume":"152","author":"Young","year":"2016","journal-title":"REPRODUCTION"},{"key":"10.1016\/j.lfs.2025.123603_bb0130","first-page":"14","article-title":"Placenta extracellular vesicles: messengers connecting maternal and fetal systems","author":"Rosenfeld","year":"2024","journal-title":"BIOMOLECULES"},{"issue":"Pt 3","key":"10.1016\/j.lfs.2025.123603_bb0135","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1469-7793.1999.0783p.x","article-title":"In vivo pH and metabolite changes during a single contraction in rat uterine smooth muscle","volume":"518","author":"Larcombe-McDouall","year":"1999","journal-title":"J PHYSIOL-LONDON."},{"key":"10.1016\/j.lfs.2025.123603_bb0140","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0002-9378(65)90150-X","article-title":"Effect of labor on uterine blood flow. Observations on gravid ewes","volume":"93","author":"Greiss","year":"1965","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2025.123603_bb0145","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ajog.2015.07.050","article-title":"What is the placenta?","volume":"213","author":"Burton","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2025.123603_bb0150","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1146\/annurev-cellbio-100814-125620","article-title":"Placenta: the forgotten organ","volume":"31","author":"Maltepe","year":"2015","journal-title":"ANNU REV CELL DEV BI."},{"key":"10.1016\/j.lfs.2025.123603_bb0155","first-page":"11","article-title":"Ferroptosis: the potential target in heart failure with preserved ejection fraction","author":"Li","year":"2022","journal-title":"CELLS-BASEL"},{"key":"10.1016\/j.lfs.2025.123603_bb0160","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.2147\/JIR.S351799","article-title":"Ferroptosis and its potential role in the nervous system diseases","volume":"15","author":"Zhou","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.lfs.2025.123603_bb0165","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"AUTOPHAGY"},{"key":"10.1016\/j.lfs.2025.123603_bb0170","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70121","article-title":"The role and applied value of mitochondria in glioma-related research","volume":"30","author":"Chen","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.lfs.2025.123603_bb0175","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41422-023-00864-6","article-title":"Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation","volume":"34","author":"Mao","year":"2024","journal-title":"Cell Res."},{"key":"10.1016\/j.lfs.2025.123603_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101343","article-title":"Hypoxia and brain aging: neurodegeneration or neuroprotection?","volume":"68","author":"Burtscher","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.lfs.2025.123603_bb0185","doi-asserted-by":"crossref","DOI":"10.1038\/oncsis.2015.50","article-title":"Hypoxia and metabolic adaptation of cancer cells","volume":"5","author":"Eales","year":"2016","journal-title":"ONCOGENESIS"},{"key":"10.1016\/j.lfs.2025.123603_bb0190","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12992","article-title":"Melatonin alleviates osteoarthritis by regulating NADPH oxidase 4-induced ferroptosis and mitigating mitochondrial dysfunction","volume":"76","author":"Wang","year":"2024","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.lfs.2025.123603_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110148","article-title":"Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes","volume":"366","author":"Wang","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2025.123603_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111304","article-title":"AMPD3 promotes doxorubicin-induced cardiomyopathy through HSP90alpha-mediated ferroptosis","volume":"27","author":"Cheng","year":"2024","journal-title":"ISCIENCE"},{"key":"10.1016\/j.lfs.2025.123603_bb0205","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41389-020-00251-5","article-title":"Suppressing DRP1-mediated mitochondrial fission and mitophagy increases mitochondrial apoptosis of hepatocellular carcinoma cells in the setting of hypoxia","volume":"9","author":"Lin","year":"2020","journal-title":"ONCOGENESIS"},{"key":"10.1016\/j.lfs.2025.123603_bb0210","article-title":"Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria","volume":"10","author":"Zhou","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.lfs.2025.123603_bb0215","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41586-018-0211-2","article-title":"Structural basis of mitochondrial receptor binding and constriction by DRP1","volume":"558","author":"Kalia","year":"2018","journal-title":"NATURE"},{"key":"10.1016\/j.lfs.2025.123603_bb0220","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40779-023-00482-8","article-title":"Multifaceted functions of Drp1 in hypoxia\/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy","volume":"10","author":"Hao","year":"2023","journal-title":"MILITARY MED RES."},{"key":"10.1016\/j.lfs.2025.123603_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115247","article-title":"The role of dynamin-related protein 1 in cerebral ischemia\/hypoxia injury","volume":"165","author":"Huan","year":"2023","journal-title":"Biomed. Pharmacother."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525002371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525002371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:35:30Z","timestamp":1777426530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525002371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":45,"alternative-id":["S0024320525002371"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123603","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regional uterine contractility differences during pregnancy: The role of hypoxia and ferroptosis in vitro","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123603","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123603"}}