{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:04:13Z","timestamp":1773965053672,"version":"3.50.1"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023674","name":"King Khalid University Deanship of Scientific Research","doi-asserted-by":"publisher","award":["RGP2\/262\/45"],"award-info":[{"award-number":["RGP2\/262\/45"]}],"id":[{"id":"10.13039\/501100023674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.lfs.2025.123605","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T23:52:58Z","timestamp":1743983578000},"page":"123605","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Vitamin D supplementation as a prophylactic therapy in the management of pre-eclampsia: Focus on VEGF, Ki67, oxidative stress markers in correlation to placental ultra structure"],"prefix":"10.1016","volume":"372","author":[{"given":"Hanan","family":"Eissa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman Mohamed","family":"Abdelsalam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somaia A.","family":"Mokbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada H.","family":"Elhadedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania M.","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany AbdElfattah Mohamed","family":"AbdElfattah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia M.","family":"Abdel Ghaffar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-6761","authenticated-orcid":false,"given":"Eman Mohamad","family":"El Nashar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8931-3545","authenticated-orcid":false,"given":"Alshehri Hanan","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norah Saeed","family":"Al-Zahrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9933-9837","authenticated-orcid":false,"given":"Rashid A.","family":"Aldahhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neimat Abd Elhakam","family":"Yassin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.lfs.2025.123605_bb0005","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/j.mayocp.2018.04.033","article-title":"State-of-the-art diagnosis and treatment of hypertension in pregnancy","volume":"93","author":"Magee","year":"2018","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.lfs.2025.123605_bb0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.12703\/b\/9-10","article-title":"Recent advances in the diagnosis and management of pre-eclampsia","volume":"9","author":"Hurrell","year":"2020","journal-title":"Fac. Rev."},{"issue":"6","key":"10.1016\/j.lfs.2025.123605_bb0015","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1523-5378.2012.00966.x","article-title":"Antibodies anti-CagA cross-react with trophoblast cells: a risk factor for pre-eclampsia?","volume":"17","author":"Franceschi","year":"2012","journal-title":"Helicobacter"},{"key":"10.1016\/j.lfs.2025.123605_bb0020","article-title":"Pre-eclampsia predictive ability of maternal miR-125b: a clinical and experimental study","volume":"26","author":"Licini","year":"2020","journal-title":"Transl. Res."},{"issue":"2S","key":"10.1016\/j.lfs.2025.123605_bb0025","doi-asserted-by":"crossref","first-page":"S907","DOI":"10.1016\/j.ajog.2020.09.047","article-title":"Syncytiotrophoblast stress in preeclampsia: the convergence point for multiple pathways. Redman CWG, et al","volume":"226","author":"Redman","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.lfs.2025.123605_bb0030","doi-asserted-by":"crossref","first-page":"6091","DOI":"10.1002\/jcp.27344","article-title":"Pre-eclampsia onset and SPARC: a possible involvement in placenta development","volume":"234","author":"Tossetta","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2025.123605_bb0035","first-page":"H541","article-title":"Pathophysiology of hypertension during preeclampsia: linking placental ischemia with endothelial dysfunction","volume":"294","author":"Gilbert","year":"2008","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.lfs.2025.123605_bb0040","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3390\/ijms19051496","article-title":"Oxidative stress in preeclampsia and placental diseases","volume":"19","author":"Aouache","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.lfs.2025.123605_bb0045","first-page":"1248","article-title":"VEGF in signaling and disease: beyond discovery and development","volume":"176","author":"Apte","year":"2019","journal-title":"_CELL"},{"issue":"829\u2013837","key":"10.1016\/j.lfs.2025.123605_bb0050","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"F\u00f6rstermann","year":"2012","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2025.123605_bb0055","unstructured":"Jim, B. & Karumanchi, S. A. in Seminars in Nephrology. 386\u2013397 (Elsevier)."},{"key":"10.1016\/j.lfs.2025.123605_bb0060","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejphar.2016.12.010","article-title":"The effects of sildenafil citrate on uterine angiogenic status and serum inflammatory markers in an L-NAME rat model of pre-eclampsia","volume":"795","author":"Soobryan","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123605_bb0065","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.clp.2019.02.002","article-title":"Treatment and prevention of hypertensive disorders during pregnancy","volume":"46","author":"Leavitt","year":"2019","journal-title":"Clin. Perinatol."},{"key":"10.1016\/j.lfs.2025.123605_bb0070","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1111\/1471-0528.14372","article-title":"Vitamin D, pre-eclampsia, and preterm birth among pregnancies at high risk for pre-eclampsia: an analysis of data from a low-dose aspirin trial","volume":"124","author":"Gernand","year":"2017","journal-title":"BJOG"},{"key":"10.1016\/j.lfs.2025.123605_bb0075","first-page":"1566","article-title":"Ki67 is a promising molecular target in the diagnosis of cancer","author":"Li","year":"2014","journal-title":"Med. Rep."},{"key":"10.1016\/j.lfs.2025.123605_bb0080","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3945\/ajcn.112.035683","article-title":"Maternal vitamin D predominates over genetic factors in determining neonatal circulating vitamin D concentrations","volume":"96","author":"Novakovic","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.lfs.2025.123605_bb0085","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3390\/nu10111656","article-title":"Vitamin D: nutrient, hormone, and immunomodulator","volume":"10","author":"Sassi","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2025.123605_bb0090","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3390\/nu12020575","article-title":"Vitamin D and endothelial function","volume":"12","author":"Kim","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2025.123605_bb0095","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1590\/S1519-69842002000400008","article-title":"Determination of the estrous cycle phases of rats: some helpful considerations","volume":"62","author":"Marcondes","year":"2002","journal-title":"Braz. J. Biol."},{"key":"10.1016\/j.lfs.2025.123605_bb0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2621.1948.tb16591.x","article-title":"Physiological action of sodium carboxymethyl-cellulose on laboratory animals and humans","volume":"13","author":"Shelanski","year":"1948","journal-title":"Food Res."},{"key":"10.1016\/j.lfs.2025.123605_bb0105","first-page":"585","article-title":"Evaluation of blood vessel injury, oxidative stress and circulating inflammatory factors in an L-NAME-induced preeclampsia-like rat model","volume":"16","author":"Shu","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.lfs.2025.123605_bb0110","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/156563","article-title":"Effects of vitamin D supplementation during the induction and progression of osteoarthritis in a rat model","volume":"2012","author":"Castillo","year":"2012","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.lfs.2025.123605_bb0115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2025.123605_bb0120","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/00000542-198306000-00014","article-title":"Comparison of isoflurane and halothane safety margins in rats","volume":"58","author":"Kissin","year":"1983","journal-title":"Anesthesiology"},{"key":"10.1016\/j.lfs.2025.123605_bb0125","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot5455","article-title":"Homogenization of mammalian tissue","author":"Simpson","year":"2010","journal-title":"Cold Spring Harb Protoc"},{"key":"10.1016\/j.lfs.2025.123605_bb0130","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1038\/nprot.2006.378","article-title":"Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method","volume":"1","author":"Rahman","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.lfs.2025.123605_bb0135","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2025.123605_bb0140","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.freeradbiomed.2007.04.026","article-title":"Methods to detect nitric oxide and its metabolites in biological samples","volume":"43","author":"Bryan","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2025.123605_bb0145","series-title":"Bancroft's Theory and Practice of Histological Techniques","first-page":"1","author":"Cox","year":"2019"},{"key":"10.1016\/j.lfs.2025.123605_bb0150","series-title":"Bancroft\u2019s Theory and Practice of Histological Techniques E-Book","author":"Suvarna","year":"2018"},{"key":"10.1016\/j.lfs.2025.123605_bb0155","doi-asserted-by":"crossref","first-page":"R27","DOI":"10.1530\/JOE-16-0340","article-title":"Vascular adaptation in pregnancy and endothelial dysfunction in preeclampsia","volume":"232","author":"Boeldt","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.lfs.2025.123605_bb0160","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/374047","article-title":"Preeclampsia, hypoxia, thrombosis, and inflammation","volume":"2012","author":"Shamshirsaz","year":"2012","journal-title":"J. Pregnancy"},{"key":"10.1016\/j.lfs.2025.123605_bb0165","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s11906-010-0118-2","article-title":"Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets","volume":"12","author":"F\u00e9l\u00e9tou","year":"2010","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.lfs.2025.123605_bb0170","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/01.HYP.38.3.718","article-title":"Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction","volume":"38","author":"Granger","year":"2001","journal-title":"Hypertension (Dallas, Tex.\u202f: 1979)"},{"key":"10.1016\/j.lfs.2025.123605_bb0175","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1447-0756.2009.01128.x","article-title":"Role of nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia","volume":"36","author":"Matsubara","year":"2010","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.lfs.2025.123605_bb0180","first-page":"3141","article-title":"Inhibition of nitric oxide synthase lowers fatty acid oxidation in preeclampsia-like mice at early gestational stage","volume":"124","author":"Ma","year":"2011","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.lfs.2025.123605_bb0185","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mvr.2016.10.002","article-title":"Inhibition of nitric oxide synthase lowers fatty acid oxidation in preeclampsia-like mice at early gestational stage","volume":"109","author":"Hariharan","year":"2017","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.lfs.2025.123605_bb0190","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.21608\/mjcu.2018.61490","article-title":"Serum adropin levels in a preeclampsia like L-name rat model treated with sildenafil citrate","volume":"86","author":"Fathy","year":"2018","journal-title":"Med. J. Cairo Univ."},{"key":"10.1016\/j.lfs.2025.123605_bb0195","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1293\/tox.24.95","article-title":"Toxicological pathology in the rat placenta","volume":"24","author":"Furukawa","year":"2011","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.lfs.2025.123605_bb0205","article-title":"Study of placental weight in normal and pre-eclamptic pregnancies and its correlation with birth weight","volume":"4","author":"Ankit","year":"2016","journal-title":"Int. J. Med. Res. Rev."},{"key":"10.1016\/j.lfs.2025.123605_bb0210","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1177\/1093526618789310","article-title":"Associations between the features of gross placental morphology and birthweight","volume":"22","author":"Freedman","year":"2019","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.lfs.2025.123605_bb0215","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/aje\/kwi305","article-title":"Measures of placental growth in relation to birth weight and gestational age","volume":"162","author":"Salafia","year":"2005","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.lfs.2025.123605_bb0220","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1161\/HYPERTENSIONAHA.119.13763","article-title":"Combining biomarkers to predict pregnancy complications and redefine preeclampsia: the angiogenic-placental syndrome","volume":"75","author":"Stepan","year":"2020","journal-title":"Hypertension (Dallas, Tex. : 1979)"},{"key":"10.1016\/j.lfs.2025.123605_bb0225","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/s41440-020-0528-8","article-title":"Placental hypoxia-induced alterations in vascular function, morphology, and endothelial barrier integrity","volume":"43","author":"Vangrieken","year":"2020","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.lfs.2025.123605_bb0230","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.placenta.2006.02.011","article-title":"The placenta in pre-eclampsia and intrauterine growth restriction: studies on exchange surface areas, diffusion distances and villous membrane diffusive conductances","volume":"28","author":"Mayhew","year":"2007","journal-title":"Placenta"},{"key":"10.1016\/j.lfs.2025.123605_bb0235","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1136\/jcp.2008.055236","article-title":"The placenta in pre-eclampsia and intrauterine growth restriction","volume":"61","author":"Roberts","year":"2008","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.lfs.2025.123605_bb0240","article-title":"Morphometric evaluation of human placental and umbilical cord for neonatal indices: a cross-sectional study","volume":"15","author":"Tankala","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.lfs.2025.123605_bb0245","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4103\/0976-9668.136182","article-title":"Study of structural changes in placenta in pregnancy-induced hypertension","volume":"5","author":"Salmani","year":"2014","journal-title":"J. Nat. Sci. Biol. Med."},{"key":"10.1016\/j.lfs.2025.123605_bb0250","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1161\/HYPERTENSIONAHA.113.01115","article-title":"Podocyturia predates proteinuria and clinical features of preeclampsia: longitudinal prospective study","volume":"61","author":"Craici","year":"2013","journal-title":"Hypertension (Dallas, Tex.\u202f: 1979)"},{"key":"10.1016\/j.lfs.2025.123605_bb0255","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/01.HYP.38.3.718","article-title":"Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction","volume":"38","author":"Granger","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2025.123605_bb0260","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0925-4439(99)00051-4","article-title":"Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia","volume":"1455","author":"Wei","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2025.123605_bb0265","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11906-017-0786-2","article-title":"Elucidating the pathogenesis of pre-eclampsia using in vitro models of spiral uterine artery remodelling","volume":"19","author":"McNally","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.lfs.2025.123605_bb0270","doi-asserted-by":"crossref","first-page":"9565","DOI":"10.1038\/s41598-019-45959-6","article-title":"Characterisation of the selective reduced uteroplacental perfusion (sRUPP) model of preeclampsia","volume":"9","author":"Morton","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2025.123605_bb0275","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/ki.2008.507","article-title":"Spironolactone suppresses inflammation and prevents L-NAME\u2013induced renal injury in rats","volume":"75","author":"Ikeda","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2025.123605_bb0280","doi-asserted-by":"crossref","first-page":"F1008","DOI":"10.1152\/ajprenal.00354.2010","article-title":"Renal injury in angiotensin II+ l-NAME-induced hypertensive rats is independent of elevated blood pressure","volume":"300","author":"Polichnowski","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.lfs.2025.123605_bb0285","first-page":"231","article-title":"The role of vitamin D in pre-eclampsia: a systematic review","volume":"17","author":"Purswani","year":"2017"},{"key":"10.1016\/j.lfs.2025.123605_bb0290","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1080\/10641955.2019.1597108","article-title":"Protective effect of vitamin D supplementation in a rat modal of preeclampsia: a possible implication of chemerin","volume":"38","author":"Nassar","year":"2019","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.lfs.2025.123605_bb0295","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/10641955.2019.1647231","article-title":"Role of vitamin D in influencing angiogenesis in preeclampsia","volume":"38","author":"Nema","year":"2019","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.lfs.2025.123605_bb0300","first-page":"888","article-title":"Extrarenal expression of 25-hydroxyvitamin D3-1 \u03b1-hydroxylase","volume":"86","author":"Zehnder","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2025.123605_bb0305","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/10641955.2019.1647231","article-title":"Role of vitamin D in influencing angiogenesis in preeclampsia","volume":"38","author":"Nema","year":"2019","journal-title":"Hypertens. Pregnancy"},{"key":"10.1016\/j.lfs.2025.123605_bb0310","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2174\/138945011793591617","article-title":"Vitamin D in atherosclerosis, vascular disease, and endothelial function","volume":"12","author":"Brewer","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.lfs.2025.123605_bb0315","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1210\/er.2008-0004","article-title":"Vitamin D and human health: lessons from vitamin D receptor null mice","volume":"29","author":"Bouillon","year":"2008","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.lfs.2025.123605_bb0320","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0022-2828(86)80983-X","article-title":"1, 25-Dihydroxyvitamin D3 receptors identified in the rat heart","volume":"18","author":"Walters","year":"1986","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2025.123605_bb0325","doi-asserted-by":"crossref","first-page":"455","DOI":"10.2147\/IJN.S152822","article-title":"Nanomedical studies of the restoration of nitric oxide\/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D3\u2014clinical implications for cardiovascular diseases","volume":"13","author":"Khan","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.lfs.2025.123605_bb0330","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1440-1797.2011.01450.x","article-title":"Shining D\u2019 light on chronic kidney disease: mechanisms that may underpin the cardiovascular benefit of vitamin D","volume":"16","author":"Petchey","year":"2011","journal-title":"Nephrology (Carlton, Vic.)"},{"key":"10.1016\/j.lfs.2025.123605_bb0335","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ki.2010.543","article-title":"Defective renal maintenance of the vitamin D endocrine system impairs vitamin D renoprotection: a downward spiral in kidney disease","volume":"79","author":"Dusso","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2025.123605_bb0340","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1210\/er.2008-0004","article-title":"Vitamin D and human health: lessons from vitamin D receptor null mice","volume":"29","author":"Bouillon","year":"2008","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.lfs.2025.123605_bb0345","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1038\/sj.ki.5000304","article-title":"1,25-Dihydroxyvitamin D3 stimulates vascular smooth muscle cell proliferation through a VEGF-mediated pathway","volume":"69","author":"Card\u00fas","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2025.123605_bb0350","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.annepidem.2014.02.001","article-title":"Vitamin D status and hypertensive disorders in pregnancy","volume":"24","author":"Burris","year":"2014","journal-title":"Ann. Epidemiol."},{"key":"10.1016\/j.lfs.2025.123605_bb0355","first-page":"825","article-title":"Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state","volume":"119","author":"Dzik","year":"2019"},{"key":"10.1016\/j.lfs.2025.123605_bb0360","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12884-019-2258-y","article-title":"The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes","volume":"19","author":"Jamilian","year":"2019","journal-title":"BMC Pregnancy Childbirth"},{"key":"10.1016\/j.lfs.2025.123605_bb0365","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.placenta.2010.08.015","article-title":"Vitamin D effects on pregnancy and the placenta","volume":"31","author":"Shin","year":"2010","journal-title":"Placenta"},{"key":"10.1016\/j.lfs.2025.123605_bb0370","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fphys.2016.00043","article-title":"Role of the placental vitamin D receptor in modulating feto-placental growth in fetal growth restriction and preeclampsia-affected pregnancies","volume":"7","author":"Murthi","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.lfs.2025.123605_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206725","article-title":"Impact of vitamin D and vitamin D receptor on the trophoblast survival capacity in preeclampsia","volume":"13","author":"Hutabarat","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2025.123605_bb0380","article-title":"Effects of vitamin D supplementation during pregnancy on birth size: a systematic review and meta-analysis of randomized controlled trials","volume":"11","author":"Maugeri","year":"2019"},{"key":"10.1016\/j.lfs.2025.123605_bb0385","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1007\/s43032-019-00116-2","article-title":"Reduced dietary calcium and vitamin D results in preterm birth and altered placental morphogenesis in mice during pregnancy","volume":"27","author":"Wilson","year":"2020","journal-title":"Reprod. Sci. (Thousand Oaks, Calif.)"},{"key":"10.1016\/j.lfs.2025.123605_bb0390","article-title":"The interactive effect of improvement of vitamin D status and VDR FokI variants on oxidative stress in type 2 diabetic subjects: a randomized controlled trial","volume":"69","author":"Shab Bidar","year":"2014","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.lfs.2025.123605_bb0395","doi-asserted-by":"crossref","DOI":"10.3390\/biology8020030","article-title":"Vitamin D deficiency: effects on oxidative stress, epigenetics, gene regulation, and aging","volume":"8","author":"Wimalawansa","year":"2019","journal-title":"Biology"},{"issue":"1","key":"10.1016\/j.lfs.2025.123605_bb0400","article-title":"Association between vitamin D and malondialdehyde in premenopausal women & postmenopausal women","volume":"8","author":"Yadav","year":"2019","journal-title":"Asian J. Med. Res."},{"key":"10.1016\/j.lfs.2025.123605_bb0405","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4172\/2155-9864.1000137","article-title":"Electron and scanning microscopic observations on the syncytiotrophoblast microvillous membrane contribution to preeclampsia in early placental rats","volume":"4","author":"Selim","year":"2013","journal-title":"J. Blood Disord. Transfus."},{"key":"10.1016\/j.lfs.2025.123605_bb0410","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/aje\/kwt237","article-title":"Maternal vitamin D status and spontaneous preterm birth by placental histology in the US Collaborative Perinatal Project","volume":"179","author":"Bodnar","year":"2014","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.lfs.2025.123605_bb0415","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0891-5849(91)90192-6","article-title":"Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes","volume":"11","author":"Esterbauer","year":"1991","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2025.123605_bb0420","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1161\/01.HYP.0000141085.98320.01","article-title":"Oxidative stress and preeclampsia: rationale for antioxidant clinical trials","volume":"44","author":"Raijmakers","year":"2004","journal-title":"Hypertension (Dallas, Tex.\u202f: 1979)"},{"key":"10.1016\/j.lfs.2025.123605_bb0425","doi-asserted-by":"crossref","first-page":"909","DOI":"10.2353\/ajpath.2007.060665","article-title":"Glyceryl trinitrate inhibits hypoxia\/reoxygenation-induced apoptosis in the syncytiotrophoblast of the human placenta: therapeutic implications for preeclampsia","volume":"170","author":"Belkacemi","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lfs.2025.123605_bb0430","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4103\/1110-1415.168738","article-title":"Light and electron microscopic study of placenta in pre-eclampsia: a trial to define underlying changes and its clinical impact","volume":"43","author":"Abdel Salam","year":"2015","journal-title":"Tanta Med. J."},{"key":"10.1016\/j.lfs.2025.123605_bb0435","first-page":"895","article-title":"Effects of Danshensu on maternal syndrome in phosphatidylserine\/phosphatidylcholine microvesicle induced-mouse model: is it a candidate for preeclampsia remedy?","volume":"123","author":"Shen","year":"2010","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.lfs.2025.123605_bb0440","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0014-4827(03)00156-3","article-title":"Nitric oxide protects human extravillous trophoblast cells from apoptosis by a cyclic GMP-dependent mechanism and independently of caspase 3 nitrosylation","volume":"287","author":"Dash","year":"2003","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.lfs.2025.123605_bb0445","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/jog.13186","article-title":"Vitamin D restores angiogenic balance and decreases tumor necrosis factor-\u03b1 in a rat model of pre-eclampsia","volume":"43","author":"Song","year":"2017","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.lfs.2025.123605_bb0450","article-title":"Associations of serum nitric oxide with vitamin D and other metabolic factors in apparently healthy adolescents","volume":"2018","author":"Al-Daghri","year":"2018"},{"key":"10.1016\/j.lfs.2025.123605_bb0455","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/039463201402700206","article-title":"Effect of a high dose of vitamin D on a rabbit model of atherosclerosis","volume":"27","author":"Malek","year":"2014","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123605_bb0460","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.tice.2014.04.003","article-title":"The expression of cell cycle related proteins PCNA, Ki67, p27 and p57 in normal and preeclamptic human placentas","volume":"46","author":"Unek","year":"2014","journal-title":"Tissue Cell"},{"key":"10.1016\/j.lfs.2025.123605_bb0465","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/978-3-030-67171-6_18","article-title":"Extracellular vesicles and preeclampsia: current knowledge and future research directions","volume":"97","author":"Palma","year":"2021","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.lfs.2025.123605_bb0470","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/path.2719","article-title":"Pre-eclampsia: fitting together the placental, immune and cardiovascular pieces","volume":"221","author":"James","year":"2010","journal-title":"J. Pathol."},{"key":"10.1016\/j.lfs.2025.123605_bb0475","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1016\/j.ajog.2015.08.042","article-title":"Why is placentation abnormal in preeclampsia?","volume":"213","author":"Fisher","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2025.123605_bb0480","article-title":"Efficiency of sFlt-1\/PlGF ratio in preeclampsia diagnosis","volume":"58","author":"Tataru-Copos","year":"2022","journal-title":"Medicina (Kaunas, Lithuania)"},{"key":"10.1016\/j.lfs.2025.123605_bb0485","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4274\/tjod.galenos.2022.38932","article-title":"Predictive and diagnostic value of serum sVEGFR-1 level in women with preeclampsia: a prospective controlled study","volume":"19","author":"\u015ealk","year":"2022","journal-title":"Turk. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2025.123605_bb0490","doi-asserted-by":"crossref","DOI":"10.4238\/gmr16029191","article-title":"Effect of 1,25(OH)2D3 on the proliferation of human mesangial cells and their expression of Ki67","volume":"16","author":"Zhao","year":"2017","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.lfs.2025.123605_bb0495","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/7608096","article-title":"Association between vascular endothelial growth factor (VEGF) +936C\/T polymorphism (rs3025039) and preeclampsia among Myanmar pregnant women","author":"Saw","year":"2024","journal-title":"J. Pregnancy"},{"issue":"1","key":"10.1016\/j.lfs.2025.123605_bb0500","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3346\/jkms.2007.22.1.94","article-title":"The levels of circulating vascular endothelial growth factor and soluble Flt-1 in pregnancies complicated by preeclampsia","volume":"22","author":"Lee","year":"2007","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.lfs.2025.123605_bb0505","doi-asserted-by":"crossref","DOI":"10.3390\/nu9040334","article-title":"Vitamin D decreases serum VEGF correlating with clinical improvement in vitamin D-deficient women with PCOS: a randomized placebo-controlled trial","volume":"9","author":"Irani","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2025.123605_bb0510","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1925424","article-title":"Levels of serum 25(OH)VD3, HIF-1\u03b1, VEGF, vWf, and IGF-1 and their correlation in type 2 diabetes patients with different urine albumin creatinine ratio","volume":"2016","author":"Shao","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.lfs.2025.123605_bb0515","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3810\/pgm.2014.01.2730","article-title":"1\u2013alpha, 25\u2013dihydroxyvitamin D3 regresses endometriotic implants in rats by inhibiting neovascularization and altering regulation of matrix metalloproteinase","volume":"126","author":"Yildirim","year":"2014","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.lfs.2025.123605_bb0520","doi-asserted-by":"crossref","DOI":"10.3390\/nu15020422","article-title":"Serum 25-hydroxyvitamin D and cancer risk: a systematic review of Mendelian randomization studies","volume":"15","author":"Lawler","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2025.123605_bb0525","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1007\/s43032-019-00116-2","article-title":"Reduced dietary calcium and vitamin D results in preterm birth and altered placental morphogenesis in mice during pregnancy","volume":"27","author":"Wilson","year":"2020","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.lfs.2025.123605_bb0530","first-page":"449","article-title":"Morphological and immunohistochemical parameters of chronic placental insufficiency in preeclampsia. IP Pavlov Russian Medical Biological Herald","volume":"28","author":"Kulida","year":"2020"},{"key":"10.1016\/j.lfs.2025.123605_bb0535","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1097\/01.LAB.0000098424.38003.FF","article-title":"The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies","volume":"83","author":"Wartenberg","year":"2003","journal-title":"Lab. Investig."},{"key":"10.1016\/j.lfs.2025.123605_bb0540","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1093\/ajh\/hpu240","article-title":"Heme oxygenase improves renal function by potentiating podocyte-associated proteins in N \u03c9-nitro-L-arginine-methyl ester (L-NAME)-induced hypertension","volume":"28","author":"Ndisang","year":"2015","journal-title":"Am. J. Hypertens."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525002395?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525002395?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T12:58:00Z","timestamp":1749214680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525002395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":107,"alternative-id":["S0024320525002395"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123605","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D supplementation as a prophylactic therapy in the management of pre-eclampsia: Focus on VEGF, Ki67, oxidative stress markers in correlation to placental ultra structure","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123605","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123605"}}