{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:24:55Z","timestamp":1777353895972,"version":"3.51.4"},"reference-count":122,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374347"],"award-info":[{"award-number":["82374347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Commission of Health and Family Planning","doi-asserted-by":"publisher","award":["GWIV-28"],"award-info":[{"award-number":["GWIV-28"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009018","name":"Shanghai Municipal Human Resources and Social Security Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1462200"],"award-info":[{"award-number":["22ZR1462200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012235","name":"Shenzhen Municipal Human Resources and Social Security Bureau","doi-asserted-by":"publisher","award":["2023PJD094"],"award-info":[{"award-number":["2023PJD094"]}],"id":[{"id":"10.13039\/501100012235","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.lfs.2025.123614","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T04:58:43Z","timestamp":1743915523000},"page":"123614","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The role of branched-chain amino acids in cardio-oncology: A review"],"prefix":"10.1016","volume":"372","author":[{"given":"Jiaqi","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.lfs.2025.123614_bb0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.lfs.2025.123614_bb0010","series-title":"WHO Fact Sheets: Cardiovascular Diseases (CVDs)","author":"Organization, W.H","year":"2021"},{"issue":"3","key":"10.1016\/j.lfs.2025.123614_bb0015","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/cncr.31806","article-title":"Cardiovascular and other competing causes of death among patients with cancer from 2006 to 2015: an Australian population-based study","volume":"125","author":"Ye","year":"2019","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.lfs.2025.123614_bb0020","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/eurheartj\/ehae496","article-title":"Anthracycline-induced cardiovascular toxicity: validation of the heart failure association and international cardio-oncology society risk score","volume":"46","author":"Rivero-Santana","year":"2024","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.lfs.2025.123614_bb0025","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.hlc.2023.04.301","article-title":"When Cancer and cardiovascular disease intersect: the challenge and the opportunity of cardio-oncology","volume":"33","author":"Sverdlov","year":"2024","journal-title":"Heart Lung Circ."},{"issue":"41","key":"10.1016\/j.lfs.2025.123614_bb0030","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1093\/eurheartj\/ehac244","volume":"43","author":"Lyon","year":"2022","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.lfs.2025.123614_bb0035","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/eurheartj\/ehz935","article-title":"Cardiology care delivered to cancer patients","volume":"41","author":"Asteggiano","year":"2020","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0040","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12943-024-02119-3","article-title":"Altered metabolism in cancer: insights into energy pathways and therapeutic targets","volume":"23","author":"Tufail","year":"2024","journal-title":"Mol. Cancer"},{"issue":"6","key":"10.1016\/j.lfs.2025.123614_bb0045","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41569-022-00698-6","article-title":"Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer","volume":"19","author":"Karlstaedt","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"issue":"5","key":"10.1016\/j.lfs.2025.123614_bb0050","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/cvr\/cvz035","article-title":"Common risk factors for heart failure and cancer","volume":"115","author":"Meijers","year":"2019","journal-title":"Cardiovasc. Res."},{"issue":"15","key":"10.1016\/j.lfs.2025.123614_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25158465","article-title":"Mechanisms of abnormal lipid metabolism in the pathogenesis of disease","volume":"25","author":"Xu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2025.123614_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030644","article-title":"Curbing lipids: impacts ON Cancer and viral infection","volume":"20","author":"Dutta","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0065","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12964-024-01760-1","article-title":"The significant role of amino acid metabolic reprogramming in cancer","volume":"22","author":"Liu","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0070","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41392-023-01569-3","article-title":"Amino acid metabolism in health and disease","volume":"8","author":"Ling","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"12","key":"10.1016\/j.lfs.2025.123614_bb0075","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrendo.2014.171","article-title":"Branched-chain amino acids in metabolic signalling and insulin resistance","volume":"10","author":"Lynch","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0080","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.ajpath.2023.12.006","article-title":"Amino acid metabolism and atherosclerotic cardiovascular disease","volume":"194","author":"Anand","year":"2024","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.lfs.2025.123614_bb0085","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031617","article-title":"Circulating branched chain amino acids and cardiometabolic disease","volume":"13","author":"Fine","year":"2024","journal-title":"J. Am. Heart Assoc."},{"issue":"2","key":"10.1016\/j.lfs.2025.123614_bb0090","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41569-022-00760-3","article-title":"Branched-chain amino acids in cardiovascular disease","volume":"20","author":"McGarrah","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"issue":"2","key":"10.1016\/j.lfs.2025.123614_bb0095","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvad178","article-title":"Association of elevated serum branched-chain amino acid levels with longitudinal skeletal muscle loss","volume":"8","author":"Imai","year":"2024","journal-title":"J. Endocr. Soc."},{"issue":"9","key":"10.1016\/j.lfs.2025.123614_bb0100","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.7150\/ijbs.85672","article-title":"Branch chain amino acid metabolism promotes brain metastasis of NSCLC through EMT occurrence by regulating ALKBH5 activity","volume":"20","author":"Mao","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.lfs.2025.123614_bb0105","doi-asserted-by":"crossref","first-page":"1220638","DOI":"10.3389\/fonc.2023.1220638","article-title":"Branched-chain amino acids catabolism and cancer progression: focus on therapeutic interventions","volume":"13","author":"Xu","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.lfs.2025.123614_bb0110","doi-asserted-by":"crossref","unstructured":"Cheng, F., et al., Abstract 15504: impaired branched-chain amino acid catabolism is assoc iated with chemotherapy-induced heart failure and rescued by metformin. Circulation. 148(Suppl_1).","DOI":"10.1161\/circ.148.suppl_1.15504"},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0115","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/jcsm.12426","article-title":"Chemotherapy-induced cachexia dysregulates hypothalamic and systemic lipoamines and is attenuated by cannabigerol","volume":"10","author":"Brierley","year":"2019","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/metabo14010060","article-title":"Metabolite biomarkers of prolonged and intensified pain and distress in head and neck Cancer patients undergoing radio- or Chemoradiotherapy by means of NMR-based metabolomics-a preliminary study","volume":"14","author":"Boguszewicz","year":"2024","journal-title":"Metabolites"},{"issue":"2","key":"10.1016\/j.lfs.2025.123614_bb0125","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cmet.2018.10.013","article-title":"Quantitative analysis of the whole-body metabolic fate of branched-chain amino acids","volume":"29","author":"Neinast","year":"2019","journal-title":"Cell Metab."},{"issue":"7","key":"10.1016\/j.lfs.2025.123614_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23074022","article-title":"The critical role of the branched chain amino acids (BCAAs) catabolism-regulating enzymes, branched-chain aminotransferase (BCAT) and branched-chain alpha-keto acid dehydrogenase (BCKD), in human pathophysiology","volume":"23","author":"Dimou","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.lfs.2025.123614_bb0135","article-title":"An update on mitochondrial reactive oxygen species production","volume":"9","author":"Mailloux","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.lfs.2025.123614_bb0140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-physiol-020518-114455","article-title":"Branched chain amino acids","volume":"81","author":"Neinast","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.lfs.2025.123614_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.01.005","article-title":"Compartmentalised acyl-CoA metabolism and roles in chromatin regulation","volume":"38","author":"Trefely","year":"2020","journal-title":"Mol Metab"},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0150","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41392-021-00825-8","article-title":"Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0155","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nm.4057","article-title":"A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance","volume":"22","author":"Jang","year":"2016","journal-title":"Nat. Med."},{"issue":"9","key":"10.1016\/j.lfs.2025.123614_bb0160","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.17219\/acem\/104542","article-title":"Branched chain amino acids: passive biomarkers or the key to the pathogenesis of cardiometabolic diseases?","volume":"28","author":"Siomkaj\u0142o","year":"2019","journal-title":"Adv. Clin. Exp. Med."},{"issue":"10","key":"10.1016\/j.lfs.2025.123614_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/nu13103307","article-title":"The association between branched-chain amino acids (BCAAs) and Cardiometabolic risk factors in middle-aged Caucasian women stratified according to glycemic status","volume":"13","author":"Kubacka","year":"2021","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0170","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCGEN.121.003330","article-title":"Association of Plasma Branched-Chain Amino Acid with Biomarkers of inflammation and lipid metabolism in women","volume":"14","author":"Hamaya","year":"2021","journal-title":"Circ Genom Precis Med"},{"issue":"10","key":"10.1016\/j.lfs.2025.123614_bb0175","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/gerona\/glz192","article-title":"Branched chain amino acids, Cardiometabolic risk factors and outcomes in older men: the Concord health and ageing in men project","volume":"75","author":"Le Couteur","year":"2020","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"51","key":"10.1016\/j.lfs.2025.123614_bb0180","doi-asserted-by":"crossref","first-page":"88882","DOI":"10.18632\/oncotarget.21489","article-title":"Association of circulating branched-chain amino acids with cardiometabolic traits differs between adults and the oldest-old","volume":"8","author":"Sun","year":"2017","journal-title":"Oncotarget"},{"issue":"23","key":"10.1016\/j.lfs.2025.123614_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/nu14235065","article-title":"Oral Administration of Branched-Chain Amino Acids Attenuates Atherosclerosis by inhibiting the inflammatory response and regulating the gut microbiota in ApoE-deficient mice","volume":"14","author":"Li","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2025.123614_bb0190","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.yjmcc.2021.04.005","article-title":"Branched chain amino acids selectively promote cardiac growth at the end of the awake period","volume":"157","author":"Latimer","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2025.123614_bb0195","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.ijcard.2016.08.307","article-title":"Associations between branched chain amino acid intake and biomarkers of adiposity and cardiometabolic health independent of genetic factors: a twin study","volume":"223","author":"Jennings","year":"2016","journal-title":"Int. J. Cardiol."},{"issue":"6","key":"10.1016\/j.lfs.2025.123614_bb0200","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1002\/jcsm.12805","article-title":"Leucine-enriched whey protein supplementation, resistance-based exercise, and cardiometabolic health in older adults: a randomized controlled trial","volume":"12","author":"Kirk","year":"2021","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"12","key":"10.1016\/j.lfs.2025.123614_bb0205","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1016\/j.clnu.2023.10.019","article-title":"Association of plasma branched-chain amino acid with multiple cancers: a mendelian randomization analysis","volume":"42","author":"Xu","year":"2023","journal-title":"Clin. Nutr."},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0210","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s10555-021-10016-0","article-title":"Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?","volume":"40","author":"Rossmeislova","year":"2021","journal-title":"Cancer Metastasis Rev."},{"issue":"5","key":"10.1016\/j.lfs.2025.123614_bb0215","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.cmet.2018.12.020","article-title":"Loss of BCAA catabolism during carcinogenesis enhances mTORC1 activity and promotes tumor development and progression","volume":"29","author":"Ericksen","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2025.123614_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.988290","article-title":"The mechanism of branched-chain amino acid transferases in different diseases: research progress and future prospects","volume":"12","author":"Nong","year":"2022","journal-title":"Front. Oncol."},{"issue":"7","key":"10.1016\/j.lfs.2025.123614_bb0225","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s42255-023-00818-7","article-title":"Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression","volume":"5","author":"Qian","year":"2023","journal-title":"Nat. Metab."},{"issue":"7","key":"10.1016\/j.lfs.2025.123614_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23074022","article-title":"The critical role of the branched chain amino acids (BCAAs) catabolism-regulating enzymes, branched-chain aminotransferase (BCAT) and branched-chain \u03b1-keto acid dehydrogenase (BCKD), in human pathophysiology","volume":"23","author":"Dimou","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.lfs.2025.123614_bb0235","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1038\/s41416-023-02256-4","article-title":"Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma","volume":"128","author":"Kitagawa","year":"2023","journal-title":"Br. J. Cancer"},{"issue":"7680","key":"10.1016\/j.lfs.2025.123614_bb0240","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature24294","article-title":"BCAT1 restricts alphaKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation","volume":"551","author":"Raffel","year":"2017","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.lfs.2025.123614_bb0245","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/nm.3686","article-title":"Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development","volume":"20","author":"Mayers","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2025.123614_bb0250","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.887257","article-title":"Elevated BCAA suppresses the development and metastasis of breast Cancer","volume":"12","author":"Chi","year":"2022","journal-title":"Front. Oncol."},{"issue":"44","key":"10.1016\/j.lfs.2025.123614_bb0255","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.1038\/s41388-020-01480-z","article-title":"Multifaceted role of branched-chain amino acid metabolism in cancer","volume":"39","author":"Peng","year":"2020","journal-title":"Oncogene"},{"issue":"6268","key":"10.1016\/j.lfs.2025.123614_bb0260","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1126\/science.aab2674","article-title":"Sestrin2 is a leucine sensor for the mTORC1 pathway","volume":"351","author":"Wolfson","year":"2016","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.lfs.2025.123614_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030755","article-title":"mTOR signaling in Cancer and mTOR inhibitors in solid tumor targeting therapy","volume":"20","author":"Tian","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"19","key":"10.1016\/j.lfs.2025.123614_bb0270","doi-asserted-by":"crossref","first-page":"9705","DOI":"10.7150\/thno.61731","article-title":"Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis","volume":"11","author":"Mao","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.lfs.2025.123614_bb0275","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.freeradbiomed.2017.01.009","article-title":"High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation","volume":"104","author":"Zhenyukh","year":"2017","journal-title":"Free Radic. Biol. Med."},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0280","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19040954","article-title":"Branched chain amino acids: beyond nutrition metabolism","volume":"19","author":"Nie","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0285","doi-asserted-by":"crossref","first-page":"260","DOI":"10.7555\/JBR.34.20190037","article-title":"Glutamate in cancers: from metabolism to signaling","volume":"34","author":"Yi","year":"2019","journal-title":"J. Biomed. Res."},{"issue":"16","key":"10.1016\/j.lfs.2025.123614_bb0290","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1158\/1078-0432.CCR-11-1217","article-title":"Molecular pathways: dysregulated glutamatergic signaling pathways in cancer","volume":"18","author":"Prickett","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.lfs.2025.123614_bb0295","doi-asserted-by":"crossref","first-page":"1123841","DOI":"10.3389\/fimmu.2023.1123841","article-title":"The role of glutamate receptors in the regulation of the tumor microenvironment","volume":"14","author":"Koda","year":"2023","journal-title":"Front. Immunol."},{"issue":"6304","key":"10.1016\/j.lfs.2025.123614_bb0300","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1126\/science.aaf5171","article-title":"Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers","volume":"353","author":"Mayers","year":"2016","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.lfs.2025.123614_bb0305","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.cmet.2018.12.020","article-title":"Loss of BCAA catabolism during carcinogenesis enhances mTORC1 activity and promotes tumor development and progression","volume":"29","author":"Ericksen","year":"2019","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.lfs.2025.123614_bb0310","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Fearon","year":"2011","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.lfs.2025.123614_bb0315","doi-asserted-by":"crossref","first-page":"17105","DOI":"10.1038\/nrdp.2017.105","article-title":"Cancer-associated cachexia","volume":"4","author":"Baracos","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"14","key":"10.1016\/j.lfs.2025.123614_bb0320","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300577","article-title":"Bckdk-mediated branch chain amino acid metabolism reprogramming contributes to muscle atrophy during Cancer Cachexia","volume":"68","author":"Chen","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.lfs.2025.123614_bb0325","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.nut.2016.10.016","article-title":"Effect of branched-chain amino acid ratio on the proliferation, differentiation, and expression levels of key regulators involved in protein metabolism of myocytes","volume":"36","author":"Duan","year":"2017","journal-title":"Nutrition"},{"issue":"7","key":"10.1016\/j.lfs.2025.123614_bb0330","article-title":"Nutritional interventions to improve Cachexia outcomes in Cancer-a systematic review","volume":"58","author":"Braha","year":"2022","journal-title":"Medicina (Kaunas)"},{"issue":"1 Suppl","key":"10.1016\/j.lfs.2025.123614_bb0335","article-title":"Branched-chain amino acid-enriched nutritional support in surgical and cancer patients","volume":"136","author":"Choudry","year":"2006","journal-title":"J. Nutr."},{"issue":"8","key":"10.1016\/j.lfs.2025.123614_bb0340","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16081487","article-title":"The sGCa Vericiguat exhibit Cardioprotective and anti-Sarcopenic effects through NLRP-3 pathways: potential benefits for anthracycline-treated Cancer patients","volume":"16","author":"Quagliariello","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.lfs.2025.123614_bb0345","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/FJC.0000000000001620","article-title":"Sodium-glucose cotransporter 2 inhibitors, malnutrition, Cachexia, and survival in patients with heart failure with a history of anthracycline treatment","volume":"84","author":"Henson","year":"2024","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0350","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.gendis.2022.02.007","article-title":"Cancer chemotherapy and beyond: current status, drug candidates, associated risks and progress in targeted therapeutics","volume":"10","author":"Anand","year":"2023","journal-title":"Genes Dis"},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0355","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2165\/00002018-200022040-00002","article-title":"Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention","volume":"22","author":"Pai","year":"2000","journal-title":"Drug Saf."},{"issue":"5","key":"10.1016\/j.lfs.2025.123614_bb0360","doi-asserted-by":"crossref","first-page":"453","DOI":"10.5603\/CJ.2012.0084","article-title":"5-fluorouracil induced cardiotoxicity: review of the literature","volume":"19","author":"Sorrentino","year":"2012","journal-title":"Cardiol. J."},{"issue":"5","key":"10.1016\/j.lfs.2025.123614_bb0365","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1182\/blood.V68.5.1114.1114","article-title":"Cyclophosphamide cardiotoxicity: an analysis of dosing as a risk factor","volume":"68","author":"Goldberg","year":"1986","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0370","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1200\/JCO.2003.08.013","article-title":"Phase III trial of doxorubicin, paclitaxel, and the combination of doxorubicin and paclitaxel as front-line chemotherapy for metastatic breast cancer: an intergroup trial (E1193)","volume":"21","author":"Sledge","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.lfs.2025.123614_bb0375","article-title":"The research progress of trastuzumab-induced cardiotoxicity in her-2-positive breast cancer treatment","volume":"8","author":"Lin","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"25","key":"10.1016\/j.lfs.2025.123614_bb0380","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.2174\/092986709788803312","article-title":"Doxorubicin: the good, the bad and the ugly effect","volume":"16","author":"Carvalho","year":"2009","journal-title":"Curr. Med. Chem."},{"issue":"2","key":"10.1016\/j.lfs.2025.123614_bb0385","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/1097-0142(197308)32:2<302::AID-CNCR2820320205>3.0.CO;2-2","article-title":"A clinicopathologic analysis of adriamycin cardiotoxicity","volume":"32","author":"Lefrak","year":"1973","journal-title":"Cancer"},{"issue":"Suppl_1","key":"10.1016\/j.lfs.2025.123614_bb0390","doi-asserted-by":"crossref","DOI":"10.1161\/circ.148.suppl_1.15504","article-title":"Abstract 15504: impaired branched-chain amino acid catabolism is associated with chemotherapy-induced heart failure and rescued by metformin","volume":"148","author":"Cheng","year":"2023","journal-title":"Circulation"},{"issue":"Suppl_1","key":"10.1016\/j.lfs.2025.123614_bb0395","doi-asserted-by":"crossref","DOI":"10.1161\/circ.146.suppl_1.11723","article-title":"Abstract 11723: defects in the branch-chain amino acid pathway is associated with doxorubicin-induced cardiotoxicity and preventable with a BCKDK inhibitor or metformin","volume":"146","author":"Castrillon","year":"2022","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0400","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1021\/acsomega.0c04677","article-title":"Systematic evaluations of doxorubicin-induced toxicity in rats based on metabolomics","volume":"6","author":"Geng","year":"2021","journal-title":"ACS Omega"},{"issue":"11","key":"10.1016\/j.lfs.2025.123614_bb0405","doi-asserted-by":"crossref","first-page":"21629","DOI":"10.3390\/ijms141121629","article-title":"A novel insight into the cardiotoxicity of antineoplastic drug doxorubicin","volume":"14","author":"Heger","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2025.123614_bb0410","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3389\/fphys.2017.01042","article-title":"Increased dietary leucine reduces doxorubicin-associated cardiac dysfunction in rats","volume":"8","author":"Fidale","year":"2017","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.lfs.2025.123614_bb0415","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s12012-023-09817-2","article-title":"Cardioprotective effects of leucine supplementation against doxorubicin-induced Cardiotoxicit","volume":"24","author":"Guimar\u00e3es","year":"2024","journal-title":"Cardiovasc. Toxicol."},{"issue":"2","key":"10.1016\/j.lfs.2025.123614_bb0420","doi-asserted-by":"crossref","DOI":"10.3390\/nu12020282","article-title":"A special amino-acid formula tailored to boosting cell respiration prevents mitochondrial dysfunction and oxidative stress caused by doxorubicin in mouse cardiomyocytes","volume":"12","author":"Tedesco","year":"2020","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.lfs.2025.123614_bb0425","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11886-021-01441-2","article-title":"5-FU cardiotoxicity: vasospasm, myocarditis, and sudden death","volume":"23","author":"More","year":"2021","journal-title":"Curr. Cardiol. Rep."},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0430","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1038\/s41467-023-40536-y","article-title":"Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels","volume":"14","author":"Roth Flach","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0435","first-page":"121","article-title":"Effect of 5-fluorouracil on branched-chain alpha-keto acid dehydrogenase (BCKDH) complex in rat\u2019s heart","volume":"61","author":"Knapik-Czajka","year":"2021","journal-title":"Folia Med. Cracov."},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0440","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/cmdc.202000251","article-title":"Differentiation of Cancer stem cells by using synthetic small molecules: toward new therapeutic strategies against therapy resistance","volume":"16","author":"Maucort","year":"2021","journal-title":"ChemMedChem"},{"issue":"11","key":"10.1016\/j.lfs.2025.123614_bb0445","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082346","article-title":"Branched chain amino acid suppresses hepatocellular cancer stem cells through the activation of mammalian target of rapamycin","volume":"8","author":"Nishitani","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.lfs.2025.123614_bb0450","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2147\/DDDT.S443107","article-title":"Understanding sorafenib-induced cardiovascular toxicity: mechanisms and treatment implications","volume":"18","author":"Li","year":"2024","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.lfs.2025.123614_bb0455","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/bs.podrm.2018.11.003","article-title":"Sorafenib","volume":"44","author":"Abdelgalil","year":"2019","journal-title":"Profiles Drug Subst Excip Relat Methodol"},{"issue":"3","key":"10.1016\/j.lfs.2025.123614_bb0460","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/hepr.12125","article-title":"Effect of treatment with branched-chain amino acids during sorafenib therapy for unresectable hepatocellular carcinoma","volume":"44","author":"Takeda","year":"2014","journal-title":"Hepatol. Res."},{"issue":"10","key":"10.1016\/j.lfs.2025.123614_bb0465","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/hepr.12640","article-title":"Impact of branched-chain amino acid supplementation on survival in patients with advanced hepatocellular carcinoma treated with sorafenib: a multicenter retrospective cohort study","volume":"46","author":"Imanaka","year":"2016","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.lfs.2025.123614_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.107017","article-title":"Sorafenib induces cardiotoxicity through RBM20-mediated alternative splicing of sarcomeric and mitochondrial genes","volume":"198","author":"Liu","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2025.123614_bb0475","article-title":"BCAT1 contributes to the development of TKI-resistant CML","author":"Jiang","year":"2024","journal-title":"Cell. Oncol. (Dordr.)"},{"issue":"2","key":"10.1016\/j.lfs.2025.123614_bb0480","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cpt.2024.04.004","article-title":"Cardiotoxicity in platinum-based chemotherapy: mechanisms, manifestations, and management","volume":"3","author":"Rachma","year":"2025","journal-title":"Cancer Pathogen. Ther."},{"issue":"5","key":"10.1016\/j.lfs.2025.123614_bb0485","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s00280-014-2564-z","article-title":"Importance of branched-chain amino acids in patients with liver cirrhosis and advanced hepatocellular carcinoma receiving hepatic arterial infusion chemotherapy","volume":"74","author":"Kanekawa","year":"2014","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0490","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1021\/acs.jproteome.7b00014","article-title":"Branched-chain amino acids as predictors for individual differences of cisplatin nephrotoxicity in rats: a Pharmacometabonomics study","volume":"16","author":"Zhang","year":"2017","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.lfs.2025.123614_bb0495","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/bs.podrm.2018.11.001","article-title":"Paclitaxel","volume":"44","author":"Alqahtani","year":"2019","journal-title":"Profiles Drug Subst Excip Relat Methodol"},{"issue":"5","key":"10.1016\/j.lfs.2025.123614_bb0500","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/s41416-022-02095-9","article-title":"Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel","volume":"128","author":"Ibrahim","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.lfs.2025.123614_bb0505","doi-asserted-by":"crossref","first-page":"1469163","DOI":"10.3389\/fimmu.2024.1469163","article-title":"Branched-chain amino acid catabolism promotes M2 macrophage polarization","volume":"15","author":"Lu","year":"2024","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.lfs.2025.123614_bb0510","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.15252\/embr.201744154","article-title":"Branched-chain ketoacids secreted by glioblastoma cells via MCT1 modulate macrophage phenotype","volume":"18","author":"Silva","year":"2017","journal-title":"EMBO Rep."},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0515","doi-asserted-by":"crossref","first-page":"798s","DOI":"10.3945\/an.115.011221","article-title":"Leucine metabolism in T cell activation: mTOR signaling and beyond","volume":"7","author":"Ananieva","year":"2016","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.lfs.2025.123614_bb0520","doi-asserted-by":"crossref","unstructured":"Yao, C.-C., et al., Accumulation of branched-chain amino acids reprograms glucose metaboli sm in CD8+ T cells with enhanced effector function and anti -tumor response. Cell Reports 42(3): p. 112186.","DOI":"10.1016\/j.celrep.2023.112186"},{"issue":"4","key":"10.1016\/j.lfs.2025.123614_bb0525","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/MOT.0000000000000098","article-title":"Insight into the role of mTOR and metabolism in T cells reveals new potential approaches to preventing graft rejection","volume":"19","author":"Lo","year":"2014","journal-title":"Curr. Opin. Organ Transplant."},{"issue":"5882","key":"10.1016\/j.lfs.2025.123614_bb0530","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1126\/science.1157535","article-title":"The rag GTPases bind raptor and mediate amino acid signaling to mTORC1","volume":"320","author":"Sancak","year":"2008","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.lfs.2025.123614_bb0535","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.cell.2012.02.044","article-title":"Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway","volume":"149","author":"Han","year":"2012","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.lfs.2025.123614_bb0540","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/ni.2556","article-title":"Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation","volume":"14","author":"Sinclair","year":"2013","journal-title":"Nat. Immunol."},{"issue":"27","key":"10.1016\/j.lfs.2025.123614_bb0545","doi-asserted-by":"crossref","first-page":"18793","DOI":"10.1074\/jbc.M114.554113","article-title":"Cytosolic branched chain aminotransferase (BCATc) regulates mTORC1 signaling and glycolytic metabolism in CD4+ T cells","volume":"289","author":"Ananieva","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2025.123614_bb0550","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.886822","article-title":"Immunometabolism - the role of branched-chain amino acids","volume":"13","author":"Yahsi","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2025.123614_bb0555","doi-asserted-by":"crossref","unstructured":"Ikeda, K., et al., Slc3a2 mediates branched-chain amino-acid-dependent maintenance of regulatory T cells. Cell Reports. 21(7): p. 1824-1838.","DOI":"10.1016\/j.celrep.2017.10.082"},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0560","doi-asserted-by":"crossref","first-page":"304","DOI":"10.21037\/tlcr-20-380","article-title":"High indoleamine-2,3-dioxygenase 1 (IDO) activity is linked to primary resistance to immunotherapy in non-small cell lung cancer (NSCLC)","volume":"10","author":"Kocher","year":"2021","journal-title":"Transl Lung Cancer Res"},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0565","doi-asserted-by":"crossref","first-page":"6692","DOI":"10.1038\/ncomms7692","article-title":"PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation","volume":"6","author":"Patsoukis","year":"2015","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.lfs.2025.123614_bb0570","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1016\/j.ymthe.2024.05.017","article-title":"BCKDK modification enhances the anticancer efficacy of CAR-T cells by reprogramming branched chain amino acid metabolism","volume":"32","author":"Yang","year":"2024","journal-title":"Mol. Ther."},{"issue":"6 Suppl","key":"10.1016\/j.lfs.2025.123614_bb0575","doi-asserted-by":"crossref","first-page":"1583s","DOI":"10.1093\/jn\/134.6.1583S","article-title":"Exercise promotes BCAA catabolism: effects of BCAA supplementation on skeletal muscle during exercise","volume":"134","author":"Shimomura","year":"2004","journal-title":"J. Nutr."},{"issue":"19","key":"10.1016\/j.lfs.2025.123614_bb0580","doi-asserted-by":"crossref","DOI":"10.3390\/nu14194002","article-title":"Oral branched-chain amino acids supplementation in athletes: a systematic review","volume":"14","author":"Martinho","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2025.123614_bb0585","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12970-017-0184-9","article-title":"Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?","volume":"14","author":"Wolfe","year":"2017","journal-title":"J. Int. Soc. Sports Nutr."},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0590","first-page":"9","article-title":"Effect of a high-protein, high-fiber diet plus supplementation with branched-chain amino acids on the nutritional status of patients with cirrhosis","volume":"83","author":"Ruiz-Marg\u00e1in","year":"2018","journal-title":"Rev Gastroenterol Mex (Engl Ed)"},{"key":"10.1016\/j.lfs.2025.123614_bb0595","doi-asserted-by":"crossref","unstructured":"Hotta, K., et al., The effects of an oral nutritional supplement with whey peptides and b ranched-chain amino acids for cardiac rehabilitation of patients with chronic heart failure. Int. Heart J. 62(6): p. 1342\u20131347.","DOI":"10.1536\/ihj.21-102"},{"key":"10.1016\/j.lfs.2025.123614_bb0600","doi-asserted-by":"crossref","unstructured":"Ma, Y., et al., Early intravenous branched-chain amino acid-enriched nutrition supplem entation in older patients undergoing gastric surgery: a randomized cl inical trial. Nutr. J. 23(1): p. 137.","DOI":"10.1186\/s12937-024-01041-0"},{"issue":"1","key":"10.1016\/j.lfs.2025.123614_bb0605","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12986-018-0271-1","article-title":"Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements","volume":"15","author":"Holecek","year":"2018","journal-title":"Nutr. Metab. (Lond.)"},{"issue":"16","key":"10.1016\/j.lfs.2025.123614_bb0610","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1093\/eurheartj\/ehab842","article-title":"Immune cells in cardiac homeostasis and disease: emerging insights from novel technologies","volume":"43","author":"Steffens","year":"2022","journal-title":"Eur. Heart J."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525002486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525002486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:11:30Z","timestamp":1762211490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525002486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":122,"alternative-id":["S0024320525002486"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123614","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of branched-chain amino acids in cardio-oncology: A review","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123614","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"123614"}}