{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:09:58Z","timestamp":1789848598415,"version":"4.0.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104247"],"award-info":[{"award-number":["82104247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.lfs.2025.123775","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T11:44:27Z","timestamp":1748519067000},"page":"123775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Diamine oxidase acts as a novel risk factor in abnormal inflammation via mediating \u201ccytosolic ROS-autophagy-IFN-\u03b3\u201d axis in NK cells"],"prefix":"10.1016","volume":"377","author":[{"given":"Dongmei","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangqin","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyin","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rixing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/catal13010048","article-title":"Advances in the clinical application of histamine and diamine oxidase (DAO) activity: a review","volume":"13","author":"Tan","year":"2022","journal-title":"Catalysts"},{"issue":"8","key":"10.1016\/j.lfs.2025.123775_bb0010","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00399.2012","article-title":"Lymphatic diamine oxidase secretion stimulated by fat absorption is linked with histamine release","volume":"304","author":"Ji","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2025.123775_bb0015","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.2147\/CMAR.S225229","article-title":"AOC1 contributes to tumor progression by promoting the AKT and EMT pathways in gastric cancer","volume":"12","author":"Xu","year":"2020","journal-title":"Cancer Manag. Res."},{"issue":"6","key":"10.1016\/j.lfs.2025.123775_bb0020","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3892\/ol.2021.13118","article-title":"Downregulation of amine oxidase copper containing 1 inhibits tumor progression by suppressing IL-6\/JAK\/STAT3 pathway activation in hepatocellular carcinoma","volume":"22","author":"Ding","year":"2021","journal-title":"Oncol. Lett."},{"issue":"8","key":"10.1016\/j.lfs.2025.123775_bb0025","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41419-022-05108-w","article-title":"SOX15 transcriptionally increases the function of AOC1 to modulate ferroptosis and progression in prostate cancer","volume":"13","author":"Ding","year":"2022","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0030","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0167-4838(97)00039-3","article-title":"Purification and characterization of diamine oxidase from porcine kidney and intestine","volume":"1340","author":"Schwelberger","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2025.123775_bb0035","article-title":"Increased AOC1 expression promotes cancer progression in colorectal cancer","volume":"11","author":"Liu","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.lfs.2025.123775_bb0040","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.2147\/CMAR.S225229","article-title":"AOC1 contributes to tumor progression by promoting the AKT and EMT pathways in gastric cancer","author":"Xu","year":"2020","journal-title":"Cancer Manag. Res."},{"issue":"8","key":"10.1016\/j.lfs.2025.123775_bb0045","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41419-022-05108-w","article-title":"SOX15 transcriptionally increases the function of AOC1 to modulate ferroptosis and progression in prostate cancer","volume":"13","author":"Ding","year":"2022","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.lfs.2025.123775_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ol.2021.13118","article-title":"Downregulation of amine oxidase copper containing 1 inhibits tumor progression by suppressing IL-6\/JAK\/STAT3 pathway activation in hepatocellular carcinoma","volume":"22","author":"Ding","year":"2021","journal-title":"Oncol. Lett."},{"issue":"11","key":"10.1016\/j.lfs.2025.123775_bb0055","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41584-021-00694-z","article-title":"Targeting interferon-gamma in hyperinflammation: opportunities and challenges","volume":"17","author":"De Benedetti","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"issue":"9","key":"10.1016\/j.lfs.2025.123775_bb0060","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41577-018-0029-z","article-title":"IFNgamma: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy","volume":"18","author":"Ivashkiv","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2025.123775_bb0065","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41577-021-00566-3","article-title":"Interferon-gamma: teammate or opponent in the tumour microenvironment?","volume":"22","author":"Gocher","year":"2022","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2025.123775_bb0070","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cytogfr.2014.11.003","article-title":"NK cells and interferons","volume":"26","author":"Paolini","year":"2015","journal-title":"Cytokine Growth Factor Rev."},{"issue":"2","key":"10.1016\/j.lfs.2025.123775_bb0075","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1084\/jem.178.2.567","article-title":"Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice","volume":"178","author":"Scharton","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.lfs.2025.123775_bb0080","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3389\/fimmu.2019.00961","article-title":"Human gut-associated natural killer cells in health and disease","volume":"10","author":"Poggi","year":"2019","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.lfs.2025.123775_bb0085","doi-asserted-by":"crossref","first-page":"R243","DOI":"10.1186\/cc10501","article-title":"Early natural killer cell counts in blood predict mortality in severe sepsis","volume":"15","author":"Andaluz-Ojeda","year":"2011","journal-title":"Crit. Care"},{"key":"10.1016\/j.lfs.2025.123775_bb0090","doi-asserted-by":"crossref","first-page":"1101918","DOI":"10.3389\/fimmu.2023.1101918","article-title":"Natural killer cells in sepsis: friends or foes?","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0095","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nprot.2008.214","article-title":"Immunodesign of experimental sepsis by cecal ligation and puncture","volume":"4","author":"Rittirsch","year":"2009","journal-title":"Nat. Protoc."},{"issue":"7","key":"10.1016\/j.lfs.2025.123775_bb0100","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nprot.2017.044","article-title":"Chemically induced mouse models of acute and chronic intestinal inflammation","volume":"12","author":"Wirtz","year":"2017","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0105","doi-asserted-by":"crossref","first-page":"11358","DOI":"10.1038\/s41598-023-32992-9","article-title":"GPX4 is a key ferroptosis biomarker and correlated with immune cell populations and immune checkpoints in childhood sepsis","volume":"13","author":"Qu","year":"2023","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.lfs.2025.123775_bb0110","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.immuni.2015.02.001","article-title":"Human monocytes undergo functional re-programming during sepsis mediated by hypoxia-inducible factor-1\u03b1","volume":"42","author":"Shalova","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.lfs.2025.123775_bb0115","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58597","article-title":"The leukocyte non-coding RNA landscape in critically ill patients with sepsis","volume":"9","author":"Scicluna","year":"2020","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0120","doi-asserted-by":"crossref","first-page":"6081","DOI":"10.1038\/s41598-023-33388-5","article-title":"Identification of diagnostic biomarks and immune cell infiltration in ulcerative colitis","volume":"13","author":"Chen","year":"2023","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0125","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2353\/jmoldx.2006.050079","article-title":"Molecular classification of Crohn\u2019s disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells","volume":"8","author":"Burczynski","year":"2006","journal-title":"J. Mol. Diagn.\u202f: JMD"},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/756290","article-title":"Peripheral blood based discrimination of ulcerative colitis and Crohn\u2019s disease from non-IBD colitis by genome-wide gene expression profiling","volume":"30","author":"Sipos","year":"2011","journal-title":"Dis. Markers"},{"issue":"2","key":"10.1016\/j.lfs.2025.123775_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016795","article-title":"Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2025.123775_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.709173","article-title":"The role of hemoglobin Subunit Delta in the Immunopathy of multiple sclerosis: mitochondria matters","volume":"12","author":"Derakhshani","year":"2021","journal-title":"Front. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2025.123775_bb0145","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2119\/molmed.2010.00071","article-title":"Gene expression changes in multiple sclerosis relapse suggest activation of T and non-T cells","volume":"17","author":"Lindsey","year":"2011","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12969-023-00926-4","article-title":"Identification of key biomarkers in RF-negative polyarticular and oligoarticular juvenile idiopathic arthritis by bioinformatic analysis","volume":"21","author":"Liu","year":"2023","journal-title":"Pediatr. Rheumatol. Online J."},{"issue":"2","key":"10.1016\/j.lfs.2025.123775_bb0155","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41590-019-0568-x","article-title":"Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection","volume":"21","author":"Aegerter","year":"2020","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2025.123775_bb0160","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1365-2249.2006.03214.x","article-title":"Interferon-gamma is causatively involved in experimental inflammatory bowel disease in mice","volume":"146","author":"Ito","year":"2006","journal-title":"Clin. Exp. Immunol."},{"issue":"8","key":"10.1016\/j.lfs.2025.123775_bb0165","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.it.2021.06.001","article-title":"The \u2018cytokine storm\u2019: molecular mechanisms and therapeutic prospects","volume":"42","author":"Karki","year":"2021","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2025.123775_bb0170","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/all.13663","article-title":"Massive release of the histamine-degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients","volume":"74","author":"Boehm","year":"2019","journal-title":"Allergy"},{"issue":"41","key":"10.1016\/j.lfs.2025.123775_bb0175","doi-asserted-by":"crossref","first-page":"9810","DOI":"10.1021\/bi9014192","article-title":"Structure and inhibition of human diamine oxidase","volume":"48","author":"McGrath","year":"2009","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.lfs.2025.123775_bb0180","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/ajcn\/85.5.1185","article-title":"Histamine and histamine intolerance","volume":"85","author":"Maintz","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"issue":"11","key":"10.1016\/j.lfs.2025.123775_bb0185","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.4049\/jimmunol.179.11.7907","article-title":"Functional expression of H4 histamine receptor in human natural killer cells, monocytes, and dendritic cells","volume":"179","author":"Damaj","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.lfs.2025.123775_bb0190","article-title":"Busulfan as a myelosuppressive agent for generating stable high-level bone marrow chimerism in mice","volume":"98","author":"Peake","year":"2015","journal-title":"J. Vis. Exp."},{"issue":"16","key":"10.1016\/j.lfs.2025.123775_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612736","article-title":"Signaling pathways leading to mTOR activation downstream cytokine receptors in lymphocytes in health and disease","volume":"24","author":"Fallone","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.lfs.2025.123775_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/cancers9100132","article-title":"Regulation of mTOR, metabolic fitness, and effector functions by cytokines in natural killer cells","volume":"9","author":"Viel","year":"2017","journal-title":"Cancers (Basel)"},{"issue":"16","key":"10.1016\/j.lfs.2025.123775_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27165295","article-title":"Overview of research into mTOR inhibitors","volume":"27","author":"Mao","year":"2022","journal-title":"Molecules"},{"issue":"11","key":"10.1016\/j.lfs.2025.123775_bb0210","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1016\/j.cell.2022.04.013","article-title":"mTOR substrate phosphorylation in growth control","volume":"185","author":"Battaglioni","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2025.123775_bb0215","article-title":"IFN-gamma, should not be ignored in SLE","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2025.123775_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.658141","article-title":"Staphylococcus aureus beta-Hemolysin up-regulates the expression of IFN-gamma by human CD56(bright) NK cells","volume":"11","author":"Guan","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"6","key":"10.1016\/j.lfs.2025.123775_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130155","article-title":"Invasive surgery impairs the regulatory function of human CD56 bright natural killer cells in response to Staphylococcus aureus. Suppression of interferon-gamma synthesis","volume":"10","author":"Reinhardt","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.lfs.2025.123775_bb0230","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.4049\/jimmunol.176.3.1517","article-title":"CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity","volume":"176","author":"Hayakawa","year":"2006","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0235","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13045-020-01014-w","article-title":"NK cell-based cancer immunotherapy: from basic biology to clinical development","volume":"14","author":"Liu","year":"2021","journal-title":"J. Hematol. Oncol."},{"issue":"4","key":"10.1016\/j.lfs.2025.123775_bb0240","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cell.2017.04.004","article-title":"Metabolic instruction of immunity","volume":"169","author":"Buck","year":"2017","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.lfs.2025.123775_bb0245","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.immuni.2013.04.005","article-title":"Metabolic pathways in immune cell activation and quiescence","volume":"38","author":"Pearce","year":"2013","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0250","doi-asserted-by":"crossref","first-page":"4874","DOI":"10.1038\/s41467-018-07277-9","article-title":"Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.lfs.2025.123775_bb0255","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41423-022-00902-0","article-title":"Redox regulation of the immune response","volume":"19","author":"Morris","year":"2022","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.lfs.2025.123775_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101759","article-title":"Innate-adaptive immunity interplay and redox regulation in immune response","volume":"37","author":"Sun","year":"2020","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.lfs.2025.123775_bb0265","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1080\/15548627.2021.1984656","article-title":"Full-coverage regulations of autophagy by ROS: from induction to maturation","volume":"18","author":"Zhou","year":"2022","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0270","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12943-017-0648-1","article-title":"ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway","volume":"16","author":"Zhao","year":"2017","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0275","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/bab.2104","article-title":"The interplay of ROS and the PI3K\/Akt pathway in autophagy regulation","volume":"69","author":"Kma","year":"2022","journal-title":"Biotechnol. Appl. Biochem."},{"issue":"4","key":"10.1016\/j.lfs.2025.123775_bb0280","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1089\/ars.2010.3383","article-title":"Sense and sensitivity: FOXO and ROS in cancer development and treatment","volume":"14","author":"Myatt","year":"2011","journal-title":"Antioxid. Redox Signal."},{"issue":"3","key":"10.1016\/j.lfs.2025.123775_bb0285","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1080\/15548627.2016.1274486","article-title":"Involvement of autophagy in NK cell development and function","volume":"13","author":"Lopez-Soto","year":"2017","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0290","first-page":"3","article-title":"Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles","volume":"66","author":"Biederbick","year":"1995","journal-title":"Eur. J. Cell Biol."},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0295","doi-asserted-by":"crossref","first-page":"10343","DOI":"10.1038\/s41467-024-54355-2","article-title":"C\/EBP\u03b2-dependent autophagy inhibition hinders NK cell function in cancer","volume":"15","author":"Portale","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2025.123775_bb0300","doi-asserted-by":"crossref","first-page":"11023","DOI":"10.1038\/ncomms11023","article-title":"FoxO1-mediated autophagy is required for NK cell development and innate immunity","volume":"7","author":"Wang","year":"2016","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.lfs.2025.123775_bb0305","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1136\/gut.2005.079392","article-title":"Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn\u2019s disease","volume":"55","author":"Hommes","year":"2006","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.lfs.2025.123775_bb0310","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/ibd.21038","article-title":"Fontolizumab in moderate to severe Crohn\u2019s disease: a phase 2, randomized, double-blind, placebo-controlled, multiple-dose study","volume":"16","author":"Reinisch","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"issue":"8","key":"10.1016\/j.lfs.2025.123775_bb0315","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1136\/gut.2005.079434","article-title":"A dose escalating, placebo controlled, double blind, single dose and multidose, safety and tolerability study of fontolizumab, a humanised anti-interferon gamma antibody, in patients with moderate to severe Crohn\u2019s disease","volume":"55","author":"Reinisch","year":"2006","journal-title":"Gut"},{"issue":"5","key":"10.1016\/j.lfs.2025.123775_bb0320","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/art.40052","article-title":"Brief report: pharmacodynamics, safety, and clinical efficacy of AMG 811, a human anti-interferon-gamma antibody, in patients with discoid lupus erythematosus","volume":"69","author":"Werth","year":"2017","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0325","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2017-000226","article-title":"Safety, pharmacokinetics and pharmacodynamics of AMG 811, an anti-interferon-gamma monoclonal antibody, in SLE subjects without or with lupus nephritis","volume":"4","author":"Boedigheimer","year":"2017","journal-title":"Lupus Sci Med."},{"issue":"2","key":"10.1016\/j.lfs.2025.123775_bb0330","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s11095-014-1492-2","article-title":"Pharmacokinetic and pharmacodynamic relationship of AMG 811, an anti-IFN-gamma IgG1 monoclonal antibody, in patients with systemic lupus erythematosus","volume":"32","author":"Chen","year":"2015","journal-title":"Pharm. Res."},{"issue":"19","key":"10.1016\/j.lfs.2025.123775_bb0335","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMoa1911326","article-title":"Emapalumab in children with primary Hemophagocytic Lymphohistiocytosis","volume":"382","author":"Locatelli","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.lfs.2025.123775_bb0340","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/ard-2022-223739","article-title":"Efficacy and safety of emapalumab in macrophage activation syndrome","volume":"82","author":"De Benedetti","year":"2023","journal-title":"Ann. Rheum. Dis."},{"issue":"7","key":"10.1016\/j.lfs.2025.123775_bb0345","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/bcp.13938","article-title":"Adverse immunostimulation caused by impurities: the dark side of biopharmaceuticals","volume":"85","author":"Reijers","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2025.123775_bb0350","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12929-020-00652-z","article-title":"Ab locks for improving the selectivity and safety of antibody drugs","volume":"27","author":"Lin","year":"2020","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.lfs.2025.123775_bb0355","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev-immunol-101819-074948","article-title":"Natural killer cells: from innate to adaptive features","volume":"39","author":"Mujal","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.lfs.2025.123775_bb0360","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.761920","article-title":"Expression regulation and function of T-bet in NK cells","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.lfs.2025.123775_bb0365","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.it.2018.01.005","article-title":"Reactive oxygen species: involvement in T cell signaling and metabolism","volume":"39","author":"Franchina","year":"2018","journal-title":"Trends Immunol."},{"issue":"6","key":"10.1016\/j.lfs.2025.123775_bb0370","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41419-022-04907-5","article-title":"Mitochondrial reactive oxygen is critical for IL-12\/IL-18-induced IFN-gamma production by CD4(+) T cells and is regulated by Fas\/FasL signaling","volume":"13","author":"Rackov","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2025.123775_bb0375","doi-asserted-by":"crossref","first-page":"8819","DOI":"10.1038\/ncomms9819","article-title":"NADH oxidase-dependent CD39 expression by CD8(+) T cells modulates interferon gamma responses via generation of adenosine","volume":"6","author":"Bai","year":"2015","journal-title":"Nat. Commun."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525004102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525004102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:12:47Z","timestamp":1762211567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525004102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":75,"alternative-id":["S0024320525004102"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123775","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diamine oxidase acts as a novel risk factor in abnormal inflammation via mediating \u201ccytosolic ROS-autophagy-IFN-\u03b3\u201d axis in NK cells","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123775","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123775"}}