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Lett."},{"key":"10.1016\/j.lfs.2025.123796_bb0680","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1097\/AJP.0000000000000987","article-title":"Changes in brain-derived neurotrophic factor from active and sham transcranial direct current stimulation in older adults with knee osteoarthritis","volume":"37","author":"Suchting","year":"2021","journal-title":"Clin. J. Pain"},{"key":"10.1016\/j.lfs.2025.123796_bb0685","doi-asserted-by":"crossref","first-page":"15831","DOI":"10.3390\/ijms242115831","article-title":"Switching rat resident macrophages from M1 to M2 phenotype by Iba1 silencing has analgesic effects in SNL-induced neuropathic pain","volume":"24","author":"Gheorghe","year":"2023","journal-title":"Int. J. Mol. 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Cartil."},{"key":"10.1016\/j.lfs.2025.123796_bb1005","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.pain.2011.03.030","article-title":"Tonic and phasic descending dopaminergic controls of nociceptive transmission in the medullary dorsal horn","volume":"152","author":"Lapirot","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2025.123796_bb1010","article-title":"Interplay between subthalamic nucleus and spinal cord controls parkinsonian nociceptive disorders","author":"Charles","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.lfs.2025.123796_bb1015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1129-2377-15-7","article-title":"Release of CGRP from mouse brainstem slices indicates central inhibitory effect of triptans and kynurenate","volume":"15","author":"Kageneck","year":"2014","journal-title":"J. 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