{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:08:18Z","timestamp":1783127298670,"version":"3.54.6"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004728","name":"VIT University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004728","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["3\/1\/2(20)\/OBS\/2022-NCD-II"],"award-info":[{"award-number":["3\/1\/2(20)\/OBS\/2022-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.lfs.2025.123802","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T11:28:44Z","timestamp":1749209324000},"page":"123802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The role of TP53INP2 as an adaptor protein in the regulation of lipophagy in mature adipocytes"],"prefix":"10.1016","volume":"377","author":[{"given":"Mouliganesh","family":"Sekar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-4099","authenticated-orcid":false,"given":"Kavitha","family":"Thirumurugan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2025.123802_bb0005","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.cmet.2023.02.002","article-title":"Adipose tissue at single-cell resolution","volume":"35","author":"Maniyadath","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2025.123802_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2020.00022","article-title":"Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease","author":"Chait","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.lfs.2025.123802_bb0015","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1055\/s-0029-1192044","article-title":"Adipose tissue dysfunction in obesity","volume":"117","author":"Bl\u00fcher","year":"2009","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.lfs.2025.123802_bb0020","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2017","key":"10.1016\/j.lfs.2025.123802_bb0025","first-page":"1","article-title":"Lipid droplets in health and disease","volume":"16","author":"Onal","year":"2017","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.lfs.2025.123802_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2019.00185","article-title":"Emerging roles of lipophagy in health and disease","volume":"7","author":"Kounakis","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2025.123802_bb0035","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.259402","article-title":"Lipophagy at a glance","volume":"135","author":"Schott","year":"2022","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.lfs.2025.123802_bb0040","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/jcb.21964","article-title":"Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes","volume":"105","author":"Miyoshi","year":"2008","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.lfs.2025.123802_bb0045","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/282041","article-title":"Lipophagy: connecting autophagy and lipid metabolism","volume":"2012","author":"Singh","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.lfs.2025.123802_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21176113","article-title":"Lipophagy and lipolysis status in lipid storage and lipid metabolism diseases","volume":"21","author":"Kloska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2025.123802_bb0055","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1083\/jcb.200803137","article-title":"Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum","volume":"182","author":"Axe","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.lfs.2025.123802_bb0060","doi-asserted-by":"crossref","DOI":"10.1007\/s11010-021-04324-w","article-title":"Autophagy: a molecular switch to regulate adipogenesis and lipolysis","author":"Sekar","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.lfs.2025.123802_bb0065","doi-asserted-by":"crossref","first-page":"19860","DOI":"10.1073\/pnas.0906048106","article-title":"Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis","volume":"106","author":"Zhang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.lfs.2025.123802_bb0070","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2025.123802_bb0075","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1016\/j.cub.2011.11.034","article-title":"Mechanisms of autophagosome biogenesis","volume":"22","author":"Rubinsztein","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.lfs.2025.123802_bb0080","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/15548627.2017.1378838","article-title":"Autophagy pathway: cellular and molecular mechanisms","volume":"14","author":"Yu","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.lfs.2025.123802_bb0085","article-title":"The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2025.123802_bb0090","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1021\/acs.biochem.2c00252","article-title":"p62 phase-separation as the foundation of autophagy-based degraders","volume":"62","author":"Takahashi","year":"2023","journal-title":"Biochemistry"},{"key":"10.1016\/j.lfs.2025.123802_bb0095","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1242\/jcs.126128","article-title":"The LIR motif - crucial for selective autophagy","volume":"126","author":"Birgisdottir","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.lfs.2025.123802_bb0100","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.molcel.2014.12.013","article-title":"Deacetylation of nuclear LC3 drives autophagy initiation under starvation","volume":"57","author":"Huang","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.lfs.2025.123802_bb0105","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1007\/s12033-023-01020-6","article-title":"Autophagic regulation of adipogenesis through TP53INP2: insights from in silico and in vitro analysis","volume":"66","author":"Sekar","year":"2024","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.lfs.2025.123802_bb0110","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41556-018-0072-9","article-title":"TP53INP2 regulates adiposity by activating \u03b2-catenin through autophagy-dependent sequestration of GSK3\u03b2","volume":"20","author":"Romero","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.lfs.2025.123802_bb0115","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1002\/1873-3468.13467","article-title":"TP53INP2 mediates autophagic degradation of ubiquitinated proteins through its ubiquitin-interacting motif","volume":"593","author":"Xu","year":"2019","journal-title":"FEBS Lett."},{"key":"10.1016\/j.lfs.2025.123802_bb0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/embor.2009.242","article-title":"The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells","volume":"11","author":"Mauvezin","year":"2010","journal-title":"EMBO Rep."},{"key":"10.1016\/j.lfs.2025.123802_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2017.07.019","article-title":"Lipid droplet proteins and metabolic diseases","author":"Xu","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.lfs.2025.123802_bb0130","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.devcel.2023.05.009","article-title":"LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy","volume":"58","author":"Omrane","year":"2023","journal-title":"Dev. Cell"},{"key":"10.1016\/j.lfs.2025.123802_bb0135","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.cub.2014.02.008","article-title":"Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis","volume":"24","author":"Dupont","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.lfs.2025.123802_bb0140","article-title":"The impact of fasting on adipose tissue metabolism","volume":"1868","author":"Kersten","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.lfs.2025.123802_bb0145","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1083\/jcb.201711002","article-title":"Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy","volume":"217","author":"Mejlvang","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.lfs.2025.123802_bb0150","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1002\/1873-3468.14792","article-title":"Molecular mechanisms of perilipin protein function in lipid droplet metabolism","volume":"598","author":"Griseti","year":"2024","journal-title":"FEBS Lett."},{"key":"10.1016\/j.lfs.2025.123802_bb0155","doi-asserted-by":"crossref","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2025.123802_bb0160","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15384101.2019.1624110","article-title":"Role of autophagy in the regulation of adipose tissue biology","volume":"18","author":"Zorzano","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.lfs.2025.123802_bb0165","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/aps.2013.5","article-title":"Application and interpretation of current autophagy inhibitors and activators","volume":"34","author":"Yang","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.lfs.2025.123802_bb0170","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1089\/ars.2010.3809","article-title":"ULK1, mammalian target of rapamycin, and mitochondria: linking nutrient availability and autophagy","volume":"14","author":"Kundu","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2025.123802_bb0175","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/oby.2000.29","article-title":"Rapamycin inhibits human adipocyte differentiation in primary culture","volume":"8","author":"Bell","year":"2000","journal-title":"Obes. Res."},{"key":"10.1016\/j.lfs.2025.123802_bb0180","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1476-5381.2012.02110.x","article-title":"The autophagic inhibitor 3-methyladenine potently stimulates PKA-dependent lipolysis in adipocytes","volume":"168","author":"Heckmann","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123802_bb0185","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"},{"key":"10.1016\/j.lfs.2025.123802_bb0190","doi-asserted-by":"crossref","DOI":"10.1210\/en.2012-1625","article-title":"Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression","author":"Jansen","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2025.123802_bb0195","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/19768354.2019.1700159","article-title":"Autophagy inhibition in 3T3-L1 adipocytes breaks the crosstalk with tumor cells by suppression of adipokine production","volume":"24","author":"Hwang","year":"2020","journal-title":"Anim. Cells Syst. (Seoul)"},{"key":"10.1016\/j.lfs.2025.123802_bb0200","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s12272-022-01412-3","article-title":"Inhibition of autophagy with chloroquine dysregulates mitochondrial quality control and energetics in adipocytes","volume":"45","author":"Javaid","year":"2022","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.lfs.2025.123802_bb0205","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1080\/15548627.2020.1713646","article-title":"The bifunctional role of TP53INP2 in transcription and autophagy","volume":"16","author":"Xu","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.lfs.2025.123802_bb0210","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1210\/en.2007-1713","article-title":"Minireview: lipid droplets in lipogenesis and lipolysis","volume":"149","author":"Ducharme","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2025.123802_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11658-016-0031-z","article-title":"p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation","volume":"21","author":"Liu","year":"2016","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"2017","key":"10.1016\/j.lfs.2025.123802_bb0220","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/cr.2017.40","article-title":"Ubiquitylation of p62\/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress","volume":"27","author":"Peng","year":"2017","journal-title":"Cell Res."},{"key":"10.1016\/j.lfs.2025.123802_bb0225","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a004838","article-title":"Not just fat: the structure and function of the lipid droplet","author":"Fujimoto","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.lfs.2025.123802_bb0230","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1091\/mbc.e08-07-0671","article-title":"The TP53INP2 protein is required for autophagy in mammalian cells","volume":"20","author":"Nowak","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.lfs.2025.123802_bb0235","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/cvr\/cvae005","article-title":"Perilipin 1: a systematic review on its functions on lipid metabolism and atherosclerosis in mice and humans","volume":"120","author":"Desgrouas","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2025.123802_bb0240","doi-asserted-by":"crossref","DOI":"10.1080\/15548627.2019.1580510","article-title":"TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction","author":"You","year":"2019","journal-title":"Autophagy"},{"key":"10.1016\/j.lfs.2025.123802_bb0245","first-page":"6853","article-title":"Tumor protein p53-induced nuclear protein 2 modulates osteogenic differentiation of human adipose derived stem\/stromal cells by activating Wnt\/\u03b2-catenin signaling","volume":"12","author":"Dong","year":"2020","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.lfs.2025.123802_bb0250","doi-asserted-by":"crossref","first-page":"24131","DOI":"10.1074\/jbc.M702824200","article-title":"p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy [S]","volume":"282","author":"Pankiv","year":"2007","journal-title":"J. Biol. Chem."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525004370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525004370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T16:16:29Z","timestamp":1752941789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525004370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":50,"alternative-id":["S0024320525004370"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123802","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of TP53INP2 as an adaptor protein in the regulation of lipophagy in mature adipocytes","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123802","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123802"}}