{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:10:53Z","timestamp":1793689853060,"version":"4.5.1"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300898"],"award-info":[{"award-number":["82300898"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270922"],"award-info":[{"award-number":["82270922"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA0806100"],"award-info":[{"award-number":["2022YFA0806100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2023MH157"],"award-info":[{"award-number":["ZR2023MH157"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2020ZD14"],"award-info":[{"award-number":["ZR2020ZD14"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.lfs.2025.123933","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T15:03:10Z","timestamp":1756479790000},"page":"123933","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Dysregulation of the TNF-\u03b1-OTUD3-PPAR\u03b3 signaling axis exacerbates retinal oxidative stress and inflammation in diabetic retinopathy"],"prefix":"10.1016","volume":"380","author":[{"given":"Jialin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.lfs.2025.123933_bb0005","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.2337\/diacare.27.10.2540","article-title":"Diabetic retinopathy","volume":"27","author":"Fong","year":"2004","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.lfs.2025.123933_bb0010","article-title":"Diabetic retinopathy","volume":"2","author":"Wong","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"2","key":"10.1016\/j.lfs.2025.123933_bb0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/IIO.0b013e31819fd5d7","article-title":"The role of genetics in susceptibility to diabetic retinopathy","volume":"49","author":"Liew","year":"2009","journal-title":"Int. Ophthalmol. Clin."},{"issue":"12","key":"10.1016\/j.lfs.2025.123933_bb0020","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s11033-016-4075-y","article-title":"Candidate gene studies of diabetic retinopathy in human","volume":"43","author":"Priscakova","year":"2016","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.lfs.2025.123933_bb0025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1076\/opge.23.1.13.2203","article-title":"The epsilon4 allele of apolipoprotein E gene is a potential risk factor for the severity of macular edema in type 2 diabetic Mexican patients","volume":"23","author":"Santos","year":"2002","journal-title":"Ophthalmic Genet."},{"issue":"9","key":"10.1016\/j.lfs.2025.123933_bb0030","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.2337\/diacare.27.9.2184","article-title":"Endothelial nitric oxide synthase gene is associated with diabetic macular edema in type 2 diabetes","volume":"27","author":"Awata","year":"2004","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.lfs.2025.123933_bb0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/13816810701209669","article-title":"Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India","volume":"28","author":"Uthra","year":"2007","journal-title":"Ophthalmic Genet."},{"issue":"12","key":"10.1016\/j.lfs.2025.123933_bb0040","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.metabol.2006.08.011","article-title":"Association of manganese superoxide dismutase gene polymorphism (V16A) with diabetic macular edema in Korean type 2 diabetic patients","volume":"55","author":"Lee","year":"2006","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.lfs.2025.123933_bb0045","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1001\/archophthalmol.2009.355","article-title":"Association between erythropoietin gene polymorphisms and diabetic retinopathy","volume":"128","author":"Abhary","year":"2010","journal-title":"Arch. Ophthalmol."},{"issue":"3","key":"10.1016\/j.lfs.2025.123933_bb0050","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.bbrc.2005.05.167","article-title":"Functional VEGF C-634G polymorphism is associated with development of diabetic macular edema and correlated with macular retinal thickness in type 2 diabetes","volume":"333","author":"Awata","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.lfs.2025.123933_bb0055","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/ceo.12182","article-title":"Vascular endothelial growth factor gene polymorphism prevalence in patients with diabetic macular oedema and its correlation with anti-vascular endothelial growth factor treatment outcomes","volume":"42","author":"El-Shazly","year":"2014","journal-title":"Clin. Experiment. Ophthalmol."},{"issue":"12","key":"10.1016\/j.lfs.2025.123933_bb0060","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1167\/iovs.09-3694","article-title":"Common sequence variation in the VEGFA gene predicts risk of diabetic retinopathy","volume":"50","author":"Abhary","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"9","key":"10.1016\/j.lfs.2025.123933_bb0065","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1016\/j.ophtha.2015.05.004","article-title":"Common sequence variation in the VEGFC gene is associated with diabetic retinopathy and diabetic macular edema","volume":"122","author":"Kaidonis","year":"2015","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.lfs.2025.123933_bb0070","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.bbrc.2007.07.025","article-title":"Promoter polymorphisms of the pigment epithelium-derived factor gene are associated with diabetic retinopathy","volume":"361","author":"Iizuka","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.lfs.2025.123933_bb0075","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/sj.eye.6700348","article-title":"Molecular genetics of microvascular disease in diabetic retinopathy","volume":"17","author":"Warpeha","year":"2003","journal-title":"Eye"},{"issue":"2","key":"10.1016\/j.lfs.2025.123933_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2020.06.020","article-title":"Acetylation-dependent deubiquitinase OTUD3 controls MAVS activation in innate antiviral immunity","volume":"79","author":"Zhang","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.lfs.2025.123933_bb0085","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54023","article-title":"Distinct regulatory ribosomal ubiquitylation events are reversible and hierarchically organized","volume":"9","author":"Garshott","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.lfs.2025.123933_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1237530","article-title":"Deubiquitinase OTUD3: a double-edged sword in immunity and disease","volume":"11","author":"Xu","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"9","key":"10.1016\/j.lfs.2025.123933_bb0095","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/ncb3218","article-title":"Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis","volume":"17","author":"Yuan","year":"2015","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.lfs.2025.123933_bb0100","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1038\/s41467-019-10824-7","article-title":"The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis","volume":"10","author":"Du","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2025.123933_bb0105","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1186\/s12885-020-07069-9","article-title":"Tumor suppressor OTUD3 induces growth inhibition and apoptosis by directly deubiquitinating and stabilizing p53 in invasive breast carcinoma cells","volume":"20","author":"Pu","year":"2020","journal-title":"BMC Cancer"},{"issue":"7","key":"10.1016\/j.lfs.2025.123933_bb0110","doi-asserted-by":"crossref","first-page":"490","DOI":"10.21037\/atm.2020.03.51","article-title":"The expression change of OTUD3-PTEN signaling axis in glioma cells","volume":"8","author":"Liu","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"11","key":"10.1016\/j.lfs.2025.123933_bb0115","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1038\/s41418-020-0571-7","article-title":"Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Death Differ."},{"issue":"11","key":"10.1016\/j.lfs.2025.123933_bb0120","doi-asserted-by":"crossref","first-page":"18629","DOI":"10.1002\/jcb.28874","article-title":"MicroRNA 32 promotes cell proliferation, migration, and suppresses apoptosis in colon cancer cells by targeting OTU domain containing 3","volume":"120","author":"Jin","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.lfs.2025.123933_bb0125","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41419-023-05900-2","article-title":"Discovery of an OTUD3 inhibitor for the treatment of non-small cell lung cancer","volume":"14","author":"Zhang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.lfs.2025.123933_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110920","article-title":"Opposing effects of deubiquitinase OTUD3 in innate immunity against RNA and DNA viruses","volume":"39","author":"Cai","year":"2022","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.lfs.2025.123933_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2022.05.005","article-title":"Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses","volume":"34","author":"Zhou","year":"2022","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.lfs.2025.123933_bb0140","doi-asserted-by":"crossref","first-page":"976","DOI":"10.4103\/1673-5374.355743","article-title":"Inflammation in diabetic retinopathy: possible roles in pathogenesis and potential implications for therapy","volume":"18","author":"Tang","year":"2023","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.lfs.2025.123933_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1055087","article-title":"The role of inflammation in immune system of diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications","volume":"13","author":"Yue","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2025.123933_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1059641","article-title":"Prevalence and clinical characteristics of T2DM patients with OTUD3 gene rs78466831 SNP at a single academic center in China","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"11","key":"10.1016\/j.lfs.2025.123933_bb0155","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1053\/meta.2000.17721","article-title":"A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat","volume":"49","author":"Reed","year":"2000","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.lfs.2025.123933_bb0160","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.phrs.2005.05.004","article-title":"Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening","volume":"52","author":"Srinivasan","year":"2005","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2025.123933_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.156108","article-title":"HDAC6 mediates NLRP3 inflammasome activation in the pathogenesis of diabetic retinopathy","volume":"164","author":"Kim","year":"2025","journal-title":"Metabolism"},{"key":"10.1016\/j.lfs.2025.123933_bb0170","article-title":"Factors associated with the recurrence of choroidal neovascularization in pathologic myopia","volume":"9","author":"Jing","year":"2022","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.lfs.2025.123933_bb0175","article-title":"Oxidative stress and diabetic retinopathy","volume":"2007","author":"Kowluru","year":"2007","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.lfs.2025.123933_bb0180","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/438238","article-title":"TXNIP links innate host defense mechanisms to oxidative stress and inflammation in retinal Muller glia under chronic hyperglycemia: implications for diabetic retinopathy","volume":"2012","author":"Devi","year":"2012","journal-title":"Exp. Diabetes Res."},{"issue":"9","key":"10.1016\/j.lfs.2025.123933_bb0185","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1007\/s00125-018-4692-1","article-title":"Neurodegeneration in diabetic retinopathy: does it really matter?","volume":"61","author":"Simo","year":"2018","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.lfs.2025.123933_bb0190","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1039\/C7MT00209B","article-title":"Protective effect of selenium supplementation following oxidative stress mediated by glucose on retinal pigment epithelium","volume":"10","author":"Gonzalez de Vega","year":"2018","journal-title":"Metallomics"},{"issue":"5","key":"10.1016\/j.lfs.2025.123933_bb0195","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.preteyeres.2011.05.002","article-title":"Inflammation in diabetic retinopathy","volume":"30","author":"Tang","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"issue":"3","key":"10.1016\/j.lfs.2025.123933_bb0200","doi-asserted-by":"crossref","first-page":"C418","DOI":"10.1152\/ajpcell.00001.2016","article-title":"High glucose promotes the migration of retinal pigment epithelial cells through increased oxidative stress and PEDF expression","volume":"311","author":"Farnoodian","year":"2016","journal-title":"Am. J. Phys. Cell Physiol."},{"issue":"1","key":"10.1016\/j.lfs.2025.123933_bb0205","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191285","article-title":"Endothelin-1 is associated with fibrosis in proliferative diabetic retinopathy membranes","volume":"13","author":"Chang","year":"2018","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.lfs.2025.123933_bb0210","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/02713680590956306","article-title":"Apoptosis and cell proliferation in proliferative retinal disorders: PCNA, Ki-67, caspase-3, and PARP expression","volume":"30","author":"Zhang","year":"2005","journal-title":"Curr. Eye Res."},{"issue":"4","key":"10.1016\/j.lfs.2025.123933_bb0215","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000093070","article-title":"Intraretinal immunohistochemistry findings in proliferative vitreoretinopathy with retinal shortening","volume":"38","author":"Pastor","year":"2006","journal-title":"Ophthalmic Res."},{"issue":"1","key":"10.1016\/j.lfs.2025.123933_bb0220","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1186\/s12951-022-01732-y","article-title":"TSPAN4-positive migrasome derived from retinal pigmented epithelium cells contributes to the development of proliferative vitreoretinopathy","volume":"20","author":"Wu","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"9","key":"10.1016\/j.lfs.2025.123933_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2023.07.001","article-title":"Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-\u03b1","volume":"35","author":"Wu","year":"2023","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.lfs.2025.123933_bb0230","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41388-022-02528-y","article-title":"TNF\u03b1-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity","volume":"42","author":"Yang","year":"2023","journal-title":"Oncogene"},{"issue":"15","key":"10.1016\/j.lfs.2025.123933_bb0235","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1093\/emboj\/cdg379","article-title":"NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death","volume":"22","author":"Sakon","year":"2003","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.lfs.2025.123933_bb0240","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.canlet.2009.11.014","article-title":"HA14-1 sensitizes TNF-alpha-induced apoptosis via inhibition of the NF-kappaB signaling pathway: involvement of reactive oxygen species and JNK","volume":"292","author":"Moon","year":"2010","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lfs.2025.123933_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101799","article-title":"Oxidative stress and diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications","volume":"37","author":"Kang","year":"2020","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.lfs.2025.123933_bb0250","article-title":"MitoTEMPOL inhibits ROS-induced retinal vascularization pattern by modulating autophagy and apoptosis in rat-injected streptozotocin model","volume":"12","author":"Virgana","year":"2022","journal-title":"Life (Basel)"},{"issue":"10","key":"10.1016\/j.lfs.2025.123933_bb0255","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11892-017-0913-0","article-title":"Animal models of diabetic retinopathy","volume":"17","author":"Olivares","year":"2017","journal-title":"Curr. Diab. Rep."},{"key":"10.1016\/j.lfs.2025.123933_bb0260","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.2147\/IJN.S294807","article-title":"Progress of nanotechnology in diabetic retinopathy treatment","volume":"16","author":"Liu","year":"2021","journal-title":"Int. J. Nanomedicine"},{"issue":"6","key":"10.1016\/j.lfs.2025.123933_bb0265","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jcjd.2020.10.009","article-title":"Diabetic retinopathy: important biochemical alterations and the main treatment strategies","volume":"45","author":"ValdezGuerrero","year":"2021","journal-title":"Can. J. Diabetes"},{"issue":"11","key":"10.1016\/j.lfs.2025.123933_bb0270","doi-asserted-by":"crossref","first-page":"11776","DOI":"10.1096\/fj.201802614RRR","article-title":"Erianin alleviates diabetic retinopathy by reducing retinal inflammation initiated by microglial cells via inhibiting hyperglycemia-mediated ERK1\/2-NF-\u03baB signaling pathway","volume":"33","author":"Zhang","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2025.123933_bb0275","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cca.2018.06.028","article-title":"Tumor necrosis factor-\u03b1 and diabetic retinopathy: review and meta-analysis","volume":"485","author":"Yao","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.lfs.2025.123933_bb0280","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/629529","article-title":"TNF-alpha levels in tears: a novel biomarker to assess the degree of diabetic retinopathy","volume":"2013","author":"Costagliola","year":"2013","journal-title":"Mediat. Inflamm."},{"issue":"12","key":"10.1016\/j.lfs.2025.123933_bb0285","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/sj.eye.6702138","article-title":"Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy","volume":"20","author":"Demircan","year":"2006","journal-title":"Eye (Lond.)"},{"issue":"1","key":"10.1016\/j.lfs.2025.123933_bb0290","first-page":"76","article-title":"Predictive value of inflammatory and hematological data in diabetic and non-diabetic retinopathy","volume":"26","author":"Atl\u0131","year":"2022","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.lfs.2025.123933_bb0295","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.biocel.2007.04.005","article-title":"Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway","volume":"39","author":"Kim","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.lfs.2025.123933_bb0300","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/720163","article-title":"Prevention of oxidative stress-induced retinal pigment epithelial cell death by the PPARgamma agonists, 15-deoxy-delta 12, 14-prostaglandin J(2)","volume":"2008","author":"Chang","year":"2008","journal-title":"PPAR Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525005685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525005685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:17:35Z","timestamp":1770916655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525005685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":60,"alternative-id":["S0024320525005685"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123933","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulation of the TNF-\u03b1-OTUD3-PPAR\u03b3 signaling axis exacerbates retinal oxidative stress and inflammation in diabetic retinopathy","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123933","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123933"}}