{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:40:18Z","timestamp":1792428018190,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K15792"],"award-info":[{"award-number":["17K15792"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.lfs.2025.123942","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T22:58:16Z","timestamp":1756335496000},"page":"123942","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Characterization of actions of the novel gabapentinoid drug mirogabalin on painful bladder hypersensitivity in rats with lipopolysaccharide-induced chronic cystitis"],"prefix":"10.1016","volume":"380","author":[{"given":"Masaru","family":"Yoshizumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Kitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chizuko","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Sakurada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Mizoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.lfs.2025.123942_bb0005","article-title":"Biomarkers in the light of the Etiopathology of IC\/BPS","volume":"11","author":"Neuhaus","year":"2021","journal-title":"Diagnostics (Basel)"},{"issue":"6","key":"10.1016\/j.lfs.2025.123942_bb0010","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/bju.16439","article-title":"The microbiota in patients with interstitial cystitis\/bladder pain syndrome: a systematic review","volume":"134","author":"Fu","year":"2024","journal-title":"BJU Int."},{"issue":"1","key":"10.1016\/j.lfs.2025.123942_bb0015","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.697","article-title":"Gabapentin reduces painful bladder hypersensitivity in rats with lipopolysaccharide-induced chronic cystitis","volume":"9","author":"Yoshizumi","year":"2021","journal-title":"Pharmacol. Res. Perspect."},{"issue":"6","key":"10.1016\/j.lfs.2025.123942_bb0020","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1523\/JNEUROSCI.21-06-01868.2001","article-title":"Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats","volume":"21","author":"Luo","year":"2001","journal-title":"J. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2025.123942_bb0025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pain.2006.04.022","article-title":"Calcium channel alpha2delta1 subunit mediates spinal hyperexcitability in pain modulation","volume":"125","author":"Li","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.lfs.2025.123942_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1099925","article-title":"Voltage-gated calcium channel subunit alpha(2)delta-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury","volume":"16","author":"Koga","year":"2023","journal-title":"Front. Mol. Neurosci."},{"issue":"10","key":"10.1016\/j.lfs.2025.123942_bb0035","doi-asserted-by":"crossref","first-page":"5768","DOI":"10.1074\/jbc.271.10.5768","article-title":"The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel","volume":"271","author":"Gee","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2025.123942_bb0040","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.neulet.2013.11.017","article-title":"Presynaptic inhibitory actions of pregabalin on excitatory transmission in superficial dorsal horn of mouse spinal cord: further characterization of presynaptic mechanisms","volume":"558","author":"Matsuzawa","year":"2014","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.lfs.2025.123942_bb0045","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/00007611-200093020-00021","article-title":"Interstitial cystitis and the potential role of gabapentin","volume":"93","author":"Hansen","year":"2000","journal-title":"South. Med. J."},{"issue":"1","key":"10.1016\/j.lfs.2025.123942_bb0050","first-page":"47","article-title":"Oral gabapentin (neurontin) treatment of refractory genitourinary tract pain","volume":"7","author":"Sasaki","year":"2001","journal-title":"Tech. Urol."},{"key":"10.1016\/j.lfs.2025.123942_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.00133","article-title":"Blocking alpha(2)delta-1 subunit reduces bladder hypersensitivity and inflammation in a cystitis mouse model by decreasing NF-kB pathway activation","volume":"10","author":"Boudieu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123942_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.01305","article-title":"Characterization and validation of a chronic model of cyclophosphamide-induced interstitial cystitis\/bladder pain syndrome in rats","volume":"11","author":"Auge","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"17","key":"10.1016\/j.lfs.2025.123942_bb0065","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1080\/14656566.2021.1958780","article-title":"A review of a new voltage-gated ca(2+) channel alpha(2)delta ligand, mirogabalin, for the treatment of peripheral neuropathic pain","volume":"22","author":"Kato","year":"2021","journal-title":"Expert. Opin. Pharmacother."},{"issue":"3","key":"10.1016\/j.lfs.2025.123942_bb0070","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1124\/jpet.117.247551","article-title":"Binding characteristics and analgesic effects of Mirogabalin, a novel ligand for the alpha(2)delta subunit of voltage-gated calcium channels","volume":"365","author":"Domon","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.lfs.2025.123942_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/ph14020112","article-title":"Mirogabalin-a novel selective ligand for the alpha2delta Calcium Channel subunit","volume":"14","author":"Zajaczkowska","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"issue":"3","key":"10.1016\/j.lfs.2025.123942_bb0080","first-page":"147","article-title":"Effects of mirogabalin, a novel ligand for the alpha(2)delta subunit of voltage-gated calcium channels, on N-type calcium channel currents of rat dorsal root ganglion culture neurons","volume":"74","author":"Kitano","year":"2019","journal-title":"Pharmazie"},{"issue":"9","key":"10.1016\/j.lfs.2025.123942_bb0085","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1016\/j.celrep.2018.02.021","article-title":"The alpha2delta-1-NMDA receptor complex is critically involved in neuropathic pain development and gabapentin therapeutic actions","volume":"22","author":"Chen","year":"2018","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.lfs.2025.123942_bb0090","doi-asserted-by":"crossref","first-page":"e70064","DOI":"10.1111\/jnc.70064","article-title":"Alpha2delta-1-linked NMDA and AMPA receptors in neuropathic pain and Gabapentinoid action","volume":"169","author":"Huang","year":"2025","journal-title":"J. Neurochem."},{"issue":"10","key":"10.1016\/j.lfs.2025.123942_bb0095","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s00018-019-03047-y","article-title":"Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain","volume":"76","author":"Deng","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.lfs.2025.123942_bb0100","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jphs.2021.01.002","article-title":"Mirogabalin activates the descending noradrenergic system by binding to the alpha(2)delta-1 subunit of voltage-gated ca(2+) channels to generate analgesic effects","volume":"146","author":"Oyama","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2025.123942_bb0105","doi-asserted-by":"crossref","DOI":"10.1177\/17448069211052167","article-title":"Analgesic characteristics of a newly developed alpha(2)delta ligand, mirogabalin, on inflammatory pain","volume":"17","author":"Komatsu","year":"2021","journal-title":"Mol. Pain"},{"key":"10.1016\/j.lfs.2025.123942_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1080302","article-title":"TRPV4 activation prevents lipopolysaccharide-induced painful bladder hypersensitivity in rats by regulating immune pathways","volume":"13","author":"Yoshizumi","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2025.123942_bb0115","series-title":"The Rat Brain in Stereotaxic Coodinates","author":"Paxinos","year":"2005"},{"issue":"4","key":"10.1016\/j.lfs.2025.123942_bb0120","doi-asserted-by":"crossref","first-page":"F785","DOI":"10.1152\/ajprenal.00553.2009","article-title":"Role of supraspinal and spinal alpha1-adrenergic receptor subtypes in micturition reflex in conscious rats","volume":"299","author":"Yoshizumi","year":"2010","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2025.123942_bb0125","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1097\/01.ju.0000079766.49550.94","article-title":"Characterization of cyclophosphamide cystitis, a model of visceral and referred pain, in the mouse: species and strain differences","volume":"170","author":"Bon","year":"2003","journal-title":"J. Urol."},{"issue":"1","key":"10.1016\/j.lfs.2025.123942_bb0130","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12974-020-1704-0","article-title":"BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis","volume":"17","author":"Ding","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.lfs.2025.123942_bb0135","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.lfs.2025.123942_bb0140","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2490-9-16","article-title":"Pharmacologic attenuation of pelvic pain in a murine model of interstitial cystitis","volume":"9","author":"Rudick","year":"2009","journal-title":"BMC Urol."},{"issue":"11","key":"10.1016\/j.lfs.2025.123942_bb0145","first-page":"659","article-title":"Analgesic effects of the novel alpha(2)delta ligand mirogabalin in a rat model of spinal cord injury","volume":"73","author":"Domon","year":"2018","journal-title":"Pharmazie"},{"issue":"3","key":"10.1016\/j.lfs.2025.123942_bb0150","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/00000542-200703000-00021","article-title":"Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery","volume":"106","author":"Hayashida","year":"2007","journal-title":"Anesthesiology"},{"issue":"7","key":"10.1016\/j.lfs.2025.123942_bb0155","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.neuropharm.2007.08.013","article-title":"Pregabalin, S-(+)-3-isobutylgaba, activates the descending noradrenergic system to alleviate neuropathic pain in the mouse partial sciatic nerve ligation model","volume":"53","author":"Takeuchi","year":"2007","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.lfs.2025.123942_bb0160","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1124\/jpet.120.000315","article-title":"Pharmacology and mechanism of action of HSK16149, a selective ligand of alpha2delta subunit of voltage-gated Calcium Channel with analgesic activity in animal models of chronic pain","volume":"376","author":"Gou","year":"2021","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.lfs.2025.123942_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1382281","article-title":"Mirogabalin inhibits scratching behavior of spontaneous model mouse of atopic dermatitis","volume":"15","author":"Matsuda","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.lfs.2025.123942_bb0170","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1254\/fpj.154.352","article-title":"Pharmacological, pharmacodynamics, and clinical profile of mirogabalin besylate (Tarlige((R)) tablets 2.5 mg\u22195 mg\u221910 mg\u221915 mg)","volume":"154","author":"Kitano","year":"2019","journal-title":"Nihon Yakurigaku Zasshi"},{"issue":"10","key":"10.1016\/j.lfs.2025.123942_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2023.168049","article-title":"Recognition mechanism of a novel Gabapentinoid drug, Mirogabalin, for recombinant human alpha(2)delta1, a voltage-gated Calcium Channel subunit","volume":"435","author":"Kozai","year":"2023","journal-title":"J. Mol. Biol."},{"issue":"5","key":"10.1016\/j.lfs.2025.123942_bb0180","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/sj.bjp.0706109","article-title":"Role of descending noradrenergic system and spinal alpha2-adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse","volume":"144","author":"Tanabe","year":"2005","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.lfs.2025.123942_bb0185","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1097\/01.anes.0000267605.40258.98","article-title":"Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil","volume":"106","author":"Hayashida","year":"2007","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.lfs.2025.123942_bb0190","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12640-014-9482-z","article-title":"DSP4, a selective neurotoxin for the locus coeruleus noradrenergic system. A review of its mode of action","volume":"27","author":"Ross","year":"2015","journal-title":"Neurotox. Res."},{"issue":"1","key":"10.1016\/j.lfs.2025.123942_bb0195","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3940(85)90222-8","article-title":"Noradrenaline depletion increases noradrenaline-induced antinociception in mice","volume":"59","author":"Post","year":"1985","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.lfs.2025.123942_bb0200","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1213\/ANE.0000000000002352","article-title":"Repeated Administration of Amitriptyline in neuropathic pain: modulation of the noradrenergic descending inhibitory system","volume":"125","author":"Hiroki","year":"2017","journal-title":"Anesth. Analg."},{"issue":"1","key":"10.1016\/j.lfs.2025.123942_bb0205","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-3940(97)13331-6","article-title":"Spinal gabapentin is antinociceptive in the rat formalin test","volume":"222","author":"Shimoyama","year":"1997","journal-title":"Neurosci. Lett."},{"issue":"5","key":"10.1016\/j.lfs.2025.123942_bb0210","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1097\/00000542-200211000-00033","article-title":"Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia","volume":"97","author":"Hurley","year":"2002","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.lfs.2025.123942_bb0215","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1124\/jpet.102.041574","article-title":"Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin","volume":"303","author":"Luo","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"6","key":"10.1016\/j.lfs.2025.123942_bb0220","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/ALN.0b013e31818dac9c","article-title":"Gabapentin acts within the locus coeruleus to alleviate neuropathic pain","volume":"109","author":"Hayashida","year":"2008","journal-title":"Anesthesiology"},{"issue":"3","key":"10.1016\/j.lfs.2025.123942_bb0225","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/j.1471-4159.2008.05212.x","article-title":"Gabapentin produces PKA-dependent pre-synaptic inhibition of GABAergic synaptic transmission in LC neurons following partial nerve injury in mice","volume":"105","author":"Takasu","year":"2008","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.lfs.2025.123942_bb0230","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1097\/ALN.0b013e318254e6fd","article-title":"Gabapentin inhibits gamma-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats","volume":"116","author":"Yoshizumi","year":"2012","journal-title":"Anesthesiology"},{"issue":"1\u20133","key":"10.1016\/j.lfs.2025.123942_bb0235","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ejphar.2011.12.015","article-title":"Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes","volume":"677","author":"Yoshizumi","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123942_bb0240","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuropharm.2014.01.040","article-title":"Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms","volume":"81","author":"Suto","year":"2014","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.lfs.2025.123942_bb0245","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11255-018-2021-8","article-title":"Investigations of urethral sphincter activity in mice with bladder hyperalgesia before and after drug administration of gabapentin","volume":"51","author":"Yeh","year":"2019","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.lfs.2025.123942_bb0250","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1113\/expphysiol.1925.sp000345","article-title":"The effect of lesions of the hind- and mid-brain on micturition in the cat","volume":"15","author":"Barrington","year":"1925","journal-title":"Q. J. Exp. Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2025.123942_bb0255","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/jemt.1070290308","article-title":"Locus coeruleus noradrenergic neurons as a micturition center","volume":"29","author":"Sasa","year":"1994","journal-title":"Microsc. Res. Tech."},{"issue":"4","key":"10.1016\/j.lfs.2025.123942_bb0260","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/cne.903550411","article-title":"Transneuronal labeling of neurons in the adult rat brainstem and spinal cord after injection of pseudorabies virus into the urethra","volume":"355","author":"Vizzard","year":"1995","journal-title":"J. Comp. Neurol."},{"issue":"12","key":"10.1016\/j.lfs.2025.123942_bb0265","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1016\/j.clinph.2017.09.102","article-title":"Feasibility of deep brain stimulation for controlling the lower urinary tract functions: an animal study","volume":"128","author":"Chen","year":"2017","journal-title":"Clin. Neurophysiol."},{"issue":"11","key":"10.1016\/j.lfs.2025.123942_bb0270","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1038\/s41593-018-0256-4","article-title":"A corticopontine circuit for initiation of urination","volume":"21","author":"Yao","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.lfs.2025.123942_bb0275","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0304-3940(95)11873-U","article-title":"Central regulation of micturition in the rat the corticotropin-releasing hormone from Barrington\u2019s nucleus","volume":"196","author":"Pavcovich","year":"1995","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.lfs.2025.123942_bb0280","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cell.2016.08.073","article-title":"Central control circuit for context-dependent micturition","volume":"167","author":"Hou","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2025.123942_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147754","article-title":"The role of lumbosacral innervating noradrenergic neurons in micturition control","volume":"1777","author":"Ma","year":"2022","journal-title":"Brain Res."},{"issue":"3","key":"10.1016\/j.lfs.2025.123942_bb0290","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/cne.20693","article-title":"Differential distribution of voltage-gated calcium channel alpha-2 delta (alpha2delta) subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia","volume":"491","author":"Cole","year":"2005","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.lfs.2025.123942_bb0295","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.juro.2015.10.198","article-title":"Urine trouble: alterations in brain function associated with bladder pain","volume":"196","author":"Sadler","year":"2016","journal-title":"J. Urol."},{"key":"10.1016\/j.lfs.2025.123942_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109030","article-title":"Sex differences in pain along the neuraxis","volume":"210","author":"Presto","year":"2022","journal-title":"Neuropharmacology"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525005776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525005776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:43:52Z","timestamp":1772822632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525005776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":60,"alternative-id":["S0024320525005776"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123942","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of actions of the novel gabapentinoid drug mirogabalin on painful bladder hypersensitivity in rats with lipopolysaccharide-induced chronic cystitis","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123942","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"123942"}}