{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:20:11Z","timestamp":1790713211160,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 110\\u20132314-B-002-126-MY3"],"award-info":[{"award-number":["NSTC 110\\u20132314-B-002-126-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114\\u20132314-B-002-082"],"award-info":[{"award-number":["NSTC 114\\u20132314-B-002-082"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.lfs.2025.123974","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T05:16:47Z","timestamp":1758086207000},"page":"123974","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Zinc protoporphyrin-triggered ferroptosis plays a critical role in renal proximal tubular cell damage and chronic kidney disease"],"prefix":"10.1016","volume":"380","author":[{"given":"Li-Ting","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh-Yun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Kang","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shing-Hwa","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2025.123974_bb0005","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41419-023-06144-w","article-title":"Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2025.123974_bb0010","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5196285","article-title":"Projecting the burden of chronic kidney disease in a developed country and its implications on public health","volume":"2018","author":"Wong","year":"2018","journal-title":"Int. J. Nephrol."},{"key":"10.1016\/j.lfs.2025.123974_bb0015","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1093\/clinchem\/45.12.2060","article-title":"Zinc protoporphyrin: a metabolite with a mission","volume":"45","author":"Labbe","year":"1999","journal-title":"Clin. Chem."},{"key":"10.1016\/j.lfs.2025.123974_bb0020","doi-asserted-by":"crossref","first-page":"36302","DOI":"10.1074\/jbc.M109.031641","article-title":"Zinc protoporphyrin regulates cyclin D1 expression independent of heme oxygenase inhibition","volume":"284","author":"La","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2025.123974_bb0025","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.kint.2021.08.022","article-title":"Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition","volume":"100","author":"Bai","year":"2021","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2025.123974_bb0030","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1046\/j.1523-1755.1999.055Suppl.69057.x","article-title":"Erythrocyte zinc protoporphyrin","volume":"69","author":"Braun","year":"1999","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.lfs.2025.123974_bb0035","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1542\/peds.2006-0156","article-title":"Comparative effectiveness of zinc protoporphyrin and hemoglobin concentrations in identifying iron deficiency in a group of low-income, preschool-aged children: practical implications of recent illness","volume":"118","author":"Crowell","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.lfs.2025.123974_bb0040","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1182\/blood.V97.5.1306","article-title":"Unique effects of zinc protoporphyrin on HO-1 induction and apoptosis","volume":"97","author":"Yang","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2025.123974_bb0045","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/162094","article-title":"Zinc protoporphyrin upregulates heme oxygenase-1 in PC-3 cells via the stress response pathway","volume":"2013","author":"Kwok","year":"2013","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.lfs.2025.123974_bb0050","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41577-020-00491-x","article-title":"Regulation of inflammation by the antioxidant haem oxygenase 1","volume":"21","author":"Campbell","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.lfs.2025.123974_bb0055","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1089\/ars.2016.6659","article-title":"Heme oxygenase-1 in kidney health and disease","volume":"25","author":"Lever","year":"2016","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2025.123974_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2012.00119","article-title":"Heme oxygenase-1, oxidation, inflammation, and atherosclerosis","volume":"3","author":"Araujo","year":"2012","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123974_bb0065","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0891-5849(98)00192-0","article-title":"Expression of the antioxidant stress protein heme oxygenase-1 (HO-1) in human leukocytes","volume":"26","author":"Niess","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2025.123974_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101971","article-title":"HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration","volume":"43","author":"Tang","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2025.123974_bb0075","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.7150\/ijbs.80775","article-title":"Mitophagy alleviates cisplatin-induced renal tubular epithelial cell ferroptosis through ROS\/HO-1\/GPX4 axis","volume":"19","author":"Lin","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.lfs.2025.123974_bb0080","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1182\/blood.2020008455","article-title":"Excess heme upregulates heme oxygenase 1 and promotes cardiac ferroptosis in mice with sickle cell disease","volume":"139","author":"Menon","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.lfs.2025.123974_bb0085","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.7150\/ijbs.59404","article-title":"Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells","volume":"17","author":"Wei","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.lfs.2025.123974_bb0090","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1021\/acschembio.8b00458","article-title":"The role of reactive oxygen species and ferroptosis in heme-mediated activation of human platelets","volume":"13","author":"NaveenKumar","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.lfs.2025.123974_bb0095","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2025.123974_bb0100","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3390\/biom11040589","article-title":"Heme oxygenase-1 signaling and redox homeostasis in physiopathological conditions","volume":"11","author":"Consoli","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.lfs.2025.123974_bb0105","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.lfs.2025.123974_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103179","article-title":"Mitochondrial GPX4 acetylation is involved in cadmium-induced renal cell ferroptosis","volume":"73","author":"Guo","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2025.123974_bb0115","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1089\/ars.2007.1893","article-title":"Intracellular iron transport and storage: from molecular mechanisms to health implications","volume":"10","author":"MacKenzie","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2025.123974_bb0120","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nchembio.1416","article-title":"The role of iron and reactive oxygen species in cell death","volume":"10","author":"Dixon","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.lfs.2025.123974_bb0125","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s43556-023-00142-2","article-title":"The mechanism of ferroptosis and its related diseases","volume":"4","author":"Feng","year":"2023","journal-title":"Mol. Biomed."},{"key":"10.1016\/j.lfs.2025.123974_bb0130","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41420-022-01212-0","article-title":"GPX4-independent ferroptosis\u2014a new strategy in disease\u2019s therapy","volume":"8","author":"Ma","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2025.123974_bb0135","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41419-022-04628-9","article-title":"Targeting ferroptosis in acute kidney injury","volume":"13","author":"Ni","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2025.123974_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12111931","article-title":"Inhibition of indoxyl sulfate-induced reactive oxygen species-related ferroptosis alleviates renal cell injury in vitro and chronic kidney disease progression in vivo","volume":"12","author":"Tsai","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.lfs.2025.123974_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.975582","article-title":"Mechanisms of ferroptosis in chronic kidney disease","volume":"9","author":"Zhuo","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.lfs.2025.123974_bb0150","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.7150\/ijbs.85674","article-title":"Broadening horizons: the multifaceted functions of ferroptosis in kidney diseases","volume":"19","author":"Feng","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.lfs.2025.123974_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.152014","article-title":"Zinc protoporphyrin accumulation as a positive regulator of renal heme oxygenase-1 participates in the progression of chronic kidney disease","volume":"770","author":"Tsai","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2025.123974_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232113387","article-title":"Therapeutic ultrasound halts progression of chronic kidney disease in vivo via the regulation of markers associated with renal epithelial-mesenchymal transition and senescence","volume":"23","author":"Lin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2025.123974_bb0165","doi-asserted-by":"crossref","DOI":"10.1542\/peds.104.3.e37","article-title":"Zinc protoporphyrin\/heme ratio for diagnosis of preanemic iron deficiency","volume":"104","author":"Rettmer","year":"1999","journal-title":"Pediatrics"},{"key":"10.1016\/j.lfs.2025.123974_bb0170","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1177\/0271678X211028475","article-title":"Endogenous zinc protoporphyrin formation critically contributes to hemorrhagic stroke-induced brain damage","volume":"41","author":"Pan","year":"2021","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.lfs.2025.123974_bb0175","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41392-023-01379-7","article-title":"Kidney fibrosis: from mechanisms to therapeutic medicines","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.lfs.2025.123974_bb0180","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3748\/wjg.v17.i3.322","article-title":"Effect of heme oxygenase-1 on renal function in rats with liver cirrhosis","volume":"17","author":"Guo","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.lfs.2025.123974_bb0185","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1203\/00006450-199302000-00021","article-title":"Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivity","volume":"33","author":"Vreman","year":"1993","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.lfs.2025.123974_bb0190","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1381-1169(01)00331-4","article-title":"Comparative study on heme-containing enzyme-like catalytic activities of water-soluble metalloporphyrins","volume":"179","author":"Liu","year":"2002","journal-title":"J. Mol. Catal. A Chem."},{"key":"10.1016\/j.lfs.2025.123974_bb0195","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0165-6147(99)01336-X","article-title":"Metalloporphyrin class of therapeutic catalytic antioxidants","volume":"20","author":"Patel","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.lfs.2025.123974_bb0200","article-title":"Protective effect of metalloporphyrins against cisplatin-induced kidney injury in mice","volume":"9","author":"Pan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2025.123974_bb0205","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1089\/ars.2013.5257","article-title":"Effects of metalloporphyrins on reducing inflammation and autoimmunity","volume":"20","author":"Delmastro-Greenwood","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2025.123974_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24076815","article-title":"Metalloporphyrins as tools for deciphering the role of heme oxygenase in renal immune injury","volume":"24","author":"Lianos","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2025.123974_bb0215","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.CIR.0000048192.52098.DD","article-title":"Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction","volume":"107","author":"Pacher","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2025.123974_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2008.02.078","article-title":"Metalloporphyrins as a therapeutic drug class against peroxynitrite in cardiovascular diseases involving ischemic reperfusion injury","volume":"586","author":"Rabkin","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2025.123974_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612777","article-title":"Metalloporphyrins reduce proteinuria in podocyte immune injury: the role of metal and porphyrin moieties","volume":"24","author":"Lianos","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2025.123974_bb0230","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2021.642296","article-title":"Anemia in chronic kidney disease: from pathophysiology and current treatments, to future agents","volume":"8","author":"Portoles","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.lfs.2025.123974_bb0235","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jinorgbio.2009.10.011","article-title":"Structural characterization of human heme oxygenase-1 in complex with azole-based inhibitors","volume":"104","author":"Rahman","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.lfs.2025.123974_bb0240","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4168\/aair.2013.5.5.329","article-title":"Suppression of heme oxygenase-1 by prostaglandin E2-protein kinase A-A-kinase anchoring protein signaling is central for augmented cyclooxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophages","volume":"5","author":"Lee","year":"2013","journal-title":"Allergy, Asthma Immunol. Res."},{"key":"10.1016\/j.lfs.2025.123974_bb0245","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1046\/j.1523-1755.2001.01000.x","article-title":"Cytoprotective role of heme oxygenase (HO)-1 in human kidney with various renal diseases","volume":"60","author":"Morimoto","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.lfs.2025.123974_bb0250","doi-asserted-by":"crossref","DOI":"10.3390\/cells9061342","article-title":"Reactive oxygen species and redox signaling in chronic kidney disease","volume":"9","author":"Irazabal","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2025.123974_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9090783","article-title":"Hippuric acid promotes renal fibrosis by disrupting redox homeostasis via facilitation of NRF2-KEAP1-CUL3 interactions in chronic kidney disease","volume":"9","author":"Sun","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.lfs.2025.123974_bb0260","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/nyas.14475","article-title":"Protective role of HO-1 against acute kidney injury caused by cutaneous exposure to arsenicals","volume":"1480","author":"Srivastava","year":"2020","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.lfs.2025.123974_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108373","article-title":"Molecular mechanisms of ferroptosis and their involvement in brain diseases","volume":"244","author":"Costa","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2025.123974_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120717","article-title":"Heme-oxygenase-1 as a target for phthalate-induced cardiomyocytes ferroptosis","volume":"317","author":"Wang","year":"2023","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.lfs.2025.123974_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111152","article-title":"HO-1 activation contributes to cadmium-induced ferroptosis in renal tubular epithelial cells via increasing the labile iron pool and promoting mitochondrial ROS generation","volume":"399","author":"Lv","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2025.123974_bb0280","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.626390","article-title":"Ferroptosis enhanced diabetic renal tubular injury via HIF-1alpha\/HO-1 pathway in db\/db mice","volume":"12","author":"Feng","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.lfs.2025.123974_bb0285","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.semcdb.2020.12.005","article-title":"Iron in immune cell function and host defense","volume":"115","author":"Haschka","year":"2021","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2025.123974_bb0290","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41581-023-00689-x","article-title":"Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney","volume":"19","author":"Bayir","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.lfs.2025.123974_bb0295","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41392-023-01679-y","article-title":"Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.lfs.2025.123974_bb0300","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrn1671","article-title":"The neurobiology of zinc in health and disease","volume":"6","author":"Frederickson","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.lfs.2025.123974_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0251554","article-title":"Effect of zinc deficiency on chronic kidney disease progression and effect modification by hypoalbuminemia","volume":"16","author":"Tokuyama","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2025.123974_bb0310","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/ndt\/gfz065","article-title":"Renal handling of zinc in chronic kidney disease patients and the role of circulating zinc levels in renal function decline","volume":"35","author":"Damianaki","year":"2020","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.lfs.2025.123974_bb0315","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jtemb.2012.12.004","article-title":"Zinc induced damage to kidney proximal tubular cells: studies on chemical speciation leading to a mechanism of damage","volume":"27","author":"Sargazi","year":"2013","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.lfs.2025.123974_bb0320","doi-asserted-by":"crossref","first-page":"F1365","DOI":"10.1152\/ajprenal.00094.2002","article-title":"Intracellular distribution of labile Zn(II) and zinc transporter expression in kidney and MDCK cells","volume":"283","author":"Ranaldi","year":"2002","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.lfs.2025.123974_bb0325","doi-asserted-by":"crossref","first-page":"15580","DOI":"10.1038\/s41598-022-19903-0","article-title":"Zinc chelator treatment in crush syndrome model mice attenuates ischemia-reperfusion-induced muscle injury due to suppressing of neutrophil infiltration","volume":"12","author":"Haruta","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2025.123974_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/nu14071353","article-title":"Role of zinc in diabetic kidney disease","volume":"14","author":"Gembillo","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2025.123974_bb0335","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1053\/jren.2002.29597","article-title":"Iron and zinc status of patients with chronic renal failure who are not on dialysis","volume":"12","author":"Mafra","year":"2002","journal-title":"J. Ren. Nutr."},{"key":"10.1016\/j.lfs.2025.123974_bb0340","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.clinbiochem.2003.10.006","article-title":"Iron assessment tests: transferrin receptor Vis-a-Vis zinc protoporphyrin","volume":"37","author":"Labbe","year":"2004","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.lfs.2025.123974_bb0345","article-title":"Ferroptosis, a new target for treatment of renal injury and fibrosis in a 5\/6 nephrectomy-induced CKD rat model","volume":"8","author":"Wang","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2025.123974_bb0350","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.7150\/ijbs.81892","article-title":"Emerging role of ferroptosis in diabetic kidney disease: molecular mechanisms and therapeutic opportunities","volume":"19","author":"Wang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.lfs.2025.123974_bb0355","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1016\/j.ymthe.2023.07.026","article-title":"STING\/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease","volume":"31","author":"Gao","year":"2023","journal-title":"Mol. Ther."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525006101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525006101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:16:41Z","timestamp":1770916601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525006101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":71,"alternative-id":["S0024320525006101"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123974","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc protoporphyrin-triggered ferroptosis plays a critical role in renal proximal tubular cell damage and chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.123974","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"123974"}}