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Chem."},{"key":"10.1016\/j.lfs.2025.123996_bb0580","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.3390\/antiox10081314","article-title":"Curcumin suppresses the lipid accumulation and oxidative stress induced by benzo[a]pyrene toxicity in HepG2 cells","volume":"10","author":"Lee","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.lfs.2025.123996_bb0585","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1093\/nar\/22.15.3038","article-title":"Tissue specific expression of the rat Ah-receptor and ARNT mRNAs","volume":"22","author":"Carver","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lfs.2025.123996_bb0590","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cotox.2017.01.006","article-title":"And now for something completely different: diversity in ligand-dependent activation of Ah receptor responses","volume":"2","author":"Denison","year":"2017","journal-title":"Curr Opin Toxicol"},{"key":"10.1016\/j.lfs.2025.123996_bb0595","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature13992","article-title":"A comparative encyclopedia of DNA elements in the mouse genome","volume":"515","author":"Yue","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2025.123996_bb0600","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.taap.2006.12.002","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure of normal human dermal fibroblasts results in AhR-dependent and -independent changes in gene expression","volume":"220","author":"Akintobi","year":"2007","journal-title":"Toxicol. 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