{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:25:55Z","timestamp":1793910355716,"version":"4.8.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112-2313-B-020-015-MY3"],"award-info":[{"award-number":["112-2313-B-020-015-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.lfs.2025.124056","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:58:29Z","timestamp":1761353909000},"page":"124056","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Developmental cardiovascular disruption triggered by polystyrene nanoplastics in zebrafish mediated through oxidative stress"],"prefix":"10.1016","volume":"382","author":[{"given":"Febriyansyah","family":"Saputra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tzu","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agoes","family":"Soegianto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azzah Dyah","family":"Pramata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Yang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2025.124056_bb0005","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/494169a","article-title":"Policy: classify plastic waste as hazardous","volume":"494","author":"Rochman","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2025.124056_bb0010","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.marpolbul.2011.05.030","article-title":"Microplastics in the marine environment","volume":"62","author":"Andrady","year":"2011","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.lfs.2025.124056_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20176667","article-title":"Plastics and Micro\/Nano-plastics (MNPs) in the environment: occurrence, impact, and toxicity","volume":"20","author":"Dube","year":"2023","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.lfs.2025.124056_bb0020","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1021\/es5053655","article-title":"Altered behavior, physiology, and metabolism in fish exposed to polystyrene nanoparticles","volume":"49","author":"Mattsson","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.lfs.2025.124056_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/nano13081404","article-title":"Micro- and nanoplastics breach the blood\u2013brain barrier (BBB): biomolecular corona\u2019s role revealed","volume":"13","author":"Kopatz","year":"2023","journal-title":"Nanomaterials"},{"key":"10.1016\/j.lfs.2025.124056_bb0030","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz5803","article-title":"More than 1000 rivers account for 80% of global riverine plastic emissions into the ocean","volume":"7","author":"Meijer","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.lfs.2025.124056_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2025.107468","article-title":"Polystyrene nanoplastics act as endocrine disruptors altering neurotransmitter levels and locomotor activity via estrogen receptor during early zebrafish development","volume":"286","author":"Saputra","year":"2025","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.lfs.2025.124056_bb0040","doi-asserted-by":"crossref","first-page":"6052","DOI":"10.1073\/pnas.1619818114","article-title":"Exceptional and rapid accumulation of anthropogenic debris on one of the world's most remote and pristine islands","volume":"114","author":"Lavers","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.lfs.2025.124056_bb0045","doi-asserted-by":"crossref","DOI":"10.1088\/1748-9326\/ac68f7","article-title":"Presence of nanoplastics in rural and remote surface waters","volume":"17","author":"Materi\u0107","year":"2022","journal-title":"Environ. Res. Lett."},{"key":"10.1016\/j.lfs.2025.124056_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.125859","article-title":"Quantitative detecting low concentration polystyrene nanoplastics in aquatic environments via an ag\/Nb2CTx (MXene) SERS substrate","volume":"273","author":"Chang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.lfs.2025.124056_bb0055","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1039\/C9EN01335K","article-title":"Nanoplastic ingestion induces behavioral disorders in terrestrial snails: trophic transfer effects via vascular plants","volume":"7","author":"Chae","year":"2020","journal-title":"Environ. Sci. Nano"},{"key":"10.1016\/j.lfs.2025.124056_bb0060","article-title":"Key mechanisms of micro- and nanoplastic (MNP) toxicity across taxonomic groups","volume":"247","author":"Matthews","year":"2021","journal-title":"Compar. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"10.1016\/j.lfs.2025.124056_bb0065","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s10661-022-10769-3","article-title":"Micro(nano)plastic pollution in terrestrial ecosystem: emphasis on impacts of polystyrene on soil biota, plants, animals, and humans","volume":"195","author":"Ullah","year":"2022","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.lfs.2025.124056_bb0070","article-title":"Avobenzone and nanoplastics affect the development of zebrafish nervous system and retinal system and inhibit their locomotor behavior","volume":"806","author":"Liu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.lfs.2025.124056_bb0075","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3390\/ijms26031216","article-title":"Vitamin E mitigates polystyrene-Nanoplastic-induced visual dysfunction in zebrafish larvae","volume":"26","author":"Saputra","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2025.124056_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17051509","article-title":"Toxicity of microplastics and nanoplastics in mammalian systems","volume":"17","author":"Yong","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.lfs.2025.124056_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117096","article-title":"Polystyrene nanoplastics mediate skeletal toxicity through oxidative stress and the BMP pathway in zebrafish (Danio rerio)","volume":"285","author":"Liu","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.lfs.2025.124056_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2022.118320","article-title":"ROS-mediated photoaging pathways of nano- and micro-plastic particles under UV irradiation","volume":"216","author":"Duan","year":"2022","journal-title":"Water Res."},{"key":"10.1016\/j.lfs.2025.124056_bb0095","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1021\/acs.est.6b00183","article-title":"Uptake and accumulation of polystyrene microplastics in zebrafish (Danio rerio) and toxic effects in liver","volume":"50","author":"Lu","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.lfs.2025.124056_bb0100","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1021\/acsnano.3c10536","article-title":"Surface-charge-driven Ferroptosis and mitochondrial dysfunction is involved in toxicity diversity in the marine bivalve exposed to Nanoplastics","volume":"18","author":"Zhou","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.lfs.2025.124056_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112837","article-title":"In vitro evaluation of nanoplastics using human lung epithelial cells, microarray analysis and co-culture model","volume":"226","author":"Yang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.lfs.2025.124056_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"160","author":"Valko","year":"2006","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2025.124056_bb0115","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/toxsci\/kfi110","article-title":"Zebrafish as a model vertebrate for investigating chemical toxicity","volume":"86","author":"Hill","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.lfs.2025.124056_bb0120","doi-asserted-by":"crossref","first-page":"5656","DOI":"10.3390\/ijms24065656","article-title":"Zebrafish as a model of cardiac pathology and toxicity: spotlight on uremic toxins","volume":"24","author":"Coppola","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2025.124056_bb0125","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-1-61779-523-7_2","article-title":"Quantifying cardiac functions in embryonic and adult zebrafish","volume":"843","author":"Hoage","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.lfs.2025.124056_bb0130","doi-asserted-by":"crossref","DOI":"10.1007\/s10695-024-01381-y","article-title":"Exposure to nitrate and nitrite disrupts cardiovascular development through estrogen receptor in zebrafish embryos and larvae","author":"Saputra","year":"2024","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.lfs.2025.124056_bb0135","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1006\/dbio.2002.0711","article-title":"In vivo imaging of embryonic vascular development using transgenic zebrafish","volume":"248","author":"Lawson","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.lfs.2025.124056_bb0140","first-page":"917","article-title":"Effect of titanium dioxide nanoparticles on zebrafish embryos and developing retina","volume":"7","author":"Wang","year":"2014","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.lfs.2025.124056_bb0145","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/13813450701661198","article-title":"The central role of glutathione in the pathophysiology of human diseases","volume":"113","author":"Franco","year":"2007","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.lfs.2025.124056_bb0150","doi-asserted-by":"crossref","first-page":"14454","DOI":"10.1038\/s41598-024-64933-5","article-title":"Oxidative stress induced by hydrogen peroxide disrupts zebrafish visual development by altering apoptosis, antioxidant and estrogen related genes","volume":"14","author":"Saputra","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2025.124056_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2024.173159","article-title":"Polystyrene nanoplastics as an ecotoxicological hazard: cellular and transcriptomic evidences on marine and freshwater in vitro teleost models","volume":"934","author":"Saraceni","year":"2024","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.lfs.2025.124056_bb0160","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1471-2199-6-21","article-title":"Evaluation of potential reference genes in real-time RT-PCR studies of Atlantic salmon","volume":"6","author":"Olsvik","year":"2005","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.lfs.2025.124056_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4781(96)00179-0","article-title":"Structure and transcription of the gene for translation elongation factor 1 subunit alpha of zebrafish (Danio rerio)","volume":"1350","author":"Gao","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2025.124056_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/genes16010009","article-title":"Determination of stable reference genes for gene expression analysis in black rockfish (Sebastes schlegeli) under hypoxia stress","volume":"16","author":"Chen","year":"2024","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.lfs.2025.124056_bb0175","doi-asserted-by":"crossref","first-page":"12692","DOI":"10.1038\/s41598-020-69423-y","article-title":"Evaluation of qPCR reference genes in GH-overexpressing transgenic zebrafish (Danio rerio)","volume":"10","author":"Rassier","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2025.124056_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12070518","article-title":"Nitrate and nitrite exposure induces visual impairments in adult zebrafish","volume":"12","author":"Saputra","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.lfs.2025.124056_bb0185","doi-asserted-by":"crossref","first-page":"11452","DOI":"10.1038\/s41598-017-10813-0","article-title":"Brain damage and behavioural disorders in fish induced by plastic nanoparticles delivered through the food chain","volume":"7","author":"Mattsson","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2025.124056_bb0190","doi-asserted-by":"crossref","first-page":"12336","DOI":"10.1021\/es503001d","article-title":"Nanoplastic affects growth of S. obliquus and reproduction of D. magna","volume":"48","author":"Besseling","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.lfs.2025.124056_bb0195","article-title":"Polystyrene nanoplastics cause developmental abnormalities, oxidative damage and immune toxicity in early zebrafish development","volume":"295","author":"Saputra","year":"2025","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol."},{"key":"10.1016\/j.lfs.2025.124056_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115025","article-title":"Polystyrene microplastics cause cardiac fibrosis by activating Wnt\/\u03b2-catenin signaling pathway and promoting cardiomyocyte apoptosis in rats","volume":"265","author":"Li","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.lfs.2025.124056_bb0205","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/658270","article-title":"\u201cZebrafishing\u201d for novel genes relevant to the glomerular filtration barrier","volume":"2013","author":"Hanke","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.lfs.2025.124056_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpc.2024.109838","article-title":"Assessing cardiovascular toxicity in zebrafish embryos exposed to copper nanoparticles","volume":"277","author":"Hsiao","year":"2024","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.lfs.2025.124056_bb0215","article-title":"Transcriptional regulation of heart development in zebrafish","volume":"3","author":"Lu","year":"2016","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"10.1016\/j.lfs.2025.124056_bb0220","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.cardiores.2004.03.025","article-title":"GATA transcription factors in the developing and adult heart","volume":"63","author":"Pikkarainen","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2025.124056_bb0225","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1242\/dev.01978","article-title":"Gata4 regulates the formation of multiple organs","volume":"132","author":"Holtzinger","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.lfs.2025.124056_bb0230","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1101\/gad.13.22.2983","article-title":"Gata5 is required for the development of the heart and endoderm in zebrafish","volume":"13","author":"Reiter","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.lfs.2025.124056_bb0235","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1093\/emboj\/cdg400","article-title":"GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation","volume":"22","author":"Peterkin","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.lfs.2025.124056_bb0240","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1242\/dev.095562","article-title":"Nkx genes are essential for maintenance of ventricular identity","volume":"140","author":"Targoff","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.lfs.2025.124056_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004249","article-title":"Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebrafish embryos","volume":"4","author":"Tu","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2025.124056_bb0250","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ydbio.2010.02.001","article-title":"Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development","volume":"341","author":"Holler","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.lfs.2025.124056_bb0255","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1242\/dev.127.12.2573","article-title":"The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development","volume":"127","author":"Yelon","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.lfs.2025.124056_bb0260","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1242\/dev.106336","article-title":"Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration","volume":"141","author":"Schindler","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.lfs.2025.124056_bb0265","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.devcel.2007.05.012","article-title":"Vessel and blood specification override cardiac potential in anterior mesoderm","volume":"13","author":"Schoenebeck","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.lfs.2025.124056_bb0270","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s00018-011-0884-2","article-title":"Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation","volume":"69","author":"Singh","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.lfs.2025.124056_bb0275","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/dvdy.22622","article-title":"Heart chamber size in zebrafish is regulated redundantly by duplicated tbx2 genes","volume":"240","author":"Sedletcaia","year":"2011","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.lfs.2025.124056_bb0280","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.chembiol.2014.07.018","article-title":"Fibroblast growth factor signaling affects vascular outgrowth and is required for the maintenance of blood vessel integrity","volume":"21","author":"De Smet","year":"2014","journal-title":"Chem. Biol."},{"key":"10.1016\/j.lfs.2025.124056_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/toxics12080617","article-title":"Impacts of environmental concentrations of nanoplastics on zebrafish neurobehavior and reproductive toxicity","volume":"12","author":"Sun","year":"2024","journal-title":"Toxics"},{"key":"10.1016\/j.lfs.2025.124056_bb0290","first-page":"2977","article-title":"Activation of apoptosis signalling pathways by reactive oxygen species","volume":"2016","author":"Redza-Dutordoir","year":"1863","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.lfs.2025.124056_bb0295","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2121-14-32","article-title":"Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis","volume":"14","author":"Brentnall","year":"2013","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.lfs.2025.124056_bb0300","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1242\/jcs.038166","article-title":"Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis","volume":"122","author":"Dewson","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.lfs.2025.124056_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162096","article-title":"Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos","volume":"872","author":"Zhou","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.lfs.2025.124056_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.137077","article-title":"Molecular effects of polystyrene nanoplastics toxicity in zebrafish embryos (Danio rerio)","volume":"312","author":"Martin-Folgar","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.lfs.2025.124056_bb0315","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1242\/jeb.012690","article-title":"Extensive apoptosis and abnormal morphogenesis in pro-caspase-3 transgenic zebrafish during development","volume":"211","author":"Yamashita","year":"2008","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.lfs.2025.124056_bb0320","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.lfs.2025.124056_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.116075","article-title":"Polystyrene nanoparticles trigger the activation of p38 MAPK and apoptosis via inducing oxidative stress in zebrafish and macrophage cells","volume":"269","author":"Hu","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.lfs.2025.124056_bb0330","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.lfs.2025.124056_bb0335","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbrc.2022.08.098","article-title":"Reactive oxygen species (ROS), oxygen radicals and antioxidants: where are we now, where is the field going and where should we go?","volume":"633","author":"Halliwell","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2025.124056_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.116426","article-title":"Nanoplastics impact on marine biota: a review","volume":"273","author":"Gon\u00e7alves","year":"2021","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.lfs.2025.124056_bb0345","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3390\/antiox13030312","article-title":"Reactive oxygen species signaling and oxidative stress: transcriptional regulation and evolution","volume":"13","author":"Hong","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.lfs.2025.124056_bb0350","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.lfs.2025.124056_bb0355","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1515\/BC.2009.033","article-title":"Glutathione dysregulation and the etiology and progression of human diseases","volume":"390","author":"Ballatori","year":"2009","journal-title":"Biol. Chem."},{"key":"10.1016\/j.lfs.2025.124056_bb0360","article-title":"The role of glutathione metabolism in chronic illness development and its potential use as a novel therapeutic target","volume":"14","author":"Hristov","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.lfs.2025.124056_bb0365","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mam.2009.01.001","article-title":"Role of nuclear glutathione as a key regulator of cell proliferation","volume":"30","author":"Pallard\u00f3","year":"2009","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.lfs.2025.124056_bb0370","doi-asserted-by":"crossref","DOI":"10.1530\/REM-22-0023","article-title":"Glutathione in cancer progression and chemoresistance: an update","volume":"2023","author":"Elda Valenti","year":"2023","journal-title":"Redox Exp. Med."},{"key":"10.1016\/j.lfs.2025.124056_bb0375","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2022.06.004","article-title":"The role of glutathione peroxidase-1 in health and disease","volume":"188","author":"Handy","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2025.124056_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.hazmp.2025.100003","article-title":"Polystyrene nanoplastics target electron transport chain complexes in brain mitochondria","author":"Seward","year":"2025","journal-title":"J. Hazard. Mater. Plastics"},{"key":"10.1016\/j.lfs.2025.124056_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101620","article-title":"Micro- and nano-plastics activation of oxidative and inflammatory adverse outcome pathways","volume":"37","author":"Hu","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2025.124056_bb0390","article-title":"Disruption of gluconeogenesis as a key mediator of male infertility in rats exposed to nanoplastics: in vivo evidence and molecular docking analysis","volume":"11","author":"Maulidah","year":"2025","journal-title":"Emerg. Contam."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525006927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525006927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:24:21Z","timestamp":1773275061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525006927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":78,"alternative-id":["S0024320525006927"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.124056","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developmental cardiovascular disruption triggered by polystyrene nanoplastics in zebrafish mediated through oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.124056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124056"}}