{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:02:06Z","timestamp":1792324926368,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006593","name":"Board of Research in Nuclear Sciences","doi-asserted-by":"publisher","award":["37(1)\/14\/57\/2014-BRNS"],"award-info":[{"award-number":["37(1)\/14\/57\/2014-BRNS"]}],"id":[{"id":"10.13039\/501100006593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007334","name":"Ministry of Health and Family Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001502","name":"Department of Atomic Energy, Government of India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001502","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009104","name":"Department of Health Research, India","doi-asserted-by":"publisher","award":["11015\/14\/2023-GIA\/HR"],"award-info":[{"award-number":["11015\/14\/2023-GIA\/HR"]}],"id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["RA\/1887\/07\\u20132025"],"award-info":[{"award-number":["RA\/1887\/07\\u20132025"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.lfs.2025.124117","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:35:48Z","timestamp":1764088548000},"page":"124117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Impaired metabolic cooperation between oocyte and granulosa cells may contribute to the disrupted folliculogenesis and poor oocyte quality in PCOS"],"prefix":"10.1016","volume":"384","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1976-6108","authenticated-orcid":false,"given":"Aalaap","family":"Naigaonkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7358-7186","authenticated-orcid":false,"given":"Gayatri","family":"Shinde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7679-9950","authenticated-orcid":false,"given":"Sushma","family":"Khavale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1930-1113","authenticated-orcid":false,"given":"Indira","family":"Hinduja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9243-4428","authenticated-orcid":false,"given":"Srabani","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2025.124117_bb0005","series-title":"Critical Reviews in Clinical Laboratory Sciences","article-title":"Insight into metabolic dysregulation of polycystic ovary syndrome utilizing metabolomic signatures: A narrative review","author":"Naigaonkar","year":"2024"},{"key":"10.1016\/j.lfs.2025.124117_bb0010","article-title":"Effects of glucose metabolism during in vitro maturation on cytoplasmic maturation of mouse oocytes","volume":"6","author":"Xie","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2025.124117_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0168329","article-title":"The role of glucose metabolism on porcine oocyte cytoplasmic maturation and its possible mechanisms","volume":"11","author":"Yuan","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2025.124117_bb0020","series-title":"International Journal of Molecular Sciences","article-title":"Essential role of granulosa cell glucose and lipid metabolism on oocytes and the potential metabolic imbalance in polycystic ovary syndrome","volume":"24","author":"Zhang","year":"2023"},{"key":"10.1016\/j.lfs.2025.124117_bb0025","series-title":"Human Reproduction Update","first-page":"27","article-title":"Metabolic co-dependence of the oocyte and cumulus cells: Essential role in determining oocyte developmental competence","volume":"27","author":"Richani","year":"2021"},{"issue":"3","key":"10.1016\/j.lfs.2025.124117_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.repbio.2023.100787","article-title":"Transcriptomic profile of GLCs of PCOS women highlights metabolic dysregulation as a plausible contributor to PCOS pathophysiology","volume":"23","author":"Patil","year":"2023","journal-title":"Reprod. Biol."},{"issue":"2","key":"10.1016\/j.lfs.2025.124117_bb0035","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10815-022-02676-w","article-title":"Granulosa cells from immature follicles exhibit restricted glycolysis and reduced energy production: a dominant problem in polycystic ovary syndrome","volume":"40","author":"Mazloomi","year":"2023","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.lfs.2025.124117_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2022.05.010","article-title":"Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3","volume":"187","author":"Zhang","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2025.124117_bb0045","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.freeradbiomed.2015.05.013","article-title":"Metabolism alteration in follicular niche: the nexus among intermediary metabolism, mitochondrial function, and classic polycystic ovary syndrome","volume":"86","author":"Zhao","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.lfs.2025.124117_bb0050","doi-asserted-by":"crossref","DOI":"10.1186\/s13048-023-01204-3","article-title":"Correlation between abnormal energy metabolism of ovarian granulosa cells and in vitro fertilization\u2013embryo transfer outcomes in patients with polycystic ovary syndrome and obesity","volume":"16","author":"Zhao","year":"2023","journal-title":"J. Ovarian Res."},{"issue":"2","key":"10.1016\/j.lfs.2025.124117_bb0055","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1210\/jc.2014-2086","article-title":"Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development","volume":"100","author":"Ambekar","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.lfs.2025.124117_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13148-019-0657-6","article-title":"DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome","volume":"11","author":"Sagvekar","year":"2019","journal-title":"Clin. Epigenetics"},{"issue":"4","key":"10.1016\/j.lfs.2025.124117_bb0065","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/humrep\/deaa351","article-title":"Alteration in angiogenic potential of granulosa-lutein cells and follicular fluid contributes to luteal defects in polycystic ovary syndrome","volume":"36","author":"Patil","year":"2021","journal-title":"Hum. Reprod."},{"issue":"10","key":"10.1016\/j.lfs.2025.124117_bb0070","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1007\/s10815-021-02241-x","article-title":"Altered redox status may contribute to aberrant folliculogenesis and poor reproductive outcomes in women with polycystic ovary syndrome","volume":"38","author":"Naigaonkar","year":"2021","journal-title":"J. Assist. Reprod. Genet."},{"issue":"2","key":"10.1016\/j.lfs.2025.124117_bb0075","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1210\/jc.2014-2086","article-title":"Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development","volume":"100","author":"Ambekar","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2025.124117_bb0080","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.gene.2018.03.083","article-title":"PON1 promoter polymorphisms contribute to PCOS susceptibility and phenotypic outcomes in Indian women","volume":"661","author":"Dadachanji","year":"2018","journal-title":"Gene"},{"issue":"1","key":"10.1016\/j.lfs.2025.124117_bb0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.atherosclerosis.2013.03.028","article-title":"Paraoxonase1 (PON1) reduces insulin resistance in mice fed a high-fat diet, and promotes GLUT4 overexpression in myocytes, via the IRS-1\/Akt pathway","volume":"229","author":"Koren-Gluzer","year":"2013","journal-title":"Atherosclerosis"},{"issue":"5","key":"10.1016\/j.lfs.2025.124117_bb0090","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/rda.12730","article-title":"Exogenous paraoxonase-1 during oocyte maturation improves bovine embryo development in vitro. Reproduction in domestic animals =","volume":"51","author":"Rinc\u00f3n","year":"2016","journal-title":"Zuchthygiene"},{"issue":"1","key":"10.1016\/j.lfs.2025.124117_bb0095","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3803\/EnM.2014.29.1.40","article-title":"Correlation between expression of glucose transporters in granulosa cells and oocyte quality in women with polycystic ovary syndrome","volume":"29","author":"Kim","year":"2014","journal-title":"Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2025.124117_bb0100","series-title":"Heliyon","article-title":"Regulation of glucose metabolism: Effects on oocyte, preimplantation embryo, assisted reproductive technology and embryonic stem cell","volume":"vol. 10, Issue 19","author":"Xiong","year":"2024"},{"issue":"1","key":"10.1016\/j.lfs.2025.124117_bb0105","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-023-01410-y","article-title":"Bisphenol a downregulates GLUT4 expression by activating aryl hydrocarbon receptor to exacerbate polycystic ovary syndrome","volume":"22","author":"Shi","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.lfs.2025.124117_bb0110","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-023-01410-y","article-title":"Bisphenol a downregulates GLUT4 expression by activating aryl hydrocarbon receptor to exacerbate polycystic ovary syndrome","volume":"22","author":"Shi","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"8","key":"10.1016\/j.lfs.2025.124117_bb0115","first-page":"912","article-title":"Effects of tumor necrosis factor-\u03b1 on glucose uptake in human granulosa cells under high androgen conditions","volume":"26","author":"Sun","year":"2023","journal-title":"Iran. J. Basic Med. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2025.124117_bb0120","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s12020-016-0949-y","article-title":"Metabolic actions of insulin in ovarian granulosa cells were unaffected by hyperandrogenism","volume":"53","author":"Zhao","year":"2016","journal-title":"Endocrine"},{"issue":"7","key":"10.1016\/j.lfs.2025.124117_bb0125","doi-asserted-by":"crossref","first-page":"9563","DOI":"10.1096\/fj.202000605RR","article-title":"HMGB1-induced aberrant autophagy contributes to insulin resistance in granulosa cells in PCOS","volume":"34","author":"Zhang","year":"2020","journal-title":"FASEB J."},{"issue":"8","key":"10.1016\/j.lfs.2025.124117_bb0130","article-title":"Humanin alleviates insulin resistance in polycystic ovary syndrome: a human and rat model-based study","volume":"162","author":"Wang","year":"2021","journal-title":"Endocrinology (United States)"},{"key":"10.1016\/j.lfs.2025.124117_bb0135","series-title":"Heliyon","article-title":"Regulation of glucose metabolism: Effects on oocyte, preimplantation embryo, assisted reproductive technology and embryonic stem cell","volume":"vol. 10, Issue 19","author":"Xiong","year":"2024"},{"issue":"8","key":"10.1016\/j.lfs.2025.124117_bb0140","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/molehr\/gaaa044","article-title":"miR-130b regulates gap junctional intercellular communication through connexin 43 in granulosa cells from patients with polycystic ovary syndrome","volume":"26","author":"Jiang","year":"2021","journal-title":"Mol. Hum. Reprod."},{"issue":"6","key":"10.1016\/j.lfs.2025.124117_bb0145","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1093\/biolre\/iox043","article-title":"Hyperandrogenemia reduces endothelium-derived hyperpolarizing factor-mediated relaxation in mesenteric artery of female rats","volume":"96","author":"Mishra","year":"2017","journal-title":"Biol. Reprod."},{"issue":"1","key":"10.1016\/j.lfs.2025.124117_bb0150","article-title":"Modulation of Cx43 and gap junctional intercellular communication by androstenedione in rat polycystic ovary and granulosa cells in vitro","volume":"13","author":"Talhouk","year":"2012","journal-title":"J Reprod Infertil"},{"issue":"1\u20132","key":"10.1016\/j.lfs.2025.124117_bb0155","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cell.2016.12.026","article-title":"Nuclear localization of mitochondrial TCA cycle enzymes as a critical step in mammalian zygotic genome activation","volume":"168","author":"Nagaraj","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2025.124117_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2023.106410","article-title":"BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment","volume":"235","author":"Gu","year":"2023","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"9","key":"10.1016\/j.lfs.2025.124117_bb0165","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1093\/humrep\/deae154","article-title":"Granulosa cell metabolism at ovulation correlates with oocyte competence and is disrupted by obesity and aging","volume":"39","author":"Morimoto","year":"2024","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.lfs.2025.124117_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1607161","article-title":"CNOT6L regulates energy metabolism in the ovarian granulosa cells associated with polycystic ovary syndrome","volume":"13","author":"Han","year":"2025","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.1016\/j.lfs.2025.124117_bb0175","series-title":"Animal Models and Experimental Medicine","first-page":"7","article-title":"Redox imbalance stress in diabetes mellitus: Role of the polyol pathway","volume":"1","author":"Yan","year":"2018"},{"key":"10.1016\/j.lfs.2025.124117_bb0180","series-title":"Trends in Endocrinology and Metabolism","first-page":"150","article-title":"Implications and future perspectives of AGEs in PCOS pathophysiology","volume":"30","author":"Merhi","year":"2019"},{"issue":"2","key":"10.1016\/j.lfs.2025.124117_bb0185","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/s43032-022-01039-1","article-title":"Comparative evaluation of aldose reductase inhibition in polycystic ovarian syndrome\u2013induced rats","volume":"30","author":"Patel","year":"2023","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.lfs.2025.124117_bb0190","author":"Azhary","year":"2020","journal-title":"Androgens increase accumulation of advanced glycation end products in granulosa cells by activating ER stress in PCOS."},{"key":"10.1016\/j.lfs.2025.124117_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117397","article-title":"Effect of advanced glycation end product on paraoxonase 2 expression: its impact on endoplasmic reticulum stress and inflammation in HUVECs","volume":"246","author":"Ravi","year":"2020","journal-title":"Life Sci."},{"issue":"12","key":"10.1016\/j.lfs.2025.124117_bb0200","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1177\/1933719116674077","article-title":"Oxidative stress in granulosa-lutein cells from in vitro fertilization patients","volume":"23","author":"\u00c1vila","year":"2016","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.lfs.2025.124117_bb0205","article-title":"Mitochondrial DNA oxidation and content in different metabolic phenotypes of women with polycystic ovary syndrome","volume":"15","author":"Rojo","year":"2024","journal-title":"Front. Endocrinol."},{"issue":"6","key":"10.1016\/j.lfs.2025.124117_bb0210","first-page":"692","article-title":"The protective effect of sulforaphane against oxidative stress through activation of NRF2\/ARE pathway in human granulosa cells","volume":"23","author":"Esfandyari","year":"2021","journal-title":"Cell J."},{"key":"10.1016\/j.lfs.2025.124117_bb0215","series-title":"Trends in Biochemical Sciences","first-page":"199","article-title":"The Nrf2 regulatory network provides an interface between redox and intermediary metabolism","volume":"39","author":"Hayes","year":"2014"},{"key":"10.1016\/j.lfs.2025.124117_bb0220","series-title":"Reviews in Endocrine and Metabolic Disorders","first-page":"1045","article-title":"Follicular fluid composition and reproductive outcomes of women with polycystic ovary syndrome undergoing in vitro fertilization: a systematic review","volume":"24","author":"Moreira","year":"2023"},{"key":"10.1016\/j.lfs.2025.124117_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2025.112536","article-title":"Follicular fluid profiling unveils anti-M\u00fcllerian hormone alongside glycolytic and mitochondrial dysfunction as markers of polycystic ovary syndrome","volume":"602","author":"Vale-Fernandes","year":"2025","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.lfs.2025.124117_bb0230","series-title":"Journal of Gynecology Obstetrics and Human Reproduction","article-title":"Artificial intelligence in in-vitro fertilization (IVF): a new era of precision and personalization in fertility treatments","volume":"54","author":"Olawade","year":"2025"},{"key":"10.1016\/j.lfs.2025.124117_bb0235","series-title":"IET Nanobiotechnology","first-page":"399","article-title":"Metabolomics and its applications in assisted reproductive technology","volume":"17","author":"Gao","year":"2023"},{"key":"10.1016\/j.lfs.2025.124117_bb0240","series-title":"npj Digital Medicine","article-title":"The prospect of artificial intelligence to personalize assisted reproductive technology","volume":"7","author":"Hanassab","year":"2024"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525007532?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525007532?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T01:23:10Z","timestamp":1780190590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525007532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":48,"alternative-id":["S0024320525007532"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.124117","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired metabolic cooperation between oocyte and granulosa cells may contribute to the disrupted folliculogenesis and poor oocyte quality in PCOS","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.124117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124117"}}