{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:48:54Z","timestamp":1788295734341,"version":"build-2803163510"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371163"],"award-info":[{"award-number":["32371163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571292"],"award-info":[{"award-number":["32571292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.lfs.2025.124140","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T16:27:53Z","timestamp":1764865673000},"page":"124140","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The PRMT-mediated arginine methylation: From molecular mechanisms to therapeutic targets in cardiovascular diseases"],"prefix":"10.1016","volume":"385","author":[{"given":"Jia-Qi","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-jiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-zhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.lfs.2025.124140_bb0005","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.clinthera.2023.09.020","article-title":"Global trends in atherosclerotic cardiovascular disease","volume":"45","author":"Nedkoff","year":"2023","journal-title":"Clin. Ther."},{"issue":"11","key":"10.1016\/j.lfs.2025.124140_bb0010","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/eurjpc\/zwae281","article-title":"Global burden of cardiovascular diseases: projections from 2025 to 2050","volume":"32","author":"Chong","year":"2024","journal-title":"Eur. J. Prev. Cardiol."},{"issue":"3","key":"10.1016\/j.lfs.2025.124140_bb0015","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1002\/ehf2.15253","article-title":"Decreased endogenous nitric oxide production in acute decompensated heart failure with a reduced ejection fraction","volume":"12","author":"Falls","year":"2025","journal-title":"ESC Heart Failure"},{"issue":"4","key":"10.1016\/j.lfs.2025.124140_bb0020","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1002\/ehf2.15285","article-title":"Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction","volume":"12","author":"Naeem","year":"2025","journal-title":"ESC Heart Failure"},{"key":"10.1016\/j.lfs.2025.124140_bb0025","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biochi.2024.11.006","article-title":"The l-arginine pathway may act as a mediator in the association between impaired one-carbon metabolism and hypertension","volume":"230","author":"Ramos-Rodr\u00edguez","year":"2025","journal-title":"Biochimie"},{"issue":"10","key":"10.1016\/j.lfs.2025.124140_bb0030","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/s12276-021-00684-x","article-title":"Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection","volume":"53","author":"Pyun","year":"2021","journal-title":"Exp. Mol. Med."},{"issue":"19","key":"10.1016\/j.lfs.2025.124140_bb0035","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1161\/CIRCULATIONAHA.121.055738","article-title":"Epigenetic regulation of cardiomyocyte maturation by arginine methyltransferase CARM1","volume":"149","author":"Garbutt","year":"2024","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.lfs.2025.124140_bb0040","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1161\/CIRCRESAHA.124.324773","article-title":"Kindlin-2 phase separation in response to flow controls vascular stability","volume":"135","author":"Ma","year":"2024","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.lfs.2025.124140_bb0045","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1161\/CIRCRESAHA.121.319456","article-title":"PRMT5 prevents dilated cardiomyopathy via suppression of protein O-GlcNAcylation","volume":"129","author":"Li","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2025.124140_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.plefa.2020.102227","article-title":"Palmitic acid methyl ester inhibits cardiac arrest-induced neuroinflammation and mitochondrial dysfunction","volume":"165","author":"Wu","year":"2021","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"issue":"10","key":"10.1016\/j.lfs.2025.124140_bb0055","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1182\/blood-2009-07-236059","article-title":"H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation","volume":"115","author":"Li","year":"2010","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.lfs.2025.124140_bb0060","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1080\/15548627.2023.2165757","article-title":"PRMT1 driven PTX3 regulates ferritinophagy in glioma","volume":"19","author":"Lathoria","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.lfs.2025.124140_bb0065","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.yjmcc.2025.07.010","article-title":"LncRNA 91234.1 targets PRMT1\/ASCL4\/GPX4 axis to regulate formaldehyde-induced cardiomyocyte ferroptosis and congenital heart disease","volume":"206","author":"Zhao","year":"2025","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"11","key":"10.1016\/j.lfs.2025.124140_bb0070","doi-asserted-by":"crossref","first-page":"6464","DOI":"10.1073\/pnas.1232272100","article-title":"Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice","volume":"100","author":"Yadav","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.lfs.2025.124140_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103414","article-title":"Redox-sensitive epigenetic activation of SUV39H1 contributes to liver ischemia-reperfusion injury","volume":"78","author":"Li","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2025.124140_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105104","article-title":"Histone H4R3 symmetric di-methylation by Prmt5 protects against cardiac hypertrophy via regulation of Filip1L\/\u03b2-catenin","volume":"161","author":"Cai","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"13","key":"10.1016\/j.lfs.2025.124140_bb0085","doi-asserted-by":"crossref","first-page":"6592","DOI":"10.7150\/thno.59816","article-title":"Targeting hyperactive TGFBR2 for treating MYOCD deficient lung cancer","volume":"11","author":"Zhou","year":"2021","journal-title":"Theranostics"},{"issue":"12","key":"10.1016\/j.lfs.2025.124140_bb0090","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1093\/cvr\/cvad110","article-title":"Epigenetic regulation of vascular smooth muscle cell phenotypic switch and neointimal formation by PRMT5","volume":"119","author":"Zhu","year":"2023","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0095","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1038\/s41467-024-46711-z","article-title":"Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice","volume":"15","author":"Katanasaka","year":"2024","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.lfs.2025.124140_bb0100","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/s41419-024-06920-2","article-title":"PRMT6 facilitates EZH2 protein stability by inhibiting TRAF6-mediated ubiquitination degradation to promote glioblastoma cell invasion and migration","volume":"15","author":"Wang","year":"2024","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.lfs.2025.124140_bb0105","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1002\/tox.24160","article-title":"Yifei Sanjie formula alleviates lung cancer progression via regulating PRMT6-YBX1-CDC25A axis","volume":"39","author":"Tang","year":"2024","journal-title":"Environ. Toxicol."},{"issue":"12","key":"10.1016\/j.lfs.2025.124140_bb0110","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00018-023-04987-2","article-title":"miR-455-5p promotes pathological cardiac remodeling via suppression of PRMT1-mediated Notch signaling pathway","volume":"80","author":"Cai","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"issue":"7","key":"10.1016\/j.lfs.2025.124140_bb0115","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1002\/jcp.30775","article-title":"Modulation of I(Ks) channel-PIP(2) interaction by PRMT1 plays a critical role in the control of cardiac repolarization","volume":"237","author":"An","year":"2022","journal-title":"J. Cell. Physiol."},{"issue":"9","key":"10.1016\/j.lfs.2025.124140_bb0120","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202403269R","article-title":"PRMT1 upregulates SIRT6 by enhancing arginine methylation of E2F7 to inhibit vascular smooth muscle cell senescence in aortic dissection","volume":"39","author":"Wu","year":"2025","journal-title":"FASEB J."},{"issue":"10","key":"10.1016\/j.lfs.2025.124140_bb0125","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1038\/s41418-022-00990-5","article-title":"PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2\/GPX4 pathway","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Death Differ."},{"issue":"11","key":"10.1016\/j.lfs.2025.124140_bb0130","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1093\/cvr\/cvad080","article-title":"Protein arginine methyltransferase 5-mediated arginine methylation stabilizes Kruppel-like factor 4 to accelerate neointimal formation","volume":"119","author":"Liu","year":"2023","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.lfs.2025.124140_bb0135","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41419-022-04719-7","article-title":"PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.lfs.2025.124140_bb0140","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41401-022-00963-x","article-title":"Adriamycin induces cardiac fibrosis in mice via PRMT5-mediated cardiac fibroblast activation","volume":"44","author":"Dong","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0145","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/FJC.0000000000001640","article-title":"Deubiquitinase USP47 ameliorates cardiac hypertrophy through reducing protein O-GlcNAcylation","volume":"85","author":"Jiang","year":"2025","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.lfs.2025.124140_bb0150","doi-asserted-by":"crossref","first-page":"1239614","DOI":"10.3389\/fimmu.2023.1239614","article-title":"Protein arginine methyltransferase 1 is a therapeutic vulnerability in multiple myeloma","volume":"14","author":"Nguyen","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0155","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12929-025-01162-6","article-title":"Cardiac-specific overexpression of PRMT5 exacerbates pressure overload-induced hypertrophy and heart failure","volume":"32","author":"Katanasaka","year":"2025","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.lfs.2025.124140_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155938","article-title":"Regulation of hepatic lipogenesis by asymmetric arginine methylation","volume":"157","author":"Han","year":"2024","journal-title":"Metab. Clin. Exp."},{"issue":"2","key":"10.1016\/j.lfs.2025.124140_bb0165","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00018-021-04097-x","article-title":"PRMT7 ablation in cardiomyocytes causes cardiac hypertrophy and fibrosis through \u03b2-catenin dysregulation","volume":"79","author":"Ahn","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"5","key":"10.1016\/j.lfs.2025.124140_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0296003","article-title":"Regulation of YAP and Wnt signaling by the endosomal protein MAMDC4","volume":"19","author":"Cox","year":"2024","journal-title":"PloS One"},{"key":"10.1016\/j.lfs.2025.124140_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107731","article-title":"Cardiac PDK4 promotes neutrophilic PFKL methylation and drives the innate immune response in diabetic myocardial infarction","volume":"215","author":"Yang","year":"2025","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.lfs.2025.124140_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119918","article-title":"Endothelial nitric oxide synthase deficient mice are protected from lipopolysaccharide induced acute lung injury","volume":"10","author":"Gross","year":"2015","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.lfs.2025.124140_bb0185","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.bbrc.2008.10.080","article-title":"Variance of DDAH\/PRMT\/ADMA pathway in atrial fibrillation dogs","volume":"377","author":"Liu","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.lfs.2025.124140_bb0190","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.2337\/db23-0124","article-title":"GPR56 promotes diabetic kidney disease through eNOS regulation in glomerular endothelial cells","volume":"72","author":"Wu","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2025.124140_bb0195","first-page":"294","article-title":"Macrophage-targeting Antisenescence nanomedicine enables in-situ NO induction for gaseous and antioxidative atherosclerosis intervention","volume":"48","author":"Peng","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.lfs.2025.124140_bb0200","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/683707","article-title":"Rho\/ROCK signal cascade mediates asymmetric dimethylarginine-induced vascular smooth muscle cells migration and phenotype change","volume":"2014","author":"Zhou","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.lfs.2025.124140_bb0205","article-title":"Endothelial Nucleoporin93 (Nup93) maintains vascular function via Sun1-dependent regulation of RhoA-eNOS signaling","author":"Nguyen","year":"2025","journal-title":"bioRxiv"},{"issue":"20","key":"10.1016\/j.lfs.2025.124140_bb0210","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.3390\/cells12202432","article-title":"The muscarinic acetylcholine M2 receptor-induced nitration of p190A by eNOS increases RhoA activity in cardiac myocytes","volume":"12","author":"Levay","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0215","doi-asserted-by":"crossref","first-page":"606","DOI":"10.3892\/mmr.2016.5241","article-title":"High salt medium activates RhoA\/ROCK and downregulates eNOS expression via the upregulation of ADMA","volume":"14","author":"Cao","year":"2016","journal-title":"Mol. Med. Rep."},{"issue":"12","key":"10.1016\/j.lfs.2025.124140_bb0220","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1161\/ATVBAHA.109.194035","article-title":"The ADMA\/DDAH pathway regulates VEGF-mediated angiogenesis","volume":"29","author":"Fiedler","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0225","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1091\/mbc.e08-04-0395","article-title":"Modulation of Rac1 activity by ADMA\/DDAH regulates pulmonary endothelial barrier function","volume":"20","author":"Wojciak-Stothard","year":"2009","journal-title":"Mol. Biol. Cell"},{"issue":"2","key":"10.1016\/j.lfs.2025.124140_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2025.108165","article-title":"Substrate adaptors are flexible tethering modules that enhance substrate methylation by the arginine methyltransferase PRMT5","volume":"301","author":"Jin","year":"2025","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2025.124140_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103344","article-title":"CARM1 phosphorylation at S595 by p38\u03b3 MAPK drives ROS-mediated cellular senescence","volume":"76","author":"Cho","year":"2024","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0240","doi-asserted-by":"crossref","first-page":"4790","DOI":"10.1038\/s41467-024-49087-2","article-title":"FBXO7 ubiquitinates PRMT1 to suppress serine synthesis and tumor growth in hepatocellular carcinoma","volume":"15","author":"Luo","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2025.124140_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102690","article-title":"METTL3\/IGF2BP1 promotes the development of triple-negative breast cancer by mediating m6A methylation modification of PRMT7","volume":"93","author":"Lu","year":"2025","journal-title":"Tissue Cell"},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0250","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1158\/2767-9764.CRC-24-0389","article-title":"Targeting PRMT1 reduces cancer persistence and tumor relapse in EGFR- and KRAS-mutant lung cancer","volume":"5","author":"Sun","year":"2025","journal-title":"Cancer Res. Commun."},{"key":"10.1016\/j.lfs.2025.124140_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217783","article-title":"Mechanistic insights into CLNS1A-mediated chemoresistance and tumor progression in non-small cell lung cancer","volume":"626","author":"Wei","year":"2025","journal-title":"Cancer Lett."},{"issue":"47","key":"10.1016\/j.lfs.2025.124140_bb0260","first-page":"e2400160","article-title":"TBL2 promotes tumorigenesis via PRMT5\/WDR77-mediated AKT activation in breast cancer","volume":"vol. 11","author":"Lu","year":"2024","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.lfs.2025.124140_bb0265","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.atherosclerosis.2021.11.001","article-title":"PRMT4 inhibitor TP-064 impacts both inflammatory and metabolic processes without changing the susceptibility for early atherosclerotic lesions in male apolipoprotein E knockout mice","volume":"338","author":"Zhang","year":"2021","journal-title":"Atherosclerosis"},{"issue":"8","key":"10.1016\/j.lfs.2025.124140_bb0270","doi-asserted-by":"crossref","first-page":"e70451","DOI":"10.1002\/ctm2.70451","article-title":"Multi-omics analysis revealed biomarkers for coronary atherosclerosis: occurrence and development","volume":"15","author":"He","year":"2025","journal-title":"Clin. Transl. Med."},{"issue":"36","key":"10.1016\/j.lfs.2025.124140_bb0275","first-page":"e2303812","article-title":"PRMT3-mediated arginine methylation of METTL14 promotes malignant progression and treatment resistance in endometrial carcinoma","volume":"vol. 10","author":"Wang","year":"2023","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0280","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12964-025-02130-1","article-title":"Specific sDMA modifications on the RGG\/RG motif of METTL14 regulate its function in AML","volume":"23","author":"Zhong","year":"2025","journal-title":"Cell Commun. Signal.: CCS"},{"issue":"3","key":"10.1016\/j.lfs.2025.124140_bb0285","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/15548627.2023.2277610","article-title":"Pycard deficiency inhibits microRNA maturation and prevents neointima formation by promoting chaperone-mediated autophagic degradation of AGO2\/argonaute 2 in adipose tissue","volume":"20","author":"Li","year":"2024","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.lfs.2025.124140_bb0290","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.70284","article-title":"METTL14 promotes vascular smooth muscle cell proliferation and Neointima formation via m6A methylation TEAD1 mRNA","volume":"39","author":"Wang","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"2","key":"10.1016\/j.lfs.2025.124140_bb0295","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1161\/CIRCRESAHA.117.306712","article-title":"Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-\/- mice by restraining noncanonical Wnt signals","volume":"117","author":"Cheng","year":"2015","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.lfs.2025.124140_bb0300","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10557-006-9065-1","article-title":"Probucol decreases asymmetrical dimethylarginine level by alternation of protein arginine methyltransferase I and dimethylarginine dimethylaminohydrolase activity","volume":"20","author":"Jiang","year":"2006","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.lfs.2025.124140_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110529","article-title":"PRMT5 knockdown enhances cell viability and suppresses cell apoptosis, oxidative stress, inflammation and endothelial dysfunction in ox-LDL-induced vascular endothelial cells via interacting with PDCD4","volume":"122","author":"Fei","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2025.124140_bb0310","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/01.hjh.0000209985.66853.1e","article-title":"Effect of vasoconstrictor coupling factor 6 on gene expression profile in human vascular endothelial cells: enhanced release of asymmetric dimethylarginine","volume":"24","author":"Tanaka","year":"2006","journal-title":"J. Hypertens."},{"issue":"2","key":"10.1016\/j.lfs.2025.124140_bb0315","doi-asserted-by":"crossref","DOI":"10.1161\/01.RES.87.2.99","article-title":"LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases","volume":"87","author":"B\u00f6ger","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2025.124140_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120336","article-title":"Hepatocellular BChE as a therapeutic target to ameliorate hypercholesterolemia through PRMT5 selective degradation to restore LDL receptor transcription","volume":"293","author":"Wang","year":"2022","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0325","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41598-021-04524-w","article-title":"PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice","volume":"12","author":"de Jong","year":"2022","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0330","doi-asserted-by":"crossref","first-page":"12031","DOI":"10.1038\/s41598-022-15349-6","article-title":"Loss of PRMT2 in myeloid cells in normoglycemic mice phenocopies impaired regression of atherosclerosis in diabetic mice","volume":"12","author":"Vurusaner","year":"2022","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.lfs.2025.124140_bb0335","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135218","article-title":"LXR-mediated ABCA1 expression and function are modulated by high glucose and PRMT2","volume":"10","author":"Hussein","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.lfs.2025.124140_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2025.106276","article-title":"miR-205-3p inhibits porphyromonas gingivalis lipopolysaccharide-induced human umbilical vein endothelial cells inflammation and apoptosis by targeting PRMT5","volume":"175","author":"Wu","year":"2025","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.lfs.2025.124140_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2022.136576","article-title":"Inhibition of PRMT5 attenuates cerebral ischemia\/reperfusion-induced inflammation and pyroptosis through suppression of NF-\u03baB\/NLRP3 axis","volume":"776","author":"Wu","year":"2022","journal-title":"Neurosci. Lett."},{"issue":"10","key":"10.1016\/j.lfs.2025.124140_bb0350","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/ajh\/hpaf071","article-title":"Salt-induced vascular damage in hypertension involves redox activation of PARP\/TRPM2 signalling and inflammasome assembly","volume":"38","author":"Alves-Lopes","year":"2025","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.lfs.2025.124140_bb0355","doi-asserted-by":"crossref","DOI":"10.2174\/0109298673349473250410132823","article-title":"Endothelial function biomarkers in hypertension","author":"Vlachakis","year":"2025","journal-title":"Curr. Med. Chem."},{"issue":"4","key":"10.1016\/j.lfs.2025.124140_bb0360","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/MBP.0000000000000753","article-title":"Association between inter-arm blood pressure difference and prevalence of renal artery stenosis in patients with ischemic stroke","volume":"30","author":"Li","year":"2025","journal-title":"Blood Press. Monit."},{"issue":"3","key":"10.1016\/j.lfs.2025.124140_bb0365","doi-asserted-by":"crossref","first-page":"F391","DOI":"10.1152\/ajprenal.00158.2025","article-title":"Impaired vascular function in patients with chronic kidney disease who have elevated symmetric dimethylarginine but not asymmetric dimethylarginine","volume":"329","author":"Grotle","year":"2025","journal-title":"Am. J. Physiol. Renal Physiol."},{"issue":"4","key":"10.1016\/j.lfs.2025.124140_bb0370","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3390\/jcm14041051","article-title":"Asymmetric dimethylarginine (ADMA) as a novel risk factor for progression of coronary artery calcification in patients with chronic kidney disease","volume":"14","author":"Kobayashi","year":"2025","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0375","doi-asserted-by":"crossref","first-page":"30520","DOI":"10.1038\/s41598-025-14842-y","article-title":"Symmetric dimethylarginine as a biomarker of renal impairment after a decade of follow-up","volume":"15","author":"Meyer","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2025.124140_bb0380","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.niox.2017.04.002","article-title":"The asymmetric dimethylarginine-mediated inhibition of nitric oxide in the rostral ventrolateral medulla contributes to regulation of blood pressure in hypertensive rats","volume":"67","author":"Tan","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.lfs.2025.124140_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115637","article-title":"The effect of exenatide (a GLP-1 analogue) and sitagliptin (a DPP-4 inhibitor) on asymmetric dimethylarginine (ADMA) metabolism and selected biomarkers of cardiac fibrosis in rats with fructose-induced metabolic syndrome","volume":"214","author":"W\u00f3jcicka","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"2","key":"10.1016\/j.lfs.2025.124140_bb0390","first-page":"749","article-title":"DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH\/ADMA\/NOS\/NO pathway in rats","volume":"43","author":"Zhu","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"10","key":"10.1016\/j.lfs.2025.124140_bb0395","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1093\/eurheartj\/ehq369","article-title":"Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes","volume":"32","author":"Haghikia","year":"2011","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0400","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s42003-024-06290-7","article-title":"PRMT5-mediated methylation of STAT3 is required for lung cancer stem cell maintenance and tumour growth","volume":"7","author":"Abe","year":"2024","journal-title":"Commun. Biol."},{"issue":"8","key":"10.1016\/j.lfs.2025.124140_bb0405","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.3724\/abbs.2024175","article-title":"PRMT1 alleviates isoprenaline-induced myocardial hypertrophy by methylating SRSF1","volume":"57","author":"Yan","year":"2024","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"key":"10.1016\/j.lfs.2025.124140_bb0410","article-title":"Aloe-emodin relieves myocardial intracellular calcium homeostasis imbalance induced by high-fat diet via protein arginine methyltransferase\/ Ca(2+)\/calmodulin- dependent protein kinase II signaling pathway in rats","volume":"17","author":"Li","year":"2024","journal-title":"Curr. Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.lfs.2025.124140_bb0415","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1165\/rcmb.2006-0097OC","article-title":"Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases","volume":"35","author":"Yildirim","year":"2006","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.lfs.2025.124140_bb0420","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/iovs.66.6.8","article-title":"PRMT5 regulates senescence in retinal ganglion cells by targeting the Wnt\/\u03b2-catenin signaling cascade","volume":"66","author":"Zhang","year":"2025","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"10.1016\/j.lfs.2025.124140_bb0425","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1213\/ANE.0000000000006595","article-title":"Protein arginine methyltransferase 5 contributes to paclitaxel-induced neuropathic pain by activating transient receptor potential Vanilloid 1 epigenetic modification in dorsal root ganglion","volume":"138","author":"Yeh","year":"2024","journal-title":"Anesth. Analg."},{"issue":"8","key":"10.1016\/j.lfs.2025.124140_bb0430","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41419-022-05180-2","article-title":"MYBL1 induces transcriptional activation of ANGPT2 to promote tumor angiogenesis and confer sorafenib resistance in human hepatocellular carcinoma","volume":"13","author":"Zhu","year":"2022","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.lfs.2025.124140_bb0435","doi-asserted-by":"crossref","first-page":"45595","DOI":"10.31083\/FBL45595","article-title":"Astragalus polysaccharide improves myocardial fibrosis in hypertrophic cardiomyopathy through the TGF-\u03b2(1)\/Smad3 signal pathway","volume":"30","author":"Qin","year":"2025","journal-title":"Front. Biosci. (Landmark Ed)"},{"issue":"3","key":"10.1016\/j.lfs.2025.124140_bb0440","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s12276-024-01193-3","article-title":"Prmt7 regulates the JAK\/STAT\/Socs3 signaling pathway in postmenopausal cardiomyopathy","volume":"56","author":"Ahn","year":"2024","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"10.1016\/j.lfs.2025.124140_bb0445","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1046\/j.1523-1755.2003.00334.x","article-title":"Plasma concentration of coupling factor 6 and cardiovascular events in patients with end-stage renal disease","volume":"64","author":"Osanai","year":"2003","journal-title":"Kidney Int."},{"issue":"8","key":"10.1016\/j.lfs.2025.124140_bb0450","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1038\/s12276-025-01517-x","article-title":"Endothelial PRMT7 prevents dysfunction, promotes revascularization and enhances cardiac recovery post-myocardial infarction","volume":"57","author":"Tran","year":"2025","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0455","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13148-025-01935-8","article-title":"Targeting PRMT1-mediated methylation of TAF15 to protect against myocardial infarction by inhibiting ferroptosis via the GPX4\/NRF2 pathway","volume":"17","author":"Huang","year":"2025","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.lfs.2025.124140_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110412","article-title":"PRMT1 suppresses doxorubicin-induced cardiotoxicity by inhibiting endoplasmic reticulum stress","volume":"98","author":"Kim","year":"2022","journal-title":"Cell. Signal."},{"issue":"11","key":"10.1016\/j.lfs.2025.124140_bb0465","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202403196R","article-title":"MicroRNA-100-5p exacerbates myocardial ischemia-reperfusion injury through downregulation of PRMT5","volume":"39","author":"Wang","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2025.124140_bb0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2025.171379","article-title":"KLF4 regulates FAM3A to promotes angiotensin II-induced proliferation and migration of vascular smooth muscle cells through the PI3K\/AKT signaling pathway","volume":"187","author":"Zhang","year":"2025","journal-title":"Peptides"},{"key":"10.1016\/j.lfs.2025.124140_bb0475","doi-asserted-by":"crossref","first-page":"1264216","DOI":"10.3389\/fphar.2023.1264216","article-title":"Hypertrophic cardiomyopathy is characterized by alterations of the mitochondrial calcium uniporter complex proteins: insights from patients with aortic valve stenosis versus hypertrophic obstructive cardiomyopathy","volume":"14","author":"Paar","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2025.124140_bb0480","doi-asserted-by":"crossref","first-page":"19424","DOI":"10.1038\/s41598-019-55943-9","article-title":"Markers of endothelial pathology to support detection of atrial fibrillation in embolic stroke of undetermined source","volume":"9","author":"Ziegler","year":"2019","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.lfs.2025.124140_bb0485","doi-asserted-by":"crossref","DOI":"10.1007\/s00109-020-01932-9","article-title":"Arginine derivatives in atrial fibrillation progression phenotypes","volume":"98","author":"B\u00fcttner","year":"2020","journal-title":"J. Mol. Med. (Berl)"},{"issue":"3\u20134","key":"10.1016\/j.lfs.2025.124140_bb0490","doi-asserted-by":"crossref","first-page":"79","DOI":"10.18071\/isz.72.0079","article-title":"L-arginine pathway metabolites can discriminate paroxysmal from permanent atrial fibrillation in acute ischemic stroke","volume":"72","author":"Csecsei","year":"2019","journal-title":"Ideggyogy. Sz."},{"issue":"5","key":"10.1016\/j.lfs.2025.124140_bb0495","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1083\/jcb.201406020","article-title":"GSK3- and PRMT-1-dependent modifications of desmoplakin control desmoplakin-cytoskeleton dynamics","volume":"208","author":"Albrecht","year":"2015","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.lfs.2025.124140_bb0500","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26052301","article-title":"Alternative splicing analysis reveals adrenergic signaling as a novel target for protein arginine methyltransferase 5 (PRMT5) in the heart","volume":"26","author":"Jiao","year":"2025","journal-title":"Int. J. Mol. Sci."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525007763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525007763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T05:06:06Z","timestamp":1768021566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525007763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":100,"alternative-id":["S0024320525007763"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.124140","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The PRMT-mediated arginine methylation: From molecular mechanisms to therapeutic targets in cardiovascular diseases","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.124140","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124140"}}