{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:08:41Z","timestamp":1771650521133,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20251967"],"award-info":[{"award-number":["BK20251967"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170877"],"award-info":[{"award-number":["82170877"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82205025"],"award-info":[{"award-number":["82205025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.lfs.2025.124151","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T17:21:26Z","timestamp":1765560086000},"page":"124151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["NIK suppresses AKT\/ACLY pathway-mediated lipogenesis in liver by stabilizing INPP5B during chronic ethanol exposure"],"prefix":"10.1016","volume":"386","author":[{"given":"Wen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manzhi","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2025.124151_bb0005","doi-asserted-by":"crossref","DOI":"10.1172\/JCI176345","article-title":"Alcohol-associated liver disease","volume":"134","author":"Mackowiak","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.lfs.2025.124151_bb0010","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1097\/HEP.0000000000000899","article-title":"Alcohol-associated liver disease-global epidemiology","volume":"80","author":"\u00c5berg","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2025.124151_bb0015","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1097\/HEP.0000000000000978","article-title":"Liver transplantation for alcohol-associated liver disease","volume":"80","author":"Simonetto","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2025.124151_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155402","article-title":"IL-8 exacerbates alcohol-induced fatty liver disease via the Akt\/HIF-1\u03b1 pathway in human IL-8-expressing mice","volume":"138","author":"Wang","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.lfs.2025.124151_bb0025","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1002\/jcp.30811","article-title":"Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-\u03baB signaling and reducing oxidative stress","volume":"237","author":"Lee","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2025.124151_bb0030","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1007\/s11010-022-04448-7","article-title":"Reverse pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating the levels of inflammatory cytokines in zebrafish larval model","volume":"477","author":"Sudhakaran","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.lfs.2025.124151_bb0035","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.7150\/thno.40149","article-title":"NIK links inflammation to hepatic steatosis by suppressing PPAR\u03b1 in alcoholic liver disease","volume":"10","author":"Li","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.lfs.2025.124151_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109176","article-title":"Roles of peroxisome proliferator-activated receptor \u03b1 in the pathogenesis of ethanol-induced liver disease","volume":"327","author":"Meng","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2025.124151_bb0045","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jcmgh.2022.09.010","article-title":"Interplay between liver type 1 innate lymphoid cells and NK cells drives the development of alcoholic steatohepatitis","volume":"15","author":"Cheng","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2025.124151_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108353","article-title":"Immune cells and their derived microRNA-enriched extracellular vesicles in nonalcoholic fatty liver diseases: novel therapeutic targets","volume":"243","author":"Yang","year":"2023","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2025.124151_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154113","article-title":"Protective effects of E Se tea extracts against alcoholic fatty liver disease induced by high fat\/alcohol diet: in vivo biological evaluation and molecular docking study","volume":"101","author":"Wang","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2025.124151_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25063496","article-title":"Hepatoprotective effect of allium ochotense extracts on chronic alcohol-induced fatty liver and hepatic inflammation in C57BL\/6 mice","volume":"25","author":"Go","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2025.124151_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.116321","article-title":"Vine tea (Ampelopsis grossedentata) ameliorates chronic alcohol-induced hepatic steatosis, oxidative stress, and inflammation via YTHDF2\/PGC-1\u03b1\/SIRT3 axis","volume":"209","author":"Luo","year":"2025","journal-title":"Food Res. Int."},{"key":"10.1016\/j.lfs.2025.124151_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/nu13114155","article-title":"Chlorogenic acid protects against advanced alcoholic steatohepatitis in rats via modulation of redox homeostasis, inflammation, and lipogenesis","volume":"13","author":"Buko","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2025.124151_bb0075","first-page":"81","article-title":"Noncanonical NF-\u03baB signaling pathway in liver diseases","volume":"9","author":"Chen","year":"2021","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.lfs.2025.124151_bb0080","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1210\/en.2016-1582","article-title":"Liver NF-\u03baB-inducing kinase promotes liver steatosis and glucose counterregulation in male mice with obesity","volume":"158","author":"Liu","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.lfs.2025.124151_bb0085","doi-asserted-by":"crossref","first-page":"18615","DOI":"10.1002\/jcp.28500","article-title":"Sirt6 deletion in hepatocytes increases insulin sensitivity of female mice by enhancing ER\u03b1 expression","volume":"234","author":"Tang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2025.124151_bb0090","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1038\/s41467-023-41757-x","article-title":"Cytoplasmic endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2025.124151_bb0095","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1093\/cvr\/cvad045","article-title":"Periodontitis exacerbates atherosclerosis through Fusobacterium nucleatum-promoted hepatic glycolysis and lipogenesis","volume":"119","author":"Zhou","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2025.124151_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101635","article-title":"Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy","volume":"36","author":"Gao","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2025.124151_bb0105","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1091\/mbc.e11-06-0489","article-title":"Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling","volume":"23","author":"Bohdanowicz","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.lfs.2025.124151_bb0110","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.252411","article-title":"Rab5 regulates macropinocytosis by recruiting the inositol 5-phosphatases OCRL and Inpp5b that hydrolyse PtdIns(4,5)P2","volume":"134","author":"Maxson","year":"2021","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.lfs.2025.124151_bb0115","first-page":"212","article-title":"Impact of binge drinking on alcoholic liver disease","volume":"48","author":"Kang","year":"2025","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.lfs.2025.124151_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.134809","article-title":"Oxidative stress in alcoholic liver disease, focusing on proteins, nucleic acids, and lipids: a review","volume":"278","author":"Lai","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.lfs.2025.124151_bb0125","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1097\/HEP.0000000000000303","article-title":"The outcome of boosting mitochondrial activity in alcohol-associated liver disease is organ-dependent","volume":"78","author":"Goikoetxea-Usandizaga","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2025.124151_bb0130","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jhep.2022.09.020","article-title":"Mitochondrial alterations in fatty liver diseases","volume":"78","author":"Fromenty","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2025.124151_bb0135","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/hep.23837","article-title":"Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3","volume":"52","author":"Ki","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2025.124151_bb0140","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nm.2756","article-title":"NF-\u03baB\u2013inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action","volume":"18","author":"Sheng","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.lfs.2025.124151_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315330","article-title":"The PI3K\/Akt pathway in meta-inflammation","volume":"23","author":"Acosta-Martinez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2025.124151_bb0150","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10571-018-0644-z","article-title":"Retinoic acid-induced protein 14 (RAI14) PROMOTES mTOR-mediated inflammation under inflammatory stress and chemical hypoxia in a U87 glioblastoma cell line","volume":"39","author":"Shen","year":"2019","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2025.124151_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217146","article-title":"ERBB3 targeting: a promising approach to overcoming cancer therapeutic resistance","volume":"599","author":"Chen","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lfs.2025.124151_bb0160","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.21037\/atm-21-2563","article-title":"Silencing c-Jun inhibits autophagy and abrogates radioresistance in nasopharyngeal carcinoma by activating the PI3K\/AKT\/mTOR pathway","volume":"9","author":"Sun","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.lfs.2025.124151_bb0165","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mce.2015.10.002","article-title":"The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus","volume":"419","author":"Kaur","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.lfs.2025.124151_bb0170","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/labinvest.2011.192","article-title":"ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival","volume":"92","author":"Zhang","year":"2011","journal-title":"Lab. Investig."},{"key":"10.1016\/j.lfs.2025.124151_bb0175","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s11427-010-4042-0","article-title":"Expression and function of heregulin-alpha and its receptors in the mouse mammary gland","volume":"53","author":"Geng","year":"2010","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.lfs.2025.124151_bb0180","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1073\/pnas.1115802109","article-title":"The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium","volume":"109","author":"Balko","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.lfs.2025.124151_bb0185","doi-asserted-by":"crossref","first-page":"G16","DOI":"10.1152\/ajpgi.00328.2005","article-title":"The emergence of ErbB2 expression in cultured rat hepatocytes correlates with enhanced and diversified EGF-mediated signaling","volume":"291","author":"Scheving","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2025.124151_bb0190","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ijcard.2019.03.003","article-title":"Remote ischemic perconditioning attenuates adverse cardiac remodeling and preserves left ventricular function in a rat model of reperfused myocardial infarction","volume":"285","author":"Pilz","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.lfs.2025.124151_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53419-4","article-title":"The inhibition of Bax activation-induced apoptosis by RasGRP2 via R-Ras-PI3K-Akt signaling pathway in the endothelial cells","volume":"9","author":"Takino","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2025.124151_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119183","article-title":"SeMet attenuates zearalenone-induced autophagy in rabbit kidney to alleviate apoptosis through activation of PI3K\/Akt\/mTOR signaling pathway","volume":"305","author":"Lv","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.lfs.2025.124151_bb0205","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.metabol.2016.02.014","article-title":"Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease","volume":"65","author":"Mota","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.lfs.2025.124151_bb0210","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s12072-020-10121-2","article-title":"How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?","volume":"15","author":"Geng","year":"2021","journal-title":"Hepatol. Int."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525007878?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320525007878?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:41:57Z","timestamp":1768970517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320525007878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":42,"alternative-id":["S0024320525007878"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2025.124151","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NIK suppresses AKT\/ACLY pathway-mediated lipogenesis in liver by stabilizing INPP5B during chronic ethanol exposure","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2025.124151","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124151"}}