{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:37:18Z","timestamp":1792460238930,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.lfs.2026.124216","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:21:01Z","timestamp":1768807261000},"page":"124216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["ERCC6L promotes cutaneous melanoma progression via PLK1-mediated aerobic glycolysis: Mechanisms and therapeutic implications"],"prefix":"10.1016","volume":"389","author":[{"given":"Mengdi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2026.124216_bb0005","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/jamadermatol.2022.0160","article-title":"Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040","volume":"158","author":"Arnold","year":"2022","journal-title":"JAMA Dermatol."},{"key":"10.1016\/j.lfs.2026.124216_bb0010","first-page":"1071","article-title":"Cutaneous melanoma: From pathogenesis to therapy (Review)","volume":"52","author":"Leonardi","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.lfs.2026.124216_bb0015","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.lfs.2026.124216_bb0020","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.hoc.2024.05.003","article-title":"Epidemiology and Screening for Melanoma","volume":"38","author":"Bolick","year":"2024","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"10.1016\/j.lfs.2026.124216_bb0025","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/bjd.15510","article-title":"The global burden of melanoma: results from the Global Burden of Disease Study 2015","volume":"177","author":"Karimkhani","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.lfs.2026.124216_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115881","article-title":"Cutaneous Melanoma: A Review of Multifactorial Pathogenesis, Immunohistochemistry, and Emerging Biomarkers for Early Detection and Management","volume":"24","author":"Gosman","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2026.124216_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032606","article-title":"Modulating Glycolysis to Improve Cancer Therapy","volume":"24","author":"Chelakkot","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2026.124216_bb0040","doi-asserted-by":"crossref","DOI":"10.1017\/erm.2022.42","article-title":"Lactate, histone lactylation and cancer hallmarks","volume":"25","author":"Lv","year":"2023","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.lfs.2026.124216_bb0045","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1158\/1078-0432.CCR-23-3053","article-title":"Onvansertib in Combination with FOLFIRI and Bevacizumab in Second-Line Treatment of KRAS-Mutant Metastatic Colorectal Cancer: A Phase Ib Clinical Study","volume":"30","author":"Ahn","year":"2024","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.lfs.2026.124216_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1507\/endocrj.EJ19-0335","article-title":"Newer perspective on the coupling between glucose-mediated signaling and beta-cell functionality","volume":"67","author":"Shirakawa","year":"2020","journal-title":"Endocr. J."},{"key":"10.1016\/j.lfs.2026.124216_bb0055","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1038\/s41388-025-03571-1","article-title":"PLK1-mediated PDHA1 phosphorylation drives metabolic reprogramming in lung cancer","volume":"44","author":"Peng","year":"2025","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2026.124216_bb0060","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1158\/1535-7163.MCT-20-0654","article-title":"PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways","volume":"20","author":"Su","year":"2021","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.lfs.2026.124216_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/genes9120623","article-title":"The Unresolved Problem of DNA Bridging","volume":"9","author":"Fernandez-Casanas","year":"2018","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.lfs.2026.124216_bb0070","doi-asserted-by":"crossref","first-page":"42116","DOI":"10.18632\/oncotarget.14998","article-title":"ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers","volume":"8","author":"Pu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.lfs.2026.124216_bb0075","first-page":"237","article-title":"ERCC6L promotes cell growth and invasion in human colorectal cancer","volume":"18","author":"Xie","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.lfs.2026.124216_bb0080","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1186\/s12885-022-10452-3","article-title":"A pan-cancer analysis of the oncogenic role of ERCC6L","volume":"22","author":"Lu","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.lfs.2026.124216_bb0085","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.21037\/jgo-20-192","article-title":"Upregulation of ERCC6L is associated with tumor progression and unfavorable prognosis in hepatocellular carcinoma","volume":"11","author":"Yu","year":"2020","journal-title":"J. Gastrointest. Oncol."},{"key":"10.1016\/j.lfs.2026.124216_bb0090","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1080\/14737140.2025.2518278","article-title":"RASGEF1C affects aerobic glycolysis and facilitates lung cancer progression through the PLK1 signaling pathway","volume":"25","author":"Wu","year":"2025","journal-title":"Expert. Rev. Anticancer. Ther."},{"key":"10.1016\/j.lfs.2026.124216_bb0095","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1128\/MCB.00814-14","article-title":"Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state","volume":"34","author":"Li","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.lfs.2026.124216_bb0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.canlet.2017.02.013","article-title":"Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma","volume":"394","author":"Gutteridge","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.lfs.2026.124216_bb0105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41417-018-0064-8","article-title":"ERCC6L that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating MAPK signalling pathway","volume":"26","author":"Zhang","year":"2019","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.lfs.2026.124216_bb0110","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s10620-020-06277-4","article-title":"Upregulation of Excision Repair Cross-Complementation Group 6-Like (ERCC6L) Promotes Tumor Growth in Hepatocellular Carcinoma","volume":"66","author":"Zhang","year":"2021","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.lfs.2026.124216_bb0115","doi-asserted-by":"crossref","first-page":"992","DOI":"10.14336\/AD.2022.1021","article-title":"An Integrative Multi-Omics Analysis of The Molecular Links between Aging and Aggressiveness in Thyroid Cancers","volume":"14","author":"Ruiz","year":"2023","journal-title":"Aging Dis."},{"key":"10.1016\/j.lfs.2026.124216_bb0120","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41420-023-01609-5","article-title":"Correction: ERCC6L facilitates the progression of laryngeal squamous cell carcinoma by the binding of FOXM1 and KIF4A","volume":"9","author":"Cui","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.lfs.2026.124216_bb0125","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1186\/s12885-020-07367-2","article-title":"ERCC6L promotes the progression of hepatocellular carcinoma through activating PI3K\/AKT and NF-kappaB signaling pathway","volume":"20","author":"Chen","year":"2020","journal-title":"BMC Cancer"},{"key":"10.1016\/j.lfs.2026.124216_bb0130","doi-asserted-by":"crossref","first-page":"20218","DOI":"10.18632\/aging.203387","article-title":"ERCC6L promotes cell growth and metastasis in gastric cancer through activating NF-kappaB signaling","volume":"13","author":"Chen","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.lfs.2026.124216_bb0135","doi-asserted-by":"crossref","first-page":"14190","DOI":"10.1038\/s41598-018-31170-6","article-title":"Mitochondrial transcription factor A (TFAM) shapes metabolic and invasion gene signatures in melanoma","volume":"8","author":"Araujo","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2026.124216_bb0140","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41419-021-03523-z","article-title":"Long noncoding RNA LINC00518 induces radioresistance by regulating glycolysis through an miR-33a-3p\/HIF-1alpha negative feedback loop in melanoma","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2026.124216_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/cells10113197","article-title":"Mitochondrial Metabolism in Melanoma","volume":"10","author":"Huang","year":"2021","journal-title":"Cells"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052600024X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052600024X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:21:11Z","timestamp":1770830471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002432052600024X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":29,"alternative-id":["S002432052600024X"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124216","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ERCC6L promotes cutaneous melanoma progression via PLK1-mediated aerobic glycolysis: Mechanisms and therapeutic implications","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124216","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124216"}}