{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:48:13Z","timestamp":1790372893608,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["SCU2023D006"],"award-info":[{"award-number":["SCU2023D006"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160066"],"award-info":[{"award-number":["32160066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019542","name":"Basic Research Project of Wenzhou City","doi-asserted-by":"publisher","award":["Y20240013"],"award-info":[{"award-number":["Y20240013"]}],"id":[{"id":"10.13039\/501100019542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["25JRRA066"],"award-info":[{"award-number":["25JRRA066"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["JRRA066"],"award-info":[{"award-number":["JRRA066"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["25JRRA070"],"award-info":[{"award-number":["25JRRA070"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2024KF02"],"award-info":[{"award-number":["2024KF02"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.lfs.2026.124255","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T07:50:56Z","timestamp":1770364256000},"page":"124255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Ferroptosis in plants: Regulatory mechanisms and potential applications from plant physiology to human diseases"],"prefix":"10.1016","volume":"390","author":[{"given":"Fang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3762-6421","authenticated-orcid":false,"given":"Yonggang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.lfs.2026.124255_bb0005","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.lfs.2026.124255_bb0010","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1105\/tpc.18.00535","article-title":"Iron- and reactive oxygen species-dependent ferroptotic cell death in rice-Magnaporthe oryzae interactions","volume":"31","author":"Dangol","year":"2019","journal-title":"Plant Cell"},{"issue":"2","key":"10.1016\/j.lfs.2026.124255_bb0015","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1083\/jcb.201605110","article-title":"Heat stress induces ferroptosis-like cell death in plants","volume":"216","author":"DIST\u00e9FANO","year":"2017","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.lfs.2026.124255_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.xplc.2025.101299","article-title":"Ferroptosis in plant immunity","volume":"6","author":"Jwa","year":"2025","journal-title":"Plant Commun."},{"issue":"1","key":"10.1016\/j.lfs.2026.124255_bb0025","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/nph.70428","article-title":"Abolishment of N-glycan trimming in the early Golgi triggers ferroptosis under salt stress in Arabidopsis root tips","volume":"249","author":"Li","year":"2026","journal-title":"New Phytol."},{"issue":"3","key":"10.1016\/j.lfs.2026.124255_bb0030","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"12","key":"10.1016\/j.lfs.2026.124255_bb0035","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1016\/j.apsb.2021.03.036","article-title":"Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1","volume":"11","author":"Kong","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.lfs.2026.124255_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153370","article-title":"Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2\/HO-1 axis in EGFR wild-type non-small-cell lung cancer","volume":"80","author":"Lou","year":"2021","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.lfs.2026.124255_bb0045","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/1759-7714.13904","article-title":"Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy","volume":"12","author":"Tang","year":"2021","journal-title":"Thorac. Cancer"},{"issue":"1","key":"10.1016\/j.lfs.2026.124255_bb0050","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-024-02213-6","article-title":"Tailoring traditional Chinese medicine in cancer therapy","volume":"24","author":"Li","year":"2025","journal-title":"Mol. Cancer"},{"issue":"6","key":"10.1016\/j.lfs.2026.124255_bb0055","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s10753-013-9663-6","article-title":"Therapeutic effect of emodin on collagen-induced arthritis in mice","volume":"36","author":"Zhu","year":"2013","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.lfs.2026.124255_bb0060","first-page":"177","article-title":"Modulation of ferroptosis by poria acid via the Nrf2\/SLC7A11\/GPX4 signaling pathway ameliorates cognitive impairment in rats with Alzheimer\u2019s disease","volume":"27","author":"Fan","year":"2024","journal-title":"Chin. Gen. Pract."},{"key":"10.1016\/j.lfs.2026.124255_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115021","article-title":"Rehmannioside a improves cognitive impairment and alleviates ferroptosis via activating PI3K\/AKT\/Nrf2 and SLC7A11\/GPX4 signaling pathway after ischemia","volume":"289","author":"Fu","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.lfs.2026.124255_bb0070","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1002\/ptr.8423","article-title":"Mangiferin attenuates myocardial ischemia reperfusion injury by regulating the GAS6\/Axl signaling pathway","volume":"39","author":"Zhao","year":"2025","journal-title":"Phytother. Res."},{"key":"10.1016\/j.lfs.2026.124255_bb0075","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3737137","article-title":"Ginsenoside Rg1 ameliorates acute renal ischemia\/reperfusion injury via upregulating AMPK\u03b11 expression","volume":"2022","author":"Zhou","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.lfs.2026.124255_bb0080","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tibs.2015.11.012","article-title":"Regulators of iron homeostasis: new players in metabolism, cell death, and disease","volume":"41","author":"Bogdan","year":"2016","journal-title":"Trends Biochem. Sci."},{"issue":"2","key":"10.1016\/j.lfs.2026.124255_bb0085","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.lfs.2026.124255_bb0090","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124255_bb0095","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"issue":"34","key":"10.1016\/j.lfs.2026.124255_bb0100","doi-asserted-by":"crossref","first-page":"E4966","DOI":"10.1073\/pnas.1603244113","article-title":"Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.lfs.2026.124255_bb0105","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"Kagan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.lfs.2026.124255_bb0110","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.lfs.2026.124255_bb0115","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","article-title":"Lipid peroxidation and ferroptosis: the role of GSH and GPx4","volume":"152","author":"Ursini","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"7679","key":"10.1016\/j.lfs.2026.124255_bb0120","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature24297","article-title":"Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition","volume":"551","author":"Hangauer","year":"2017","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.lfs.2026.124255_bb0125","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2026.124255_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2024.1326345","article-title":"Ecophysiological responses of Phragmites australis populations to a tidal flat gradient in the Yangtze River estuary, China","volume":"15","author":"Jia","year":"2024","journal-title":"Front. Plant Sci."},{"issue":"8","key":"10.1016\/j.lfs.2026.124255_bb0135","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.tplants.2023.03.007","article-title":"Beyond iron-storage pool: functions of plant apoplastic iron during stress","volume":"28","author":"Liu","year":"2023","journal-title":"Trends Plant Sci."},{"issue":"6","key":"10.1016\/j.lfs.2026.124255_bb0140","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.tplants.2019.03.005","article-title":"Ferroptosis: yet another way to die","volume":"24","author":"Kazan","year":"2019","journal-title":"Trends Plant Sci."},{"issue":"13","key":"10.1016\/j.lfs.2026.124255_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.05.003","article-title":"The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling","volume":"184","author":"Bi","year":"2021","journal-title":"Cell"},{"issue":"6435","key":"10.1016\/j.lfs.2026.124255_bb0150","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav5868","article-title":"Ligand-triggered allosteric ADP release primes a plant NLR complex","volume":"364","author":"Wang","year":"2019","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.lfs.2026.124255_bb0155","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1093\/jxb\/eraa425","article-title":"Ferroptosis in plants: triggers, proposed mechanisms, and the role of iron in modulating cell death","volume":"72","author":"DIST\u00e9FANO","year":"2021","journal-title":"J. Exp. Bot."},{"issue":"1","key":"10.1016\/j.lfs.2026.124255_bb0160","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-49099-y","article-title":"Ferroptosis induction in host rice by endophyte OsiSh-2 is necessary for mutualism and disease resistance in symbiosis","volume":"15","author":"Xiong","year":"2024","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.lfs.2026.124255_bb0165","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1111\/ijfs.17210","article-title":"Antifungal activity of Cinnamomum camphora essential oil against Fusarium oxysporum and its application on postharvest blueberry fruits preservation","volume":"59","author":"Chen","year":"2024","journal-title":"Int. J. Food Sci. Technol."},{"issue":"3","key":"10.1016\/j.lfs.2026.124255_bb0170","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1142\/S0192415X23500271","article-title":"Targeting ferroptosis in cancer by natural products: an updated review","volume":"51","author":"Guo","year":"2023","journal-title":"Am. J. Chin. Med."},{"issue":"5","key":"10.1016\/j.lfs.2026.124255_bb0175","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.7150\/ijbs.77979","article-title":"Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation","volume":"19","author":"Zhou","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2026.124255_bb0180","doi-asserted-by":"crossref","DOI":"10.3892\/ol.2020.12332","article-title":"Effective ferroptotic small-cell lung cancer cell death from SLC7A11 inhibition by sulforaphane","volume":"21","author":"Iida","year":"2021","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.lfs.2026.124255_bb0185","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1186\/s12931-024-03076-7","article-title":"Ferritinophagy mediated by the AMPK\/ULK1 pathway is involved in ferroptosis subsequent to ventilator-induced lung injury","volume":"25","author":"Ou","year":"2024","journal-title":"Respir. Res."},{"key":"10.1016\/j.lfs.2026.124255_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.759346","article-title":"MiR-27a-3p promotes non-small cell lung cancer through SLC7A11-mediated-ferroptosis","volume":"11","author":"Lu","year":"2021","journal-title":"Front. Oncol."},{"issue":"11","key":"10.1016\/j.lfs.2026.124255_bb0195","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1089\/ars.2008.2089","article-title":"Molecular mechanisms and clinical implications of reversible protein S-glutathionylation","volume":"10","author":"Mieyal","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2026.124255_bb0200","first-page":"23","article-title":"Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19\/miR-19b-3p\/FTH1 axis","volume":"13","author":"Zhang","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.lfs.2026.124255_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154950","article-title":"Ginsenoside Rh2 promotes hepatic stellate cell ferroptosis and inactivation via regulation of IRF1-inhibited SLC7A11","volume":"118","author":"Lang","year":"2023","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.lfs.2026.124255_bb0210","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18335","article-title":"Dihydroartemisinin induces ferroptosis of hepatocellular carcinoma via inhibiting ATF4-xCT pathway","volume":"28","author":"Ji","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2026.124255_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155177","article-title":"Cucurbitacin B suppresses hepatocellular carcinoma progression through inducing DNA damage-dependent cell cycle arrest","volume":"126","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.lfs.2026.124255_bb0220","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1039\/D2FO02716J","article-title":"Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation","volume":"14","author":"Li","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.lfs.2026.124255_bb0225","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbrc.2023.06.086","article-title":"Saikosaponin a triggers cell ferroptosis in hepatocellular carcinoma by inducing endoplasmic reticulum stress-stimulated ATF3 expression","volume":"674","author":"Lan","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2026.124255_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113524","article-title":"Ferroptosis in colorectal cancer: potential mechanisms and effective therapeutic targets","volume":"153","author":"Wang","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"7","key":"10.1016\/j.lfs.2026.124255_bb0235","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.tem.2024.09.003","article-title":"Targeting ACSLs to modulate ferroptosis and cancer immunity","volume":"36","author":"Lin","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"issue":"18","key":"10.1016\/j.lfs.2026.124255_bb0240","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800311","article-title":"GPX4 at the crossroads of lipid homeostasis and ferroptosis","volume":"19","author":"Forcina","year":"2019","journal-title":"Proteomics"},{"issue":"4","key":"10.1016\/j.lfs.2026.124255_bb0245","article-title":"Shikonin derivative suppresses colorectal cancer cells growth via reactive oxygen species-mediated mitochondrial apoptosis and PI3K\/AKT pathway","volume":"22","author":"Han","year":"2025","journal-title":"Chem. Biodivers."},{"issue":"11","key":"10.1016\/j.lfs.2026.124255_bb0250","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.7150\/thno.44705","article-title":"Combinative treatment of \u03b2-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.lfs.2026.124255_bb0255","doi-asserted-by":"crossref","DOI":"10.1177\/09603271241266106","article-title":"Sulforaphane triggers sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5\u2032-monophosphate (AMP)-activated protein kinase\/ mechanistic target of rapamycin signaling pathway","volume":"43","author":"Hu","year":"2024","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.lfs.2026.124255_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156860","article-title":"Serum pharmacochemistry and network pharmacology reveal the effect and mechanism of licorice extracts on colorectal cancer","volume":"145","author":"Li","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2026.124255_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119359","article-title":"Synergistic efficacy of curcumin and anti-programmed cell death-1 in hepatocellular carcinoma","volume":"279","author":"Guo","year":"2021","journal-title":"Life Sci."},{"issue":"11","key":"10.1016\/j.lfs.2026.124255_bb0270","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.7150\/ijbs.59404","article-title":"Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells","volume":"17","author":"Wei","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2026.124255_bb0275","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/toxres\/tfad021","article-title":"Resveratrol inhibits AhR\/notch axis and reverses Th17\/Treg imbalance in purpura by activating Foxp3","volume":"12","author":"Cheng","year":"2023","journal-title":"Toxicol. Res. (Camb.)."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2026.124255_bb0280","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11010-017-3230-7","article-title":"Evaluation of the effect of the new methoxy-stilbenes on expression of receptors and enzymes involved in estrogen synthesis in cancer breast cells","volume":"444","author":"Licznerska","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.lfs.2026.124255_bb0285","article-title":"Ginsenoside Rg3 targets glycosylation of PD-L1 to enhance anti-tumor immunity in non-small cell lung cancer","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.lfs.2026.124255_bb0290","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.18632\/oncotarget.6451","article-title":"Ginsenoside Rg3 inhibits epithelial-mesenchymal transition (EMT) and invasion of lung cancer by down-regulating FUT4","volume":"7","author":"Tian","year":"2016","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.lfs.2026.124255_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2021.02.015","article-title":"CD36-mediated ferroptosis dampens intratumoral CD8(+) T cell effector function and impairs their antitumor ability","volume":"33","author":"Ma","year":"2021","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.lfs.2026.124255_bb0300","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1142\/S0192415X2450023X","article-title":"Quercetin limits tumor immune escape through PDK1\/CD47 axis in melanoma","volume":"52","author":"Li","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.lfs.2026.124255_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.107032","article-title":"Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: a comprehensive review with future perspectives","volume":"199","author":"Wang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2026.124255_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2024.102137","article-title":"Inhibition of hERG by ESEE suppresses the progression of colorectal cancer","volume":"50","author":"Wan","year":"2024","journal-title":"Transl. Oncol."},{"issue":"2","key":"10.1016\/j.lfs.2026.124255_bb0315","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ki.2013.343","article-title":"Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-\u03baB-mediated inflammatory response","volume":"85","author":"Jiang","year":"2014","journal-title":"Kidney Int."},{"issue":"11","key":"10.1016\/j.lfs.2026.124255_bb0320","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1002\/ptr.70092","article-title":"Crocin attenuates Nrf2\/GPX4 mediated ferroptosis in obstructive nephropathy by selectively targeting MKK4","volume":"39","author":"Xu","year":"2025","journal-title":"Phytother. Res."},{"key":"10.1016\/j.lfs.2026.124255_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177846","article-title":"Investigating the role of 1,8-cineole in mitigating ferroptosis in a HFSD\/STZ diabetes mellitus type 2-induced model: a GEO data analysis approach","volume":"1002","author":"Yang","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2026.124255_bb0330","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.689044","article-title":"Potential implications of quercetin in autoimmune diseases","volume":"12","author":"Shen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2026.124255_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105580","article-title":"Regulation of ferroptosis by bioactive phytochemicals: implications for medical nutritional therapy","volume":"168","author":"Zheng","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2026.124255_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111459","article-title":"The anti-Alzheimer\u2019s disease effects of ganoderic acid a by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2\/SLC7A11\/GPX4 signaling pathway","volume":"412","author":"Lu","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.lfs.2026.124255_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117101","article-title":"Pharmacological mechanisms of puerarin in the treatment of Parkinson\u2019s disease: an overview","volume":"177","author":"Zhang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2026.124255_bb0350","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.freeradbiomed.2022.09.001","article-title":"Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway","volume":"191","author":"Xie","year":"2022","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.lfs.2026.124255_bb0355","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.lfs.2026.124255_bb0360","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuroscience.2022.10.020","article-title":"Emerging treatment strategies for cerebral ischemia-reperfusion injury","volume":"507","author":"Li","year":"2022","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.lfs.2026.124255_bb0365","doi-asserted-by":"crossref","first-page":"2164813","DOI":"10.1080\/08941939.2022.2164813","article-title":"Curcumin alleviates hepatic ischemia-reperfusion injury by inhibiting neutrophil extracellular traps formation","volume":"36","author":"Zhu","year":"2023","journal-title":"J. Investig. Surg."},{"key":"10.1016\/j.lfs.2026.124255_bb0370","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.freeradbiomed.2018.10.439","article-title":"Iron transport and its regulation in plants","volume":"133","author":"Kobayashi","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"5937","key":"10.1016\/j.lfs.2026.124255_bb0375","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1126\/science.1168243","article-title":"Drug discovery and natural products: end of an era or an endless frontier?","volume":"325","author":"Li","year":"2009","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.lfs.2026.124255_bb0380","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: problems and promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharm."},{"issue":"7","key":"10.1016\/j.lfs.2026.124255_bb0385","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.lfs.2026.124255_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105580","article-title":"Regulation of ferroptosis by bioactive phytochemicals: implications for medical nutritional therapy","volume":"168","author":"Zheng","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.lfs.2026.124255_bb0395","doi-asserted-by":"crossref","DOI":"10.1177\/1177932219899051","article-title":"Multi-omics data integration, interpretation, and its application","volume":"14","author":"Subramanian","year":"2020","journal-title":"Bioinform. Biol. Insights"},{"issue":"1","key":"10.1016\/j.lfs.2026.124255_bb0400","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12951-018-0392-8","article-title":"Nano based drug delivery systems: recent developments and future prospects","volume":"16","author":"Patra","year":"2018","journal-title":"J. Nanobiotechnol."},{"issue":"5","key":"10.1016\/j.lfs.2026.124255_bb0405","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526000639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526000639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T01:18:00Z","timestamp":1772241480000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526000639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":81,"alternative-id":["S0024320526000639"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124255","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroptosis in plants: Regulatory mechanisms and potential applications from plant physiology to human diseases","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124255","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124255"}}