{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:16:58Z","timestamp":1777627018938,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.lfs.2026.124282","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T15:57:05Z","timestamp":1771516625000},"page":"124282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Transcriptional and post-transcriptional activation of GATA4 contributes to liver regeneration"],"prefix":"10.1016","volume":"392","author":[{"given":"Xiulian","family":"Miao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanwen","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2026.124282_bb0005","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrgastro.2016.97","article-title":"Liver regeneration - mechanisms and models to clinical application","volume":"13","author":"Forbes","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2026.124282_bb0010","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.141024","article-title":"Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration","volume":"5","author":"Chen","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.lfs.2026.124282_bb0015","article-title":"Sequential activation of transcription factors promotes liver regeneration through specific and developmental enhancers","volume":"5","author":"Llorens-Giralt","year":"2025","journal-title":"Cell Genom."},{"key":"10.1016\/j.lfs.2026.124282_bb0020","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1073\/pnas.83.17.6489","article-title":"Purification and characterization of a growth factor from rat platelets for mature parenchymal hepatocytes in primary cultures","volume":"83","author":"Nakamura","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.lfs.2026.124282_bb0025","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/emmm.201000085","article-title":"Regulation of liver regeneration by growth factors and cytokines","volume":"2","author":"Bohm","year":"2010","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.lfs.2026.124282_bb0030","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.274.5291.1379","article-title":"Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice","volume":"274","author":"Cressman","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.lfs.2026.124282_bb0035","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1073\/pnas.0306068101","article-title":"Hepatocyte growth factor\/c-met signaling pathway is required for efficient liver regeneration and repair","volume":"101","author":"Huh","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.lfs.2026.124282_bb0040","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1080\/15384101.2018.1542893","article-title":"Role of IL-17RA in the proliferative priming of hepatocytes in liver regeneration","volume":"17","author":"Piobbico","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.lfs.2026.124282_bb0045","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1073\/pnas.94.4.1441","article-title":"Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor","volume":"94","author":"Yamada","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.lfs.2026.124282_bb0050","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jcmgh.2019.09.006","article-title":"The dynamic chromatin architecture of the regenerating liver","volume":"9","author":"Wang","year":"2020","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2026.124282_bb0055","doi-asserted-by":"crossref","DOI":"10.1242\/dev.164384","article-title":"GATA transcription factors in development and disease","volume":"145","author":"Tremblay","year":"2018","journal-title":"Development"},{"key":"10.1016\/j.lfs.2026.124282_bb0060","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-213X-7-37","article-title":"Development of the mammalian liver and ventral pancreas is dependent on GATA4","volume":"7","author":"Watt","year":"2007","journal-title":"BMC Dev. Biol."},{"key":"10.1016\/j.lfs.2026.124282_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083723","article-title":"Function of GATA factors in the adult mouse liver","volume":"8","author":"Zheng","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2026.124282_bb0070","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jhep.2020.08.033","article-title":"Endothelial GATA4 controls liver fibrosis and regeneration by preventing a pathogenic switch in angiocrine signaling","volume":"74","author":"Winkler","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2026.124282_bb0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-04944-0","article-title":"Trans-activation of eotaxin-1 by Brg1 contributes to liver regeneration","volume":"13","author":"Fan","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2026.124282_bb0080","article-title":"Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation","volume":"5","author":"Jiang","year":"2023","journal-title":"JHEP Rep. Innov. Hepatol."},{"key":"10.1016\/j.lfs.2026.124282_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.705302","article-title":"Choline kinase alpha is a novel transcriptional target of the Brg1 in hepatocyte: implication in liver regeneration","volume":"9","author":"Kong","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2026.124282_bb0090","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1016\/j.bbadis.2018.08.003","article-title":"The chromatin remodeling protein BRG1 regulates APAP-induced liver injury by modulating CYP3A11 transcription in hepatocyte","volume":"1864","author":"Li","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.lfs.2026.124282_bb0095","article-title":"TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response","volume":"14","author":"Sun","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2026.124282_bb0100","doi-asserted-by":"crossref","first-page":"22237","DOI":"10.1073\/pnas.1015793108","article-title":"Hepatocyte-specific deletion of DDB1 induces liver regeneration and tumorigenesis","volume":"107","author":"Yamaji","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.lfs.2026.124282_bb0105","doi-asserted-by":"crossref","first-page":"15745","DOI":"10.1074\/jbc.M112.439844","article-title":"NADPH oxidase 4 regulates cardiomyocyte differentiation via redox activation of c-Jun protein and the cis-regulation of GATA-4 gene transcription","volume":"288","author":"Murray","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2026.124282_bb0110","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/emboj\/21.7.1782","article-title":"Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver","volume":"21","author":"Behrens","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.lfs.2026.124282_bb0115","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1101\/gad.390506","article-title":"c-Jun\/AP-1 controls liver regeneration by repressing p53\/p21 and p38 MAPK activity","volume":"20","author":"Stepniak","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.lfs.2026.124282_bb0120","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1038\/onc.2009.86","article-title":"Proliferation defects and genome instability in cells lacking Cul4A","volume":"28","author":"Kopanja","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2026.124282_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101085","article-title":"Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo","volume":"42","author":"Mittenbuhler","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.lfs.2026.124282_bb0130","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-017-0449-4","article-title":"A novel lncRNA uc.134 represses hepatocellular carcinoma progression by inhibiting CUL4A-mediated ubiquitination of LATS1","volume":"10","author":"Ni","year":"2017","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.lfs.2026.124282_bb0135","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202215924","article-title":"Targeting WDxR motif reprograms immune microenvironment and inhibits hepatocellular carcinoma progression","volume":"15","author":"Zhang","year":"2023","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.lfs.2026.124282_bb0140","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1002\/hep.27005","article-title":"GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis in mice","volume":"59","author":"Delgado","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2026.124282_bb0145","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.150059","article-title":"GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells","volume":"6","author":"Arroyo","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.lfs.2026.124282_bb0150","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1101\/gad.350145.122","article-title":"Hepatic GATA4 regulates cholesterol and triglyceride homeostasis in collaboration with LXRs","volume":"36","author":"Bideyan","year":"2022","journal-title":"Genes Dev."},{"key":"10.1016\/j.lfs.2026.124282_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109157","article-title":"Deleting Gata4 in hepatocytes promoted the progression of NAFLD via increasing steatosis and apoptosis, and desensitizing insulin signaling","volume":"111","author":"He","year":"2023","journal-title":"J. Nutr. Biochem."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526000901?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526000901?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:48:24Z","timestamp":1777423704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526000901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":31,"alternative-id":["S0024320526000901"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124282","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptional and post-transcriptional activation of GATA4 contributes to liver regeneration","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124282","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124282"}}