{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:00:10Z","timestamp":1777496410031,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012434","name":"Middle-aged and Young Teachers' Basic Ability Promotion Project of Guangxi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["AB24010080"],"award-info":[{"award-number":["AB24010080"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["AB20159031"],"award-info":[{"award-number":["AB20159031"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012470","name":"Doctoral Program Foundation of Institutions of Higher Education of China","doi-asserted-by":"publisher","award":["YCBZ2022081"],"award-info":[{"award-number":["YCBZ2022081"]}],"id":[{"id":"10.13039\/501100012470","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009329","name":"Scientific Research and Technology Development Program of Guangxi","doi-asserted-by":"publisher","award":["Z20210809"],"award-info":[{"award-number":["Z20210809"]}],"id":[{"id":"10.13039\/501100009329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2024GXNSFBA010058"],"award-info":[{"award-number":["2024GXNSFBA010058"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960281"],"award-info":[{"award-number":["81960281"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260306"],"award-info":[{"award-number":["82260306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013091","name":"Science and Technology Major Project of Guangxi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018602","name":"Guangxi Innovation-Driven Development Project","doi-asserted-by":"publisher","award":["YYZS2022006"],"award-info":[{"award-number":["YYZS2022006"]}],"id":[{"id":"10.13039\/501100018602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.lfs.2026.124316","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:57:49Z","timestamp":1773129469000},"page":"124316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["LncRNA SNHG1 promotes the development of preeclampsia by interacting with PTBP1 and modulating NGFR mRNA stability"],"prefix":"10.1016","volume":"392","author":[{"given":"Linlin","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shijin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjie","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2026.124316_bb0005","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1016\/j.jacc.2020.03.028","article-title":"Incidence and long-term outcomes of hypertensive disorders of pregnancy","volume":"75","author":"Garovic","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2026.124316_bb0010","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(15)00070-7","article-title":"Pre-eclampsia","volume":"387","author":"Mol","year":"2016","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.lfs.2026.124316_bb0015","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/uog.26032","article-title":"Clinical utility of sFlt-1 and PlGF in screening, prediction, diagnosis and monitoring of pre-eclampsia and fetal growth restriction","volume":"61","author":"Stepan","year":"2023","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2026.124316_bb0020","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.omtn.2020.09.033","article-title":"Preeclampsia-associated lncRNA INHBA-AS1 regulates the proliferation, invasion, and migration of placental trophoblast cells","volume":"22","author":"Jiang","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.lfs.2026.124316_bb0025","doi-asserted-by":"crossref","first-page":"S1108","DOI":"10.1016\/j.ajog.2020.08.045","article-title":"Prevention of preeclampsia with aspirin","volume":"226","author":"Rolnik","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2026.124316_bb0030","article-title":"Pre-eclampsia","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.lfs.2026.124316_bb0035","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.3390\/ijms20112837","article-title":"The role of epigenetics in placental development and the etiology of preeclampsia","volume":"20","author":"Apicella","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2026.124316_bb0040","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1161\/HYPERTENSIONAHA.122.20085","article-title":"BCAM deficiency may contribute to preeclampsia by suppressing the PIK3R6\/p-STAT3 signaling","volume":"79","author":"Liu","year":"2022","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2026.124316_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2024.01.008","article-title":"OLFML3 suppresses trophoblast apoptosis via the PI3K\/AKT pathway: a possible therapeutic target in preeclampsia","volume":"147","author":"Chen","year":"2024","journal-title":"Placenta"},{"key":"10.1016\/j.lfs.2026.124316_bb0050","first-page":"1","article-title":"Cooperation between NSPc1 and DNA methylation represses HOXA11 expression and promotes apoptosis of trophoblast cells during preeclampsia","volume":"55","author":"Xie","year":"2023","journal-title":"Acta Biochim. Biophys. Sin. Shanghai"},{"key":"10.1016\/j.lfs.2026.124316_bb0055","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1210\/er.2005-0003","article-title":"The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy","volume":"26","author":"Straszewski-Chavez","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.lfs.2026.124316_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.102.014977","article-title":"Endovascular trophoblast invasion: Implications for the pathogenesis of intrauterine growth retardation and preeclampsia","volume":"69","author":"Kaufmann","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.lfs.2026.124316_bb0065","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tig.2017.11.005","article-title":"Nuclear long noncoding RNAs: Key regulators of gene expression","volume":"34","author":"Sun","year":"2018","journal-title":"Trends Genet."},{"key":"10.1016\/j.lfs.2026.124316_bb0070","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev-animal-020420-031544","article-title":"The coevolution of placentation and cancer","volume":"10","author":"Wagner","year":"2022","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"10.1016\/j.lfs.2026.124316_bb0075","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/humupd\/dmaa017","article-title":"Investigation of human trophoblast invasion in vitro","volume":"26","author":"Abbas","year":"2020","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.lfs.2026.124316_bb0080","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12958-021-00783-4","article-title":"Roles of noncoding RNAs in preeclampsia","volume":"19","author":"Sun","year":"2021","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.lfs.2026.124316_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119121","article-title":"Long noncoding RNA expression profiling identifies MIR210HG as a novel molecule in severe preeclampsia","volume":"270","author":"Lei","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2026.124316_bb0090","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s12958-022-01036-8","article-title":"The long noncoding RNA TARID regulates the CXCL3\/ERK\/MAPK pathway in trophoblasts and is associated with preeclampsia","volume":"20","author":"Liao","year":"2022","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.lfs.2026.124316_bb0095","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/s41419-022-05256-z","article-title":"LncRNA SNHG1 regulates neuroblastoma cell fate via interactions with HDAC1\/2","volume":"13","author":"Hsu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2026.124316_bb0100","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3389\/fonc.2020.00389","article-title":"An emerging class of long non-coding RNA with oncogenic role arises from the snorna host genes","volume":"10","author":"Zimta","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.lfs.2026.124316_bb0105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s11658-023-00492-3","article-title":"lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization","volume":"28","author":"Han","year":"2023","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.lfs.2026.124316_bb0110","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1038\/cdd.2016.60","article-title":"PTBP1 modulation of MCL1 expression regulates cellular apoptosis induced by antitubulin chemotherapeutics","volume":"23","author":"Cui","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.lfs.2026.124316_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910652","article-title":"Non-coding RNAs in preeclampsia-molecular mechanisms and diagnostic potential","volume":"22","author":"Munjas","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2026.124316_bb0120","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.semcdb.2022.03.039","article-title":"Human placental development and function","volume":"131","author":"Cindrova-Davies","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.lfs.2026.124316_bb0125","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41580-020-00315-9","article-title":"Gene regulation by long non-coding RNAs and its biological functions","volume":"22","author":"Statello","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.lfs.2026.124316_bb0130","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/hep.28882","article-title":"Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay","volume":"65","author":"Zhang","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2026.124316_bb0135","doi-asserted-by":"crossref","first-page":"14270","DOI":"10.1002\/jcp.28126","article-title":"Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5","volume":"234","author":"Liu","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.lfs.2026.124316_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.113705","article-title":"NGFR regulates stromal cell activation in germinal centers","volume":"43","author":"Hern\u00e1ndez-Barranco","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.lfs.2026.124316_bb0145","doi-asserted-by":"crossref","first-page":"11911","DOI":"10.1523\/JNEUROSCI.0591-15.2015","article-title":"Detection of p75NTR trimers: Implications for receptor stoichiometry and activation","volume":"35","author":"Anastasia","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.lfs.2026.124316_bb0150","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/bs.vh.2016.10.007","article-title":"Structural characterization of the p75 neurotrophin receptor: A stranger in the TNFR superfamily","volume":"104","author":"Vilar","year":"2017","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.lfs.2026.124316_bb0155","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1158\/1535-7163.MCT-18-1319","article-title":"Exportin 1 inhibition induces nerve growth factor receptor expression to inhibit the NF-\u03baB pathway in preclinical models of pediatric high-grade glioma","volume":"19","author":"DeSisto","year":"2020","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.lfs.2026.124316_bb0160","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0959-4388(00)00208-7","article-title":"Trk receptors: Mediators of neurotrophin action","volume":"11","author":"Patapoutian","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.lfs.2026.124316_bb0165","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/112_2017_6","article-title":"Neurotrophin Trk receptors: New targets for cancer therapy","volume":"174","author":"Meldolesi","year":"2018","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2026.124316_bb0170","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.ajog.2005.07.035","article-title":"Divergent trophoblast invasion and apoptosis in placental bed spiral arteries from pregnancies complicated by maternal anemia and early-onset preeclampsia\/intrauterine growth restriction","volume":"194","author":"Kadyrov","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.lfs.2026.124316_bb0175","doi-asserted-by":"crossref","first-page":"496","DOI":"10.2353\/ajpath.2007.070094","article-title":"Hypoxic switch in mitochondrial myeloid cell leukemia factor-1\/Mtd apoptotic rheostat contributes to human trophoblast cell death in preeclampsia","volume":"171","author":"Soleymanlou","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.lfs.2026.124316_bb0180","doi-asserted-by":"crossref","first-page":"S745","DOI":"10.1016\/j.ajog.2017.11.577","article-title":"Pathophysiology of placental-derived fetal growth restriction","volume":"218","author":"Burton","year":"2018","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526001256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526001256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:04:02Z","timestamp":1777388642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526001256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":36,"alternative-id":["S0024320526001256"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124316","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA SNHG1 promotes the development of preeclampsia by interacting with PTBP1 and modulating NGFR mRNA stability","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124316","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124316"}}