{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:38:24Z","timestamp":1791837504285,"version":"4.3.4"},"reference-count":103,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2023AFB238"],"award-info":[{"award-number":["2023AFB238"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019076","name":"Outstanding Young and Middle-aged Scientific Innovation Team of Colleges and Universities of Hubei Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401976"],"award-info":[{"award-number":["82401976"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.lfs.2026.124344","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T07:32:36Z","timestamp":1774078356000},"page":"124344","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Research progress on histone epigenetic modifications in placental trophoblast syncytialization"],"prefix":"10.1016","volume":"394","author":[{"given":"Yu-xin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-zhen","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-zhou","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-nan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5\u20136","key":"10.1016\/j.lfs.2026.124344_bb0005","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.thromres.2004.06.038","article-title":"Growth and function of the normal human placenta","volume":"114","author":"Gude","year":"2004","journal-title":"Thromb. Res."},{"issue":"5","key":"10.1016\/j.lfs.2026.124344_bb0010","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.celrep.2017.10.019","article-title":"Fine-tuned and cell-cycle-restricted expression of fusogenic protein syncytin-2 maintains functional placental syncytia","volume":"21","author":"Lu","year":"2017","journal-title":"Cell Rep."},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2026.124344_bb0015","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.placenta.2014.12.015","article-title":"Review: an overview of molecular events occurring in human trophoblast fusion","volume":"36","author":"Gerbaud","year":"2015","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.lfs.2026.124344_bb0020","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1051\/jbio\/2016017","article-title":"Role and regulation of cAMP signaling in human trophoblast fusion","volume":"210","author":"Gerbaud","year":"2016","journal-title":"Biol Aujourdhui"},{"issue":"1","key":"10.1016\/j.lfs.2026.124344_bb0025","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41392-024-01918-w","article-title":"Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases","volume":"9","author":"Yao","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"18","key":"10.1016\/j.lfs.2026.124344_bb0030","doi-asserted-by":"crossref","first-page":"7578","DOI":"10.1074\/jbc.M116.765800","article-title":"A repressive role of enhancer of zeste homolog 2 in 11\u03b2-hydroxysteroid dehydrogenase type 2 expression in the human placenta","volume":"292","author":"Zuo","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.lfs.2026.124344_bb0035","doi-asserted-by":"crossref","DOI":"10.1530\/REP-17-0603","article-title":"MicroRNAs: crucial regulators of placental development","volume":"155","author":"Hayder","year":"2018","journal-title":"Reproduction"},{"issue":"2","key":"10.1016\/j.lfs.2026.124344_bb0040","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.devcel.2015.12.027","article-title":"Maternal DNA methylation regulates early trophoblast development","volume":"36","author":"Branco","year":"2016","journal-title":"Dev. Cell"},{"issue":"11","key":"10.1016\/j.lfs.2026.124344_bb0045","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00109-010-0656-8","article-title":"Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes","volume":"88","author":"Ruebner","year":"2010","journal-title":"J. Mol. Med."},{"issue":"5","key":"10.1016\/j.lfs.2026.124344_bb0050","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.ajpath.2013.01.011","article-title":"Membrane-type matrix metalloproteinase 1 regulates trophoblast functions and is reduced in fetal growth restriction","volume":"182","author":"Hiden","year":"2013","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.lfs.2026.124344_bb0055","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00018-015-2069-x","article-title":"Morphological changes of placental syncytium and their implications for the pathogenesis of preeclampsia","volume":"73","author":"Roland","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.lfs.2026.124344_bb0060","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fphys.2016.00040","article-title":"Placental nutrient transport and intrauterine growth restriction","volume":"7","author":"Gaccioli","year":"2016","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124344_bb0065","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00018-018-2918-5","article-title":"Mechanisms for establishment of the placental glucocorticoid barrier, a guard for life","volume":"76","author":"Zhu","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"issue":"19","key":"10.1016\/j.lfs.2026.124344_bb0070","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1080\/14767058.2016.1245285","article-title":"Genetic, metabolic and endocrine aspect of intrauterine growth restriction: an update","volume":"30","author":"Sharma","year":"2017","journal-title":"J. Matern. Fetal Neonatal Med."},{"issue":"1","key":"10.1016\/j.lfs.2026.124344_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0143-4004(86)80012-1","article-title":"Differentiation and secretory activities of cultured human placental cytotrophoblast","volume":"7","author":"Nelson","year":"1986","journal-title":"Placenta"},{"issue":"1","key":"10.1016\/j.lfs.2026.124344_bb0080","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000145857","article-title":"Some new findings about Hofbauer cells in the chorionic villi of the human placenta","volume":"119","author":"Demir","year":"1984","journal-title":"Cells Tissues Organs"},{"issue":"8034","key":"10.1016\/j.lfs.2026.124344_bb0085","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/s41586-024-07937-5","article-title":"Temporal BMP4 effects on mouse embryonic and extraembryonic development","volume":"634","author":"Hadas","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2026.124344_bb0090","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ceb.2020.08.010","article-title":"Progress in deciphering trophoblast cell differentiation during human placentation","volume":"67","author":"Xiao","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"issue":"4","key":"10.1016\/j.lfs.2026.124344_bb0095","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/cbic.202000332","article-title":"Nucleosomes and epigenetics from a chemical perspective","volume":"22","author":"Feng","year":"2021","journal-title":"Chembiochem"},{"issue":"2","key":"10.1016\/j.lfs.2026.124344_bb0100","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0959-437X(02)00284-8","article-title":"Heterochromatin: new possibilities for the inheritance of structure","volume":"12","author":"Grewal","year":"2002","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"9","key":"10.1016\/j.lfs.2026.124344_bb0105","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nrm.2017.47","article-title":"Understanding nucleosome dynamics and their links to gene expression and DNA replication","volume":"18","author":"Lai","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5532","key":"10.1016\/j.lfs.2026.124344_bb0110","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science"},{"issue":"6765","key":"10.1016\/j.lfs.2026.124344_bb0115","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications","volume":"403","author":"Strahl","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2026.124344_bb0120","series-title":"Overview of histone modification. Histone mutations and cancer","first-page":"1","author":"Zhang","year":"2020"},{"issue":"2","key":"10.1016\/j.lfs.2026.124344_bb0125","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.gde.2007.12.005","article-title":"A glimpse into the epigenetic landscape of gene regulation","volume":"18","author":"Mellor","year":"2008","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"1","key":"10.1016\/j.lfs.2026.124344_bb0130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrg2008","article-title":"Heterochromatin revisited","volume":"8","author":"Grewal","year":"2007","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.lfs.2026.124344_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13072-023-00519-1","article-title":"The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease","volume":"16","author":"Luo","year":"2023","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.lfs.2026.124344_bb0140","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mrrev.2016.03.005","article-title":"The many faces of histone H3K79 methylation","volume":"768","author":"Farooq","year":"2016","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"issue":"9","key":"10.1016\/j.lfs.2026.124344_bb0145","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41580-022-00483-w","article-title":"Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance","volume":"23","author":"Padeken","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124344_bb0150","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.mce.2013.05.002","article-title":"Canonical and non-canonical roles of the histone methyltransferase EZH2 in mammary development and cancer","volume":"382","author":"Bae","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.lfs.2026.124344_bb0155","doi-asserted-by":"crossref","first-page":"1204463","DOI":"10.3389\/fgene.2023.1204463","article-title":"SETD2-H3K36ME3: an important bridge between the environment and tumors","volume":"14","author":"He","year":"2023","journal-title":"Front. Genet."},{"issue":"6824","key":"10.1016\/j.lfs.2026.124344_bb0160","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/35065138","article-title":"Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain","volume":"410","author":"Bannister","year":"2001","journal-title":"Nature"},{"issue":"6824","key":"10.1016\/j.lfs.2026.124344_bb0165","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/35065132","article-title":"Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins","volume":"410","author":"Lachner","year":"2001","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.lfs.2026.124344_bb0170","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.molcel.2013.02.013","article-title":"Occupying chromatin: polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put","volume":"49","author":"Simon","year":"2013","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.lfs.2026.124344_bb0175","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-resolution profiling of histone methylations in the human genome","volume":"129","author":"Barski","year":"2007","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.lfs.2026.124344_bb0180","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ng1966","article-title":"Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome","volume":"39","author":"Heintzman","year":"2007","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.lfs.2026.124344_bb0185","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cell.2009.02.045","article-title":"Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5\u2032 transcribed regions","volume":"137","author":"Kim","year":"2009","journal-title":"Cell"},{"issue":"7153","key":"10.1016\/j.lfs.2026.124344_bb0190","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature06008","article-title":"Genome-wide maps of chromatin state in pluripotent and lineage-committed cells","volume":"448","author":"Mikkelsen","year":"2007","journal-title":"Nature"},{"issue":"7773","key":"10.1016\/j.lfs.2026.124344_bb0195","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41586-019-1534-3","article-title":"The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape","volume":"573","author":"Weinberg","year":"2019","journal-title":"Nature"},{"issue":"6733","key":"10.1016\/j.lfs.2026.124344_bb0200","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1126\/science.adn6319","article-title":"Structural basis of H3K36 trimethylation by SETD2 during chromatin transcription","volume":"387","author":"Markert","year":"2025","journal-title":"Science"},{"issue":"0","key":"10.1016\/j.lfs.2026.124344_bb0205","article-title":"Emerging roles of JmjC domain-containing proteins","volume":"319","author":"Sandra","year":"2015","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.lfs.2026.124344_bb0210","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-031-38176-8_2","article-title":"Targeting the LSD1\/KDM1 family of lysine demethylases in cancer and other human diseases. Targeting lysine demethylases in cancer and other human diseases","author":"Mao","year":"2023","journal-title":"Adv. Exp. Med. Biol."},{"issue":"2","key":"10.1016\/j.lfs.2026.124344_bb0215","article-title":"LSD1 in drug discovery: from biological function to clinical application","volume":"44","author":"Hui-Min","year":"2023","journal-title":"Med. Res. Rev."},{"issue":"7078","key":"10.1016\/j.lfs.2026.124344_bb0220","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nature04433","article-title":"Histone demethylation by a family of JmjC domain-containing proteins","volume":"439","author":"Tsukada","year":"2006","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.lfs.2026.124344_bb0225","article-title":"Regulation of histone methylation by demethylimination and demethylation","volume":"8","author":"Robert","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.lfs.2026.124344_bb0230","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejim.2023.05.036","article-title":"How epigenetics impacts on human diseases","volume":"114","author":"Farsetti","year":"2023","journal-title":"Eur. J. Intern. Med."},{"issue":"3","key":"10.1016\/j.lfs.2026.124344_bb0235","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/embo-reports\/kvf053","article-title":"Histone acetylation: a switch between repressive and permissive chromatin","volume":"3","author":"Eberharter","year":"2002","journal-title":"EMBO Rep."},{"issue":"10","key":"10.1016\/j.lfs.2026.124344_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107744","article-title":"KAT tales: Functions of Gcn5 and PCAF lysine acetyltransferases in SAGA and ATAC","volume":"300","author":"Dent","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2026.124344_bb0245","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02024","article-title":"MOF-associated complexes ensure stem cell identity and Xist repression","volume":"3","author":"Chelmicki","year":"2014","journal-title":"Elife"},{"issue":"7333","key":"10.1016\/j.lfs.2026.124344_bb0250","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nature09692","article-title":"A unique chromatin signature uncovers early developmental enhancers in humans","volume":"470","author":"Rada-Iglesias","year":"2011","journal-title":"Nature"},{"issue":"D1","key":"10.1016\/j.lfs.2026.124344_bb0255","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv1002","article-title":"dbSUPER: a database of super-enhancers in mouse and human genome","volume":"44","author":"Khan","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"6711","key":"10.1016\/j.lfs.2026.124344_bb0260","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/25166","article-title":"Regulation of activity of the transcription factor GATA-1 by acetylation","volume":"396","author":"Boyes","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2026.124344_bb0265","first-page":"103","article-title":"The multifunctional role of the co-activator CBP in transcriptional regulation","volume":"52","author":"Goldman","year":"1997","journal-title":"Recent Prog. Horm. Res."},{"issue":"4","key":"10.1016\/j.lfs.2026.124344_bb0270","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0092-8674(00)80521-8","article-title":"Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain","volume":"90","author":"Gu","year":"1997","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.lfs.2026.124344_bb0275","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1128\/MCB.26.5.1770-1785.2006","article-title":"Sp1 deacetylation induced by phorbol ester recruits p300 to activate 12 (S)-lipoxygenase gene transcription","volume":"26","author":"Hung","year":"2006","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.lfs.2026.124344_bb0280","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/emboj.2010.318","article-title":"Distinct roles of GCN5\/PCAF-mediated H3K9ac and CBP\/p300-mediated H3K18\/27ac in nuclear receptor transactivation","volume":"30","author":"Jin","year":"2011","journal-title":"EMBO J."},{"issue":"11","key":"10.1016\/j.lfs.2026.124344_bb0285","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.prp.2017.06.013","article-title":"Histone modifications: A review about the presence of this epigenetic phenomenon in carcinogenesis","volume":"213","author":"Chrun","year":"2017","journal-title":"Pathol.-Res. Pract."},{"issue":"4","key":"10.1016\/j.lfs.2026.124344_bb0290","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a018713","article-title":"Erasers of histone acetylation: the histone deacetylase enzymes","volume":"6","author":"Seto","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.lfs.2026.124344_bb0295","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","article-title":"Histone deacetylases (HDACs): characterization of the classical HDAC family","volume":"370","author":"de Ruijter","year":"2003","journal-title":"Biochem. J."},{"issue":"23","key":"10.1016\/j.lfs.2026.124344_bb0300","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.2217\/epi-2022-0437","article-title":"The landscape of histone modifications in epigenomics since 2020","volume":"14","author":"Shirvaliloo","year":"2022","journal-title":"Epigenomics"},{"issue":"9","key":"10.1016\/j.lfs.2026.124344_bb0305","article-title":"Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease","volume":"56","author":"Bo","year":"2021","journal-title":"Dev. Cell"},{"issue":"2\u20133","key":"10.1016\/j.lfs.2026.124344_bb0310","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1387\/ijdb.082717ph","article-title":"Mechanisms of transcriptional repression by histone lysine methylation","volume":"53","author":"Hublitz","year":"2009","journal-title":"Int. J. Dev. Biol."},{"issue":"8","key":"10.1016\/j.lfs.2026.124344_bb0315","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1071\/RD13169","article-title":"EZH2 is essential for development of mouse preimplantation embryos","volume":"26","author":"Huang","year":"2014","journal-title":"Reprod. Fertil. Dev."},{"issue":"1","key":"10.1016\/j.lfs.2026.124344_bb0320","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12916-022-02391-4","article-title":"Role of EZH2-mediated H3K27me3 in placental ADAM12-S expression: implications for fetoplacental growth","volume":"20","author":"Zhu","year":"2022","journal-title":"BMC Med."},{"issue":"10","key":"10.1016\/j.lfs.2026.124344_bb0325","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1093\/nar\/gkad109","article-title":"Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization","volume":"51","author":"Yu","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.lfs.2026.124344_bb0330","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1152\/physrev.00001.2023","article-title":"The placenta: epigenetic insights into trophoblast developmental models of a generation-bridging organ with long-lasting impact on lifelong health","volume":"103","author":"Hemberger","year":"2023","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.lfs.2026.124344_bb0335","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/biof.1542","article-title":"The role of epigenetic changes in preeclampsia","volume":"45","author":"Kamrani","year":"2019","journal-title":"BioFactors"},{"key":"10.1016\/j.lfs.2026.124344_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2021.103287","article-title":"Epigenetic modification via H3K4me3 and H3K9ac in human placenta is reduced in preeclampsia","volume":"145","author":"Meister","year":"2021","journal-title":"J. Reprod. Immunol."},{"issue":"4","key":"10.1016\/j.lfs.2026.124344_bb0345","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3892\/ijmm.2025.5499","article-title":"Importance of STAT3 signaling in preeclampsia","volume":"55","author":"Marzioni","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.lfs.2026.124344_bb0350","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.placenta.2025.09.017","article-title":"NNMT expression in preeclampsia: analyses on placental tissues and cell lines","volume":"171","author":"Tossetta","year":"2025","journal-title":"Placenta"},{"issue":"3","key":"10.1016\/j.lfs.2026.124344_bb0355","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1007\/s13577-023-00901-x","article-title":"Downregulation of argininosuccinate synthase 1 (ASS1) is associated with hypoxia in placental development","volume":"36","author":"Fantone","year":"2023","journal-title":"Hum. Cell"},{"issue":"5","key":"10.1016\/j.lfs.2026.124344_bb0360","doi-asserted-by":"crossref","DOI":"10.3390\/biom12050707","article-title":"Gal-2 increases H3K4me3 and H3K9ac in trophoblasts and preeclampsia","volume":"12","author":"Hahn","year":"2022","journal-title":"Biomolecules"},{"issue":"9","key":"10.1016\/j.lfs.2026.124344_bb0365","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrg887","article-title":"Chromatin modification and epigenetic reprogramming in mammalian development","volume":"3","author":"Li","year":"2002","journal-title":"Nat. Rev. Genet."},{"issue":"6","key":"10.1016\/j.lfs.2026.124344_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2021.129867","article-title":"SUV39H2 controls trophoblast stem cell fate","volume":"1865","author":"Wang","year":"2021","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"issue":"15","key":"10.1016\/j.lfs.2026.124344_bb0375","article-title":"Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment","volume":"137","author":"Olivia","year":"2010","journal-title":"Development"},{"issue":"46","key":"10.1016\/j.lfs.2026.124344_bb0380","article-title":"Regulation of human trophoblast syncytialization by histone demethylase LSD1","volume":"294","author":"Jessica","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"0","key":"10.1016\/j.lfs.2026.124344_bb0385","article-title":"Maternal LSD1\/KDM1A is an essential regulator of chromatin and transcription landscapes during zygotic genome activation","volume":"5","author":"Katia","year":"2016","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.lfs.2026.124344_bb0390","article-title":"Inactivation of Lsd1 triggers senescence in trophoblast stem cells by induction of Sirt4","volume":"8","author":"Josefina","year":"2017","journal-title":"Cell Death Dis."},{"issue":"0","key":"10.1016\/j.lfs.2026.124344_bb0395","article-title":"Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells","volume":"6","author":"Paulina","year":"2015","journal-title":"Nat. Commun."},{"issue":"14","key":"10.1016\/j.lfs.2026.124344_bb0400","article-title":"EED and KDM6B coordinate the first mammalian cell lineage commitment to ensure embryo implantation","volume":"33","author":"Biswarup","year":"2013","journal-title":"Mol. Cell. Biol."},{"issue":"5","key":"10.1016\/j.lfs.2026.124344_bb0405","article-title":"Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells","volume":"10","author":"Yasunao","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.lfs.2026.124344_bb0410","doi-asserted-by":"crossref","first-page":"E899","DOI":"10.1210\/jc.2010-2852","article-title":"The Sp1 transcription factor is crucial for the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts","volume":"96","author":"Li","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"10.1016\/j.lfs.2026.124344_bb0415","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.placenta.2009.10.005","article-title":"Role of human chorionic gonadotropin in maintaining 11beta-hydroxysteroid dehydrogenase type 2 expression in human placental syncytiotrophoblasts","volume":"30","author":"Ni","year":"2009","journal-title":"Placenta"},{"issue":"22","key":"10.1016\/j.lfs.2026.124344_bb0420","doi-asserted-by":"crossref","DOI":"10.1242\/dev.204290","article-title":"SLC25A1 regulates placental development to ensure embryonic heart morphogenesis","volume":"151","author":"Fan","year":"2024","journal-title":"Development"},{"issue":"9","key":"10.1016\/j.lfs.2026.124344_bb0425","article-title":"Human trophoblast differentiation is associated with profound gene regulatory and epigenetic changes","volume":"160","author":"Youn-Tae","year":"2019","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.lfs.2026.124344_bb0430","article-title":"Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation","volume":"5","author":"Irving","year":"2022","journal-title":"Commun. Biol."},{"issue":"6","key":"10.1016\/j.lfs.2026.124344_bb0435","article-title":"Estrogen receptor alpha (ERalpha) mediates stimulatory effects of estrogen on aromatase (CYP19) gene expression in human placenta","volume":"23","author":"Premlata","year":"2009","journal-title":"Mol. Endocrinol."},{"issue":"12","key":"10.1016\/j.lfs.2026.124344_bb0440","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.placenta.2015.10.010","article-title":"Transcriptomic and epigenomic landscapes during cell fusion in BeWo trophoblast cells","volume":"36","author":"Shankar","year":"2015","journal-title":"Placenta"},{"issue":"9","key":"10.1016\/j.lfs.2026.124344_bb0445","article-title":"Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells","volume":"31","author":"Xin","year":"2024","journal-title":"Cell Stem Cell"},{"issue":"11","key":"10.1016\/j.lfs.2026.124344_bb0450","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20112837","article-title":"The role of epigenetics in placental development and the etiology of preeclampsia","volume":"20","author":"Apicella","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.lfs.2026.124344_bb0455","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1093\/nar\/gkl048","article-title":"Histone deacetylase 3 binds to and regulates the GCMa transcription factor","volume":"34","author":"Chuang","year":"2006","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.lfs.2026.124344_bb0460","article-title":"Transcriptional reprogramming and chromatin remodeling accompanies Oct4 and Nanog silencing in mouse trophoblast lineage","volume":"23","author":"Timothy","year":"2013","journal-title":"Stem Cells Dev."},{"issue":"1","key":"10.1016\/j.lfs.2026.124344_bb0465","article-title":"KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2","volume":"15","author":"Shilei","year":"2024","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.lfs.2026.124344_bb0470","article-title":"Regulation of epigenetic modifications in the placenta during preeclampsia: PPAR\u03b3 influences H3K4me3 and H3K9ac in extravillous trophoblast cells","volume":"22","author":"Sarah","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.lfs.2026.124344_bb0475","article-title":"Conserved and divergent features of trophoblast stem cells","volume":"72","author":"Nirvay","year":"2024","journal-title":"J. Mol. Endocrinol."},{"issue":"5","key":"10.1016\/j.lfs.2026.124344_bb0480","article-title":"Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts","volume":"11","author":"Gargi","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.lfs.2026.124344_bb0485","article-title":"HDAC5 inactivates CYR61-regulated CD31\/mTOR axis to prevent the occurrence of preeclampsia","volume":"390","author":"Peiyue","year":"2022","journal-title":"Cell Tissue Res."},{"issue":"11","key":"10.1016\/j.lfs.2026.124344_bb0490","article-title":"Involvement of Epac1\/Rap1\/CaMKI\/HDAC5 signaling cascade in the regulation of placental cell fusion","volume":"19","author":"Ching-Wen","year":"2013","journal-title":"Mol. Hum. Reprod."},{"issue":"5","key":"10.1016\/j.lfs.2026.124344_bb0495","article-title":"Histone acetyltransferases and histone deacetyl transferases play crucial role during oogenesis and early embryo development","volume":"61","author":"Nazlican","year":"2023","journal-title":"Genesis"},{"issue":"22","key":"10.1016\/j.lfs.2026.124344_bb0500","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112012","article-title":"CBP\/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos","volume":"41","author":"Wang","year":"2022","journal-title":"EMBO J."},{"issue":"11","key":"10.1016\/j.lfs.2026.124344_bb0505","doi-asserted-by":"crossref","DOI":"10.1242\/dev.200854","article-title":"The lysine deacetylase activity of histone deacetylases 1 and 2 is required to safeguard zygotic genome activation in mice and cattle","volume":"149","author":"Dang","year":"2022","journal-title":"Development"},{"issue":"0","key":"10.1016\/j.lfs.2026.124344_bb0510","article-title":"SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development","volume":"8","author":"Katerina","year":"2017","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"24","key":"10.1016\/j.lfs.2026.124344_bb0515","article-title":"BRG1 governs Nanog transcription in early mouse embryos and embryonic stem cells via antagonism of histone H3 lysine 9\/14 acetylation","volume":"35","author":"Timothy","year":"2015","journal-title":"Mol. Cell. Biol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526001530?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526001530?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:12:41Z","timestamp":1778944361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526001530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":103,"alternative-id":["S0024320526001530"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124344","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Research progress on histone epigenetic modifications in placental trophoblast syncytialization","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124344","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124344"}}