{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:21:15Z","timestamp":1791894075309,"version":"4.3.4"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023JJ40994"],"award-info":[{"award-number":["2023JJ40994"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ6693"],"award-info":[{"award-number":["2024JJ6693"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011790","name":"Central South University Xiangya Hospital","doi-asserted-by":"publisher","award":["2022Q10"],"award-info":[{"award-number":["2022Q10"]}],"id":[{"id":"10.13039\/501100011790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008253","name":"Shaoxing University","doi-asserted-by":"publisher","award":["13011001002\/295"],"award-info":[{"award-number":["13011001002\/295"]}],"id":[{"id":"10.13039\/501100008253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200776"],"award-info":[{"award-number":["82200776"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170598"],"award-info":[{"award-number":["82170598"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.lfs.2026.124442","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:39:57Z","timestamp":1778049597000},"page":"124442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The key regulator of ferroptosis: HIF-1\u03b1 and its complex roles and treatment strategies in related diseases"],"prefix":"10.1016","volume":"397","author":[{"given":"Xiaoxiao","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Yuan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2026.124442_bb0005","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.lfs.2026.124442_bb0010","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.lfs.2026.124442_bb0015","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2026.124442_bb0020","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.lfs.2026.124442_bb0025","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","article-title":"Targeting ferroptosis opens new avenues for the development of novel therapeutics","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.lfs.2026.124442_bb0030","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2026.124442_bb0035","doi-asserted-by":"crossref","first-page":"24209","DOI":"10.1074\/jbc.270.41.24209","article-title":"Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron(II)","volume":"270","author":"Breuer","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2026.124442_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/cells11132040","article-title":"Ferroptosis and Its Role in Chronic Diseases","volume":"11","author":"Hu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2026.124442_bb0045","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.lfs.2026.124442_bb0050","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1007\/s10571-023-01388-8","article-title":"The Mechanisms of Ferroptosis Under Hypoxia","volume":"43","author":"Gao","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2026.124442_bb0055","doi-asserted-by":"crossref","first-page":"17771","DOI":"10.1074\/jbc.271.30.17771","article-title":"Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1","volume":"271","author":"Jiang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2026.124442_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/emm.2004.1","article-title":"Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions","volume":"36","author":"Lee","year":"2004","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.lfs.2026.124442_bb0065","first-page":"366","article-title":"Differential Gene Analysis of Ferroptosis in the Treatment of Allergic Rhinitis with Bu-Zhong-Yi-Qi-Decoction Based on GEO Using Network Pharmacology and Molecular Docking","volume":"30","author":"Cen","year":"2024","journal-title":"Altern. Ther. Health Med."},{"key":"10.1016\/j.lfs.2026.124442_bb0070","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1186\/s12951-022-01617-0","article-title":"Hemin-incorporating DNA nanozyme enabling catalytic oxygenation and GSH depletion for enhanced photodynamic therapy and synergistic tumor ferroptosis","volume":"20","author":"Xiao","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.lfs.2026.124442_bb0075","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11010-006-9393-2","article-title":"Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins","volume":"301","author":"Christova","year":"2007","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.lfs.2026.124442_bb0080","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1089\/ars.2023.0380","article-title":"Scavenger Receptor Class B Type I Deficiency Induces Iron Overload and Ferroptosis in Renal Tubular Epithelial Cells via Hypoxia-Inducible Factor-1\u03b1\/Transferrin Receptor 1 Signaling Pathway","volume":"41","author":"Yang","year":"2024","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.lfs.2026.124442_bb0085","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.2174\/0109298673271261231213051410","article-title":"Modulation of the HIF-1\u03b1-NCOA4-FTH1 Signaling Axis Regulating Ferroptosis-induced Hepatic Stellate Cell Senescence to Explore the Anti-Hepatic Fibrosis Mechanism of Curcumol","volume":"31","author":"Zheng","year":"2024","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.lfs.2026.124442_bb0090","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s10020-023-00694-7","article-title":"Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1alpha\/HMOX1 axis","volume":"29","author":"Shi","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.lfs.2026.124442_bb0095","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s10020-023-00733-3","article-title":"Targeted inhibition of CX3CL1 limits podocytes ferroptosis to ameliorate cisplatin-induced acute kidney injury","volume":"29","author":"Gong","year":"2023","journal-title":"Mol. Med."},{"key":"10.1016\/j.lfs.2026.124442_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.117135","article-title":"Chronic hypoxia drives the occurrence of ferroptosis in liver of fat greening (Hexagrammos otakii) by activating HIF-1\u03b1 and promoting iron production","volume":"285","author":"Gao","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.lfs.2026.124442_bb0105","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.7150\/thno.71029","article-title":"Neuronal STAT3\/HIF-1\u03b1\/PTRF axis-mediated bioenergetic disturbance exacerbates cerebral ischemia-reperfusion injury via PLA2G4A","volume":"12","author":"Jin","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.lfs.2026.124442_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116481","article-title":"Manganese overexposure results in ferroptosis through the HIF-1alpha\/p53\/SLC7A11 pathway in ICR mouse brain and PC12 cells","volume":"279","author":"Chen","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.lfs.2026.124442_bb0115","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13158","article-title":"Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF-1alpha\/SLC7A11 pathway","volume":"55","author":"Yuan","year":"2022","journal-title":"Cell Prolif."},{"key":"10.1016\/j.lfs.2026.124442_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112945","article-title":"HIF-1alpha drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1","volume":"42","author":"Yang","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.lfs.2026.124442_bb0125","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.2147\/COPD.S422835","article-title":"Screening of potential key ferroptosis-related genes in Chronic Obstructive Pulmonary Disease","volume":"18","author":"Cao","year":"2023","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.lfs.2026.124442_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2023.113851","article-title":"Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12","volume":"433","author":"Li","year":"2023","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.lfs.2026.124442_bb0135","first-page":"41","article-title":"Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor","volume":"23","author":"Eleftheriadis","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.lfs.2026.124442_bb0140","doi-asserted-by":"crossref","first-page":"176007","DOI":"10.1016\/j.ejphar.2023.176007","article-title":"Evodiamine impairs HIF1A histone lactylation to inhibit Sema3A-mediated angiogenesis and PD-L1 by inducing ferroptosis in prostate cancer","volume":"957","author":"Ying","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.lfs.2026.124442_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294263","article-title":"HSP70 via HIF-1 alpha SUMOylation inhibits ferroptosis inducing lung cancer recurrence after insufficient radiofrequency ablation","volume":"18","author":"Peng","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2026.124442_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103073","article-title":"Hypoxia causes trophoblast cell ferroptosis to induce miscarriage through lnc-HZ06\/HIF1\u03b1-SUMO\/NCOA4 axis","volume":"70","author":"Tian","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2026.124442_bb0155","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.2147\/DDDT.S480514","article-title":"Ciprofol Ameliorates Myocardial Ischemia\/Reperfusion Injury by Inhibiting Ferroptosis Through Upregulating HIF-1\u03b1","volume":"18","author":"Ding","year":"2024","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.lfs.2026.124442_bb0160","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1038\/s41388-018-0315-z","article-title":"The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma","volume":"37","author":"Miess","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2026.124442_bb0165","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1186\/s12885-023-11637-0","article-title":"Knockdown of SLC39A14 inhibits glioma progression by promoting erastin-induced ferroptosis SLC39A14 knockdown inhibits glioma progression","volume":"23","author":"Zhang","year":"2023","journal-title":"BMC Cancer"},{"key":"10.1016\/j.lfs.2026.124442_bb0170","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7862430","article-title":"Hypoxia enhances glioma resistance to sulfasalazine-induced ferroptosis by upregulating SLC7A11 via PI3K\/AKT\/HIF-1\u03b1 axis","volume":"2022","author":"Sun","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2026.124442_bb0175","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1038\/s41388-022-02460-1","article-title":"ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma","volume":"41","author":"Green","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.lfs.2026.124442_bb0180","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1038\/s41598-023-35796-z","article-title":"Identification of ferroptosis and drug resistance related hub genes to predict the prognosis in Hepatocellular Carcinoma","volume":"13","author":"Li","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2026.124442_bb0185","first-page":"1","article-title":"Combined HIF-1\u03b1 and SHH up-regulation is a potential biomarker to predict poor prognosis in postoperative hepatocellular carcinoma","author":"Z.","year":"2022","journal-title":"J. Investig. Surg."},{"key":"10.1016\/j.lfs.2026.124442_bb0190","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.jhep.2022.01.009","article-title":"COMMD10 inhibits HIF1\u03b1\/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma","volume":"76","author":"Yang","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.lfs.2026.124442_bb0195","doi-asserted-by":"crossref","first-page":"22240","DOI":"10.1021\/acsnano.3c01199","article-title":"Long Noncoding RNA URB1-Antisense RNA 1 (AS1) Suppresses Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma by Driving Ferritin Phase Separation","volume":"17","author":"Gao","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.lfs.2026.124442_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111939","article-title":"Hypoxia-elicited exosomal HIF-1\u03b1 promotes drug resistance of melanoma through modulating SLC7A11 ubiquitination","volume":"134","author":"Chen","year":"2025","journal-title":"Cell. Signal."},{"key":"10.1016\/j.lfs.2026.124442_bb0205","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jare.2021.10.001","article-title":"Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancer","volume":"37","author":"Yang","year":"2022","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.lfs.2026.124442_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102312","article-title":"Hypoxia-induced HIF-1\u03b1\/lncRNA-PMAN inhibits ferroptosis by promoting the cytoplasmic translocation of ELAVL1 in peritoneal dissemination from gastric cancer","volume":"52","author":"Lin","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2026.124442_bb0215","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401119R","article-title":"Hypoxia-inducible factor-1alpha can reverse the Adriamycin resistance of breast cancer adjuvant chemotherapy by upregulating transferrin receptor and activating ferroptosis","volume":"38","author":"Yu","year":"2024","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2026.124442_bb0220","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1021\/acsnano.2c10893","article-title":"Oxygen Self-Generating Nanoreactor Mediated Ferroptosis Activation and Immunotherapy in Triple-Negative Breast Cancer","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.lfs.2026.124442_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110686","article-title":"Modulation of the local angiotensin II: Suppression of ferroptosis and radiosensitivity in nasopharyngeal carcinoma via the HIF-1\u03b1-HILPDA axis","volume":"203","author":"Huang","year":"2025","journal-title":"Radiother. Oncol."},{"key":"10.1016\/j.lfs.2026.124442_bb0230","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12935-024-03494-z","article-title":"Hypoxia-induced BAP1 enhances erastin-induced ferroptosis in nasopharyngeal carcinoma by stabilizing H2A","volume":"24","author":"Cai","year":"2024","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.lfs.2026.124442_bb0235","article-title":"A novel nanomedicine integrating ferroptosis and photothermal therapy, well-suitable for PD-L1-mediated immune checkpoint blockade","volume":"29","author":"Bao","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.lfs.2026.124442_bb0240","article-title":"Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro-Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia","volume":"20","author":"Wang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.lfs.2026.124442_bb0245","doi-asserted-by":"crossref","first-page":"899","DOI":"10.32604\/or.2023.042604","article-title":"Hydroxysafflor yellow A induced ferroptosis of Osteosarcoma cancer cells by HIF-1alpha\/HK2 and SLC7A11 pathway","volume":"32","author":"Zhu","year":"2024","journal-title":"Oncol. Res."},{"key":"10.1016\/j.lfs.2026.124442_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156224","article-title":"Icariin promoted ferroptosis by activating mitochondrial dysfunction to inhibit colorectal cancer and synergistically enhanced the efficacy of PD-1 inhibitors","volume":"136","author":"Haoyue","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2026.124442_bb0255","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.cmet.2019.06.005","article-title":"A breakdown in metabolic reprogramming causes microglia dysfunction in Alzheimer\u2019s disease","volume":"30","author":"Baik","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2026.124442_bb0260","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1038\/s41467-021-23111-1","article-title":"Transcriptional signature in microglia associated with Abeta plaque phagocytosis","volume":"12","author":"Grubman","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2026.124442_bb0265","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/jnc.15519","article-title":"Ferroptosis as a mechanism of neurodegeneration in Alzheimer\u2019s disease","volume":"159","author":"Jakaria","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.lfs.2026.124442_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2025.149776","article-title":"Ferroptosis and its contribution to cognitive impairment in Alzheimer\u2019s disease: mechanisms and therapeutic potential","volume":"1864","author":"Khan","year":"2025","journal-title":"Brain Res."},{"key":"10.1016\/j.lfs.2026.124442_bb0275","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1186\/s12864-024-10534-5","article-title":"Uncovering the ferroptosis related mechanism of laduviglusib in the cell-type-specific targets of the striatum in Huntington\u2019s disease","volume":"25","author":"Liu","year":"2024","journal-title":"BMC Genomics"},{"key":"10.1016\/j.lfs.2026.124442_bb0280","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.2174\/092986711797200426","article-title":"Hypoxia inducible factor-1 as a target for neurodegenerative diseases","volume":"18","author":"Z","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.lfs.2026.124442_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102077","article-title":"Ferroptosis in Parkinson\u2019s disease: Molecular mechanisms and therapeutic potential","volume":"91","author":"Ding","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.lfs.2026.124442_bb0290","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12974-024-03070-2","article-title":"Hypoxia inducible factor-1alpha regulates microglial innate immune memory and the pathology of Parkinson\u2019s disease","volume":"21","author":"Dong","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.lfs.2026.124442_bb0295","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s10072-024-07832-x","article-title":"Hypoxia-inducible factor-1 as targets for neuroprotection\u202f: from ferroptosis to Parkinson\u2019s disease","volume":"46","author":"Wang","year":"2024","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.lfs.2026.124442_bb0300","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.freeradbiomed.2025.06.030","article-title":"Herbacetin alleviates ferroptosis via Hif-1\u03b1\/SLC7A11\/GPX4 axis in traumatic brain injury","volume":"238","author":"Qian","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2026.124442_bb0305","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1007\/s12035-024-03964-5","article-title":"HIF-1alpha Induced by Hypoxia Promotes Peripheral Nerve Injury Recovery Through Regulating Ferroptosis in DRG Neuron","volume":"61","author":"An","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2026.124442_bb0310","first-page":"1","article-title":"Enriched Environment Attenuates Ferroptosis after Cerebral Ischemia\/Reperfusion Injury via the HIF-1\u03b1-ACSL4 Pathway","volume":"2023","author":"Liu","year":"2023","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2026.124442_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156900","article-title":"Protocatechuic acid suppresses ferroptosis to protect against hypoxic-ischemic encephalopathy by targeting the HIF-1\u03b1\/VEGFA axis","volume":"143","author":"Zhang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2026.124442_bb0320","article-title":"Pretreatment with Roxadustat (FG-4592) attenuates Folic Acid-induced kidney injury through antiferroptosis via Akt\/GSK-3 \u03b2 \/Nrf2 pathway","volume":"2020","author":"Li","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.lfs.2026.124442_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167277","article-title":"HIF-1 induced tiRNA-Lys-CTT-003 is protective against cisplatin induced ferroptosis of renal tubular cells in mouse AKI model","volume":"1870","author":"Li","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.lfs.2026.124442_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102262","article-title":"ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury","volume":"51","author":"Wang","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.lfs.2026.124442_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118517","article-title":"Proteomic and lipidomic analysis of the mechanism underlying astragaloside IV in mitigating ferroptosis through hypoxia-inducible factor 1alpha\/heme oxygenase 1 pathway in renal tubular epithelial cells in diabetic kidney disease","volume":"334","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.lfs.2026.124442_bb0340","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.626390","article-title":"Ferroptosis Enhanced Diabetic Renal Tubular Injury via HIF-1alpha\/HO-1 Pathway in db\/db Mice","volume":"12","author":"Feng","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.lfs.2026.124442_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119478","article-title":"Modulating HIF-1\u03b1\/HIF-2\u03b1 homeostasis with Shen-Qi-Huo-Xue formula alleviates tubular ferroptosis and epithelial-mesenchymal transition in diabetic kidney disease","volume":"343","author":"Yang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.lfs.2026.124442_bb0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156738","article-title":"Diosmin attenuates UUO-induced renal ferroptosis and fibrosis by inhibiting the HIF-1\u03b1\/FABP4 signaling axis","volume":"141","author":"Zhao","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2026.124442_bb0355","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13020-024-00901-5","article-title":"SKP alleviates the ferroptosis in diabetic kidney disease through suppression of HIF-1\u03b1\/HO-1 pathway based on network pharmacology analysis and experimental validation","volume":"19","author":"Yan","year":"2024","journal-title":"Chin. Med."},{"key":"10.1016\/j.lfs.2026.124442_bb0360","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13807","article-title":"The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF-1alpha to inhibit knee osteoarthritis-induced ferroptosis","volume":"22","author":"Guan","year":"2023","journal-title":"Aging Cell"},{"key":"10.1016\/j.lfs.2026.124442_bb0365","article-title":"Functionalized Biomimetic Nanoparticles Targeting the IL-10\/IL-10R\u03b1\/Glycolytic Axis in Synovial Macrophages Alleviate Cartilage Degeneration in Osteoarthritis","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.lfs.2026.124442_bb0370","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1016\/j.ajhg.2024.10.008","article-title":"Proteome-wide Mendelian randomization and functional studies uncover therapeutic targets for polycystic ovarian syndrome","volume":"111","author":"Ni","year":"2024","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.lfs.2026.124442_bb0375","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.freeradbiomed.2024.05.026","article-title":"Fine particulate matter (PM(2.5)) induces testosterone disruption by triggering ferroptosis through SIRT1\/HIF-1alpha signaling pathway in male mice","volume":"221","author":"Zheng","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2026.124442_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127807","article-title":"Di-(2-ethylhexyl) phthalate exposure leads to ferroptosis via the HIF-1\u03b1\/HO-1 signaling pathway in mouse testes","volume":"426","author":"Wu","year":"2022","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.lfs.2026.124442_bb0385","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70175","article-title":"Caffeic acid inhibits Staphylococcus aureus-induced endometritis through regulating AMPK\u03b1\/mTOR\/HIF-1\u03b1 signalling pathway","volume":"28","author":"Cao","year":"2024","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.lfs.2026.124442_bb0390","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2024.2387465","article-title":"Hyperoxia exposure induces ferroptosis and apoptosis by downregulating PLAGL2 and repressing HIF-1alpha\/VEGF signaling pathway in newborn alveolar typeII epithelial cell","volume":"29","author":"Zhu","year":"2024","journal-title":"Redox Rep."},{"key":"10.1016\/j.lfs.2026.124442_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113065","article-title":"Esketamine alleviates ferroptosis-mediated acute lung injury by modulating the HIF-1\u03b1\/HO-1 pathway","volume":"142","author":"Shi","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2026.124442_bb0400","doi-asserted-by":"crossref","first-page":"17601","DOI":"10.1038\/s41598-025-02675-8","article-title":"2-Methoxyestradiol attenuates lung injury induced by chronic intermittent hypoxia via inhibiting the HIF1-\u03b1\/SLC7A11 pathway","volume":"15","author":"Chen","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2026.124442_bb0405","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1389","article-title":"METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury","volume":"13","author":"Zhang","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.lfs.2026.124442_bb0410","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.freeradbiomed.2025.05.433","article-title":"siHIF-1\u03b1-loaded micellar nanoparticles inhibit M1 macrophage activation to ameliorate chronic rhinosinusitis","volume":"237","author":"Wang","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.lfs.2026.124442_bb0415","first-page":"C927","article-title":"Mu-opioid receptor alleviated ferroptosis in hepatic ischemia-reperfusion injury via the HIF-1alpha\/KCNQ1OT1 axis","volume":"324","author":"Zou","year":"2023","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.lfs.2026.124442_bb0420","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.3390\/nu15153411","article-title":"Hydroxysafflor Yellow A Alleviates Acute Myocardial Ischemia\/Reperfusion Injury in Mice by Inhibiting Ferroptosis via the Activation of the HIF-1\u03b1\/SLC7A11\/GPX4 Signaling Pathway","volume":"15","author":"Ge","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2026.124442_bb0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114333","article-title":"Autophagy inhibition and ferroptosis activation during atherosclerosis: Hypoxia-inducible factor 1\u03b1 inhibitor PX-478 alleviates atherosclerosis by inducing autophagy and suppressing ferroptosis in macrophages","volume":"161","author":"Hu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2026.124442_bb0430","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.jgg.2024.10.003","article-title":"bmp10 maintains cardiac function by regulating iron homeostasis","volume":"51","author":"Hu","year":"2024","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.lfs.2026.124442_bb0435","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2025.2544412","article-title":"HIF1A\/BNIP3 pathway affects ferroptosis in sepsis-induced cardiomyopathy through binding to BCL-2","volume":"30","author":"Wang","year":"2025","journal-title":"Redox Rep."},{"key":"10.1016\/j.lfs.2026.124442_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22857","article-title":"Oxidative stress drives vascular smooth muscle cell damage in acute Stanford type A aortic dissection through HIF-1\u03b1\/HO-1 mediated ferroptosis","volume":"9","author":"Song","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.lfs.2026.124442_bb0445","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1411513","article-title":"LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1\u03b1 pathway","volume":"15","author":"Deng","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2026.124442_bb0450","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41419-025-07883-8","article-title":"HIF-1\u03b1 alleviates ferroptosis in ulcerative colitis by regulation of GPX4","volume":"16","author":"Hu","year":"2025","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.lfs.2026.124442_bb0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115151","article-title":"Propionate alleviated colitis by modulating iron homeostasis to inhibit ferroptosis and macrophage polarization","volume":"162","author":"Yao","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.lfs.2026.124442_bb0460","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cmet.2024.11.010","article-title":"Adipocyte-derived ferroptotic signaling mitigates obesity","volume":"37","author":"Wang","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2026.124442_bb0465","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00011-023-01842-9","article-title":"Alleviated NCOA4-mediated ferritinophagy protected RA FLSs from ferroptosis in lipopolysaccharide-induced inflammation under hypoxia","volume":"73","author":"Wang","year":"2024","journal-title":"Inflamm. Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526002511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526002511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:17:15Z","timestamp":1784708235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526002511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":93,"alternative-id":["S0024320526002511"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124442","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The key regulator of ferroptosis: HIF-1\u03b1 and its complex roles and treatment strategies in related diseases","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124442","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124442"}}