{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:06:10Z","timestamp":1787162770414,"version":"build-2736575974"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301909"],"award-info":[{"award-number":["82301909"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"publisher","award":["CSTB2022NSCQ-LZX0062"],"award-info":[{"award-number":["CSTB2022NSCQ-LZX0062"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2023YFC2705900"],"award-info":[{"award-number":["2023YFC2705900"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.lfs.2026.124518","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T07:24:48Z","timestamp":1781076288000},"page":"124518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Protein N-glycosylation supports extravillous trophoblast cell lineage development in hypoxia microenvironment"],"prefix":"10.1016","volume":"402","author":[{"given":"Lijie","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enxiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.lfs.2026.124518_bb0005","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41574-020-0372-6","article-title":"Tracking placental development in health and disease","volume":"16","author":"Aplin","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"issue":"12","key":"10.1016\/j.lfs.2026.124518_bb0010","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.lfs.2026.124518_bb0015","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/humupd\/2.4.307","article-title":"Trophoblast migration during human placental implantation","volume":"2","author":"Burrows","year":"1996","journal-title":"Hum. Reprod. Update"},{"issue":"4","key":"10.1016\/j.lfs.2026.124518_bb0020","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1093\/humupd\/dms015","article-title":"Extravillous trophoblast and decidual natural killer cells: a remodelling partnership","volume":"18","author":"Wallace","year":"2012","journal-title":"Hum. Reprod. Update"},{"issue":"6","key":"10.1016\/j.lfs.2026.124518_bb0025","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00018-022-04377-0","article-title":"Early human trophoblast development: from morphology to function","volume":"79","author":"Gauster","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"issue":"9","key":"10.1016\/j.lfs.2026.124518_bb0030","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.devcel.2021.04.001","article-title":"Human placental cytotrophoblast epigenome dynamics over gestation and alterations in placental disease","volume":"56","author":"Zhang","year":"2021","journal-title":"Dev. Cell"},{"issue":"7955","key":"10.1016\/j.lfs.2026.124518_bb0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41586-023-05869-0","article-title":"Spatial multiomics map of trophoblast development in early pregnancy","volume":"616","author":"Arutyunyan","year":"2023","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.lfs.2026.124518_bb0040","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.stem.2023.12.013","article-title":"Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy","volume":"31","author":"Li","year":"2024","journal-title":"Cell Stem Cell"},{"issue":"4","key":"10.1016\/j.lfs.2026.124518_bb0045","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/humupd\/dmaa017","article-title":"Investigation of human trophoblast invasion in vitro","volume":"26","author":"Abbas","year":"2020","journal-title":"Hum. Reprod. Update"},{"issue":"10","key":"10.1016\/j.lfs.2026.124518_bb0050","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1038\/s41596-020-0381-x","article-title":"Establishment and differentiation of long-term trophoblast organoid cultures from the human placenta","volume":"15","author":"Sheridan","year":"2020","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.lfs.2026.124518_bb0055","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/7651_2022_463","article-title":"Generation of human trophoblast stem cell-dependent placental in vitro models","volume":"2767","author":"Wu","year":"2024","journal-title":"Methods Mol. Biol."},{"issue":"18","key":"10.1016\/j.lfs.2026.124518_bb0060","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2421653122","article-title":"Dysregulation of MYBL2 impairs extravillous trophoblast lineage development and function, contributing to recurrent spontaneous abortion","volume":"122","author":"Wu","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"16","key":"10.1016\/j.lfs.2026.124518_bb0065","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2426385122","article-title":"The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta","volume":"122","author":"Meinhardt","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"40","key":"10.1016\/j.lfs.2026.124518_bb0070","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2403003121","article-title":"NOTUM-mediated WNT silencing drives extravillous trophoblast cell lineage development","volume":"121","author":"Shukla","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.lfs.2026.124518_bb0075","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2016517118","article-title":"ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development","volume":"118","author":"Varberg","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.lfs.2026.124518_bb0080","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1038\/s41467-023-40424-5","article-title":"Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape","volume":"14","author":"Varberg","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2026.124518_bb0085","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/s41467-024-45669-2","article-title":"The transcriptional regulatory network modulating human trophoblast stem cells to extravillous trophoblast differentiation","volume":"15","author":"Kim","year":"2024","journal-title":"Nat. Commun."},{"issue":"14","key":"10.1016\/j.lfs.2026.124518_bb0090","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf669","article-title":"PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts","volume":"53","author":"Guo","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.lfs.2026.124518_bb0095","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1067\/mob.2001.111935","article-title":"Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16\u00a0weeks\u2019 gestation","volume":"184","author":"Jauniaux","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.lfs.2026.124518_bb0100","first-page":"283","article-title":"Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy","volume":"80","author":"Rodesch","year":"1992","journal-title":"Obstet. Gynecol."},{"issue":"7731","key":"10.1016\/j.lfs.2026.124518_bb0105","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"issue":"37","key":"10.1016\/j.lfs.2026.124518_bb0110","doi-asserted-by":"crossref","first-page":"E7786","DOI":"10.1073\/pnas.1710470114","article-title":"Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics","volume":"114","author":"Tsang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.lfs.2026.124518_bb0115","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.lfs.2026.124518_bb0120","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"issue":"6282","key":"10.1016\/j.lfs.2026.124518_bb0125","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.aad0501","article-title":"Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq","volume":"352","author":"Tirosh","year":"2016","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.lfs.2026.124518_bb0130","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41592-024-02378-4","article-title":"Gene-level alignment of single-cell trajectories","volume":"22","author":"Sumanaweera","year":"2025","journal-title":"Nat. Methods"},{"issue":"28","key":"10.1016\/j.lfs.2026.124518_bb0135","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2120667119","article-title":"Transforming growth factor-beta signaling governs the differentiation program of extravillous trophoblasts in the developing human placenta","volume":"119","author":"Haider","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.lfs.2026.124518_bb0140","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"Hanzelmann","year":"2013","journal-title":"BMC Bioinformatics"},{"issue":"6","key":"10.1016\/j.lfs.2026.124518_bb0145","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database (MSigDB) hallmark gene set collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"issue":"D1","key":"10.1016\/j.lfs.2026.124518_bb0150","doi-asserted-by":"crossref","first-page":"D545","DOI":"10.1093\/nar\/gkaa970","article-title":"KEGG: integrating viruses and cellular organisms","volume":"49","author":"Kanehisa","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.lfs.2026.124518_bb0155","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giz037","article-title":"GenPipes: an open-source framework for distributed and scalable genomic analyses","volume":"8","author":"Bourgey","year":"2019","journal-title":"Gigascience"},{"issue":"17","key":"10.1016\/j.lfs.2026.124518_bb0160","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.lfs.2026.124518_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13040-014-0034-0","article-title":"Performance of genetic programming optimised Bowtie2 on genome comparison and analytic testing (GCAT) benchmarks","volume":"8","author":"Langdon","year":"2015","journal-title":"BioData Min."},{"issue":"16","key":"10.1016\/j.lfs.2026.124518_bb0170","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"2","key":"10.1016\/j.lfs.2026.124518_bb0175","doi-asserted-by":"crossref","DOI":"10.1093\/gigascience\/giab008","article-title":"Twelve years of SAMtools and BCFtools","volume":"10","author":"Danecek","year":"2021","journal-title":"Gigascience"},{"issue":"4","key":"10.1016\/j.lfs.2026.124518_bb0180","doi-asserted-by":"crossref","DOI":"10.5808\/GI.2020.18.4.e42","article-title":"Comparative analysis of commonly used peak calling programs for ChIP-Seq analysis","volume":"18","author":"Jeon","year":"2020","journal-title":"Genomics Inform."},{"issue":"10","key":"10.1016\/j.lfs.2026.124518_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.585","article-title":"Exploring epigenomic datasets by ChIPseeker","volume":"2","author":"Wang","year":"2022","journal-title":"Curr. Protoc."},{"issue":"14","key":"10.1016\/j.lfs.2026.124518_bb0190","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/bioinformatics\/btv145","article-title":"ChIPseeker: an R\/Bioconductor package for ChIP peak annotation, comparison and visualization","volume":"31","author":"Yu","year":"2015","journal-title":"Bioinformatics"},{"issue":"D1","key":"10.1016\/j.lfs.2026.124518_bb0195","doi-asserted-by":"crossref","first-page":"D1243","DOI":"10.1093\/nar\/gkae974","article-title":"The UCSC Genome Browser database: 2025 update","volume":"53","author":"Perez","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"Web Server issue","key":"10.1016\/j.lfs.2026.124518_bb0200","doi-asserted-by":"crossref","first-page":"W187","DOI":"10.1093\/nar\/gku365","article-title":"deepTools: a flexible platform for exploring deep-sequencing data","volume":"42","author":"Ramirez","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.lfs.2026.124518_bb0205","doi-asserted-by":"crossref","first-page":"W554","DOI":"10.1093\/nar\/gkaf387","article-title":"WashU Epigenome Browser update 2025","volume":"53","author":"Seng","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.lfs.2026.124518_bb0210","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.43","article-title":"Complex heatmap visualization","volume":"1","author":"Gu","year":"2022","journal-title":"iMeta"},{"key":"10.1016\/j.lfs.2026.124518_bb0215","article-title":"Three differential expression analysis methods for RNA sequencing: limma, EdgeR, DESeq2","volume":"175","author":"Liu","year":"2021","journal-title":"J. Vis. Exp."},{"issue":"5","key":"10.1016\/j.lfs.2026.124518_bb0220","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"issue":"1","key":"10.1016\/j.lfs.2026.124518_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.stem.2017.11.004","article-title":"Derivation of human trophoblast stem cells","volume":"22","author":"Okae","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.lfs.2026.124518_bb0230","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1749-0774.2004.tb00018.x","article-title":"Establishment and characterization of a human gestational choriocarcinoma cell line (HOCC)","volume":"17","author":"Ishiwata","year":"2004","journal-title":"Hum. Cell"},{"issue":"16","key":"10.1016\/j.lfs.2026.124518_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/nu15163564","article-title":"Trophoblast differentiation: mechanisms and implications for pregnancy complications","volume":"15","author":"Lawless","year":"2023","journal-title":"Nutrients"},{"issue":"13","key":"10.1016\/j.lfs.2026.124518_bb0240","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3390\/cells14130970","article-title":"Epigenetic changes regulating the epithelial-mesenchymal transition in human trophoblast differentiation","volume":"14","author":"Ackerman","year":"2025","journal-title":"Cells"},{"issue":"18","key":"10.1016\/j.lfs.2026.124518_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189675","article-title":"The impact of hypoxia in early pregnancy on placental cells","volume":"22","author":"Zhao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2026.124518_bb0250","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/humupd\/dmaa053","article-title":"Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction","volume":"27","author":"Colson","year":"2021","journal-title":"Hum. Reprod. Update"},{"issue":"4","key":"10.1016\/j.lfs.2026.124518_bb0255","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/humupd\/dmp046","article-title":"Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy","volume":"16","author":"Pringle","year":"2010","journal-title":"Hum. Reprod. Update"},{"issue":"1","key":"10.1016\/j.lfs.2026.124518_bb0260","doi-asserted-by":"crossref","first-page":"F53","DOI":"10.1530\/REP-20-0153","article-title":"Hypoxia and reproductive health: oxygen and development of the human placenta","volume":"161","author":"Burton","year":"2021","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.lfs.2026.124518_bb0265","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2020-001243","article-title":"Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity","volume":"8","author":"Nteeba","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"issue":"18","key":"10.1016\/j.lfs.2026.124518_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184370","article-title":"Molecular targets of aspirin and prevention of preeclampsia and their potential association with circulating extracellular vesicles during pregnancy","volume":"20","author":"Dutta","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.lfs.2026.124518_bb0275","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.cmet.2025.04.001","article-title":"Protein O-GlcNAcylation and hexokinase mitochondrial dissociation drive heart failure with preserved ejection fraction","volume":"37","author":"Tatekoshi","year":"2025","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.lfs.2026.124518_bb0280","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1038\/s41598-024-55189-0","article-title":"Dynamic and distinct histone modifications facilitate human trophoblast lineage differentiation","volume":"14","author":"Lee","year":"2024","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.lfs.2026.124518_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.stemcr.2025.102481","article-title":"Hypoxia and loss of GCM1 expression prevent differentiation and contact inhibition in human trophoblast stem cells","volume":"20","author":"Cinkornpumin","year":"2025","journal-title":"Stem Cell Rep."},{"issue":"6","key":"10.1016\/j.lfs.2026.124518_bb0290","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1530\/REP-20-0483","article-title":"Implications for preeclampsia: hypoxia-induced Notch promotes trophoblast migration","volume":"161","author":"Perlman","year":"2021","journal-title":"Reproduction"},{"issue":"46","key":"10.1016\/j.lfs.2026.124518_bb0295","doi-asserted-by":"crossref","first-page":"E7212","DOI":"10.1073\/pnas.1612626113","article-title":"HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia","volume":"113","author":"Chakraborty","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.lfs.2026.124518_bb0300","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1172\/JCI8316","article-title":"Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFbeta(3)","volume":"105","author":"Caniggia","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.lfs.2026.124518_bb0305","doi-asserted-by":"crossref","first-page":"8077","DOI":"10.1038\/s41598-017-07560-7","article-title":"Hypoxia-induced TET1 facilitates trophoblast cell migration and invasion through HIF1alpha signaling pathway","volume":"7","author":"Zhu","year":"2017","journal-title":"Sci. Rep."},{"issue":"5332","key":"10.1016\/j.lfs.2026.124518_bb0310","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.277.5332.1669","article-title":"Regulation of human placental development by oxygen tension","volume":"277","author":"Genbacev","year":"1997","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.lfs.2026.124518_bb0315","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70115","article-title":"Hypoxia-induced O-GlcNAcylation of GATA3 leads to excessive testosterone production in preeclamptic placentas","volume":"6","author":"Liu","year":"2025","journal-title":"MedComm"},{"issue":"1","key":"10.1016\/j.lfs.2026.124518_bb0320","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3164\/jcbn.11-015FR","article-title":"Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle","volume":"48","author":"Shirato","year":"2011","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"1","key":"10.1016\/j.lfs.2026.124518_bb1000","doi-asserted-by":"crossref","first-page":"F53","DOI":"10.1530\/REP-20-0153","article-title":"HYPOXIA AND REPRODUCTIVE HEALTH: Oxygen and development of the human placenta","volume":"161","author":"Burton","year":"2021","journal-title":"Reproduction"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526003279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526003279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:29:04Z","timestamp":1786480144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526003279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":65,"alternative-id":["S0024320526003279"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124518","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protein N-glycosylation supports extravillous trophoblast cell lineage development in hypoxia microenvironment","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124518","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124518"}}