{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:46:25Z","timestamp":1785905185695,"version":"3.56.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00dcB\u0130TAK","doi-asserted-by":"publisher","award":["222S560"],"award-info":[{"award-number":["222S560"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.lfs.2026.124545","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:44:07Z","timestamp":1782283447000},"page":"124545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The generation of brown and white adipose organoids from induced pluripotent stem cells through differentiation into a neuromesodermal stage"],"prefix":"10.1016","volume":"401","author":[{"given":"Ezgi","family":"Bulut-Okumu\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6z\u00fcm Beg\u00fcm","family":"B\u00f6ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selinay","family":"\u015eenkal-Turhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazar Eren","family":"Soydan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engin","family":"S\u00fcmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Beydilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4160-2270","authenticated-orcid":false,"given":"Ay\u015feg\u00fcl","family":"Do\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2026.124545_bb0005","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trsl.2009.05.003","article-title":"Fat storage and the biology of energy expenditure","volume":"154","author":"Redinger","year":"2009","journal-title":"Transl. Res."},{"key":"10.1016\/j.lfs.2026.124545_bb0010","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ","volume":"89","author":"Kershaw","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2026.124545_bb0015","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13017","article-title":"Energy metabolism of white adipose tissue and insulin resistance in humans","volume":"48","author":"B\u00f3dis","year":"2018","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.lfs.2026.124545_bb0020","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00015.2003","article-title":"Brown adipose tissue: function and physiological significance","volume":"84","author":"Cannon","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.lfs.2026.124545_bb0025","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cell.2013.12.012","article-title":"What we talk about when we talk about fat","volume":"156","author":"Rosen","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2026.124545_bb0030","first-page":"1","article-title":"A mesodermal fate map for adipose tissue","volume":"145","author":"Sebo","year":"2018","journal-title":"Development (Cambridge)"},{"key":"10.1016\/j.lfs.2026.124545_bb0035","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3389\/fendo.2020.00634","article-title":"Beige fat maintenance; toward a sustained metabolic health","volume":"11","author":"Rabiee","year":"2020","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.lfs.2026.124545_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20205058","article-title":"The beige adipocyte as a therapy for metabolic diseases","volume":"20","author":"Lizcano","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2026.124545_bb0045","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1242\/dev.119768","article-title":"Neuromesodermal progenitors and the making of the spinal cord","volume":"142","author":"Henrique","year":"2015","journal-title":"Development (Cambridge)"},{"key":"10.1016\/j.lfs.2026.124545_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001937","article-title":"In vitro generation of neuromesodermal progenitors reveals distinct roles for Wnt signalling in the specification of spinal cord and paraxial mesoderm identity","volume":"12","author":"Gouti","year":"2014","journal-title":"PLoS Biol."},{"key":"10.1016\/j.lfs.2026.124545_bb0055","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41587-020-00762-x","article-title":"The organoid cell atlas","volume":"39","author":"Bock","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.lfs.2026.124545_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s43586-022-00174-y","article-title":"Organoids","volume":"2","author":"Zhao","year":"2022","journal-title":"Nat. Rev. Methods Primers"},{"key":"10.1016\/j.lfs.2026.124545_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.110778","article-title":"Development of a hepatic differentiation method in 2D culture from primary human hepatocyte-derived organoids for pharmaceutical research","volume":"27","author":"Ueyama-Toba","year":"2024","journal-title":"IScience"},{"key":"10.1016\/j.lfs.2026.124545_bb0070","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature17982","article-title":"Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis","volume":"536","author":"Takasato","year":"2016","journal-title":"Nat"},{"key":"10.1016\/j.lfs.2026.124545_bb0075","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202400105","article-title":"Pluripotent stem cell-derived organoids: a brief history of curiosity-led discoveries","volume":"46","author":"Lancaster","year":"2024","journal-title":"BioEssays"},{"key":"10.1016\/j.lfs.2026.124545_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122758","article-title":"From development to future prospects: the adipose tissue & adipose tissue organoids","volume":"351","author":"Okumu\u015f","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.lfs.2026.124545_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-43624-6","article-title":"Human adipose stromal-vascular fraction self-organizes to form vascularized adipose tissue in 3D cultures","volume":"9","author":"Muller","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2026.124545_bb0090","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.eng.2025.06.031","article-title":"Direct differentiation of human adult adipose tissue into multilineage functional organoids","volume":"53","author":"Huang","year":"2025","journal-title":"Engineering"},{"key":"10.1016\/j.lfs.2026.124545_bb0095","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11010-017-3265-9","article-title":"The role of adipose-derived stem cells in a self-organizing 3D model with regard to human soft tissue healing","volume":"445","author":"Oberringer","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.lfs.2026.124545_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-78015-9","article-title":"Generation of immune cell containing adipose organoids for in vitro analysis of immune metabolism","volume":"10","author":"Taylor","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2026.124545_bb0105","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/abe187","article-title":"Vascularized adipocyte organoid model using isolated human microvessel fragments","volume":"13","author":"Strobel","year":"2021","journal-title":"Biofabrication"},{"key":"10.1016\/j.lfs.2026.124545_bb0110","article-title":"Scalable generation of pre-vascularized and functional human beige adipose organoids","volume":"10","author":"Escudero","year":"2023","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.lfs.2026.124545_bb0115","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.cmet.2013.03.008","article-title":"Mechanisms and metabolic implications of regional differences among fat depots","volume":"17","author":"Tchkonia","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2026.124545_bb0120","doi-asserted-by":"crossref","first-page":"206","DOI":"10.5966\/sctm.2013-0125","article-title":"Comparison of human adipose-derived stem cells isolated from subcutaneous, omental, and intrathoracic adipose tissue depots for regenerative applications","volume":"3","author":"Russo","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.lfs.2026.124545_bb0125","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/scrt452","article-title":"Immortalization of human adipose-derived stromal cells: production of cell lines with high growth rate, mesenchymal marker expression and capability to secrete high levels of angiogenic factors","volume":"5","author":"Balducci","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.lfs.2026.124545_bb0130","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/ncb2411","article-title":"Programming human pluripotent stem cells into white and brown adipocytes","volume":"14","author":"Ahfeldt","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.lfs.2026.124545_bb0135","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.febslet.2009.02.031","article-title":"Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells","volume":"583","author":"Taura","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.lfs.2026.124545_bb0140","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.plipres.2008.03.003","article-title":"Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake","volume":"47","author":"Hodson","year":"2008","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.lfs.2026.124545_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep18366","article-title":"Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance","volume":"5","author":"Yew Tan","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2026.124545_bb0150","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/2091145a0","article-title":"Fatty acid composition of triglycerides from adipose tissue [37]","volume":"209","author":"Dawkins","year":"1966","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2026.124545_bb0155","first-page":"142","article-title":"The colors of adipose tissue","volume":"156","author":"Frigolet","year":"2020","journal-title":"Gac. Med. Mex."},{"key":"10.1016\/j.lfs.2026.124545_bb0160","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1007\/s00018-010-0263-4","article-title":"Adipocyte extracellular matrix composition, dynamics and role in obesity","volume":"67","author":"Mariman","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.lfs.2026.124545_bb0165","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1080\/15548627.2024.2338576","article-title":"TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytes","volume":"20","author":"Zhang","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.lfs.2026.124545_bb0170","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/s12276-021-00672-1","article-title":"Pyruvate dehydrogenase kinase 1 and 2 deficiency reduces high-fat diet-induced hypertrophic obesity and inhibits the differentiation of preadipocytes into mature adipocytes","volume":"53","author":"Kang","year":"2021","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.lfs.2026.124545_bb0175","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bcp.2013.03.021","article-title":"A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway","volume":"86","author":"Mazein","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.lfs.2026.124545_bb0180","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.cell.2018.10.016","article-title":"Secretin-activated brown fat mediates prandial thermogenesis to induce satiation","volume":"175","author":"Li","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.lfs.2026.124545_bb0185","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.stem.2020.07.013","article-title":"Generation of functional Brown adipocytes from human pluripotent stem cells via progression through a paraxial mesoderm state","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.lfs.2026.124545_bb0190","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4081\/ejh.2010.e48","article-title":"Subcutaneous adipose tissue classification","volume":"54","author":"Sbarbati","year":"2010","journal-title":"Eur. J. Histochem."},{"issue":"2","key":"10.1016\/j.lfs.2026.124545_bb0195","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11095-022-03195-0","article-title":"Engineering and characterization of a biomimetic microchip for differentiating mouse adipocytes in a 3D microenvironment","volume":"39","author":"Chen","year":"2022","journal-title":"Pharmaceutical Research"},{"key":"10.1016\/j.lfs.2026.124545_bb0200","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12015-015-9634-4","article-title":"Effects of cryopreservation on canine multipotent stromal cells from subcutaneous and infrapatellar adipose tissue","volume":"12","author":"Duan","year":"2016","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.lfs.2026.124545_bb0205","doi-asserted-by":"crossref","DOI":"10.1007\/s11306-017-1185-z","article-title":"LysoPC-acyl C16:0 is associated with brown adipose tissue activity in men","volume":"13","author":"Boon","year":"2017","journal-title":"Metabolomics"},{"key":"10.1016\/j.lfs.2026.124545_bb0210","first-page":"1","article-title":"Mitophagy is required for brown adipose tissue mitochondrial homeostasis during cold challenge","volume":"8","author":"Lu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2026.124545_bb0215","doi-asserted-by":"crossref","DOI":"10.1177\/1753466621998246","article-title":"PINK1\/Parkin-mediated mitophagy in mechanical ventilation-induced diaphragmatic dysfunction","volume":"15","author":"Yong","year":"2021","journal-title":"Ther. Adv. Respir. Dis."},{"key":"10.1016\/j.lfs.2026.124545_bb0220","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.lfs.2026.124545_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154770","article-title":"PI3K\/AKT signaling pathway is essential for survival of induced pluripotent stem cells","volume":"11","author":"Hossini","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2026.124545_bb0230","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14499","article-title":"Caloric restriction and telomere preservation in TERT knockout adipocyte progenitors does not rescue mice from metabolic dysfunction due to a TERT function in adipocyte mitochondria","volume":"24","author":"Gao","year":"2025","journal-title":"Aging Cell"},{"key":"10.1016\/j.lfs.2026.124545_bb0235","article-title":"SAMM50 regulates thermogenesis of beige adipocytes differentiated from human adipose-derived stem cells by balancing mitochondrial dynamics","volume":"23","author":"Park","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2026.124545_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100452","article-title":"The thermogenic characteristics of adipocytes are dependent on the regulation of iron homeostasis","volume":"296","author":"Yook","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2026.124545_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2024.101871","article-title":"Adipose knockout of H-ferritin improves energy metabolism in mice","volume":"80","author":"Lu","year":"2024","journal-title":"Mol. Metab."},{"key":"10.1016\/j.lfs.2026.124545_bb0250","doi-asserted-by":"crossref","first-page":"E562","DOI":"10.1152\/ajpendo.00153.2023","article-title":"Unraveling adipose tissue proteomic landscapes in severe obesity: insights into metabolic complications and potential biomarkers","volume":"325","author":"Hruska","year":"2023","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2026.124545_bb0255","doi-asserted-by":"crossref","first-page":"7298","DOI":"10.1126\/sciadv.abn7298","article-title":"Development of a physiological insulin resistance model in human stem cell\u2013derived adipocytes","volume":"8","author":"Friesen","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.lfs.2026.124545_bb0260","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.cmet.2015.09.007","article-title":"Brown and Beige fat: physiological roles beyond heat generation","volume":"22","author":"Kajimura","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2026.124545_bb0265","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-002107","article-title":"Depth of tumor implantation affects response to in situ vaccination in a syngeneic murine melanoma model","volume":"9","author":"Carlson","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.lfs.2026.124545_bb0270","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/ten.tea.2014.0299","article-title":"Engineering vascularized adipose tissue using the stromal-vascular fraction and fibrin hydrogels","volume":"21","author":"Wittmann","year":"2015","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.lfs.2026.124545_bb0275","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1172\/JCI62308","article-title":"Brown adipose tissue regulates glucose homeostasis and insulin sensitivity","volume":"123","author":"Stanford","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.lfs.2026.124545_bb0280","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1038\/s41587-024-02551-2","article-title":"Implantation of engineered adipocytes suppresses tumor progression in cancer models","volume":"43","author":"Nguyen","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.lfs.2026.124545_bb0285","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202407567","article-title":"Induced pluripotent stem cell-derived parathyroid organoids resemble parathyroid morphology and function","author":"\u015eenkal-Turhan","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.lfs.2026.124545_bb0290","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/7651_2021_404","article-title":"Feeder-free human embryonic stem cell culture under defined culture conditions","volume":"2520","author":"Hayal","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.lfs.2026.124545_bb0295","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.biochi.2025.06.016","article-title":"Neuromesodermal progenitor derived mesenchymal stem cells: a new source for osteogenesis and adipogenesis in vitro","volume":"236","author":"Do\u011fan","year":"2025","journal-title":"Biochimie"},{"key":"10.1016\/j.lfs.2026.124545_bb0300","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s12015-021-10281-0","article-title":"Human ESC-derived Neuromesodermal progenitors (NMPs) successfully differentiate into mesenchymal stem cells (MSCs)","volume":"18","author":"\u015eenkal","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.lfs.2026.124545_bb0305","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.68925","article-title":"Paraxial mesoderm organoids model development of human somites","volume":"11","author":"Budjan","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.lfs.2026.124545_bb0310","article-title":"Directed differentiation of hPSCs through lateral plate mesoderm for generation of articular cartilage progenitors","author":"Smith","year":"2021","journal-title":"BioRxiv"},{"key":"10.1016\/j.lfs.2026.124545_bb0315","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.scr.2014.04.015","article-title":"Highly efficient differentiation of embryonic stem cells into adipocytes by ascorbic acid","volume":"13","author":"Cuaranta-Monroy","year":"2014","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.lfs.2026.124545_bb0320","series-title":"Mouse Intestinal Organoid Culture Protocol","author":"B\u00f6ke","year":"2025"},{"key":"10.1016\/j.lfs.2026.124545_bb0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11033-024-09660-w","article-title":"Azoxymethane-induced carcinogenesis-like model of mouse intestine and mouse embryonic stem cell-derived intestinal organoids","volume":"51","author":"\u015ei\u015fli","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.lfs.2026.124545_bb0330","first-page":"1","article-title":"Establishment and drug resistance characterization of paired organoids using human primary colorectal cancer and matched tumor deposit specimens","volume":"38","author":"Deng","year":"2025","journal-title":"Hum. Cell"},{"key":"10.1016\/j.lfs.2026.124545_bb0335","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.metabol.2017.01.021","article-title":"A new hope for obesity management: boron inhibits adipogenesis in progenitor cells through the Wnt\/\u03b2-catenin pathway","volume":"69","author":"Do\u011fan","year":"2017","journal-title":"Metabolism"},{"key":"10.1016\/j.lfs.2026.124545_bb0340","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-0716-2675-7_16","article-title":"Nile red and BODIPY staining of lipid droplets in mouse oocytes and embryos","volume":"2566","author":"Bisogno","year":"2023","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.lfs.2026.124545_bb0345","first-page":"4849","article-title":"Differentiation of human stem cells is promoted by amphiphilic pluronic block copolymers","volume":"7","author":"Do\u011fan","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.lfs.2026.124545_bb0350","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11064-006-9217-5","article-title":"Spinal morphine administration reduces the fatty acid contents in spinal cord and brain by increasing oxidative stress","volume":"32","author":"\u00d6zmen","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.lfs.2026.124545_bb0355","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-31805-3","article-title":"Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism","volume":"13","author":"Cho","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2026.124545_bb0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13577-025-01200-3","article-title":"Derivation of functional neurons from induced pluripotent stem cells using a simple neuromesodermal progenitor generation and rapid spinal cord neuron differentiation process","volume":"38","author":"\u015eenkal-Turhan","year":"2025","journal-title":"Hum. Cell"},{"key":"10.1016\/j.lfs.2026.124545_bb0365","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.2337\/db10-1628","article-title":"Cross-talk between interferon-\u03b3 and hedgehog signaling regulates adipogenesis","volume":"60","author":"Todoric","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2026.124545_bb0370","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s10068-016-0183-7","article-title":"Lithium chloride\u2019s inhibition of 3T3-L1 cell differentiation by regulating the Wnt\/\u03b2-catenin pathway and enhancing villin 2 expression","volume":"25","author":"Chi","year":"2016","journal-title":"Food Sci. Biotechnol."},{"key":"10.1016\/j.lfs.2026.124545_bb0375","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1634\/stemcells.2006-0006","article-title":"Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells","volume":"24","author":"Zaragosi","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.lfs.2026.124545_bb0380","first-page":"121","article-title":"Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes","volume":"296","author":"Widberg","year":"2009"},{"key":"10.1016\/j.lfs.2026.124545_bb0385","first-page":"2873","article-title":"The importance of the canonical Wnt signaling pathway in the porcine endometrial stromal stem\/progenitor cells: implications for regeneration","volume":"24","author":"Bukowska","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.lfs.2026.124545_bb0390","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s13577-023-00861-2","article-title":"Regulatory role of apelin receptor signaling in migration and differentiation of mouse embryonic stem cell-derived mesoderm cells and mesenchymal stem\/stromal cells","volume":"36","author":"\u015ei\u015fli","year":"2023","journal-title":"Hum. Cell"},{"key":"10.1016\/j.lfs.2026.124545_bb0395","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00232-021-00190-1","article-title":"Search for novel plasma membrane proteins as potential biomarkers in human mesenchymal stem cells derived from dental pulp, adipose tissue, bone marrow, and hair follicle","volume":"254","author":"Akpinar","year":"2021","journal-title":"J. Membr. Biol."},{"issue":"9","key":"10.1016\/j.lfs.2026.124545_bb0400","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.lfs.2026.124545_bb0405","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2026.124545_bb0410","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.lfs.2026.124545_bb0415","doi-asserted-by":"crossref","first-page":"W566","DOI":"10.1093\/nar\/gkv468","article-title":"ClustVis: a web tool for visualizing clustering of multivariate data using principal component analysis and heatmap","volume":"43","author":"Metsalu","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lfs.2026.124545_bb0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12859-015-0611-3","article-title":"InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams","volume":"16","author":"Heberle","year":"2015","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.lfs.2026.124545_bb0425","doi-asserted-by":"crossref","first-page":"W191","DOI":"10.1093\/nar\/gkz369","article-title":"g:Profiler: a web server for functional enrichment analysis and conversions of gene lists","volume":"47","author":"Raudvere","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lfs.2026.124545_bb0430","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.202300217","article-title":"The role of Aplnr signaling in the developmental regulation of mesenchymal stem cell differentiation from human pluripotent stem cells","volume":"8","author":"\u015ei\u015fli","year":"2024","journal-title":"Adv. Biol."},{"key":"10.1016\/j.lfs.2026.124545_bb0435","doi-asserted-by":"crossref","DOI":"10.1007\/s11033-024-09375-y","article-title":"Conditioned medium of induced pluripotent stem cell derived neuromesodermal progenitors enhances cell migration in vitro","volume":"51","author":"Do\u011fan","year":"2024","journal-title":"Mol. Biol. Rep."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526003541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526003541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T04:02:32Z","timestamp":1785902552000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526003541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":87,"alternative-id":["S0024320526003541"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124545","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The generation of brown and white adipose organoids from induced pluripotent stem cells through differentiation into a neuromesodermal stage","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124545","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124545"}}