{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:27:25Z","timestamp":1786483645623,"version":"build-2736575974"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012576","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012576","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.lfs.2026.124560","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T22:58:34Z","timestamp":1783378714000},"page":"124560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["RPS20 phosphorylation acts as a molecular switch to integrate inflammatory and oxidative stress signals in sepsis"],"prefix":"10.1016","volume":"402","author":[{"given":"Gang","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qudi","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Jie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzheng","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0005","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-024-00397-7","article-title":"Role of macrophage in intervertebral disc degeneration","volume":"13","author":"Dou","year":"2025","journal-title":"Bone Res"},{"issue":"Pt 2","key":"10.1016\/j.lfs.2026.124560_bb0010","article-title":"Immunologic role of macrophages in sepsis-induced acute liver injury","volume":"143","author":"Xu","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"Pt 21","key":"10.1016\/j.lfs.2026.124560_bb0015","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1242\/jcs.111948","article-title":"Eukaryotic ribosome biogenesis at a glance","volume":"126","author":"Thomson","year":"2013","journal-title":"J. Cell Sci."},{"issue":"12","key":"10.1016\/j.lfs.2026.124560_bb0020","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1038\/s41594-024-01356-w","article-title":"A roadmap for ribosome assembly in human mitochondria","volume":"31","author":"Lavdovskaia","year":"2024","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"2","key":"10.1016\/j.lfs.2026.124560_bb0025","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/jmcb\/mjv014","article-title":"Ribosomal proteins: functions beyond the ribosome","volume":"7","author":"Zhou","year":"2015","journal-title":"J. Mol. Cell Biol."},{"issue":"7681","key":"10.1016\/j.lfs.2026.124560_bb0030","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature24482","article-title":"Visualization of chemical modifications in the human 80S ribosome structure","volume":"551","author":"Natchiar","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0035","doi-asserted-by":"crossref","DOI":"10.3892\/or.2022.8459","article-title":"Biochemical and clinical effects of RPS20 expression in renal clear cell carcinoma","volume":"49","author":"Shen","year":"2023","journal-title":"Oncol. Rep."},{"issue":"19","key":"10.1016\/j.lfs.2026.124560_bb0040","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1016\/j.yexcr.2013.09.013","article-title":"Late-assembly of human ribosomal protein S20 in the cytoplasm is essential for the functioning of the small subunit ribosome","volume":"319","author":"Tai","year":"2013","journal-title":"Exp. Cell Res."},{"issue":"16","key":"10.1016\/j.lfs.2026.124560_bb0045","doi-asserted-by":"crossref","first-page":"3804","DOI":"10.1016\/j.febslet.2006.05.073","article-title":"Mapping the essential structures of human ribosomal protein L7 for nuclear entry, ribosome assembly and function","volume":"580","author":"Ko","year":"2006","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.lfs.2026.124560_bb0050","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1139\/O08-032","article-title":"The role of expansion segment of human ribosomal protein L35 in nuclear entry, translation activity, and endoplasmic reticulum docking","volume":"86","author":"Chen","year":"2008","journal-title":"Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0055","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbrc.2005.07.069","article-title":"Identification of an unconventional nuclear localization signal in human ribosomal protein S2","volume":"335","author":"Antoine","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.lfs.2026.124560_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2020.566266","article-title":"New pathogenic germline variants in very early onset and familial colorectal Cancer patients","volume":"11","author":"Djursby","year":"2020","journal-title":"Front. Genet."},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0065","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1053\/j.gastro.2016.09.041","article-title":"Validation of recently proposed colorectal Cancer susceptibility gene variants in an analysis of families and patients-a systematic review","volume":"152","author":"Broderick","year":"2017","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.lfs.2026.124560_bb0070","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1053\/j.gastro.2014.06.009","article-title":"Germline mutation of RPS20, encoding a ribosomal protein, causes predisposition to hereditary nonpolyposis colorectal carcinoma without DNA mismatch repair deficiency","volume":"147","author":"Nieminen","year":"2014","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0075","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s10689-025-00446-y","article-title":"New RPS20 gene variant in colorectal cancer diagnosis: insight from a large series of patients","volume":"24","author":"Amiot","year":"2025","journal-title":"Fam. Cancer"},{"issue":"4","key":"10.1016\/j.lfs.2026.124560_bb0080","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.molcel.2016.12.026","article-title":"ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal Ubiquitylation","volume":"65","author":"Sundaramoorthy","year":"2017","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0085","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41467-017-00188-1","article-title":"Ubiquitination of stalled ribosome triggers ribosome-associated quality control","volume":"8","author":"Matsuo","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.molcel.2015.04.026","article-title":"The unfolded protein response triggers site-specific regulatory Ubiquitylation of 40S ribosomal proteins","volume":"59","author":"Higgins","year":"2015","journal-title":"Mol. Cell"},{"issue":"39","key":"10.1016\/j.lfs.2026.124560_bb0095","doi-asserted-by":"crossref","first-page":"27891","DOI":"10.1074\/jbc.274.39.27891","article-title":"Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB","volume":"274","author":"Hirota","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0100","doi-asserted-by":"crossref","first-page":"11421","DOI":"10.1038\/s41598-018-29802-y","article-title":"Interplay between human nucleolar GNL1 and RPS20 is critical to modulate cell proliferation","volume":"8","author":"Krishnan","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2026.124560_bb0105","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev.bi.54.070185.001321","article-title":"Thioredoxin","volume":"54","author":"Holmgren","year":"1985","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202249948","article-title":"The thioredoxin system: balancing redox responses in immune cells and tumors","volume":"53","author":"Muri","year":"2023","journal-title":"Eur. J. Immunol."},{"issue":"13","key":"10.1016\/j.lfs.2026.124560_bb0115","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1089\/ars.2012.4599","article-title":"Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling","volume":"19","author":"Hanschmann","year":"2013","journal-title":"Antioxid. Redox Signal."},{"issue":"5","key":"10.1016\/j.lfs.2026.124560_bb0120","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"Matute-Bello","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.lfs.2026.124560_bb0125","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1165\/rcmb.2021-0531ST","article-title":"Update on the features and measurements of experimental acute lung injury in animals: an official American Thoracic Society workshop report","volume":"66","author":"Kulkarni","year":"2022","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"6","key":"10.1016\/j.lfs.2026.124560_bb0130","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1097\/SHK.0000000000001310","article-title":"Methane-rich saline protects against sepsis-induced liver damage by regulating the PPAR-\u03b3\/NF-\u03baB signaling pathway","volume":"52","author":"Li","year":"2019","journal-title":"Shock"},{"key":"10.1016\/j.lfs.2026.124560_bb0135","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jare.2021.11.005","article-title":"The multiomics landscape of serum exosomes during the development of sepsis","volume":"39","author":"Li","year":"2022","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0140","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.gpb.2020.11.004","article-title":"Integrative proteomic analysis of multiple posttranslational modifications in inflammatory response","volume":"20","author":"Ji","year":"2022","journal-title":"Genomics Proteomics Bioinformatics"},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0145","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s13054-020-02950-2","article-title":"Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019- results from a systematic review and meta-analysis","volume":"24","author":"Bauer","year":"2020","journal-title":"Crit. Care"},{"issue":"3\u20134","key":"10.1016\/j.lfs.2026.124560_bb0150","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1089\/ars.2005.7.395","article-title":"Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus","volume":"7","author":"Kabe","year":"2005","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0155","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.lfs.2026.124560_bb0160","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1089\/ars.2009.3021","article-title":"Redox control systems in the nucleus: mechanisms and functions","volume":"13","author":"Go","year":"2010","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0165","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/mp\/sst162","article-title":"NTR\/NRX define a new thioredoxin system in the nucleus of Arabidopsis thaliana cells","volume":"7","author":"Marchal","year":"2014","journal-title":"Mol. Plant"},{"issue":"5","key":"10.1016\/j.lfs.2026.124560_bb0170","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/jcb.21762","article-title":"Oxidation and nuclear localization of thioredoxin-1 in sparse cell cultures","volume":"104","author":"Spielberger","year":"2008","journal-title":"J. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.lfs.2026.124560_bb0175","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1007\/s10753-025-02282-9","article-title":"TXM-CB13 improves the intestinal mucosal barrier and alleviates colitis by inhibiting the ROS\/TXNIP\/TRX\/NLRP3 and TLR4\/MyD88\/NF-\u03baB\/NLRP3 pathways","volume":"48","author":"Cao","year":"2025","journal-title":"Inflammation"},{"key":"10.1016\/j.lfs.2026.124560_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103897","article-title":"GDF15 nanotherapy ameliorates NLRP3-associated redox imbalance and cardiac injury in sepsis","volume":"88","author":"Guo","year":"2025","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.lfs.2026.124560_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.167916","article-title":"SLP65\/SLP76 Csk-interacting membrane protein promotes hepatic ischemia-reperfusion injury by activating TLR4\/Erk1\/2-mediated macrophages M1 polarization","volume":"1871","author":"Liu","year":"2025","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"17","key":"10.1016\/j.lfs.2026.124560_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179437","article-title":"Peroxiredoxin 1 controls ovulation and ovulated cumulus-oocyte complex activity through TLR4-derived ERK1\/2 signaling in mice","volume":"22","author":"Park","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"24","key":"10.1016\/j.lfs.2026.124560_bb0195","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.3123","article-title":"Method for studying the effect of gene silencing on bacterial infection-induced ERK1\/2 signaling in bone-marrow derived macrophages","volume":"8","author":"Kumar","year":"2018","journal-title":"Bio-protocol"},{"key":"10.1016\/j.lfs.2026.124560_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105743","article-title":"Carvacrol suppresses LPS-induced pro-inflammatory activation in RAW 264.7 macrophages through ERK1\/2 and NF-kB pathway","volume":"75","author":"Somensi","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0205","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12974-020-01758-9","article-title":"Mutant huntingtin affects toll-like receptor 4 intracellular trafficking and cytokine production in mast cells","volume":"17","author":"P\u00e9rez-Rodr\u00edguez","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"4","key":"10.1016\/j.lfs.2026.124560_bb0210","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/jnr.10875","article-title":"Regulation of a Ca2+\u2212activated K+ channel by calcium-sensing receptor involves p38 MAP kinase","volume":"75","author":"Ye","year":"2004","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.lfs.2026.124560_bb0215","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1007\/s10787-021-00877-w","article-title":"Dexmedetomidine attenuates haemorrhage-induced thalamic pain by inhibiting the TLR4\/NF-\u03baB\/ERK1\/2 pathway in mice","volume":"29","author":"Huang","year":"2021","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.lfs.2026.124560_bb0220","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbrc.2019.02.146","article-title":"Diesel exhaust particles elevate MUC5AC and MUC5B expression via the TLR4-mediated activation of ERK1\/2, p38 MAPK, and NF-\u03baB signaling pathways in human airway epithelial cells","volume":"512","author":"Na","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.lfs.2026.124560_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/cells10092500","article-title":"Interleukin-26 has synergistic catabolic effects with palmitate in human articular chondrocytes via the TLR4-ERK1\/2-c-Jun signaling pathway","volume":"10","author":"Chen","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2026.124560_bb0230","article-title":"S100A4 protects myeloid-derived suppressor cells from intrinsic apoptosis via TLR4-ERK1\/2 signaling","volume":"9","author":"Li","year":"2018","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.lfs.2026.124560_bb0235","article-title":"Evolutionarily conserved role of thioredoxin systems in determining longevity","volume":"12","author":"AlOkda","year":"2023","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"4","key":"10.1016\/j.lfs.2026.124560_bb0240","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1172\/JCI117482","article-title":"C\/EBP beta regulation of the tumor necrosis factor alpha gene","volume":"94","author":"Pope","year":"1994","journal-title":"J. Clin. Invest."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526003693?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526003693?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:28:38Z","timestamp":1786480118000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526003693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":48,"alternative-id":["S0024320526003693"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124560","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RPS20 phosphorylation acts as a molecular switch to integrate inflammatory and oxidative stress signals in sepsis","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124560","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124560"}}