{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:27:24Z","timestamp":1786483644668,"version":"build-2736575974"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Jilin Provincial Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.lfs.2026.124590","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:58:22Z","timestamp":1783954702000},"page":"124590","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Aerobic exercise reduces lipid accumulation via ACLY-mediated metabolic remodeling to alleviate cardiac remodeling"],"prefix":"10.1016","volume":"402","author":[{"given":"Gaoning","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingzheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimeng","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2026.124590_bb0005","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: a comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2026.124590_bb0010","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1161\/CIRCULATIONAHA.120.050498","article-title":"Myocardial gene expression signatures in human heart failure with preserved ejection fraction","volume":"143","author":"Hahn","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2026.124590_bb0015","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41569-021-00605-5","article-title":"Heart failure with mid-range or mildly reduced ejection fraction","volume":"19","author":"Savarese","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.lfs.2026.124590_bb0020","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","article-title":"Cardiac energy metabolism in heart failure","volume":"128","author":"Lopaschuk","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2026.124590_bb0025","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1096\/fj.04-2263com","article-title":"Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart","volume":"18","author":"Sharma","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2026.124590_bb0030","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1161\/CIRCULATIONAHA.111.060889","article-title":"Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure","volume":"125","author":"Chokshi","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2026.124590_bb0035","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.ejmech.2018.09.001","article-title":"ATP citrate lyase (ACLY) inhibitors: an anti-cancer strategy at the crossroads of glucose and lipid metabolism","volume":"157","author":"Granchi","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.lfs.2026.124590_bb0040","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41586-025-09297-0","article-title":"ACLY inhibition promotes tumour immunity and suppresses liver cancer","volume":"645","author":"Gautam","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.lfs.2026.124590_bb0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cmet.2025.11.015","article-title":"Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH","volume":"38","author":"Di Pastena","year":"2026","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2026.124590_bb0050","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.7150\/thno.105782","article-title":"A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY","volume":"15","author":"Zhang","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.lfs.2026.124590_bb0055","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1016\/j.apsb.2024.10.008","article-title":"Aclysiran, an RNAi therapeutic agent targeting ACLY, treats hypercholesterolemia and atherosclerosis in ApoE (\u2212\/\u2212) mice","volume":"14","author":"Chen","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.lfs.2026.124590_bb0060","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1161\/CIRCULATIONAHA.105.551457","article-title":"Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment","volume":"112","author":"Lee","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2026.124590_bb0065","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2165\/00129784-200101030-00005","article-title":"Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease","volume":"1","author":"Killalea","year":"2001","journal-title":"Am. J. Cardiovasc. Drugs Drugs Devices Other Intervent."},{"key":"10.1016\/j.lfs.2026.124590_bb0070","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0008-6363(01)00560-0","article-title":"Pyruvate dehydrogenase and the regulation of glucose oxidation in hypertrophied rat hearts","volume":"53","author":"Lydell","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2026.124590_bb0075","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1161\/CIRCRESAHA.112.268128","article-title":"Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy","volume":"111","author":"Kolwicz","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2026.124590_bb0080","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/01.CIR.0000081780.38477.FA","article-title":"Antiremodeling effect of long-term exercise training in patients with stable chronic heart failure results of the exercise in left ventricular dysfunction and chronic heart failure (ELVD-CHF) trial","volume":"108","author":"Giannuzzi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2026.124590_bb0085","doi-asserted-by":"crossref","first-page":"e71481","DOI":"10.1096\/fj.202500863RRRR","article-title":"Deficiency of FNDC5\/irisin impairs the protective effect of exercise against post-infarction myocardial mitochondrial injury","volume":"40","author":"Qin","year":"2026","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2026.124590_bb0090","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/eurheartj\/ehad118","article-title":"Cardiac rehabilitation for heart failure: \u2018Cinderella\u2019 or evidence-based pillar of care?","volume":"44","author":"Taylor","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2026.124590_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.ab.2020.113828","article-title":"Commercially available transfection reagents and negative control siRNA are not inert","volume":"606","author":"Kleefeldt","year":"2020","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.lfs.2026.124590_bb0100","doi-asserted-by":"crossref","first-page":"e71491","DOI":"10.1096\/fj.202503525R","article-title":"RNA processing in cardiac hypertrophy: coordinating physiological adaptation and pathological remodeling","volume":"40","author":"Peng","year":"2026","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2026.124590_bb0105","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1038\/s41467-024-48970-2","article-title":"Semaglutide ameliorates cardiac remodeling in male mice by optimizing energy substrate utilization through the Creb5\/NR4a1 axis","volume":"15","author":"Ma","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2026.124590_bb0110","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/CIRCULATIONAHA.119.043319","article-title":"Increasing fatty acid oxidation prevents high-fat diet-induced cardiomyopathy through regulating Parkin-mediated mitophagy","volume":"142","author":"Shao","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.lfs.2026.124590_bb0115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/CIRCRESAHA.118.312017","article-title":"Metabolic coordination of physiological and pathological cardiac remodeling","volume":"123","author":"Gibb","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2026.124590_bb0125","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cmet.2022.05.004","article-title":"Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia","volume":"34","author":"Morrow","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2026.124590_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.plipres.2019.101006","article-title":"ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: an updated review","volume":"77","author":"Feng","year":"2020","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.lfs.2026.124590_bb0135","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJMoa1806747","article-title":"Mendelian randomization study of ACLY and cardiovascular disease","volume":"380","author":"Ference","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2026.124590_bb0140","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/eurheartj\/ehz962","article-title":"Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel","volume":"41","author":"Bor\u00e9n","year":"2020","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2026.124590_bb0145","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s13046-019-1391-9","article-title":"ACLY facilitates colon cancer cell metastasis by CTNNB1","volume":"38","author":"Wen","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.lfs.2026.124590_bb0150","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/hep.31249","article-title":"The IKK\u03b2-USP30-ACLY axis controls lipogenesis and tumorigenesis","volume":"73","author":"Gu","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2026.124590_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/cells10112962","article-title":"ACLY nuclear translocation in human macrophages drives proinflammatory gene expression by NF-\u03baB acetylation","volume":"10","author":"Santarsiero","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2026.124590_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2025.102233","article-title":"Nuclear functional role of metabolic enzymes and related metabolites: focus on gene expression regulation","volume":"100","author":"Todisco","year":"2025","journal-title":"Mol. Metab."},{"key":"10.1016\/j.lfs.2026.124590_bb0165","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1056\/NEJMoa2215024","article-title":"Bempedoic acid and cardiovascular outcomes in statin-intolerant patients","volume":"388","author":"Nissen","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.lfs.2026.124590_bb0170","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.jacc.2013.05.050","volume":"62","author":"Ballantyne","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2026.124590_bb0175","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1161\/ATVBAHA.113.302677","article-title":"Efficacy and safety of ETC-1002, a novel investigational low-density lipoprotein-cholesterol-lowering therapy for the treatment of patients with hypercholesterolemia and type 2 diabetes mellitus","volume":"34","author":"Gutierrez","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.lfs.2026.124590_bb0180","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1001\/jamacardio.2023.2402","article-title":"Adenosine triphosphate citrate lyase and fatty acid synthesis inhibition: a narrative review","volume":"8","author":"Duarte Lau","year":"2023","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.lfs.2026.124590_bb0185","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1001\/jama.2023.9696","article-title":"Bempedoic acid for primary prevention of cardiovascular events in statin-intolerant patients","volume":"330","author":"Nissen","year":"2023","journal-title":"Jama"},{"key":"10.1016\/j.lfs.2026.124590_bb0190","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/s12967-023-04431-w","article-title":"ACLY as a modulator of liver cell functions and its role in metabolic dysfunction-associated steatohepatitis","volume":"21","author":"Convertini","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.lfs.2026.124590_bb0195","article-title":"The nuclear localization of ACLY guards early embryo development through recruiting P300 and HAT1 to promote histone acetylation and transcription","volume":"12","author":"Ma","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.lfs.2026.124590_bb0200","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jacc.2024.04.048","article-title":"Comparative cardiovascular benefits of bempedoic acid and statin drugs","volume":"84","author":"Lincoff","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.lfs.2026.124590_bb0205","article-title":"ATP-citrate lyase supports cardiac function and NAD(+)\/NADH balance and is depressed in human failing myocardium","volume":"10","author":"Meddeb","year":"2025","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.lfs.2026.124590_bb0210","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1161\/HYPERTENSIONAHA.124.24088","article-title":"ACLY promotes cardiac fibrosis via the regulation of DNL and histone acetylation","volume":"82","author":"Kuwahara","year":"2025","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2026.124590_bb0215","article-title":"Exercise-based cardiac rehabilitation for adults with heart failure","volume":"3","author":"Molloy","year":"2024","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.lfs.2026.124590_bb0220","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD011273","article-title":"Cardiac rehabilitation for people with heart disease: an overview of Cochrane systematic reviews","volume":"2014","author":"Anderson","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.lfs.2026.124590_bb0225","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009305","article-title":"High-intensity interval training for patients with cardiovascular disease-is it safe? A systematic review","volume":"7","author":"Wewege","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.lfs.2026.124590_bb0230","article-title":"Effects of exercise combined with undenatured type II collagen on endurance capacity, antioxidant status, muscle lipogenic genes and E3 ubiquitin ligases in rats","volume":"11","author":"Orhan","year":"2021","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.lfs.2026.124590_bb0235","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1161\/CIRCRESAHA.123.321759","article-title":"Cardiac metabolism in heart failure and implications for uremic cardiomyopathy","volume":"132","author":"Nguyen","year":"2023","journal-title":"Circ. Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526003991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526003991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:28:29Z","timestamp":1786480109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526003991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":46,"alternative-id":["S0024320526003991"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124590","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aerobic exercise reduces lipid accumulation via ACLY-mediated metabolic remodeling to alleviate cardiac remodeling","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124590","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124590"}}