{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:13:55Z","timestamp":1789751635931,"version":"4.0.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.lfs.2026.124616","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T05:54:55Z","timestamp":1785995695000},"page":"124616","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Catestatin improves cardiac function during ischemia\/reperfusion via activation of ATP-sensitive potassium channel in rats"],"prefix":"10.1016","volume":"403","author":[{"given":"Hua","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid N.","family":"Maslov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia V.","family":"Naryzhnaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suibing","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2026.124616_bb0005","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1093\/eurheartj\/ehaf205","article-title":"Ischaemic conditioning: a renaissance with wider perspectives?","volume":"46","author":"Heusch","year":"2025","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.lfs.2026.124616_bb0010","doi-asserted-by":"crossref","DOI":"10.1177\/10742484231179613","article-title":"Cardioprotection and its translation: a need for new paradigms? Or for new pragmatism? An opinionated retro- and perspective","volume":"28","author":"Heusch","year":"2023","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2026.124616_bb0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1124\/pharmrev.121.000348","article-title":"Interaction of cardiovascular nonmodifiable risk factors, comorbidities and Comedications with ischemia\/reperfusion injury and Cardioprotection by pharmacological treatments and ischemic conditioning","volume":"75","author":"Ferdinandy","year":"2023","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.lfs.2026.124616_bb0020","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.medj.2023.12.007","article-title":"Myocardial ischemia\/reperfusion: translational pathophysiology of ischemic heart disease","volume":"5","author":"Heusch","year":"2024","journal-title":"Med"},{"key":"10.1016\/j.lfs.2026.124616_bb0025","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0167-0115(98)00040-8","article-title":"Mechanism of action of chromogranin a on catecholamine release: molecular modeling of the catestatin region reveals a beta-strand\/loop\/beta-strand structure secured by hydrophobic interactions and predictive of activity","volume":"77","author":"Tsigelny","year":"1998","journal-title":"Regul. Pept."},{"key":"10.1016\/j.lfs.2026.124616_bb0030","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/cvr\/cvn155","article-title":"Catestatin is a novel endogenous peptide that regulates cardiac function and blood pressure","volume":"80","author":"Mahapatra","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.lfs.2026.124616_bb0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.regpep.2010.01.006","article-title":"Catestatin: a multifunctional peptide from chromogranin a","volume":"162","author":"Mahata","year":"2010","journal-title":"Regul. Pept."},{"key":"10.1016\/j.lfs.2026.124616_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.909480","article-title":"Role of Catestatin in the cardiovascular system and metabolic disorders","volume":"9","author":"Zalewska","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.lfs.2026.124616_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9121757","article-title":"Catestatin as a biomarker of cardiovascular diseases: a clinical perspective","volume":"9","author":"Bozic","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.lfs.2026.124616_bb0050","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.3760\/cma.j.issn.0366-6999.20120757","article-title":"Catestatin could ameliorate proliferating changes of target organs in spontaneously hypertensive rats","volume":"126","author":"Liu","year":"2013","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.lfs.2026.124616_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2022.170904","article-title":"Chronic catestatin treatment reduces atrial fibrillation susceptibility via improving calcium handling in post-infarction heart failure rats","volume":"159","author":"Yan","year":"2023","journal-title":"Peptides"},{"key":"10.1016\/j.lfs.2026.124616_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119790","article-title":"Catestatin exerts direct protective effects on rat cardiomyocytes undergoing ischemia\/reperfusion by stimulating PI3K-Akt-GSK3beta pathway and preserving mitochondrial membrane potential","volume":"10","author":"Bassino","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.lfs.2026.124616_bb0065","doi-asserted-by":"crossref","DOI":"10.1177\/1074248416628676","article-title":"Chronic Administration of Catestatin Improves Autonomic Function and Exerts Cardioprotective Effects in myocardial infarction rats","author":"Wang","year":"2016","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.lfs.2026.124616_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.npep.2025.102550","article-title":"Catestatin attenuates cerebral ischemia\/reperfusion injury and suppresses endoplasmic reticulum stress","volume":"113","author":"Zhang","year":"2025","journal-title":"Neuropeptides"},{"key":"10.1016\/j.lfs.2026.124616_bb0075","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00395-025-01108-x","article-title":"Tyrosine phosphorylation of Kir6.2 subunit negatively regulates cardiac K(ATP) channel activity","volume":"120","author":"Zhi","year":"2025","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.lfs.2026.124616_bb0080","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000342481","article-title":"Ischemic preconditioning reduces right ventricular infarct size through opening of mitochondrial potassium channels","volume":"123","author":"Andersen","year":"2012","journal-title":"Cardiology"},{"key":"10.1016\/j.lfs.2026.124616_bb0085","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1111\/bph.16390","article-title":"Identification and characterisation of functional K(ir)6.1-containing ATP-sensitive potassium channels in the cardiac ventricular sarcolemmal membrane","volume":"181","author":"Brennan","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2026.124616_bb0090","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.026304","article-title":"ATP-sensitive potassium channel opener Diazoxide reduces myocardial stunning in a porcine regional with subsequent global ischemia model","volume":"11","author":"Velez","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.lfs.2026.124616_bb0095","doi-asserted-by":"crossref","first-page":"10052","DOI":"10.1039\/D3FO02633G","article-title":"Fucoxanthin alleviated myocardial ischemia and reperfusion injury through inhibition of ferroptosis via the NRF2 signaling pathway","volume":"14","author":"Yan","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.lfs.2026.124616_bb0100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1023\/A:1016198011919","article-title":"Ischemic shortening of action potential duration as a result of KATP channel opening attenuates myocardial stunning by reducing calcium influx","volume":"236","author":"Lascano","year":"2002","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.lfs.2026.124616_bb0105","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.vph.2005.02.008","article-title":"Mechanisms by which K(ATP) channel openers produce acute and delayed cardioprotection","volume":"42","author":"Wang","year":"2005","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.lfs.2026.124616_bb0110","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/00005344-200109000-00009","article-title":"K(ATP) channel opening during ischemia: effects on myocardial noradrenaline release and ventricular arrhythmias","volume":"38","author":"Remme","year":"2001","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.lfs.2026.124616_bb0115","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.035415","article-title":"Electrophysiological mechanism of Catestatin Antiarrhythmia: enhancement of I(to), I(K,) and I(K1) and inhibition of I(ca)(\u2212L) in rat ventricular myocytes","volume":"13","author":"Zhang","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.lfs.2026.124616_bb0120","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","article-title":"Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches","volume":"391","author":"Hamill","year":"1981","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.lfs.2026.124616_bb0125","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s10571-010-9598-5","article-title":"Catestatin improves post-ischemic left ventricular function and decreases ischemia\/reperfusion injury in heart","volume":"30","author":"Penna","year":"2010","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.lfs.2026.124616_bb0130","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1152\/physiol.00030.2013","article-title":"Mechanisms of exercise-induced cardioprotection","volume":"29","author":"Powers","year":"2014","journal-title":"Physiology"},{"key":"10.1016\/j.lfs.2026.124616_bb0135","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10974-012-9310-0","article-title":"The velocity of cardiac sarcomere shortening: mechanisms and implications","volume":"33","author":"de Tombe","year":"2012","journal-title":"J. Muscle Res. Cell Motil."},{"key":"10.1016\/j.lfs.2026.124616_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112893","article-title":"Protective effects of natural products against myocardial ischemia\/reperfusion: mitochondria-targeted therapeutics","volume":"149","author":"Su","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.lfs.2026.124616_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104708","article-title":"Mitochondrial membrane potential instability on reperfusion after ischemia does not depend on mitochondrial ca(2+) uptake","volume":"299","author":"Ashok","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2026.124616_bb0150","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1161\/01.RES.0000181171.65293.65","article-title":"Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice","volume":"97","author":"Heinzel","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2026.124616_bb0155","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1161\/01.RES.87.6.460","article-title":"Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals","volume":"87","author":"Pain","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2026.124616_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1173462","article-title":"Diazoxide is a powerful cardioprotectant but is not feasible in a realistic infarct scenario","volume":"10","author":"Kleinbongard","year":"2023","journal-title":"Front. Cardiovasc. Med."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052600425X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052600425X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:57:50Z","timestamp":1789750670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002432052600425X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":32,"alternative-id":["S002432052600425X"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124616","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Catestatin improves cardiac function during ischemia\/reperfusion via activation of ATP-sensitive potassium channel in rats","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124616","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124616"}}