{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:00:50Z","timestamp":1790154050576,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370416"],"award-info":[{"award-number":["82370416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800426"],"award-info":[{"award-number":["81800426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.lfs.2026.124639","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:13:53Z","timestamp":1787181233000},"page":"124639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Epigenetic repression of RGS2 transcription by HDAC5 contributes to deep vein thrombosis"],"prefix":"10.1016","volume":"404","author":[{"given":"Mengzhu","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmeng","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingxi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.lfs.2026.124639_bb0005","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/ATVBAHA.124.322395","article-title":"Transforming growth factors in venous Thrombus formation and resolution","volume":"45","author":"Davis","year":"2025","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"10294","key":"10.1016\/j.lfs.2026.124639_bb0010","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(20)32658-1","article-title":"Venous thromboembolism","volume":"398","author":"Khan","year":"2021","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.lfs.2026.124639_bb0015","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1161\/ATVBAHA.108.162545","article-title":"The epidemiology of venous thromboembolism in the community","volume":"28","author":"Heit","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.lfs.2026.124639_bb0020","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/jim-2017-000442","article-title":"Anti-inflammatory effects of simvastatin during the resolution phase of experimentally formed venous thrombi","volume":"65","author":"Feng","year":"2017","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.lfs.2026.124639_bb0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.thromres.2017.06.017","article-title":"Late outcomes of pulmonary embolism: the post-PE syndrome","volume":"164","author":"Sista","year":"2018","journal-title":"Thromb. Res."},{"issue":"1","key":"10.1016\/j.lfs.2026.124639_bb0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-0034-1398376","article-title":"Coagulation in patients with severe sepsis","volume":"41","author":"Levi","year":"2015","journal-title":"Semin. Thromb. Hemost."},{"issue":"9465","key":"10.1016\/j.lfs.2026.124639_bb0035","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/S0140-6736(05)71880-8","article-title":"Deep vein thrombosis","volume":"365","author":"Kyrle","year":"2005","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.lfs.2026.124639_bb0040","doi-asserted-by":"crossref","first-page":"Itc129","DOI":"10.7326\/AITC202209200","article-title":"Deep venous thrombosis","volume":"175","author":"Duffett","year":"2022","journal-title":"Ann. Intern. Med."},{"issue":"1","key":"10.1016\/j.lfs.2026.124639_bb0045","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jtha.2023.07.020","article-title":"Thromboinflammation in acute injury: infections, heatstroke, and trauma","volume":"22","author":"Iba","year":"2024","journal-title":"J. Thromb. Haemost."},{"issue":"Suppl. 1","key":"10.1016\/j.lfs.2026.124639_bb0050","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/jth.12261","article-title":"Crossroads of coagulation and innate immunity: the case of deep vein thrombosis","volume":"11","author":"Schulz","year":"2013","journal-title":"J. Thromb. Haemost."},{"issue":"9","key":"10.1016\/j.lfs.2026.124639_bb0055","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1056\/NEJMra0801082","article-title":"Mechanisms of thrombus formation","volume":"359","author":"Furie","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.lfs.2026.124639_bb0060","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1161\/ATVBAHA.118.311194","article-title":"Contribution of the TNF-\u03b1 (tumor necrosis factor-\u03b1)-TNF-Rp55 (tumor necrosis factor receptor p55) Axis in the resolution of venous Thrombus","volume":"38","author":"Nosaka","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.lfs.2026.124639_bb0065","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1161\/ATVBAHA.119.313137","article-title":"IL (interleukin)-6 contributes to deep vein thrombosis and is negatively regulated by miR-338-5p","volume":"40","author":"Zhang","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124639_bb0070","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jtha.2023.09.022","article-title":"COVID-19 promotes endothelial dysfunction and thrombogenicity: role of proinflammatory cytokines\/SGLT2 prooxidant pathway","volume":"22","author":"Mroueh","year":"2024","journal-title":"J. Thromb. Haemost."},{"issue":"13","key":"10.1016\/j.lfs.2026.124639_bb0075","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1182\/blood.2022016424","article-title":"The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis","volume":"140","author":"Kondreddy","year":"2022","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.lfs.2026.124639_bb0080","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1093\/cvr\/cvab198","article-title":"HDAC1: an environmental sensor regulating endothelial function","volume":"118","author":"Dunaway","year":"2022","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.lfs.2026.124639_bb0085","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1161\/CIRCRESAHA.120.316743","article-title":"Histone deacetylase 9 activates IKK to regulate atherosclerotic plaque vulnerability","volume":"127","author":"Asare","year":"2020","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.lfs.2026.124639_bb0090","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1471-4892(03)00084-5","article-title":"Histone deacetylases","volume":"3","author":"Marks","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"issue":"2","key":"10.1016\/j.lfs.2026.124639_bb0095","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S1097-2765(00)00025-3","article-title":"Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases","volume":"6","author":"Lu","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.lfs.2026.124639_bb0100","article-title":"Insights into the function and clinical application of HDAC5 in Cancer management","volume":"11","author":"Yang","year":"2021","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.lfs.2026.124639_bb0105","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.bbadis.2019.04.009","article-title":"Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2","volume":"1865","author":"Tian","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.lfs.2026.124639_bb0110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.lfs.2019.02.004","article-title":"HDAC5 promotes mycoplasma pneumoniae-induced inflammation in macrophages through NF-\u03baB activation","volume":"221","author":"Zhao","year":"2019","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.lfs.2026.124639_bb0115","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s13023-023-02896-y","article-title":"HDAC5 inhibition attenuates ventricular remodeling and cardiac dysfunction","volume":"18","author":"Zhu","year":"2023","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.lfs.2026.124639_bb0120","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.thromres.2022.09.015","article-title":"Epigenetic repression of THBD transcription by BRG1 contributes to deep vein thrombosis","volume":"219","author":"Wu","year":"2022","journal-title":"Thromb. Res."},{"issue":"23","key":"10.1016\/j.lfs.2026.124639_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315330","article-title":"The PI3K\/Akt pathway in Meta-inflammation","volume":"23","author":"Acosta-Martinez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2026.124639_bb0140","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03172-24","article-title":"A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation","volume":"16","author":"Majerciak","year":"2025","journal-title":"mBio"},{"issue":"1","key":"10.1016\/j.lfs.2026.124639_bb0145","article-title":"A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation","volume":"16","year":"2025","journal-title":"mBio"},{"issue":"4","key":"10.1016\/j.lfs.2026.124639_bb0150","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1111\/jcmm.14188","article-title":"Histone deacetylase inhibitor LMK235 attenuates vascular constriction and aortic remodelling in hypertension","volume":"23","author":"Choi","year":"2019","journal-title":"J. Cell. Mol. Med."},{"issue":"24","key":"10.1016\/j.lfs.2026.124639_bb0155","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1158\/0008-5472.CAN-21-4362","article-title":"HDAC5 loss enhances phospholipid-derived arachidonic acid generation and confers sensitivity to cPLA2 inhibition in pancreatic Cancer","volume":"82","author":"Pan","year":"2022","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.lfs.2026.124639_bb0160","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1158\/0008-5472.CAN-20-2828","article-title":"HDAC5 loss impairs RB repression of pro-oncogenic genes and confers CDK4\/6 inhibitor resistance in Cancer","volume":"81","author":"Zhou","year":"2021","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.lfs.2026.124639_bb0165","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/s41416-019-0625-0","article-title":"HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer","volume":"121","author":"Xue","year":"2019","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.lfs.2026.124639_bb0170","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.7150\/thno.69444","article-title":"HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer","volume":"12","author":"Zhou","year":"2022","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.lfs.2026.124639_bb0175","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.molcel.2013.09.003","article-title":"HDAC5, a key component in temporal regulation of p53-mediated transactivation in response to genotoxic stress","volume":"52","author":"Sen","year":"2013","journal-title":"Mol. Cell"},{"issue":"8","key":"10.1016\/j.lfs.2026.124639_bb0180","doi-asserted-by":"crossref","first-page":"5438","DOI":"10.1074\/jbc.M007699200","article-title":"Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling","volume":"276","author":"Cunningham","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"29","key":"10.1016\/j.lfs.2026.124639_bb0185","doi-asserted-by":"crossref","first-page":"19402","DOI":"10.1074\/jbc.M109.024711","article-title":"Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2)","volume":"284","author":"Kimple","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.lfs.2026.124639_bb0190","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S1357-2725(01)00141-8","article-title":"RGS2: a multifunctional regulator of G-protein signaling","volume":"34","author":"Kehrl","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"11","key":"10.1016\/j.lfs.2026.124639_bb0195","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1111\/j.1538-7836.2012.04903.x","article-title":"Regulators of G protein signaling: role in hematopoiesis, megakaryopoiesis and platelet function","volume":"10","author":"Louwette","year":"2012","journal-title":"J. Thromb. Haemost."},{"issue":"11","key":"10.1016\/j.lfs.2026.124639_bb0200","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/s12276-021-00702-y","article-title":"The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats","volume":"53","author":"Gan","year":"2021","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"10.1016\/j.lfs.2026.124639_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12331","article-title":"Extracellular vesicles from human plasma dampen inflammation and promote tissue repair functions in macrophages","volume":"12","author":"Adamczyk","year":"2023","journal-title":"J. Extracell. Vesicles"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526004480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526004480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:05:46Z","timestamp":1790150746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526004480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":39,"alternative-id":["S0024320526004480"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124639","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic repression of RGS2 transcription by HDAC5 contributes to deep vein thrombosis","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124639","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124639"}}