{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:00:48Z","timestamp":1790154048785,"version":"4.0.1"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002822","name":"Central South University","doi-asserted-by":"publisher","award":["YX202201"],"award-info":[{"award-number":["YX202201"]}],"id":[{"id":"10.13039\/501100002822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ20093"],"award-info":[{"award-number":["2022JJ20093"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ30852"],"award-info":[{"award-number":["2023JJ30852"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202391"],"award-info":[{"award-number":["82202391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.lfs.2026.124647","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:44:17Z","timestamp":1787388257000},"page":"124647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["GALNT6-mediated O-glycosylation suppresses NLRP3 inflammasome activation to alleviate atopic dermatitis"],"prefix":"10.1016","volume":"404","author":[{"given":"Yingshan","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenming","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0005","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jaci.2022.09.020","article-title":"Allergen immunotherapy for atopic dermatitis: systematic review and meta-analysis of benefits and harms","volume":"151","author":"Yepes-Nu\u00f1ez","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2026.124647_bb0010","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12016-021-08880-3","article-title":"Update on the pathogenesis and therapy of atopic dermatitis","volume":"61","author":"Li","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"10478","key":"10.1016\/j.lfs.2026.124647_bb0015","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(24)02519-4","article-title":"Atopic dermatitis","volume":"405","author":"Guttman-Yassky","year":"2025","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.lfs.2026.124647_bb0020","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.jaci.2023.08.029","article-title":"Systemic treatments for atopic dermatitis (eczema): systematic review and network meta-analysis of randomized trials","volume":"152","author":"Chu","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-021-00266-6","article-title":"Atopic dermatitis: an expanding therapeutic pipeline for a complex disease","volume":"21","author":"Bieber","year":"2022","journal-title":"Nat. Rev. Drug Discov."},{"issue":"8","key":"10.1016\/j.lfs.2026.124647_bb0030","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1111\/all.15807","article-title":"Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"78","author":"Shin","year":"2023","journal-title":"Allergy"},{"issue":"5","key":"10.1016\/j.lfs.2026.124647_bb0035","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S2213-2600(25)00003-7","article-title":"Global, regional, and national burden of asthma and atopic dermatitis, 1990-2021, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021","volume":"13","year":"2025","journal-title":"Lancet Respir. Med."},{"issue":"10440","key":"10.1016\/j.lfs.2026.124647_bb0040","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/S0140-6736(24)00685-8","article-title":"Burden of disease scenarios for 204 countries and territories, 2022-2050: a forecasting analysis for the Global Burden of Disease Study 2021","volume":"403","year":"2024","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0045","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaad.2014.03.023","article-title":"Guidelines of care for the management of atopic dermatitis: section 2. Management and treatment of atopic dermatitis with topical therapies","volume":"71","author":"Eichenfield","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0050","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jaad.2022.12.029","article-title":"Guidelines of care for the management of atopic dermatitis in adults with topical therapies","volume":"89","author":"Sidbury","year":"2023","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0055","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jaad.2022.08.068","article-title":"Executive summary: American Academy of Dermatology guidelines of care for the management of atopic dermatitis in adults with topical therapies","volume":"89","author":"Sidbury","year":"2023","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.lfs.2026.124647_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.139757","article-title":"AP2M1 as the potential biomarker for prediction of the response of atopic dermatitis to Dupilumab therapy: multi-omics analysis and evidence","volume":"297","author":"Peng","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.lfs.2026.124647_bb0065","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/jdv.19723","article-title":"Atopic dermatitis: a global health perspective","volume":"38","author":"Faye","year":"2024","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"6","key":"10.1016\/j.lfs.2026.124647_bb0070","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1093\/bjd\/ljae287","article-title":"A prospective observational cohort study comparing the treatment effectiveness and safety of ciclosporin, dupilumab and methotrexate in adult and paediatric patients with atopic dermatitis: results from the UK-Irish A-STAR register","volume":"191","author":"Alexander","year":"2024","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.lfs.2026.124647_bb0075","article-title":"Therapeutic potential of Licochalcone A in dermatological diseases: from basic to clinical research","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.lfs.2026.124647_bb0080","first-page":"234","article-title":"A \u201ccontrolled assembly\u201d strategy for constructing Coptidis Rhizoma self-assembled nanoparticles to ameliorate inflammatory damage in Atopic dermatitis","volume":"56","author":"Song","year":"2026","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.lfs.2026.124647_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2025.149633","article-title":"Thiolutin alleviates DNCB-induced atopic dermatitis-like symptoms via the inactivation of NLRP3 inflammasome","volume":"964","author":"Yang","year":"2025","journal-title":"Gene"},{"key":"10.1016\/j.lfs.2026.124647_bb0090","article-title":"Regulation of the NLRP3 inflammasome by post-translational modifications and small molecules","volume":"11","author":"Seok","year":"2020","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2026.124647_bb0095","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/s12276-026-01656-9","article-title":"Molecular mechanisms of NLRP3 inflammasome activation","volume":"58","author":"Shin","year":"2026","journal-title":"Exp. Mol. Med."},{"issue":"6","key":"10.1016\/j.lfs.2026.124647_bb0100","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/glycob\/cwr182","article-title":"Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family","volume":"22","author":"Bennett","year":"2012","journal-title":"Glycobiology"},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0105","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-57401-9","article-title":"ER O-glycosylation in synovial fibroblasts drives cartilage degradation","volume":"16","author":"Tran","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0110","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s12935-024-03492-1","article-title":"GALNT6 promotes bladder cancer malignancy and immune escape by epithelial-mesenchymal transition and CD8(+) T cells","volume":"24","author":"Sun","year":"2024","journal-title":"Cancer Cell Int."},{"issue":"4","key":"10.1016\/j.lfs.2026.124647_bb0115","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2147\/ciia.2006.1.4.327","article-title":"Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety","volume":"1","author":"Mukherjee","year":"2006","journal-title":"Clin. Interv. Aging"},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0120","doi-asserted-by":"crossref","DOI":"10.1080\/09546634.2026.2644003","article-title":"Oral isotretinoin plus desloratadine for acne vulgaris: an updated global meta-analysis of efficacy, safety, and patient-centered outcomes","volume":"37","author":"Alrubaiaan","year":"2026","journal-title":"J. Dermatol. Treat."},{"key":"10.1016\/j.lfs.2026.124647_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2026.03.001","article-title":"Efficacy and safety of fish oil supplementation combined with low-dose isotretinoin for moderate-to-severe acne vulgaris: a randomized controlled non-inferiority trial","author":"Sungkhasunya","year":"2026","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.lfs.2026.124647_bb0130","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3067126","article-title":"Impact of retinoic acid on immune cells and inflammatory diseases","volume":"2018","author":"Oliveira","year":"2018","journal-title":"Mediat. Inflamm."},{"issue":"7","key":"10.1016\/j.lfs.2026.124647_bb0135","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.4049\/jimmunol.1303245","article-title":"Modulation of T cell and innate immune responses by retinoic acid","volume":"192","author":"Raverdeau","year":"2014","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0140","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mam.2011.11.001","article-title":"Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance","volume":"33","author":"Cassani","year":"2012","journal-title":"Mol. Asp. Med."},{"issue":"2","key":"10.1016\/j.lfs.2026.124647_bb0145","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.clindermatol.2026.02.005","article-title":"Vitamins and the skin: vitamin A and retinoids in dermatology","volume":"44","author":"Dessinioti","year":"2026","journal-title":"Clin. Dermatol."},{"issue":"7","key":"10.1016\/j.lfs.2026.124647_bb0150","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/exd.14806","article-title":"Topical emollient prevents the development of atopic dermatitis and atopic march in mice","volume":"32","author":"Zhang","year":"2023","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.lfs.2026.124647_bb0155","article-title":"Knocking down GALNT6 promotes pyroptosis of pancreatic ductal adenocarcinoma cells through NF-\u03baB\/NLRP3\/GSDMD and GSDME signaling pathway","volume":"13","author":"Ding","year":"2023","journal-title":"Front. Oncol."},{"issue":"10","key":"10.1016\/j.lfs.2026.124647_bb0160","doi-asserted-by":"crossref","first-page":"11251","DOI":"10.18632\/oncotarget.7081","article-title":"Mucin glycosylating enzyme GALNT2 suppresses malignancy in gastric adenocarcinoma by reducing MET phosphorylation","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.lfs.2026.124647_bb0165","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1177\/39.6.1709656","article-title":"Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections","volume":"39","author":"Shi","year":"1991","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.lfs.2026.124647_bb0170","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-4939-3566-6_9","article-title":"Measuring NLR oligomerization II: detection of ASC speck formation by confocal microscopy and immunofluorescence","volume":"1417","author":"Beilharz","year":"2016","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0175","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neo.2016.11.007","article-title":"GALNT6 stabilizes GRP78 protein by O-glycosylation and enhances its activity to suppress apoptosis under stress condition","volume":"19","author":"Lin","year":"2017","journal-title":"Neoplasia"},{"issue":"3","key":"10.1016\/j.lfs.2026.124647_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.695","article-title":"A mouse model of MC903-induced atopic dermatitis","volume":"3","author":"Alam","year":"2023","journal-title":"Curr. Protoc."},{"issue":"4","key":"10.1016\/j.lfs.2026.124647_bb0185","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.90","article-title":"Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells","volume":"8","author":"Li","year":"2017","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.lfs.2026.124647_bb0190","doi-asserted-by":"crossref","DOI":"10.1111\/exd.70098","article-title":"Glycosylation in dermatology: unveiling the sugar coating of skin disease","volume":"34","author":"Shen","year":"2025","journal-title":"Exp. Dermatol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/s41572-018-0004-9","article-title":"Atopic dermatitis","volume":"4","author":"Brunello","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0200","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66871-w","article-title":"Structure, function, and implications of fucosyltransferases in health and disease","volume":"16","author":"Ghirardello","year":"2025","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.lfs.2026.124647_bb0205","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41581-019-0129-4","article-title":"Glycosylation in health and disease","volume":"15","author":"Reily","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.lfs.2026.124647_bb0210","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jdermsci.2006.08.004","article-title":"Macrophage-derived chemokine (MDC)\/CCL22 produced by monocyte derived dendritic cells reflects the disease activity in patients with atopic dermatitis","volume":"44","author":"Hashimoto","year":"2006","journal-title":"J. Dermatol. Sci."},{"issue":"5","key":"10.1016\/j.lfs.2026.124647_bb0215","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/intimm\/dxq030","article-title":"IL-6: from its discovery to clinical applications","volume":"22","author":"Kishimoto","year":"2010","journal-title":"Int. Immunol."},{"issue":"5","key":"10.1016\/j.lfs.2026.124647_bb0220","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.lfs.2026.124647_bb0225","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00011-020-01322-4","article-title":"Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes via JAK\/STAT3 signaling","volume":"69","author":"Dao","year":"2020","journal-title":"Inflamm. Res."},{"issue":"5","key":"10.1016\/j.lfs.2026.124647_bb0230","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.pharep.2017.04.006","article-title":"Apamin inhibits TNF-\u03b1- and IFN-\u03b3-induced inflammatory cytokines and chemokines via suppressions of NF-\u03baB signaling pathway and STAT in human keratinocytes","volume":"69","author":"Kim","year":"2017","journal-title":"Pharmacol. Rep."},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0235","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-025-02630-6","article-title":"IL-33-primed NLRP3 inflammasome in basophils drives IL-1\u03b2 production and initiates atopic dermatitis inflammation","volume":"11","author":"Gunji","year":"2025","journal-title":"Cell Death Discov."},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0240","doi-asserted-by":"crossref","DOI":"10.1080\/10641963.2025.2608225","article-title":"Inflammatory mechanisms and targeted drugs in heart failure","volume":"48","author":"Han","year":"2026","journal-title":"Clin. Exp. Hypertens."},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0245","article-title":"Premature coronary artery disease in women: sex-specific risk factors, pathogenetic mechanisms and clinical implications","volume":"58","author":"Li","year":"2026","journal-title":"Ann. Med."},{"issue":"2","key":"10.1016\/j.lfs.2026.124647_bb0250","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"issue":"12","key":"10.1016\/j.lfs.2026.124647_bb0255","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.lfs.2026.124647_bb0260","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41418-022-01054-4","article-title":"FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system","volume":"30","author":"Zhu","year":"2023","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.lfs.2026.124647_bb0265","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70660","article-title":"The NLRP3 inflammasome: mechanisms of activation, regulation, and therapeutic opportunities","volume":"7","author":"Zou","year":"2026","journal-title":"MedComm"},{"issue":"36","key":"10.1016\/j.lfs.2026.124647_bb0270","doi-asserted-by":"crossref","first-page":"16410","DOI":"10.1021\/jacs.2c04477","article-title":"Development of a GalNAc-tyrosine-specific monoclonal antibody and detection of tyrosine O-GalNAcylation in numerous human tissues and cell lines","volume":"144","author":"Xia","year":"2022","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"10.1016\/j.lfs.2026.124647_bb0275","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/anie.201610082","article-title":"Structural basis of sirtuin 6 activation by synthetic small molecules","volume":"56","author":"You","year":"2017","journal-title":"Angew. Chem. Int. Ed. Eng."},{"issue":"8","key":"10.1016\/j.lfs.2026.124647_bb0280","doi-asserted-by":"crossref","DOI":"10.1172\/JCI189044","article-title":"Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression","volume":"136","author":"Kuprasertkul","year":"2026","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.lfs.2026.124647_bb0285","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.198021","article-title":"Spatial transcriptomics identifies differentiation, lipid metabolism, and retinoid pathway alterations in acne vulgaris","volume":"11","author":"Durgin","year":"2026","journal-title":"JCI Insight"},{"issue":"7","key":"10.1016\/j.lfs.2026.124647_bb0290","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250342","article-title":"Vitamin A-treated natural killer cells reduce interferon-gamma production and support regulatory T-cell differentiation","volume":"54","author":"Jeong","year":"2024","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.lfs.2026.124647_bb0295","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.572960","article-title":"Regulation of RLR-mediated antiviral responses of human dendritic cells by mTOR","volume":"11","author":"Fekete","year":"2020","journal-title":"Front. Immunol."},{"issue":"706","key":"10.1016\/j.lfs.2026.124647_bb0300","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abe3410","article-title":"Tyrosine phosphorylation of NLRP3 by the Src family kinase Lyn suppresses the activity of the NLRP3 inflammasome","volume":"14","author":"Tang","year":"2021","journal-title":"Sci. Signal."},{"issue":"8","key":"10.1016\/j.lfs.2026.124647_bb0305","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1007\/s12033-023-00846-4","article-title":"O-GlcNAcylation of NLRP3 contributes to lipopolysaccharide-induced pyroptosis of human gingival fibroblasts","volume":"66","author":"Yang","year":"2024","journal-title":"Mol. Biotechnol."},{"issue":"10","key":"10.1016\/j.lfs.2026.124647_bb0310","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41419-021-04159-9","article-title":"A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis","volume":"12","author":"Zheng","year":"2021","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.lfs.2026.124647_bb0315","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jcp.21784","article-title":"Retinoid-responsive transcriptional changes in epidermal keratinocytes","volume":"220","author":"Lee","year":"2009","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.lfs.2026.124647_bb0320","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/1523-1747.ep12469889","article-title":"Retinoic acid receptor gene expression in human skin","volume":"96","author":"Elder","year":"1991","journal-title":"J. Invest. Dermatol."},{"issue":"7","key":"10.1016\/j.lfs.2026.124647_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071591","article-title":"All-trans retinoic acid enhances both the signaling for priming and the glycolysis for activation of NLRP3 inflammasome in human macrophage","volume":"9","author":"Alatshan","year":"2020","journal-title":"Cells"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052600456X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002432052600456X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:04:36Z","timestamp":1790150676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002432052600456X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":65,"alternative-id":["S002432052600456X"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124647","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GALNT6-mediated O-glycosylation suppresses NLRP3 inflammasome activation to alleviate atopic dermatitis","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124647","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"124647"}}