{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:00:27Z","timestamp":1790154027566,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["246Z7758G"],"award-info":[{"award-number":["246Z7758G"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017959","name":"Health Commission of Hebei Province","doi-asserted-by":"publisher","award":["20251429"],"award-info":[{"award-number":["20251429"]}],"id":[{"id":"10.13039\/100017959","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.lfs.2026.124648","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:48:15Z","timestamp":1787669295000},"page":"124648","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dysregulated JAK2 signaling delays fracture healing by enhancing STAT3\/NF-\u03baB signaling and inhibiting BMP2-mediated osteogenesis"],"prefix":"10.1016","volume":"404","author":[{"given":"Cheng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhua","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixuan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2 Suppl","key":"10.1016\/j.lfs.2026.124648_bb0005","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ajog.2005.08.047","article-title":"Epidemiology, etiology, and diagnosis of osteoporosis","volume":"194","author":"Lane","year":"2006","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.lfs.2026.124648_bb0010","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ecl.2024.08.008","article-title":"Postmenopausal osteoporosis: a review of latest guidelines","volume":"53","author":"Subarajan","year":"2024","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"10.1016\/j.lfs.2026.124648_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.675385","article-title":"The role of osteoclast energy metabolism in the occurrence and development of osteoporosis","volume":"12","author":"Da","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.lfs.2026.124648_bb0020","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s13287-018-0995-x","article-title":"Osteogenesis and aging: lessons from mesenchymal stem cells","volume":"9","author":"Infante","year":"2018","journal-title":"Stem Cell Res. Ther."},{"issue":"6","key":"10.1016\/j.lfs.2026.124648_bb0025","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/jbmr.3408","article-title":"High-fat diet-induced obesity promotes expansion of bone marrow adipose tissue and impairs skeletal stem cell functions in mice","volume":"33","author":"Tencerova","year":"2018","journal-title":"J. Bone Miner. Res."},{"issue":"7","key":"10.1016\/j.lfs.2026.124648_bb0030","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1016\/j.celrep.2019.04.066","article-title":"Obesity-associated hypermetabolism and accelerated senescence of bone marrow stromal stem cells suggest a potential mechanism for bone fragility","volume":"27","author":"Tencerova","year":"2019","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.lfs.2026.124648_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043772","article-title":"Oxidative stress and inflammation in osteoporosis: molecular mechanisms involved and the relationship with microRNAs","volume":"24","author":"Iantomasi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.lfs.2026.124648_bb0040","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/jcsm.13447","article-title":"Frailty phenotype as mediator between systemic inflammation and osteoporosis and fracture risks: a prospective study","volume":"15","author":"Di","year":"2024","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"2","key":"10.1016\/j.lfs.2026.124648_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ph15020160","article-title":"JAK2 in myeloproliferative neoplasms: still a protagonist","volume":"15","author":"Bader","year":"2022","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"10.1016\/j.lfs.2026.124648_bb0050","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/ajh.26050","article-title":"Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management","volume":"96","author":"Tefferi","year":"2021","journal-title":"Am. J. Hematol."},{"issue":"6","key":"10.1016\/j.lfs.2026.124648_bb0055","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1182\/blood-2016-10-695940","article-title":"Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms","volume":"129","author":"Vainchenker","year":"2017","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.lfs.2026.124648_bb0060","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/ajh.26751","article-title":"The international consensus classification of myeloid neoplasms and acute leukemias: myeloproliferative neoplasms","volume":"98","author":"Thiele","year":"2023","journal-title":"Am. J. Hematol."},{"issue":"9","key":"10.1016\/j.lfs.2026.124648_bb0065","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1038\/leu.2016.377","article-title":"Mass cytometry analysis reveals hyperactive NF Kappa B signaling in myelofibrosis and secondary acute myeloid leukemia","volume":"31","author":"Fisher","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.lfs.2026.124648_bb0070","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.intimp.2018.03.021","article-title":"Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-\u03baB pathways","volume":"58","author":"Li","year":"2018","journal-title":"Int. Immunopharmacol."},{"issue":"12","key":"10.1016\/j.lfs.2026.124648_bb0075","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41419-023-06325-7","article-title":"Deletion of Mettl3 in mesenchymal stem cells promotes acute myeloid leukemia resistance to chemotherapy","volume":"14","author":"Liao","year":"2023","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.lfs.2026.124648_bb0080","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ccr.2010.05.015","article-title":"Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells","volume":"17","author":"Mullally","year":"2010","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.lfs.2026.124648_bb0085","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/ame2.12084","article-title":"Characterization of inflammation and insulin resistance in high-fat diet-induced male C57BL\/6J mouse model of obesity","volume":"2","author":"Avtanski","year":"2019","journal-title":"Animal Model Exp Med"},{"issue":"3","key":"10.1016\/j.lfs.2026.124648_bb0090","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1530\/JOE-14-0721","article-title":"BBT improves glucose homeostasis by ameliorating \u03b2-cell dysfunction in type 2 diabetic mice","volume":"224","author":"Yao","year":"2015","journal-title":"J. Endocrinol."},{"issue":"2","key":"10.1016\/j.lfs.2026.124648_bb0095","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/stmcls\/sxab011","article-title":"Impaired bone fracture healing in type 2 diabetes is caused by defective functions of skeletal progenitor cells","volume":"40","author":"Figeac","year":"2022","journal-title":"Stem Cells"},{"issue":"3","key":"10.1016\/j.lfs.2026.124648_bb0100","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/jor.26015","article-title":"Polytrauma impairs fracture healing accompanied by increased persistence of innate inflammatory stimuli and reduced adaptive response","volume":"43","author":"Saiz","year":"2025","journal-title":"J. Orthop. Res."},{"issue":"3","key":"10.1016\/j.lfs.2026.124648_bb0105","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0092-8674(00)81167-8","article-title":"Jak2 is essential for signaling through a variety of cytokine receptors","volume":"93","author":"Parganas","year":"1998","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.lfs.2026.124648_bb0110","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0092-8674(00)81168-X","article-title":"Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis","volume":"93","author":"Neubauer","year":"1998","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.lfs.2026.124648_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059675","article-title":"Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans","volume":"8","author":"Park","year":"2013","journal-title":"PLoS One"},{"issue":"9464","key":"10.1016\/j.lfs.2026.124648_bb0120","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(05)71142-9","article-title":"Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders","volume":"365","author":"Baxter","year":"2005","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.lfs.2026.124648_bb0125","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ccr.2005.03.023","article-title":"Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis","volume":"7","author":"Levine","year":"2005","journal-title":"Cancer Cell"},{"issue":"17","key":"10.1016\/j.lfs.2026.124648_bb0130","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1056\/NEJMoa051113","article-title":"A gain-of-function mutation of JAK2 in myeloproliferative disorders","volume":"352","author":"Kralovics","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.lfs.2026.124648_bb0135","doi-asserted-by":"crossref","first-page":"197","DOI":"10.32725\/jab.2024.021","article-title":"Syringin protects high glucose-induced BMSC injury, cell senescence, and osteoporosis by inhibiting JAK2\/STAT3 signaling","volume":"22","author":"Zou","year":"2024","journal-title":"J. Appl. Biomed."},{"issue":"5","key":"10.1016\/j.lfs.2026.124648_bb0140","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/bjh.12581","article-title":"Chronic myeloproliferative neoplasms and risk of osteoporotic fractures; a nationwide population-based cohort study","volume":"163","author":"Farmer","year":"2013","journal-title":"Br. J. Haematol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124648_bb0145","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/1440-1681.13591","article-title":"Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2\/STAT3 signalling","volume":"49","author":"Wang","year":"2022","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"3","key":"10.1016\/j.lfs.2026.124648_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26030606","article-title":"JAK2 inhibition by fedratinib reduces osteoblast differentiation and mineralisation of human mesenchymal stem cells","volume":"26","author":"Almuraikhi","year":"2021","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.lfs.2026.124648_bb0155","first-page":"3719","article-title":"PDGF-BB promotes the differentiation and proliferation of MC3T3-E1 cells through the Src\/JAK2 signaling pathway","volume":"18","author":"Liu","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"11","key":"10.1016\/j.lfs.2026.124648_bb0160","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1515\/hsz-2018-0253","article-title":"Inhibition of JAK2\/STAT3 signaling suppresses bone marrow stromal cells proliferation and osteogenic differentiation, and impairs bone defect healing","volume":"399","author":"Yu","year":"2018","journal-title":"Biol. Chem."},{"issue":"1","key":"10.1016\/j.lfs.2026.124648_bb0165","doi-asserted-by":"crossref","DOI":"10.1177\/1559325819901239","article-title":"miR-21 may act as a potential mediator between inflammation and abnormal bone formation in ankylosing spondylitis based on TNF-\u03b1 concentration-dependent manner through the JAK2\/STAT3 pathway","volume":"18","author":"Zou","year":"2020","journal-title":"Dose-Response"},{"key":"10.1016\/j.lfs.2026.124648_bb0170","article-title":"The investigation of bone fracture healing under intramembranous and endochondral ossification","volume":"14","author":"Ghimire","year":"2021","journal-title":"Bone Rep"},{"issue":"1","key":"10.1016\/j.lfs.2026.124648_bb0175","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12967-026-07699-w","article-title":"MSDC-0160, a novel clinical-stage mitochondrial pyruvate carrier inhibitor, suppresses osteoclast differentiation and alleviates type 2 diabetes-related bone loss","volume":"24","author":"Wang","year":"2026","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.lfs.2026.124648_bb0180","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.stem.2016.02.015","article-title":"Leptin receptor promotes adipogenesis and reduces osteogenesis by regulating mesenchymal stromal cells in adult bone marrow","volume":"18","author":"Yue","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"5","key":"10.1016\/j.lfs.2026.124648_bb0185","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/ajh.26857","article-title":"Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management","volume":"98","author":"Tefferi","year":"2023","journal-title":"Am. J. Hematol."},{"issue":"5","key":"10.1016\/j.lfs.2026.124648_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11051301","article-title":"Polypharmacy, potentially inappropriate medications, and drug-to-drug interactions in patients with chronic myeloproliferative neoplasms","volume":"11","author":"Kre\u010dak","year":"2023","journal-title":"Biomedicines"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526004571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526004571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:06:01Z","timestamp":1790150761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526004571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":38,"alternative-id":["S0024320526004571"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124648","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulated JAK2 signaling delays fracture healing by enhancing STAT3\/NF-\u03baB signaling and inhibiting BMP2-mediated osteogenesis","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124648","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"124648"}}