{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:01:07Z","timestamp":1790154067992,"version":"4.0.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004077","name":"Kocaeli University","doi-asserted-by":"publisher","award":["TKA-2024-3891"],"award-info":[{"award-number":["TKA-2024-3891"]}],"id":[{"id":"10.13039\/501100004077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.lfs.2026.124660","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:52:01Z","timestamp":1787921521000},"page":"124660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Western-style cafeteria diet is linked to impaired colonic barrier integrity and alterations in mitochondrial respiratory proteins"],"prefix":"10.1016","volume":"404","author":[{"given":"Sevinc","family":"Yanar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songul","family":"Doganay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fcan","family":"Korak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve Gulsen","family":"Bal Albayrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smail","family":"Bolat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Kasap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurler","family":"Akpinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2026.124660_bb0005","article-title":"Low-grade inflammation and ultra-processed foods consumption: a review","volume":"15","author":"Asensi","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2026.124660_bb0010","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/cbf.3693","article-title":"Elucidation of the changes occurring at the proteome level in ovaries of high-fat diet-induced obese rats","volume":"40","author":"Simsek","year":"2022","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.lfs.2026.124660_bb0015","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cmet.2019.05.008","article-title":"Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake","volume":"30","author":"Hall","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2026.124660_bb0020","article-title":"Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses","volume":"384","author":"Lane","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.lfs.2026.124660_bb0025","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neubiorev.2020.11.003","article-title":"The cafeteria diet: a standardized protocol and its effects on behavior","volume":"122","author":"Lalanza","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.lfs.2026.124660_bb0030","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/oby.2011.18","article-title":"Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet","volume":"19","author":"Sampey","year":"2011","journal-title":"Obesity"},{"key":"10.1016\/j.lfs.2026.124660_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/nu15010086","article-title":"Characterization of the cafeteria diet as simulation of the human western diet and its impact on the lipidomic profile and gut microbiota in obese rats","volume":"15","author":"de la Garza","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2026.124660_bb0040","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.physbeh.2016.09.029","article-title":"A physiological characterization of the Cafeteria diet model of metabolic syndrome in the rat","volume":"167","author":"Gomez-Smith","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.lfs.2026.124660_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2023.109338","article-title":"Physiological, metabolic and microbial responses to obesogenic cafeteria diet in rats: the impact of strain and sex","volume":"117","author":"Gual-Grau","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.lfs.2026.124660_bb0050","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13673","article-title":"The role of the gastrointestinal barrier in obesity-associated systemic inflammation","volume":"25","author":"Acciarino","year":"2024","journal-title":"Obes. Rev."},{"key":"10.1016\/j.lfs.2026.124660_bb0055","doi-asserted-by":"crossref","first-page":"G840","DOI":"10.1152\/ajpgi.00029.2015","article-title":"Changes in intestinal barrier function and gut microbiota in high-fat diet-fed rats are dynamic and region dependent","volume":"308","author":"Hamilton","year":"2015","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2026.124660_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2022.114068","article-title":"Impact of cafeteria diet and n3 supplementation on the intestinal microbiota, fatty acids levels, neuroinflammatory markers and social memory in male rats","volume":"260","author":"Neto","year":"2023","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.lfs.2026.124660_bb0065","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/s41575-023-00766-3","article-title":"Paracellular permeability and tight junction regulation in gut health and disease","volume":"20","author":"Horowitz","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.lfs.2026.124660_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24087548","article-title":"Zonulin as a potential therapeutic target in microbiota-gut-brain axis disorders: encouraging results and emerging questions","volume":"24","author":"Veres-Sz\u00e9kely","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2026.124660_bb0075","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1017\/S0007114516004608","article-title":"A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats","volume":"117","author":"Gil-Cardoso","year":"2017","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.lfs.2026.124660_bb0080","article-title":"Prolonged high-fat diet consumption throughout adulthood in mice induced neurobehavioral deterioration via gut-brain axis","volume":"15","author":"Wu","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2026.124660_bb0085","doi-asserted-by":"crossref","first-page":"11580","DOI":"10.1158\/0008-5472.CAN-06-3562","article-title":"Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium\u2013induced colitis","volume":"66","author":"Khor","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.lfs.2026.124660_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1200111","article-title":"The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis","volume":"14","author":"Peng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2026.124660_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13081012","article-title":"Mechanism of action and therapeutic implications of Nrf2\/HO-1 in inflammatory bowel disease","volume":"13","author":"Yuan","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.lfs.2026.124660_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.626349","article-title":"The role of gut barrier dysfunction and microbiome dysbiosis in colorectal cancer development","volume":"11","author":"Genua","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.lfs.2026.124660_bb0105","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.6656","article-title":"Cafeteria diet increased adiposity in comparison to high fat diet in young male rats","volume":"7","author":"Buyukdere","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.lfs.2026.124660_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-026-41954-w","article-title":"Semaglutide restores metabolic and structural homeostasis along the gut-heart-metabolic axis in a cafeteria diet-induced obesity model","volume":"16","author":"Doganay","year":"2026","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2026.124660_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2024.137949","article-title":"Investigation of preconditioning and the protective effects of nicotinamide against cerebral ischemia-reperfusion injury in rats","volume":"840","author":"Arslan","year":"2024","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.lfs.2026.124660_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2023\/5562120","article-title":"Exploring the impact of ketogenic diet and intermittent fasting on male rats\u2019 testicular health: an analysis of hormonal regulation, oxidative stress, and spermatogenesis","volume":"2023","author":"\u00dcst\u00fcnda\u011f","year":"2023","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.lfs.2026.124660_bb0125","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1258\/002367707779399518","article-title":"Anthropometrical parameters and markers of obesity in rats","volume":"41","author":"Novelli","year":"2007","journal-title":"Lab. Anim."},{"key":"10.1016\/j.lfs.2026.124660_bb0130","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s12032-022-01795-9","article-title":"Investigation of the effect of meclofenamic acid on the proteome of LNCaP cells reveals changes in alternative polyadenylation and splicing machinery","volume":"39","author":"Saglam","year":"2022","journal-title":"Med. Oncol."},{"key":"10.1016\/j.lfs.2026.124660_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26093943","article-title":"Targeting the Hippo pathway in breast cancer: a proteomic analysis of Yes-associated protein inhibition","volume":"26","author":"Yanar","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2026.124660_bb0140","first-page":"90","article-title":"The immunohistochemical and bioinformatics analysis of the placental expressions of vascular cell adhesion protein 1 (VCAM-1) and high mobility group box 1 (HMGB1) proteins in gestational diabetic mothers","volume":"229","author":"O\u011flak","year":"2024","journal-title":"Z. Geburtshilfe Neonatol."},{"key":"10.1016\/j.lfs.2026.124660_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.70124","article-title":"Thymoquinone and metabolic reprogramming in breast cancer: a new dimension from proteomic analysis","volume":"39","author":"Korak","year":"2025","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.lfs.2026.124660_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/metabo15120784","article-title":"Ultra-processed foods and metabolic dysfunction: a narrative review of dietary processing, behavioral drivers and chronic disease risk","volume":"15","author":"Godsey","year":"2025","journal-title":"Metabolites"},{"key":"10.1016\/j.lfs.2026.124660_bb0155","article-title":"Alternating or continuous exposure to cafeteria diet leads to similar shifts in gut microbiota compared to chow diet","volume":"61","author":"Kaakoush","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.lfs.2026.124660_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e01412","article-title":"Cafeteria-diet induced obesity results in impaired cognitive functioning in a rodent model","volume":"5","author":"Lewis","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.lfs.2026.124660_bb0165","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000338073","article-title":"Dietary factors affect food reward and motivation to eat","volume":"5","author":"Pandit","year":"2012","journal-title":"Obes. Facts"},{"key":"10.1016\/j.lfs.2026.124660_bb0170","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202201971R","article-title":"Obesogenic diet leads to luminal overproduction of the complex IV inhibitor H2S and mitochondrial dysfunction in mouse colonocytes","volume":"37","author":"Guerbette","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.lfs.2026.124660_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/nu11050979","article-title":"Grape-seed proanthocyanidins are able to reverse intestinal dysfunction and metabolic endotoxemia induced by a cafeteria diet in Wistar rats","volume":"11","author":"Gonz\u00e1lez-Quilen","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2026.124660_bb0180","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1111\/bph.12369","article-title":"Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms","volume":"171","author":"Szabo","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.lfs.2026.124660_bb0185","doi-asserted-by":"crossref","first-page":"12077","DOI":"10.1074\/jbc.RA119.009442","article-title":"Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells","volume":"294","author":"Libiad","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.lfs.2026.124660_bb0190","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.157418","article-title":"Heteroplasmic and homoplasmic m.616T>C in mitochondria tRNAPhe promote isolated chronic kidney disease and hyperuricemia","volume":"7","author":"Xu","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.lfs.2026.124660_bb0195","doi-asserted-by":"crossref","first-page":"G125","DOI":"10.1152\/ajpgi.00261.2020","article-title":"Production of hydrogen sulfide by the intestinal microbiota and epithelial cells and consequences for the colonic and rectal mucosa","volume":"320","author":"Blachier","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.lfs.2026.124660_bb0200","article-title":"Plakophilin 2 regulates intestinal barrier function by modulating protein kinase C activity in vitro","volume":"11","author":"Nagler","year":"2022","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.lfs.2026.124660_bb0205","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01849-22","article-title":"Plakoglobin and high-mobility group box 1 mediate intestinal epithelial cell apoptosis induced by Clostridioides difficile TcdB","volume":"13","author":"Li","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.lfs.2026.124660_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.114364","article-title":"Ferric citrate-induced colonic mucosal damage associated with oxidative stress, inflammation responses, apoptosis, and the changes of gut microbial composition","volume":"249","author":"Xia","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.lfs.2026.124660_bb0215","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.3945\/jn.108.104125","article-title":"Western-style diets induce oxidative stress and dysregulate immune responses in the colon in a mouse model of sporadic colon cancer","volume":"139","author":"Erdelyi","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.lfs.2026.124660_bb0220","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/ar.25083","article-title":"Defects in the expression of colonic host defense factors associate with barrier dysfunction induced by a high-fat\/high-cholesterol diet","volume":"306","author":"Valdes","year":"2023","journal-title":"Anat. Rec."},{"key":"10.1016\/j.lfs.2026.124660_bb0225","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.3390\/nu14193921","article-title":"Zinc supplementation partially decreases the harmful effects of a cafeteria diet in rats but does not prevent intestinal dysbiosis","volume":"14","author":"Squizani","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2026.124660_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11072015","article-title":"Impact of western diet and ultra-processed food on the intestinal mucus barrier","volume":"11","author":"Stolfi","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.lfs.2026.124660_bb0235","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13492","article-title":"Targeting desmosomal adhesion and signalling for intestinal barrier stabilization in inflammatory bowel diseases\u2014lessons from experimental models and patients","volume":"231","author":"Schlegel","year":"2021","journal-title":"Acta Physiol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526004698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526004698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:07:31Z","timestamp":1790150851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526004698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":47,"alternative-id":["S0024320526004698"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124660","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Western-style cafeteria diet is linked to impaired colonic barrier integrity and alterations in mitochondrial respiratory proteins","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124660"}}