{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:51:35Z","timestamp":1791510695915,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.lfs.2026.124661","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T13:41:58Z","timestamp":1787924518000},"page":"124661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["MC4R modulates autophagy and pyroptosis regulated by UCP1 in experimental autoimmune uveitis"],"prefix":"10.1016","volume":"405","author":[{"given":"ChunYing","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HongYu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiangHong","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4\u20135","key":"10.1016\/j.lfs.2026.124661_bb0005","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.autrev.2014.01.006","article-title":"Diagnosis and classification of autoimmune uveitis","volume":"13","author":"Selmi","year":"2014","journal-title":"Autoimmun. Rev."},{"issue":"10","key":"10.1016\/j.lfs.2026.124661_bb0010","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1089\/jir.2011.0042","article-title":"Cytokines in autoimmune uveitis","volume":"31","author":"Horai","year":"2011","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.lfs.2026.124661_bb0015","article-title":"Therapeutic effect of rapamycin-loaded small extracellular vesicles derived from mesenchymal stem cells on experimental autoimmune uveitis","volume":"13","author":"Li","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124661_bb0020","article-title":"Targeting ocular drug delivery: an examination of local anatomy and current approaches","volume":"9","author":"Dosmar","year":"2022","journal-title":"Bioengineering (Basel)."},{"issue":"1","key":"10.1016\/j.lfs.2026.124661_bb0025","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/09273948.2016.1196713","article-title":"A focus on the epidemiology of uveitis","volume":"26","author":"Tsirouki","year":"2018","journal-title":"Ocul. Immunol. Inflamm."},{"issue":"4","key":"10.1016\/j.lfs.2026.124661_bb0030","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1167\/tvst.7.4.21","article-title":"A controlled release system for long-acting intravitreal delivery of small molecules","volume":"7","author":"Machinaga","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"38","key":"10.1016\/j.lfs.2026.124661_bb0035","doi-asserted-by":"crossref","first-page":"26525","DOI":"10.1074\/jbc.M114.575860","article-title":"Deficiency of autophagy in dendritic cells protects against experimental autoimmune encephalomyelitis","volume":"289","author":"Bhattacharya","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.lfs.2026.124661_bb0040","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1172\/JCI88415","article-title":"Excessive expression of miR-27 impairs Treg-mediated immunological tolerance","volume":"127","author":"Cruz","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.lfs.2026.124661_bb0045","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.4049\/jimmunol.0801143","article-title":"Autophagy is essential for mitochondrial clearance in mature T lymphocytes","volume":"182","author":"Pua","year":"2009","journal-title":"J. Immunol."},{"issue":"10","key":"10.1016\/j.lfs.2026.124661_bb0050","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1080\/15548627.2016.1207857","article-title":"Impaired autophagy in macrophages promotes inflammatory eye disease","volume":"12","author":"Santeford","year":"2016","journal-title":"Autophagy"},{"issue":"8","key":"10.1016\/j.lfs.2026.124661_bb0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104404","article-title":"Grouping annotations on the subcellular layered interactome demonstrates enhanced autophagy activity in a recurrent experimental autoimmune uveitis T cell line","volume":"9","author":"Jia","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.lfs.2026.124661_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02312","article-title":"Setmelanotide, a novel, selective melanocortin receptor-4 agonist exerts anti-inflammatory actions in astrocytes and promotes an anti-inflammatory macrophage phenotype","volume":"10","author":"Kamermans","year":"2019","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2026.124661_bb0065","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1210\/en.2005-0692","article-title":"Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia","volume":"147","author":"Giuliani","year":"2006","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.lfs.2026.124661_bb0070","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1159\/000487029","article-title":"\u0391-melanocyte-stimulating hormone protects early diabetic retina from blood-retinal barrier breakdown and vascular leakage via MC4R","volume":"45","author":"Cai","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"issue":"4","key":"10.1016\/j.lfs.2026.124661_bb0075","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1080\/09273948.2020.1849735","article-title":"Melanocortin 5 receptor expression and recovery of ocular immune privilege after uveitis","volume":"30","author":"Ng","year":"2022","journal-title":"Ocul. Immunol. Inflamm."},{"issue":"8","key":"10.1016\/j.lfs.2026.124661_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24086928","article-title":"Stimulating the melanocortin system in uveitis and diabetes preserves the structure and anti-inflammatory activity of the retina","volume":"24","author":"Ng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"7716","key":"10.1016\/j.lfs.2026.124661_bb0085","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41586-018-0353-2","article-title":"Accumulation of succinate controls activation of adipose tissue thermogenesis","volume":"560","author":"Mills","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.lfs.2026.124661_bb0090","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1038\/s41467-020-16340-3","article-title":"Human beige adipocytes for drug discovery and cell therapy in metabolic diseases","volume":"11","author":"Singh","year":"2020","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.lfs.2026.124661_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205726","article-title":"Uncoupling protein-1 deficiency promotes brown adipose tissue inflammation and ER stress","volume":"13","author":"Bond","year":"2018","journal-title":"PloS One"},{"issue":"50","key":"10.1016\/j.lfs.2026.124661_bb0100","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl4024","article-title":"Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome-dependent interleukin-1\u03b2 production","volume":"7","author":"Gu","year":"2021","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.lfs.2026.124661_bb0105","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41435-023-00195-x","article-title":"Selective deficiency of UCP-1 and adropin may lead to different subtypes of anti-neutrophil cytoplasmic antibody-associated vasculitis","volume":"24","author":"Chen","year":"2023","journal-title":"Genes Immun."},{"issue":"1","key":"10.1016\/j.lfs.2026.124661_bb0110","doi-asserted-by":"crossref","first-page":"215","DOI":"10.55730\/1300-0144.5960","article-title":"Relationship between uncoupling protein 1 (UCP1) levels and psoriasis","volume":"55","author":"Aky\u00fcrek","year":"2025","journal-title":"Turk. J. Med. Sci."},{"issue":"6","key":"10.1016\/j.lfs.2026.124661_bb0115","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/ijd.15788","article-title":"Uncoupling protein 2 and dynamin-related protein 1 mRNA expressions as genetic markers for plaque psoriasis","volume":"61","author":"Shehata","year":"2022","journal-title":"Int. J. Dermatol."},{"issue":"4","key":"10.1016\/j.lfs.2026.124661_bb0120","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1007\/s10753-024-02149-5","article-title":"Irisin alleviates autoimmune uveitis through promoting retinal microglial M1 to M2 phenotypic polarization mediated by HIF-1\u03b1 pathway","volume":"48","author":"Wang","year":"2025","journal-title":"Inflammation"},{"issue":"7","key":"10.1016\/j.lfs.2026.124661_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11072022","article-title":"Comprehensive grading system for experimental autoimmune uveitis in mice","volume":"11","author":"Shome","year":"2023","journal-title":"Biomedicines"},{"issue":"23","key":"10.1016\/j.lfs.2026.124661_bb0130","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.21037\/atm-22-2293","article-title":"Optimization of determinant factors associated with the efficiency of experimental autoimmune uveitis induction in C57BL\/6 mice","volume":"10","author":"Yang","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.lfs.2026.124661_bb0135","first-page":"641","article-title":"Tofacitinib inhibits the development of experimental autoimmune uveitis and reduces the proportions of Th1 but not of Th17 cells","volume":"26","author":"Bing","year":"2020","journal-title":"Mol. Vis."},{"issue":"5","key":"10.1016\/j.lfs.2026.124661_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019542","article-title":"AAV2-mediated subretinal gene transfer of hIFN-\u03b1 attenuates experimental autoimmune uveoretinitis in mice","volume":"6","author":"Tian","year":"2011","journal-title":"PloS One"},{"issue":"8","key":"10.1016\/j.lfs.2026.124661_bb0145","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/S1388-2457(03)00135-4","article-title":"Intracerebral somatosensory event-related potentials: effect of response type (button pressing versus mental counting) on P3-like potentials within the human brain","volume":"114","author":"Br\u00e1zdil","year":"2003","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.lfs.2026.124661_bb0150","first-page":"40","article-title":"Methodologies for analysis of patterning in the mouse RPE sheet","volume":"21","author":"Boatright","year":"2015","journal-title":"Mol. Vis."},{"issue":"1","key":"10.1016\/j.lfs.2026.124661_bb0155","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12974-021-02295-9","article-title":"Blockade of the NLRP3\/caspase-1 axis attenuates ketamine-induced hippocampus pyroptosis and cognitive impairment in neonatal rats","volume":"18","author":"Zhang","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.lfs.2026.124661_bb0160","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13046-020-01587-x","article-title":"RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer","volume":"39","author":"Li","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"9","key":"10.1016\/j.lfs.2026.124661_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2019.102351","article-title":"Uveitis: autoimmunity\u2026 and beyond","volume":"18","author":"Bertrand","year":"2019","journal-title":"Autoimmun. Rev."},{"issue":"2\u20133","key":"10.1016\/j.lfs.2026.124661_bb0170","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1385\/IR:27:2-3:149","article-title":"Regulation, counter-regulation, and immunotherapy of autoimmune responses to immunologically privileged retinal antigens","volume":"27","author":"Caspi","year":"2003","journal-title":"Immunol. Res."},{"key":"10.1016\/j.lfs.2026.124661_bb0175","article-title":"Inhibiting TLR7 expression in the retinal pigment epithelium suppresses experimental autoimmune uveitis","volume":"12","author":"Lo","year":"2021","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.lfs.2026.124661_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093261","article-title":"Suppression of the reactive oxygen response alleviates experimental autoimmune uveitis in mice","volume":"21","author":"Hsu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2026.124661_bb0185","article-title":"MC5r and A2Ar deficiencies during experimental autoimmune uveitis identifies distinct T cell polarization programs and a biphasic regulatory response","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.lfs.2026.124661_bb0190","doi-asserted-by":"crossref","first-page":"8862","DOI":"10.1167\/iovs.11-8153","article-title":"Following EAU recovery there is an associated MC5r-dependent APC induction of regulatory immunity in the spleen","volume":"52","author":"Lee","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"8","key":"10.1016\/j.lfs.2026.124661_bb0195","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.4049\/jimmunol.1300182","article-title":"Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice","volume":"191","author":"Lee","year":"2013","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.lfs.2026.124661_bb0200","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/JLB.MA0119-030RR","article-title":"Exacerbation of autoimmune uveitis by obesity occurs through the melanocortin 5 receptor","volume":"106","author":"Muhammad","year":"2019","journal-title":"J. Leukoc. Biol."},{"issue":"9","key":"10.1016\/j.lfs.2026.124661_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/diseases13090305","article-title":"Polymorphism of melanocortin receptor genes-association with inflammatory traits and diseases","volume":"13","author":"Bardhan","year":"2025","journal-title":"Diseases"},{"issue":"5","key":"10.1016\/j.lfs.2026.124661_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051131","article-title":"Impact of the uncoupling protein 1 on cardiovascular risk in patients with rheumatoid arthritis","volume":"10","author":"Lyngfelt","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2026.124661_bb0215","article-title":"Regulatory T cell dysfunction and exhaustion in uveitis: immunometabolic mechanisms, microenvironmental drivers, and emerging therapeutic strategies","volume":"17","author":"Su","year":"2026","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.lfs.2026.124661_bb0220","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1189\/jlb.3A1014-466RR","article-title":"Recovery from experimental autoimmune uveitis promotes induction of antiuveitic inducible Tregs","volume":"97","author":"Lee","year":"2015","journal-title":"J. Leukoc. Biol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124661_bb0225","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010096","article-title":"AU-rich element RNA binding proteins: at the crossroads of post-transcriptional regulation and genome integrity","volume":"23","author":"Sidali","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.lfs.2026.124661_bb0230","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.7150\/ijbs.105446","article-title":"Mitochondrial regulation of ferroptosis in cancer cells","volume":"21","author":"Ding","year":"2025","journal-title":"Int. J. Biol. Sci."},{"issue":"12","key":"10.1016\/j.lfs.2026.124661_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111477","article-title":"Therapeutic potential of 5-aminolevulinic acid in metabolic disorders: current insights and future directions","volume":"27","author":"Kuryata","year":"2024","journal-title":"iScience"},{"issue":"4","key":"10.1016\/j.lfs.2026.124661_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043844","article-title":"Transplantation of adipose-tissue-engineered constructs with CRISPR-mediated UCP1 activation","volume":"24","author":"Michurina","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.lfs.2026.124661_bb0245","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1167\/iovs.63.8.23","article-title":"Apolipoprotein A1 modulates Teff\/Treg balance through scavenger receptor class B type I-dependent mechanisms in experimental autoimmune uveitis","volume":"63","author":"Huang","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526004704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526004704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:28:22Z","timestamp":1791509302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526004704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":49,"alternative-id":["S0024320526004704"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124661","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MC4R modulates autophagy and pyroptosis regulated by UCP1 in experimental autoimmune uveitis","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124661","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"124661"}}