{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:51:21Z","timestamp":1791510681179,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL148585"],"award-info":[{"award-number":["R01HL148585"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL143082"],"award-info":[{"award-number":["R01-HL143082"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL171401"],"award-info":[{"award-number":["R01-HL171401"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI144115"],"award-info":[{"award-number":["R01AI144115"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["AHA-TPA-971237"],"award-info":[{"award-number":["AHA-TPA-971237"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["25TPA1473648"],"award-info":[{"award-number":["25TPA1473648"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["26CDA1587519"],"award-info":[{"award-number":["26CDA1587519"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.lfs.2026.124671","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:36:30Z","timestamp":1788795390000},"page":"124671","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["TRPV4 deletion remodels the gut microbiota and increases colonic ammonia levels"],"prefix":"10.1016","volume":"405","author":[{"given":"Ramakumar","family":"Tummala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra Babu","family":"Kondapalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkatesh","family":"Katari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishan","family":"Manandhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesha","family":"Dalal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Adapala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sailaja","family":"Paruchuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bina","family":"Joe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Thodeti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2026.124671_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13081807","article-title":"The role of gut microbiota in gastrointestinal immune homeostasis and inflammation: implications for inflammatory bowel disease","volume":"13","author":"Bretto","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.lfs.2026.124671_bb0010","article-title":"Gut dysbiosis and cardiovascular health: a comprehensive review of mechanisms and therapeutic potential","volume":"16","author":"Trehan","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.lfs.2026.124671_bb0015","doi-asserted-by":"crossref","DOI":"10.37349\/etat.2025.1002329","article-title":"Dysbiosis and colorectal cancer: conducive factors, biological and molecular role, and therapeutic prospectives","volume":"6","author":"Singh","year":"2025","journal-title":"Explor. Target. Antitumor Ther."},{"key":"10.1016\/j.lfs.2026.124671_bb0020","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/ismej.2013.80","article-title":"Dysbiosis in inflammatory bowel diseases: the oxygen hypothesis","volume":"7","author":"Rigottier-Gois","year":"2013","journal-title":"ISME J."},{"key":"10.1016\/j.lfs.2026.124671_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/cph4.70024","article-title":"Microbiota in gut-heart axis: metabolites and mechanisms in cardiovascular disease","volume":"15","author":"Kondapalli","year":"2025","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.lfs.2026.124671_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/cells10113053","article-title":"TRPV4 Mechanotransduction in fibrosis","volume":"10","author":"Adapala","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.lfs.2026.124671_bb0035","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.1002\/j.2040-4603.2024.tb00295.x","article-title":"A TRP to pathological angiogenesis and vascular normalization","volume":"14","author":"Katari","year":"2024","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.lfs.2026.124671_bb0040","doi-asserted-by":"crossref","first-page":"9307","DOI":"10.2147\/JIR.S483350","article-title":"The role of the TRPV4 channel in intestinal physiology and pathology","volume":"17","author":"Liu","year":"2024","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.lfs.2026.124671_bb0045","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00401-013-1166-x","article-title":"Glial cell-expressed mechanosensitive channel TRPV4 mediates infrasound-induced neuronal impairment","volume":"126","author":"Shi","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.lfs.2026.124671_bb0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12950-024-00425-7","article-title":"TRPV4 modulates inflammatory responses and apoptosis in enteric glial cells triggered by Clostridioides difficile toxins A and B","volume":"22","author":"Pacifico","year":"2025","journal-title":"J. Inflamm. (Lond.)"},{"key":"10.1016\/j.lfs.2026.124671_bb0055","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4049\/immunohorizons.2200100","article-title":"Anti-inflammatory role of TRPV4 in human macrophages","volume":"7","author":"Atsumi","year":"2023","journal-title":"Immunohorizons"},{"key":"10.1016\/j.lfs.2026.124671_bb0060","article-title":"TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility","author":"Rajasekhar","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.lfs.2026.124671_bb0065","article-title":"The multifaceted functions of TRPV4 and calcium oscillations in tissue repair","volume":"25","author":"Jiang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.lfs.2026.124671_bb0070","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/CIRCRESAHA.108.192930","article-title":"TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling","volume":"104","author":"Thodeti","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.lfs.2026.124671_bb0075","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00395-020-0775-5","article-title":"TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation","volume":"115","author":"Adapala","year":"2020","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.lfs.2026.124671_bb0080","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/s41467-017-01201-3","article-title":"TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells","volume":"8","author":"Alpizar","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.lfs.2026.124671_bb0085","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12876-023-02647-0","article-title":"Colonic TRPV4 overexpression is related to constipation severity","volume":"23","author":"Mihara","year":"2023","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.lfs.2026.124671_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00413","article-title":"TRPV4-a missing link between mechanosensation and immunity","volume":"11","author":"Michalick","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2026.124671_bb0095","article-title":"Diverse roles of TRPV4 in macrophages: a need for unbiased profiling","volume":"12","author":"Nguyen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.lfs.2026.124671_bb0100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.yjmcc.2025.08.001","article-title":"Genetical TRPV4 deletion-associated gut microbiota alleviates cardiac dysfunction in mice with diabetic cardiomyopathy","volume":"207","author":"Zhou","year":"2025","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.lfs.2026.124671_bb0105","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13694","article-title":"TRPV3 and TRPV4 as candidate proteins for intestinal ammonium absorption","volume":"233","author":"Manneck","year":"2021","journal-title":"Acta Physiol."},{"key":"10.1016\/j.lfs.2026.124671_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/nu17142373","article-title":"Dietary nitrogen and its role in the gut microbiome and inflammatory bowel disease: a narrative review","volume":"17","author":"Herrera","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2026.124671_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155740","article-title":"Gut-derived ammonia contributes to alcohol-related fatty liver development via facilitating ethanol metabolism and provoking ATF4-dependent de novo lipogenesis activation","volume":"151","author":"Song","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.lfs.2026.124671_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155378","article-title":"Phenolic acids from Chicory roots ameliorate dextran sulfate sodium-induced colitis in mice by targeting TRP signaling pathways and the gut microbiota","volume":"128","author":"Tian","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.lfs.2026.124671_bb0125","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.cmet.2025.01.004","article-title":"Targeting gut S. aureofaciens Tu117 serves as a new potential therapeutic intervention for the prevention and treatment of hypertension","volume":"37","author":"Zhou","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.lfs.2026.124671_bb0130","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1007\/s12265-024-10543-5","article-title":"TMAO impairs mouse aortic vasodilation by inhibiting TRPV4 channels in endothelial cells","volume":"17","author":"Zhang","year":"2024","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.lfs.2026.124671_bb0135","article-title":"Measurement of the intestinal pH in mice under various conditions reveals alkalization induced by antibiotics","volume":"10","author":"Shimizu","year":"2021","journal-title":"Antibiotics (Basel)."},{"key":"10.1016\/j.lfs.2026.124671_bb0140","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.lfs.2026.124671_bb0145","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.lfs.2026.124671_bb0150","doi-asserted-by":"crossref","first-page":"W310","DOI":"10.1093\/nar\/gkad407","article-title":"MicrobiomeAnalyst 2.0: comprehensive statistical, functional and integrative analysis of microbiome data","volume":"51","author":"Lu","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.lfs.2026.124671_bb0155","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2 for prediction of metagenome functions","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.lfs.2026.124671_bb0160","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00424-021-02647-7","article-title":"Effects of butyrate(\u2212) on ruminal Ca(2+) transport: evidence for the involvement of apically expressed TRPV3 and TRPV4 channels","volume":"474","author":"Liebe","year":"2022","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.lfs.2026.124671_bb0165","doi-asserted-by":"crossref","DOI":"10.1002\/ece3.10594","article-title":"Elevational patterns of microbial species richness and evenness across climatic zones and taxonomic scales","volume":"13","author":"Huang","year":"2023","journal-title":"Ecol. Evol."},{"key":"10.1016\/j.lfs.2026.124671_bb0170","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.20835.1","article-title":"The influence of host genetics on the microbiome","volume":"9","author":"Tabrett","year":"2020","journal-title":"F1000Res"},{"key":"10.1016\/j.lfs.2026.124671_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/nu12051474","article-title":"The Firmicutes\/Bacteroidetes ratio: a relevant marker of gut dysbiosis in obese patients?","volume":"12","author":"Magne","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.lfs.2026.124671_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11010013","article-title":"Gallstone disease, obesity and the Firmicutes\/Bacteroidetes ratio as a possible biomarker of gut dysbiosis","volume":"11","author":"Grigor\u2019eva","year":"2020","journal-title":"J. Pers. Med."},{"key":"10.1016\/j.lfs.2026.124671_bb0185","doi-asserted-by":"crossref","first-page":"511","DOI":"10.7150\/ijms.51164","article-title":"The association of targeted gut microbiota with body composition in type 2 diabetes mellitus","volume":"18","author":"Hung","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.lfs.2026.124671_bb0190","doi-asserted-by":"crossref","first-page":"L158","DOI":"10.1152\/ajplung.00065.2014","article-title":"TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury","volume":"307","author":"Balakrishna","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.lfs.2026.124671_bb0195","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1161\/HYPERTENSIONAHA.123.21528","article-title":"Deletion of Endothelial TRPV4 Protects Heart From Pressure Overload-Induced Hypertrophy","volume":"80","author":"Adapala","year":"2023","journal-title":"Hypertension"},{"key":"10.1016\/j.lfs.2026.124671_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106920","article-title":"Genetically engineered Lactobacillus paracasei rescues colonic angiotensin converting enzyme 2 (ACE2) and attenuates hypertension in female Ace2 knock out rats","volume":"196","author":"Mei","year":"2023","journal-title":"Pharmacol. Res."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526004807?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526004807?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:28:28Z","timestamp":1791509308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526004807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":40,"alternative-id":["S0024320526004807"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124671","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRPV4 deletion remodels the gut microbiota and increases colonic ammonia levels","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124671","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"124671"}}