{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:51:06Z","timestamp":1791510666475,"version":"4.3.4"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2025-25436571"],"award-info":[{"award-number":["RS-2025-25436571"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2026-25474307"],"award-info":[{"award-number":["RS-2026-25474307"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2026-25517589"],"award-info":[{"award-number":["RS-2026-25517589"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.lfs.2026.124703","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:43:42Z","timestamp":1790264622000},"page":"124703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mammary gland-specific deletion of MTA1 causes abrupt involution through activation of STAT3 signaling in lactating mice"],"prefix":"10.1016","volume":"405","author":[{"given":"Seung-Su","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Heon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheolhee","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Min","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sewon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga Young","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Lee","family":"Ka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Ock","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.lfs.2026.124703_bb0005","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/bcr1401","article-title":"Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ","volume":"8","author":"Watson","year":"2006","journal-title":"Breast Cancer Res."},{"issue":"1","key":"10.1016\/j.lfs.2026.124703_bb0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.lfs.2014.02.034","article-title":"Natural and abrupt involution of the mammary gland affects differently the metabolic and health consequences of weaning","volume":"102","author":"Silanikove","year":"2014","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.lfs.2026.124703_bb0015","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1083\/jcb.118.5.1271","article-title":"Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution","volume":"118","author":"Talhouk","year":"1992","journal-title":"J. Cell Biol."},{"issue":"7\u20139","key":"10.1016\/j.lfs.2026.124703_bb0020","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1387\/ijdb.113414cw","article-title":"Remodeling mechanisms of the mammary gland during involution","volume":"55","author":"Watson","year":"2011","journal-title":"Int. J. Dev. Biol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124703_bb0025","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13058-019-1163-7","article-title":"Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer","volume":"21","author":"Basree","year":"2019","journal-title":"Breast Cancer Res."},{"issue":"46","key":"10.1016\/j.lfs.2026.124703_bb0030","doi-asserted-by":"crossref","first-page":"16886","DOI":"10.1073\/pnas.0508599102","article-title":"Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8","volume":"102","author":"Hanayama","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.lfs.2026.124703_bb0035","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1158\/0008-5472.CAN-19-3448","article-title":"Postpartum involution and Cancer: An opportunity for targeted breast Cancer prevention and treatments?","volume":"80","author":"Borges","year":"2020","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.lfs.2026.124703_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19061695","article-title":"The multifaceted role of STAT3 in mammary gland involution and breast Cancer","volume":"19","author":"Hughes","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.lfs.2026.124703_bb0045","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.mce.2013.03.014","article-title":"STAT signaling in mammary gland differentiation, cell survival and tumorigenesis","volume":"382","author":"Haricharan","year":"2014","journal-title":"Mol. Cell. Endocrinol."},{"issue":"11","key":"10.1016\/j.lfs.2026.124703_bb0050","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/ncb3043","article-title":"Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization","volume":"16","author":"Sargeant","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.lfs.2026.124703_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1160719","article-title":"Advances in the role of STAT3 in macrophage polarization","volume":"14","author":"Xia","year":"2023","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.lfs.2026.124703_bb0060","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2353\/ajpath.2010.090735","article-title":"Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species","volume":"176","author":"O\u2019Brien","year":"2010","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.lfs.2026.124703_bb0065","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S1097-2765(00)80299-3","article-title":"NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities","volume":"2","author":"Xue","year":"1998","journal-title":"Mol. Cell"},{"issue":"6898","key":"10.1016\/j.lfs.2026.124703_bb0070","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nature00889","article-title":"A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm","volume":"418","author":"Kumar","year":"2002","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.lfs.2026.124703_bb0075","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1158\/0008-5472.CAN-13-2020","article-title":"Differential regulation of estrogen receptor \u03b1 expression in breast cancer cells by metastasis-associated protein 1","volume":"74","author":"Kang","year":"2014","journal-title":"Cancer Res."},{"issue":"12","key":"10.1016\/j.lfs.2026.124703_bb0080","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1158\/0008-5472.CAN-12-3998","article-title":"MTA1 promotes STAT3 transcription and pulmonary metastasis in breast cancer","volume":"73","author":"Pakala","year":"2013","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.lfs.2026.124703_bb0085","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1080\/15548627.2017.1388476","article-title":"MTA1 is a novel regulator of autophagy that induces tamoxifen resistance in breast cancer cells","volume":"14","author":"Lee","year":"2018","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.lfs.2026.124703_bb0090","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ab.2011.01.020","article-title":"MMTV-Cre transgenes can adversely affect lactation: considerations for conditional gene deletion in mammary tissue","volume":"412","author":"Robinson","year":"2011","journal-title":"Anal. Biochem."},{"issue":"53","key":"10.1016\/j.lfs.2026.124703_bb0095","doi-asserted-by":"crossref","DOI":"10.3791\/2828","article-title":"Evaluation of mammary gland development and function in mouse models","author":"Plante","year":"2011","journal-title":"J. Vis. Exp."},{"issue":"1","key":"10.1016\/j.lfs.2026.124703_bb0100","doi-asserted-by":"crossref","first-page":"11798","DOI":"10.1038\/s41598-019-48171-8","article-title":"ROR\u03b1 suppresses interleukin-6-mediated hepatic acute phase response","volume":"9","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.lfs.2026.124703_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2026.101286","article-title":"Tamoxifen promotes metastasis of breast cancer via reshaping lipid-driven fibrotic microenvironments in the lung","volume":"73","author":"Kim","year":"2026","journal-title":"Neoplasia"},{"issue":"1","key":"10.1016\/j.lfs.2026.124703_bb0110","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13058-024-01958-8","article-title":"Secreted LGALS3BP facilitates distant metastasis of breast cancer","volume":"27","author":"Kim","year":"2025","journal-title":"Breast Cancer Res."},{"issue":"12","key":"10.1016\/j.lfs.2026.124703_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110138","article-title":"IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer","volume":"37","author":"Ka","year":"2021","journal-title":"Cell Rep."},{"issue":"37","key":"10.1016\/j.lfs.2026.124703_bb0120","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adr7174","article-title":"Genomic characterization of normal and aberrant human milk production","volume":"11","author":"Golan","year":"2025","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.lfs.2026.124703_bb0125","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1038\/s41467-017-02001-5","article-title":"Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing","volume":"8","author":"Bach","year":"2017","journal-title":"Nat. Commun."},{"issue":"1\u20132","key":"10.1016\/j.lfs.2026.124703_bb0130","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0167-4781(00)00168-8","article-title":"Structure and functional analysis of the human STAT3 gene promoter: alteration of chromatin structure as a possible mechanism for the upregulation in cisplatin-resistant cells","volume":"1493","author":"Kato","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.lfs.2026.124703_bb0135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ydbio.2018.11.002","article-title":"Molecular mechanism of mammary gland involution: An update","volume":"445","author":"Jena","year":"2019","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.lfs.2026.124703_bb0140","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s10911-024-09568-y","article-title":"Immune cell contribution to mammary gland development","volume":"29","author":"Vickers","year":"2024","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"issue":"2","key":"10.1016\/j.lfs.2026.124703_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017135","article-title":"Gene profiling of MTA1 identifies novel gene targets and functions","volume":"6","author":"Ghanta","year":"2011","journal-title":"PLoS One"},{"issue":"9328","key":"10.1016\/j.lfs.2026.124703_bb0150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0140-6736(02)09454-0","article-title":"Breast cancer and breastfeeding: collaborative reanalysis of individual data from 47 epidemiological studies in 30 countries, including 50302 women with breast cancer and 96973 women without the disease","volume":"360","year":"2002","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.lfs.2026.124703_bb0155","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1093\/jnci\/djac117","article-title":"Distinct reproductive risk profiles for intrinsic-like breast Cancer subtypes: pooled analysis of population-based studies","volume":"114","author":"Jung","year":"2022","journal-title":"J. Natl. Cancer Inst."},{"issue":"10","key":"10.1016\/j.lfs.2026.124703_bb0160","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju237","article-title":"Parity, lactation, and breast cancer subtypes in African American women: results from the AMBER consortium","volume":"106","author":"Palmer","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"issue":"1","key":"10.1016\/j.lfs.2026.124703_bb0165","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41523-025-00755-6","article-title":"Breastfeeding attributable fraction of triple negative breast cancer in the US","volume":"11","author":"Chehayeb","year":"2025","journal-title":"NPJ Breast Cancer"},{"issue":"1","key":"10.1016\/j.lfs.2026.124703_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13058-024-01933-3","article-title":"Divergent paths of mammary gland involution: unveiling the cellular dynamics in abruptly and gradually involuted mouse models","volume":"27","author":"Majumder","year":"2025","journal-title":"Breast Cancer Res."},{"issue":"3","key":"10.1016\/j.lfs.2026.124703_bb0175","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s43587-025-01058-y","article-title":"Induction of senescence during postpartum mammary gland involution supports tissue remodeling and promotes postpartum tumorigenesis","volume":"6","author":"Chiche","year":"2026","journal-title":"Nat. Aging"},{"issue":"3","key":"10.1016\/j.lfs.2026.124703_bb0180","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10911-021-09495-2","article-title":"Changes in immune cell types with age in breast are consistent with a decline in immune surveillance and increased immunosuppression","volume":"26","author":"Zirbes","year":"2021","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"issue":"4","key":"10.1016\/j.lfs.2026.124703_bb0185","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s10555-014-9515-3","article-title":"Role of MTA1 in cancer progression and metastasis","volume":"33","author":"Sen","year":"2014","journal-title":"Cancer Metastasis Rev."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526005126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320526005126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:27:10Z","timestamp":1791509230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320526005126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":37,"alternative-id":["S0024320526005126"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124703","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mammary gland-specific deletion of MTA1 causes abrupt involution through activation of STAT3 signaling in lactating mice","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2026.124703","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"124703"}}