{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:11:36Z","timestamp":1790237496572,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["La Presse M\u00e9dicale"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.lpm.2012.04.011","type":"journal-article","created":{"date-parts":[[2012,5,28]],"date-time":"2012-05-28T18:45:15Z","timestamp":1338230715000},"page":"e28-e36","source":"Crossref","is-referenced-by-count":11,"title":["Strat\u00e9gies d\u2019arr\u00eat du traitement de substitution par m\u00e9thadone"],"prefix":"10.1016","volume":"42","author":[{"given":"Kamilia","family":"Ksouda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Dugarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Dupuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Laqueille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"L\u00e9pine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Vorspan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lpm.2012.04.011_bib0005","first-page":"549","article-title":"Toxicomanie\u00a0: historique et classifications","volume":"7","author":"Dugarin","year":"1988","journal-title":"Hist Econ Soc"},{"key":"10.1016\/j.lpm.2012.04.011_bib0010","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.amp.2009.07.002","article-title":"\u00c9pid\u00e9miologie des usages de substances addictives\u00a0: r\u00e9sultats d\u2019\u00e9tudes r\u00e9alis\u00e9es en France et perspectives internationales","volume":"167","author":"Dupuy","year":"2009","journal-title":"Ann Med Psychol (Paris)"},{"key":"10.1016\/j.lpm.2012.04.011_bib0015","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1001\/archpsyc.1972.01750220001001","article-title":"Heroin addiction and the role of methadone in its treatment","volume":"26","author":"Goldstein","year":"1972","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.lpm.2012.04.011_bib0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1126\/science.278.5335.45","article-title":"Addiction is a brain disease, and it matters","volume":"278","author":"Leshner","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.lpm.2012.04.011_bib0025","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1001\/jama.1965.03090080008002","article-title":"A medical treatment for diacetylmorphine (heroin) addiction. A clinical trial with methadone hydrochloride","volume":"193","author":"Dole","year":"1965","journal-title":"JAMA"},{"key":"10.1016\/j.lpm.2012.04.011_bib0030","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1001\/jama.2008.648","article-title":"Methadone maintenance 4\u00a0decades later: thousands of lives saved but still controversial","volume":"300","author":"Kleber","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/j.lpm.2012.04.011_bib0035","first-page":"447","article-title":"Les toxicomanies anciennes aux opiac\u00e9s, essai de th\u00e9rapeutique substitutive par chlorhydrate de m\u00e9thadone","volume":"125","author":"Fournier","year":"1974","journal-title":"Ann Med Interne (Paris)"},{"key":"10.1016\/j.lpm.2012.04.011_bib0040","first-page":"459","article-title":"Essais pr\u00e9liminaires de la m\u00e9thadone dans le traitement des toxicomanies aux opiac\u00e9s","volume":"125","author":"Deniker","year":"1974","journal-title":"Ann Med Interne (Paris)"},{"key":"10.1016\/j.lpm.2012.04.011_bib0045","first-page":"1975","article-title":"\u00c0 propos d\u2019une exp\u00e9rience fran\u00e7aise de la m\u00e9thadone","volume":"1","author":"Deniker","year":"1975","journal-title":"Encephale"},{"key":"10.1016\/j.lpm.2012.04.011_bib0050","series-title":"Methadone maintenance treatment and other opioid replacement therapies","author":"Ward","year":"1998"},{"key":"10.1016\/j.lpm.2012.04.011_bib0055","first-page":"133","volume":"4","author":"Touzeau","year":"2003"},{"key":"10.1016\/j.lpm.2012.04.011_bib0060","unstructured":"Jacques, JP. De l\u2019opportunit\u00e9 d\u2019arr\u00eater ou non, la methadone. Le Flyer 2004;16:5\u201312. www.rvh-synergie.org\/."},{"key":"10.1016\/j.lpm.2012.04.011_bib0065","unstructured":"HAS. (Haute Autorit\u00e9 de Sant\u00e9)\u00a0: strat\u00e9gies th\u00e9rapeutiques pour les personnes d\u00e9pendantes des opiac\u00e9s\u00a0: place des traitements de substitution, 2004. http:\/\/www.hassante.fr\/portail\/upload\/docs\/application\/pdf\/TSO_court.pdf."},{"key":"10.1016\/j.lpm.2012.04.011_bib0070","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1753-6405.2001.tb01832.x","article-title":"Withdrawal from methadone maintenance treatment: prognosis and participant perspectives","volume":"25","author":"Lenn\u00e9","year":"2001","journal-title":"Aust N Z J Public Health"},{"key":"10.1016\/j.lpm.2012.04.011_bib0075","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/10826089409047374","article-title":"Phases of treatment: a practical approach to methadone maintenance treatment","volume":"29","author":"Moolchan","year":"1994","journal-title":"Int J Addict"},{"issue":"3","key":"10.1016\/j.lpm.2012.04.011_bib0080","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/09595230500170241","article-title":"From opioid maintenance to abstinence: a literature review","volume":"24","author":"Kornor","year":"2005","journal-title":"Drug Alcohol Rev"},{"key":"10.1016\/j.lpm.2012.04.011_bib0085","series-title":"Principles of methadone dose determination. State methadone treatment guidelines: a treatment improvement protocol","author":"Payte","year":"1993"},{"key":"10.1016\/j.lpm.2012.04.011_bib0090","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1001\/archpsyc.1977.01770150119014","article-title":"Withdrawal from methadone maintenance. Rate of withdrawal and expectation","volume":"34","author":"Senay","year":"1977","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.lpm.2012.04.011_bib0095","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0376-8716(03)00071-1","article-title":"Cessation of methadone maintenance treatment using buprenorphine: transfer from methadone to buprenorphine and subsequent buprenorphine reductions","volume":"71","author":"Breen","year":"2003","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.lpm.2012.04.011_bib0100","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1521-0391.2011.00159.x","article-title":"Transdermal buprenorphine to switch patients from higher dose methadone to buprenorphine without severe withdrawal symptoms","volume":"20","author":"Hess","year":"2011","journal-title":"Am J Addict"},{"key":"10.1016\/j.lpm.2012.04.011_bib0105","unstructured":"AFSSAPS (Agence Fran\u00e7aise de s\u00e9curit\u00e9 sanitaire des produits de sant\u00e9). Indication et suivi du traitement substitutif de la pharmacod\u00e9pendance majeure aux opiac\u00e9s par bupr\u00e9norphine haut dosage. Mise au point. 2011. http:\/\/www.afssaps.fr\/Infos-desecurite\/Recommandations\/Initiation-et-suivi-du-traitement-substitutif-de-lapharmacodependance-majeure-aux-opiaces-par-buprenorphine-haut-dosage-BHD-Miseau-point\/(language)\/fre-FR."},{"key":"10.1016\/j.lpm.2012.04.011_bib0110","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1151\/spp04224","article-title":"Practical considerations for the clinical use of buprenorphine","volume":"2","author":"Jones","year":"2004","journal-title":"Sci Pract Perspect"},{"key":"10.1016\/j.lpm.2012.04.011_bib0115","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3109\/10826087309033105","article-title":"Voluntary detoxification of patients on methadone maintenance","volume":"8","author":"Berger","year":"1973","journal-title":"Int J Addict"},{"key":"10.1016\/j.lpm.2012.04.011_bib0120","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1001\/archpsyc.1985.01790270081009","article-title":"Clonidine in outpatient detoxification from methadone maintenance","volume":"42","author":"Kleber","year":"1985","journal-title":"Arch Gen Psychiatry"},{"issue":"2","key":"10.1016\/j.lpm.2012.04.011_bib0125","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0376-8716(94)90096-5","article-title":"Opiate detoxification of methadone maintenance patients using lefetamine, clonidine and buprenorphine","volume":"36","author":"Janiri","year":"1994","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.lpm.2012.04.011_bib0130","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3109\/10826089409047404","article-title":"Detoxification from methadone maintenance treatment in Sweden: long-term outcome and effects on quality of life and life situation","volume":"29","author":"Eklund","year":"1994","journal-title":"Int J Addict"},{"key":"10.1016\/j.lpm.2012.04.011_bib0135","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1001\/jama.1976.03260500020019","article-title":"Successful detoxification from methadone maintenance. Follow-up study of 38\u00a0patients","volume":"235","author":"Riordan","year":"1976","journal-title":"JAMA"},{"key":"10.1016\/j.lpm.2012.04.011_bib0140","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/713659314","article-title":"Nine-year follow-up of 86\u00a0consecutive patients treated with methadone in general practice, Sydney, Australia","volume":"19","author":"Byrne","year":"2000","journal-title":"Drug Alcohol Rev"},{"key":"10.1016\/j.lpm.2012.04.011_bib0145","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0740-5472(87)80013-2","article-title":"Bridges and barriers to recovery: clinical observations from an opiate recovery project","volume":"4","author":"Wermuth","year":"1987","journal-title":"J Subst Abuse Treat"},{"key":"10.1016\/j.lpm.2012.04.011_bib0150","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jsat.2005.11.007","article-title":"Slow tapering from methadone maintenance in a program encouraging indefinite maintenance","volume":"30","author":"Calsyn","year":"2006","journal-title":"J Subst Abuse Treat"},{"issue":"3","key":"10.1016\/j.lpm.2012.04.011_bib0155","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/09595230412331289464","article-title":"Naltrexone maintenance for heroine dependence: uptake, attrition, and retention","volume":"23","author":"Tucker","year":"2004","journal-title":"Drug Alcohol Rev"},{"key":"10.1016\/j.lpm.2012.04.011_bib0160","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3109\/10826089409047387","article-title":"Client variables associated with selection and outcome in a methadone tapering program","volume":"29","author":"Capone","year":"1994","journal-title":"Int J Addict"},{"key":"10.1016\/j.lpm.2012.04.011_bib0165","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3109\/08039488.2010.503904","article-title":"The first 38\u00a0methadone maintenance treatment patients in Stockholm: 15-year follow-up with a main focus on detoxification from methadone","volume":"65","author":"Hiltunen","year":"2011","journal-title":"Nord J Psychiatry"},{"key":"10.1016\/j.lpm.2012.04.011_bib0170","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0740-5472(88)90037-2","article-title":"Tapering from methadone maintenance: attitudes of clients and staff","volume":"5","author":"Gold","year":"1988","journal-title":"J Subst Abuse Treat"}],"container-title":["La Presse M\u00e9dicale"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0755498212002795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0755498212002795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T04:57:32Z","timestamp":1542949052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0755498212002795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0755498212002795"],"URL":"https:\/\/doi.org\/10.1016\/j.lpm.2012.04.011","relation":{},"ISSN":["0755-4982"],"issn-type":[{"value":"0755-4982","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}