{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:44:25Z","timestamp":1791251065792,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["La Presse M\u00e9dicale"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.lpm.2013.02.310","type":"journal-article","created":{"date-parts":[[2013,3,11]],"date-time":"2013-03-11T13:21:17Z","timestamp":1363008077000},"page":"411-418","source":"Crossref","is-referenced-by-count":7,"special_numbering":"P1","title":["\u00c0 propos de l\u2019expertise des dossiers benfluorex (Mediator\u00ae et g\u00e9n\u00e9riques)"],"prefix":"10.1016","volume":"42","author":[{"given":"Philippe","family":"Nicot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ir\u00e8ne","family":"Frachon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lpm.2013.02.310_bib0005","unstructured":"Lettre d\u2019information des Laboratoires Servier. Information importante\u00a0: suspension de mise sur le march\u00e9 du M\u00e9diator. 26\u00a0novembre 2009."},{"key":"10.1016\/j.lpm.2013.02.310_bib0010","unstructured":"Afssaps. M\u00e9diator. Courrier aux patients 02\u00a0d\u00e9cembre 2010. Accessible sur\u00a0: http:\/\/ansm.sante.fr\/var\/ansm_site\/storage\/original\/application\/f0f082933e1e724c3af2fdfda9cffa5c.pdf."},{"key":"10.1016\/j.lpm.2013.02.310_bib0015","doi-asserted-by":"crossref","unstructured":"D\u00e9cret no\u00a02011-932\u00a0du 1er\u00a0ao\u00fbt 2011\u00a0relatif \u00e0 l\u2019indemnisation des victimes du benfluorex.","DOI":"10.1016\/S1773-035X(11)71074-7"},{"key":"10.1016\/j.lpm.2013.02.310_bib0020","unstructured":"Formulaires de demande d\u2019indemnisation aupr\u00e8s de l\u2019Office national de l\u2019indemnisation des accidents m\u00e9dicamenteux (Oniam). Dommages caus\u00e9s par le benfluorex. Accessible sur\u00a0: http:\/\/www.ONIAM.fr\/IMG\/formulaires\/formulair-et-fiche.pdf."},{"key":"10.1016\/j.lpm.2013.02.310_bib0025","unstructured":"La nomenclature Dinthilhac. Accessible sur\u00a0: http:\/\/www.sante.gouv.fr\/la-nomenclature-dintilhac.html."},{"key":"10.1016\/j.lpm.2013.02.310_bib0030","unstructured":"\u00ab\u00a0Statistiques benfluorex au 4\u00a0d\u00e9cembre\u00a0\u00bb, document Word transmis au Conseil d\u2019Administration de l\u2019Oniam le 6\u00a0d\u00e9cembre 2012."},{"key":"10.1016\/j.lpm.2013.02.310_bib0035","unstructured":"Bertrand X. Message adress\u00e9 aux associations de victimes du Mediator le 6\u00a0d\u00e9cembre 2012."},{"key":"10.1016\/j.lpm.2013.02.310_bib0040","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/ejechocard\/jeq172","article-title":"Valvular heart disease associated with benfluorex therapy: results from the Frenche multicentre registry","volume":"12","author":"Le Ven","year":"2011","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.lpm.2013.02.310_bib0045","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.lpm.2011.09.001","article-title":"Benfluorex (Mediator) et atteintes valvulaires","volume":"40","author":"Tribouilloy","year":"2011","journal-title":"Presse Med"},{"key":"10.1016\/j.lpm.2013.02.310_bib0050","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.lpm.2012.01.002","article-title":"Letter on the article: \u201cbenfluorex and valvular heart disease\u201d","volume":"41","author":"Jobic","year":"2012","journal-title":"Presse Med"},{"key":"10.1016\/j.lpm.2013.02.310_bib0055","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/ejechocard\/jer116","article-title":"Valvular heart disease associated with ben\ufb02uorex therapy: high prevalence in patients with unexplained restrictive valvular heart disease","volume":"12","author":"Boudes","year":"2011","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.lpm.2013.02.310_bib0060","first-page":"348","article-title":"Mitral and aortic valvular disease associated with benfluorex use","volume":"20","author":"Etienne","year":"2011","journal-title":"J Heart Valve Dis"},{"issue":"6","key":"10.1016\/j.lpm.2013.02.310_bib0065","doi-asserted-by":"crossref","first-page":"e38273","DOI":"10.1371\/journal.pone.0038273","article-title":"Echocardiographic evidence for valvular toxicity of benfluorex: a double-blind randomised trial in patients with type 2\u00a0diabetes mellitus","volume":"7","author":"Derumeaux","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.lpm.2013.02.310_bib0070","series-title":"Cardiopathies valvulaires acquises","author":"Acar","year":"2000"},{"key":"10.1016\/j.lpm.2013.02.310_bib0075","first-page":"45","article-title":"Rhumatisme articulaire aigu\u00a0: r\u00e9sultats d\u2019une enqu\u00eate nationale (1995\u20131997)","volume":"12","author":"Olivier","year":"1999","journal-title":"BEH"},{"issue":"24","key":"10.1016\/j.lpm.2013.02.310_bib0080","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1161\/CIRCULATIONAHA.112.111260","article-title":"Increased risk of left heart valve regurgitation associated with benfluorex use in patients with diabetes mellitus. A multicenter study","volume":"126","author":"Tribouilloy","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.lpm.2013.02.310_bib0085","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/pds.2044","article-title":"Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus","volume":"19","author":"Weill","year":"2010","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"4","key":"10.1016\/j.lpm.2013.02.310_bib0090","doi-asserted-by":"crossref","first-page":"e10128","DOI":"10.1371\/journal.pone.0010128","article-title":"Benfluorex and unexplained valvular heart disease: a case-control study","volume":"5","author":"Frachon","year":"2010","journal-title":"PloS One"},{"issue":"7","key":"10.1016\/j.lpm.2013.02.310_bib0095","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/ejechocard\/jeq027","article-title":"Restrictive organic mitral regurgitation associated with benfluorex therapy","volume":"11","author":"Tribouilloy","year":"2010","journal-title":"Eur J Echocardiogr"},{"key":"10.1016\/j.lpm.2013.02.310_bib0100","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1741-7015-6-34","article-title":"Valvular regurgitation and surgery associated with fenfluramine use: an analysis of 5743\u00a0individuals","volume":"6","author":"Dahl","year":"2008","journal-title":"BMC Med"},{"key":"10.1016\/j.lpm.2013.02.310_bib0105","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/clpt.2009.252","article-title":"ALDEN, an algorithm for assessment of drug causality in Stevens-Johnson syndrome and toxic epidermal necrolysis: comparison with case-control analysis","volume":"88","author":"Sassolas","year":"2010","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.lpm.2013.02.310_bib0110","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0002-9149(98)01064-9","article-title":"Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framinghman Heart Study)","volume":"83","author":"Singh","year":"1999","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.lpm.2013.02.310_bib0115","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/S0140-6736(09)60692-9","article-title":"Mitral regurgitation","volume":"373","author":"Enriquez-Sarano","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.lpm.2013.02.310_bib0120","unstructured":"Guide m\u00e9thodologique d\u2019expertise sur pi\u00e8ces (23\u00a0janvier 2013). Accessible \u00e0 http:\/\/www.oniam.fr\/IMG\/benflux\/imputabilite-benfluorex.pdf."}],"container-title":["La Presse M\u00e9dicale"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075549821300420X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S075549821300420X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T17:30:55Z","timestamp":1562779855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S075549821300420X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S075549821300420X"],"URL":"https:\/\/doi.org\/10.1016\/j.lpm.2013.02.310","relation":{},"ISSN":["0755-4982"],"issn-type":[{"value":"0755-4982","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}