{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:06:12Z","timestamp":1790676372401,"version":"4.1.0"},"reference-count":105,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["La Presse M\u00e9dicale"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.lpm.2014.09.005","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T08:52:29Z","timestamp":1415091149000},"page":"e413-e421","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"P2","title":["Origin and immunoescape of uterine cervical cancer"],"prefix":"10.1016","volume":"43","author":[{"given":"Dorien","family":"Van hede","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"Langers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Delvenne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lpm.2014.09.005_bib0005","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0140-6736(11)61351-2","article-title":"Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis","volume":"378","author":"Forouzanfar","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.lpm.2014.09.005_bib0010","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.ejca.2012.12.027","article-title":"Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012","volume":"49","author":"Ferlay","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0015","first-page":"117","article-title":"Site and origin of squamous cervical cancer: a histomorphologic study","volume":"62","author":"Burghardt","year":"1983","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0020","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.virol.2010.02.002","article-title":"Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments","volume":"401","author":"Bernard","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.lpm.2014.09.005_bib0025","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/sj.bjc.6600688","article-title":"Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis","volume":"88","author":"Clifford","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0030","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1086\/516784","article-title":"A 2-year prospective study of human papillomavirus persistence among women with a cytological diagnosis of atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesion","volume":"195","author":"Plummer","year":"2007","journal-title":"J Infect Dis"},{"key":"10.1016\/j.lpm.2014.09.005_bib0035","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.virol.2013.07.015","article-title":"A systematic review of the prevalence of mucosal and cutaneous human papillomavirus types","volume":"445","author":"Bzhalava","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.lpm.2014.09.005_bib0040","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.virol.2013.04.023","article-title":"Cross-roads in the classification of papillomaviruses","volume":"445","author":"de Villiers","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.lpm.2014.09.005_bib0045","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S1470-2045(09)70096-8","article-title":"A review of human carcinogens\u00a0\u2013\u00a0part B: biological agents","volume":"10","author":"Bouvard","year":"2009","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0050","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.virol.2008.11.046","article-title":"Papillomaviruses in the causation of human cancers\u00a0\u2013\u00a0a brief historical account","volume":"384","author":"zur Hausen","year":"2009","journal-title":"Virology"},{"key":"10.1016\/j.lpm.2014.09.005_bib0055","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1750-9378-4-8","article-title":"Classification of weakly carcinogenic human papillomavirus types: addressing the limits of epidemiology at the borderline","volume":"4","author":"Schiffman","year":"2009","journal-title":"Infect Agents Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0060","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/ijc.22527","article-title":"Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update","volume":"121","author":"Smith","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0065","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1001\/jama.283.8.1031","article-title":"Incidence of cervical squamous intraepithelial lesions in HIV-infected women","volume":"283","author":"Ellerbrock","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.lpm.2014.09.005_bib0070","first-page":"1481","article-title":"Carcinoma of the cervix and tobacco smoking: collaborative reanalysis of individual data on 13,541 women with carcinoma of the cervix and 23,017 women without carcinoma of the cervix from 23 epidemiological studies","volume":"118","author":"Cancer ICoESoC","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2006.10.014","article-title":"Role of hormone cofactors in the human papillomavirus-induced carcinogenesis of the uterine cervix","volume":"264","author":"Delvenne","year":"2007","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0080","first-page":"444","article-title":"Original site of cervical carcinoma; topographical relationship of carcinoma of the cervix to the external os and to the squamocolumnar junction","volume":"7","author":"Marsh","year":"1956","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0085","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/1097-0142(195111)4:6<1210::AID-CNCR2820040607>3.0.CO;2-9","article-title":"A study of the incidence and histogenesis of endocervical metaplasia and intraepithelial carcinoma; observations on 400 uteri removed for non-cervical disease","volume":"4","author":"Howard","year":"1951","journal-title":"Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0090","first-page":"297","article-title":"Cancer du col de l\u2019ut\u00e9rus d\u2019origine intra-cervicale","volume":"5","author":"Beclere","year":"1954","journal-title":"Gynecol Prat"},{"key":"10.1016\/j.lpm.2014.09.005_bib0095","first-page":"497","article-title":"Keratin expression in cervical cancer","volume":"141","author":"Smedts","year":"1992","journal-title":"Am J Pathol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0100","first-page":"4171","article-title":"Genetic alterations accumulate during cervical tumorigenesis and indicate a common origin for multifocal lesions","volume":"57","author":"Larson","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.lpm.2014.09.005_bib0105","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0140-6736(86)90360-0","article-title":"Intracellular surveillance of persisting viral infections. Human genital cancer results from deficient cellular control of papillomavirus gene expression","volume":"2","author":"zur Hausen","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.lpm.2014.09.005_bib0110","doi-asserted-by":"crossref","first-page":"10516","DOI":"10.1073\/pnas.1202684109","article-title":"A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer","volume":"109","author":"Herfs","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.lpm.2014.09.005_bib0115","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1128\/JVI.61.5.1630-1638.1987","article-title":"Transcriptional trans-activation by the human papillomavirus type 16 E2 gene product","volume":"61","author":"Phelps","year":"1987","journal-title":"J Virol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0120","first-page":"11","article-title":"The natural history of cervical HPV infection: unresolved issues. Nature reviews","volume":"7","author":"Woodman","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0125","doi-asserted-by":"crossref","first-page":"F55","DOI":"10.1016\/j.vaccine.2012.06.083","article-title":"The biology and life-cycle of human papillomaviruses","volume":"30","author":"Doorbar","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.lpm.2014.09.005_bib0130","doi-asserted-by":"crossref","first-page":"4442","DOI":"10.1073\/pnas.89.10.4442","article-title":"Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses","volume":"89","author":"Heck","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.lpm.2014.09.005_bib0135","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1128\/JVI.70.7.4509-4516.1996","article-title":"High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation","volume":"70","author":"Li","year":"1996","journal-title":"J Virol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0140","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1128\/MCB.13.8.4918","article-title":"Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins","volume":"13","author":"Huibregtse","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0145","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0092-8674(93)90384-3","article-title":"The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53","volume":"75","author":"Scheffner","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.lpm.2014.09.005_bib0150","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1101\/gad.1214704","article-title":"Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6\/E6-AP complex","volume":"18","author":"Gewin","year":"2004","journal-title":"Genes Dev"},{"key":"10.1016\/j.lpm.2014.09.005_bib0155","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1128\/JVI.77.12.6957-6964.2003","article-title":"The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo","volume":"77","author":"Nguyen","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0160","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1073\/pnas.94.13.6670","article-title":"Binding of human virus oncoproteins to hDlg\/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein","volume":"94","author":"Lee","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.lpm.2014.09.005_bib0165","doi-asserted-by":"crossref","first-page":"8244","DOI":"10.1128\/MCB.20.21.8244-8253.2000","article-title":"Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase","volume":"20","author":"Nakagawa","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0170","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/sj.onc.1203374","article-title":"HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligase","volume":"19","author":"Pim","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.lpm.2014.09.005_bib0175","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/annonc\/mdg407","article-title":"Heparanase expression is an independent prognostic factor in patients with invasive cervical cancer","volume":"14","author":"Shinyo","year":"2003","journal-title":"Ann Oncol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0180","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s12032-012-0403-9","article-title":"Heparanase overexpression participates in tumor growth of cervical cancer in vitro and in vivo","volume":"30","author":"Zeng","year":"2013","journal-title":"Med Oncol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0185","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/jcmm.12179","article-title":"Induction of heparanase by HPV E6 oncogene in head and neck squamous cell carcinoma","volume":"18","author":"Hirshoren","year":"2014","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.lpm.2014.09.005_bib0190","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10555-011-9288-x","article-title":"The heparanase system and tumor metastasis: is heparanase the seed and soil?","volume":"30","author":"Arvatz","year":"2011","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.lpm.2014.09.005_bib0195","doi-asserted-by":"crossref","first-page":"6751","DOI":"10.1128\/JVI.03355-13","article-title":"HPV16 E6* induces oxidative stress and DNA damage","volume":"88","author":"Williams","year":"2014","journal-title":"J Virol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0200","doi-asserted-by":"crossref","first-page":"6862","DOI":"10.1128\/JVI.70.10.6862-6869.1996","article-title":"Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation","volume":"70","author":"Demers","year":"1996","journal-title":"J Virol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0205","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1099\/0022-1317-76-7-1815","article-title":"Cell cycle-dependent disruption of E2F-p107 complexes by human papillomavirus type 16 E7","volume":"76","author":"Zerfass","year":"1995","journal-title":"J Gen Virol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0210","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/bjc.2013.817","article-title":"Increased expression of RRM2 by human papillomavirus E7 oncoprotein promotes angiogenesis in cervical cancer","volume":"110","author":"Wang","year":"2014","journal-title":"Br J Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0215","first-page":"2323","article-title":"Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein","volume":"13","author":"Zerfass-Thome","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.lpm.2014.09.005_bib0220","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1101\/gad.11.16.2090","article-title":"Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein","volume":"11","author":"Funk","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.lpm.2014.09.005_bib0225","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1128\/JVI.02038-12","article-title":"Human papillomavirus E7 induces rereplication in response to DNA damage","volume":"87","author":"Fan","year":"2013","journal-title":"J Virol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0230","first-page":"27","article-title":"Human papillomavirus type 16 E5 gene stimulates the transforming activity of the epidermal growth factor receptor","volume":"7","author":"Pim","year":"1992","journal-title":"Oncogene"},{"key":"10.1016\/j.lpm.2014.09.005_bib0235","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1128\/JVI.67.8.4521-4532.1993","article-title":"The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes","volume":"67","author":"Straight","year":"1993","journal-title":"J Virol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0240","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1078\/0171-9335-00060","article-title":"Modulation of the epidermal growth factor receptor by the human papillomavirus type 16 E5 protein in raft cultures of human keratinocytes","volume":"79","author":"Tomakidi","year":"2000","journal-title":"Eur J Cell Biol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0245","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1038\/sj.onc.1208453","article-title":"HPV16 E5 protein disrupts the c-Cbl-EGFR interaction and EGFR ubiquitination in human foreskin keratinocytes","volume":"24","author":"Zhang","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.lpm.2014.09.005_bib0250","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/carcin\/bgp066","article-title":"Involvement of NF-kappaB and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein","volume":"30","author":"Kim","year":"2009","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lpm.2014.09.005_bib0255","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1038\/sj.onc.1210916","article-title":"Genes involved in cell adhesion, cell motility and mitogenic signaling are altered due to HPV 16 E5 protein expression","volume":"27","author":"Kivi","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.lpm.2014.09.005_bib0260","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1101\/gad.182100","article-title":"Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins","volume":"14","author":"Jackson","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.lpm.2014.09.005_bib0265","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1038\/sj.cdd.4401886","article-title":"Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis","volume":"13","author":"Garnett","year":"2006","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.lpm.2014.09.005_bib0270","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1128\/JVI.02007-06","article-title":"NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells","volume":"81","author":"Katzenellenbogen","year":"2007","journal-title":"J Virol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0275","first-page":"59","article-title":"Immune evasion in human papillomavirus-associated cervical cancer. Nature reviews","volume":"2","author":"Tindle","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0280","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0029-7844(95)00408-4","article-title":"Multiple recurrences of cervical intraepithelial neoplasia in women with the human immunodeficiency virus","volume":"87","author":"Fruchter","year":"1996","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0285","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1097\/QAD.0b013e3281c61201","article-title":"Anal squamous intraepithelial lesions and condyloma in HIV-infected heterosexual men, homosexual men and women: prevalence and associated factors","volume":"21","author":"Abramowitz","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.lpm.2014.09.005_bib0290","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1073\/pnas.0508033103","article-title":"Human alpha-defensins block papillomavirus infection","volume":"103","author":"Buck","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.lpm.2014.09.005_bib0295","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.3390\/v5112624","article-title":"Role of innate immunity against human papillomavirus (HPV) infections and effect of adjuvants in promoting specific immune response","volume":"5","author":"Amador-Molina","year":"2013","journal-title":"Viruses"},{"key":"10.1016\/j.lpm.2014.09.005_bib0300","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0042-6822(89)90393-0","article-title":"Macrophage killing of human papillomavirus type 16-transformed cells","volume":"170","author":"Denis","year":"1989","journal-title":"Virology"},{"key":"10.1016\/j.lpm.2014.09.005_bib0305","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1096\/fj.00-0872fje","article-title":"Dendritic cells induce the death of human papillomavirus-transformed keratinocytes","volume":"15","author":"Hubert","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.lpm.2014.09.005_bib0310","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1002\/eji.201141693","article-title":"Human papillomavirus entry into NK cells requires CD16 expression and triggers cytotoxic activity and cytokine secretion","volume":"41","author":"Renoux","year":"2011","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0315","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2249.2008.03624.x","article-title":"Innate lymphocyte and dendritic cell cross-talk: a key factor in the regulation of the immune response","volume":"152","author":"Reschner","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0320","first-page":"73","article-title":"Natural killer cells: role in local tumor growth and metastasis","volume":"6","author":"Langers","year":"2012","journal-title":"Biologics"},{"key":"10.1016\/j.lpm.2014.09.005_bib0325","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4049\/jimmunol.167.1.497","article-title":"Both E6 and E7 oncoproteins of human papillomavirus 16 inhibit IL-18-induced IFN-gamma production in human peripheral blood mononuclear and NK cells","volume":"167","author":"Lee","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0330","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1002\/ijc.22894","article-title":"CD4(+)CD25hi regulatory T-cell frequency correlates with persistence of human papillomavirus type 16 and T helper cell responses in patients with cervical intraepithelial neoplasia","volume":"121","author":"Molling","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0335","first-page":"472","article-title":"Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects","volume":"62","author":"de Jong","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.lpm.2014.09.005_bib0340","first-page":"636","article-title":"Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter","volume":"63","author":"Welters","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.lpm.2014.09.005_bib0345","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2249.2009.04006.x","article-title":"Human papillomavirus 16-specific T cell responses in classic HPV-related vulvar intra-epithelial neoplasia. Determination of strongly immunogenic regions from E6 and E7 proteins","volume":"159","author":"Bourgault Villada","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0350","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1128\/JVI.78.9.4927-4930.2004","article-title":"Intraepithelial gammadelta T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type 2","volume":"78","author":"Nishimura","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0355","first-page":"381","article-title":"Local immunologic defenses in the genital tract","volume":"70","author":"Ogra","year":"1981","journal-title":"Prog Clin Biol Res"},{"key":"10.1016\/j.lpm.2014.09.005_bib0360","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1006\/viro.1999.0060","article-title":"Naturally occurring, nonregressing canine oral papillomavirus infection: host immunity, virus characterization, and experimental infection","volume":"265","author":"Nicholls","year":"1999","journal-title":"Virology"},{"key":"10.1016\/j.lpm.2014.09.005_bib0365","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1006\/scbi.1999.0146","article-title":"The serological response to papillomaviruses","volume":"9","author":"Dillner","year":"1999","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0370","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/ijc.10084","article-title":"Influence of the mucosal epithelium microenvironment on Langerhans cells: implications for the development of squamous intraepithelial lesions of the cervix","volume":"97","author":"Giannini","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0375","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1046\/j.1365-2249.1998.00639.x","article-title":"Cytokine expression in squamous intraepithelial lesions of the uterine cervix: implications for the generation of local immunosuppression","volume":"113","author":"Giannini","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0380","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.2353\/ajpath.2008.071004","article-title":"Transforming growth factor-beta1-mediated Slug and Snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin expression","volume":"172","author":"Herfs","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0385","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017848","article-title":"Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes","volume":"6","author":"Karim","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.lpm.2014.09.005_bib0390","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2174\/156800907780006869","article-title":"Mechanisms used by human papillomaviruses to escape the host immune response","volume":"7","author":"Kanodia","year":"2007","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.lpm.2014.09.005_bib0395","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1084\/jem.20122394","article-title":"The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter","volume":"210","author":"Hasan","year":"2013","journal-title":"J Exp Med"},{"key":"10.1016\/j.lpm.2014.09.005_bib0400","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1101\/gad.12.13.2061","article-title":"Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity","volume":"12","author":"Ronco","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.lpm.2014.09.005_bib0405","doi-asserted-by":"crossref","first-page":"5727","DOI":"10.1038\/sj.onc.1202960","article-title":"The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha","volume":"18","author":"Li","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.lpm.2014.09.005_bib0410","first-page":"376","article-title":"Tumor-associated macrophages: function, phenotype, and link to prognosis in human lung cancer","volume":"4","author":"Quatromoni","year":"2012","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.lpm.2014.09.005_bib0415","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ejogrb.2003.10.026","article-title":"Langerhans\u2019 cell count and HLA class II profile in cervical intraepithelial neoplasia in the presence or absence of HIV infection","volume":"114","author":"Goncalves","year":"2004","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0420","doi-asserted-by":"crossref","first-page":"8378","DOI":"10.1128\/JVI.77.15.8378-8385.2003","article-title":"Depletion of Langerhans cells in human papillomavirus type 16-infected skin is associated with E6-mediated down regulation of E-cadherin","volume":"77","author":"Matthews","year":"2003","journal-title":"J Virol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0425","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1093\/carcin\/bgn145","article-title":"Silencing of E7 oncogene restores functional E-cadherin expression in human papillomavirus 16-transformed keratinocytes","volume":"29","author":"Caberg","year":"2008","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.lpm.2014.09.005_bib0430","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.4049\/jimmunol.169.6.3242","article-title":"Human papillomavirus virus-like particles do not activate Langerhans cells: a possible immune escape mechanism used by human papillomaviruses","volume":"169","author":"Fausch","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0435","doi-asserted-by":"crossref","first-page":"7587","DOI":"10.4049\/jimmunol.178.12.7587","article-title":"Uptake of human papillomavirus virus-like particles by dendritic cells is mediated by Fcgamma receptors and contributes to acquisition of T cell immunity","volume":"178","author":"Da Silva","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0440","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.lpm.2014.09.005_bib0445","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2172-11-27","article-title":"Interleukin-10 production by tumor infiltrating macrophages plays a role in human papillomavirus 16 tumor growth","volume":"11","author":"Bolpetti","year":"2010","journal-title":"BMC Immunol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0450","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1158\/1078-0432.CCR-09-0489","article-title":"HPV16 tumor associated macrophages suppress antitumor T cell responses","volume":"15","author":"Lepique","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.lpm.2014.09.005_bib0455","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1002\/ijc.22089","article-title":"E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domain","volume":"119","author":"Ashrafi","year":"2006","journal-title":"Int J Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0460","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00004347-198302000-00008","article-title":"Immunohistochemical study of the distribution of secretory component and IgA in the normal and diseased uterine mucosa","volume":"2","author":"Arends","year":"1983","journal-title":"Int J Gynecol Pathol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0465","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1172\/JCI28607","article-title":"Prophylactic human papillomavirus vaccines","volume":"116","author":"Lowy","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.lpm.2014.09.005_bib0470","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/S0140-6736(07)60946-5","article-title":"Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial","volume":"369","author":"Paavonen","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.lpm.2014.09.005_bib0475","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1002\/ijc.28541","article-title":"Potential cost-effectiveness of the nonavalent human papillomavirus (HPV) vaccine","volume":"134","author":"Drolet","year":"2014","journal-title":"Int J Cancer"},{"key":"10.1016\/j.lpm.2014.09.005_bib0480","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1517\/14728214.2012.744393","article-title":"Emerging human papillomavirus vaccines","volume":"17","author":"Ma","year":"2012","journal-title":"Expert Opin Emerg Drugs"},{"key":"10.1016\/j.lpm.2014.09.005_bib0485","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.1016\/j.vaccine.2005.04.049","article-title":"Therapeutic vaccination with papillomavirus E6 and E7 long peptides results in the control of both established virus-induced lesions and latently infected sites in a pre-clinical cottontail rabbit papillomavirus model","volume":"23","author":"Vambutas","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.lpm.2014.09.005_bib0490","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1479-5876-11-88","article-title":"HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial","volume":"11","author":"van Poelgeest","year":"2013","journal-title":"J Transl Med"},{"key":"10.1016\/j.lpm.2014.09.005_bib0495","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-0897.2010.00834.x","article-title":"Local applications of GM-CSF induce the recruitment of immune cells in cervical low-grade squamous intraepithelial lesions","volume":"64","author":"Hubert","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0500","doi-asserted-by":"crossref","first-page":"e81366","DOI":"10.1371\/journal.pone.0081366","article-title":"Interferon-beta induced microRNA-129-5p down-regulates HPV-18 E6 and E7 viral gene expression by targeting SP1 in cervical cancer cells","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lpm.2014.09.005_bib0505","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1128\/JVI.03091-13","article-title":"APOBEC3 deaminases induce hypermutation in human papillomavirus 16 DNA upon beta interferon stimulation","volume":"88","author":"Wang","year":"2014","journal-title":"J Virol"},{"key":"10.1016\/j.lpm.2014.09.005_bib0510","doi-asserted-by":"crossref","first-page":"e36909","DOI":"10.1371\/journal.pone.0036909","article-title":"Interferon-beta induces cellular senescence in cutaneous human papilloma virus-transformed human keratinocytes by affecting p53 transactivating activity","volume":"7","author":"Chiantore","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.lpm.2014.09.005_bib0515","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1479-5876-9-147","article-title":"Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer","volume":"9","author":"Scholten","year":"2011","journal-title":"J Transl Med"},{"key":"10.1016\/j.lpm.2014.09.005_bib0520","doi-asserted-by":"crossref","first-page":"4606","DOI":"10.1172\/JCI63287","article-title":"Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses","volume":"122","author":"Cuburu","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.lpm.2014.09.005_bib0525","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1002\/ijc.28604","article-title":"In vivo antitumor effect of an intracellular single-chain antibody fragment against the E7 oncoprotein of human papillomavirus 16","volume":"134","author":"Accardi","year":"2014","journal-title":"Int J Cancer"}],"container-title":["La Presse M\u00e9dicale"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0755498214004709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0755498214004709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T17:30:34Z","timestamp":1717522234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0755498214004709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":105,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0755498214004709"],"URL":"https:\/\/doi.org\/10.1016\/j.lpm.2014.09.005","relation":{},"ISSN":["0755-4982"],"issn-type":[{"value":"0755-4982","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Origin and immunoescape of uterine cervical cancer","name":"articletitle","label":"Article Title"},{"value":"La Presse M\u00e9dicale","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lpm.2014.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.lpm.2014.08.008","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.lpm.2014.08.010","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.lpm.2014.10.001","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.lpm.2014.09.008","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"https:\/\/doi.org\/10.1016\/j.lpm.2014.09.006","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}