{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:11Z","timestamp":1787169791849,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["La Presse M\u00e9dicale"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.lpm.2015.02.019","type":"journal-article","created":{"date-parts":[[2015,5,23]],"date-time":"2015-05-23T02:31:41Z","timestamp":1432348301000},"page":"e251-e257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"P2","title":["Risks of treatments and long-term outcomes of systemic ANCA-associated vasculitis"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5976-3609","authenticated-orcid":false,"given":"Oliver","family":"Flossmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lpm.2015.02.019_bib0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 revised international Chapel Hill consensus conference nomenclature of vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.lpm.2015.02.019_bib0255","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.lpm.2013.01.027","article-title":"L27. Antibodies versus phenotypes: a clinician's view","volume":"42","author":"Jayne","year":"2013","journal-title":"Presse Med"},{"key":"10.1016\/j.lpm.2015.02.019_bib0260","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1136\/ard.2007.071936","article-title":"Outcomes from studies of antineutrophil cytoplasm antibody-associated vasculitis: a systematic review by the European League Against Rheumatism systemic vasculitis task force","volume":"67","author":"Mukhtyar","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.lpm.2015.02.019_bib0265","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/art.27763","article-title":"Improved outcome in 445 patients with Wegener's granulomatosis in a German vasculitis center over four decades","volume":"63","author":"Holle","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.lpm.2015.02.019_bib0270","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/ndt\/gfs428","article-title":"Improved outcome in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis: a 30-year follow-up study","volume":"28","author":"Hilhorst","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.lpm.2015.02.019_bib0275","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1136\/ard.2010.137778","article-title":"Long-term patient survival in ANCA-associated vasculitis","volume":"70","author":"Flossmann","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.lpm.2015.02.019_bib0280","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00005792-199601000-00003","article-title":"Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients","volume":"75","author":"Guillevin","year":"1996","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.lpm.2015.02.019_bib0285","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.autrev.2013.10.001","article-title":"Long-term follow-up of a randomized trial on 118 patients with polyarteritis nodosa or microscopic polyangiitis without poor prognosis factors","volume":"13","author":"Samson","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.lpm.2015.02.019_bib0290","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/rheumatology\/keq351","article-title":"Mortality in Wegener's granulomatosis: a bimodal pattern","volume":"50","author":"Luqmani","year":"2011","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.lpm.2015.02.019_bib0295","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jaut.2013.03.003","article-title":"Long-term outcomes of 118 patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) enrolled in two prospective trials","volume":"43","author":"Samson","year":"2013","journal-title":"J Autoimmun"},{"key":"10.1016\/j.lpm.2015.02.019_bib0300","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/art.37721","article-title":"Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): clinical characteristics and long-term follow-up of the 383 patients enrolled in the French Vasculitis Study Group cohort","volume":"65","author":"Comarmond","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.lpm.2015.02.019_bib0305","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3899\/jrheum.131038","article-title":"A population-based study showing better renal prognosis for proteinase 3 antineutrophil cytoplasmic antibody (ANCA)-associated nephritis versus myeloperoxidase ANCA-associated nephritis","volume":"41","author":"Mohammad","year":"2014","journal-title":"J Rheumatol"},{"key":"10.1016\/j.lpm.2015.02.019_bib0310","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/ki.2013.131","article-title":"Long-term follow-up of patients with severe ANCA-associated vasculitis comparing plasma exchange to intravenous methylprednisolone treatment is unclear","volume":"84","author":"Walsh","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.lpm.2015.02.019_bib0315","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2215\/CJN.01020113","article-title":"Renal survival in proteinase 3 and myeloperoxidase ANCA-associated systemic vasculitis","volume":"8","author":"de Joode","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.lpm.2015.02.019_bib0320","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/ki.2010.489","article-title":"ANCA-associated glomerulonephritis in the very elderly","volume":"79","author":"Bomback","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.lpm.2015.02.019_bib0325","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1681\/ASN.2010050477","article-title":"Histopathologic classification of ANCA-associated glomerulonephritis","volume":"21","author":"Berden","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.lpm.2015.02.019_bib0330","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1681\/ASN.2012090912","article-title":"Estimating renal survival using the ANCA-associated GN classification","volume":"24","author":"Hilhorst","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.lpm.2015.02.019_bib0335","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1093\/ndt\/gfr643","article-title":"Re-evaluation of the histopathologic classification of ANCA-associated glomerulonephritis: a study of 121 patients in a single center","volume":"27","author":"Chang","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.lpm.2015.02.019_bib0340","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1111\/ctr.12084","article-title":"Long-term outcome of antineutrophil cytoplasmic antibody-associated small vessel vasculitis after renal transplantation","volume":"27","author":"Marco","year":"2013","journal-title":"Clin Transplant"},{"key":"10.1016\/j.lpm.2015.02.019_bib0345","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1097\/TP.0b013e31821ab9aa","article-title":"Renal transplantation in antineutrophil cytoplasmic antibody-associated vasculitis: a multicenter experience","volume":"91","author":"Geetha","year":"2011","journal-title":"Transplantation"},{"key":"10.1016\/j.lpm.2015.02.019_bib0350","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2215\/CJN.08770812","article-title":"The outcomes of patients with ESRD and ANCA-associated vasculitis in Australia and New Zealand","volume":"8","author":"Tang","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.lpm.2015.02.019_bib0355","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/qjmed\/hcu043","article-title":"Survival of patients with ANCA-associated vasculitis on chronic dialysis: data from the French REIN registry from 2002 to 2011","volume":"107","author":"Romeu","year":"2014","journal-title":"QJM"},{"key":"10.1016\/j.lpm.2015.02.019_bib0360","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/MD.0000000000000217","article-title":"Pulmonary fibrosis in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: a series of 49 patients and review of the literature","volume":"93","author":"Comarmond","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.lpm.2015.02.019_bib0365","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3899\/jrheum.131426","article-title":"Predictors for mortality in patients with antineutrophil cytoplasmic autoantibody-associated vasculitis: a study of 398 Chinese patients","volume":"41","author":"Lai","year":"2014","journal-title":"J Rheumatol"},{"key":"10.1016\/j.lpm.2015.02.019_bib0370","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1136\/ard.2009.109389","article-title":"Early mortality in systemic vasculitis: relative contribution of adverse events and active vasculitis","volume":"69","author":"Little","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.lpm.2015.02.019_bib0375","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/art.33361","article-title":"Risk factors for relapse of antineutrophil cytoplasmic antibody-associated vasculitis","volume":"64","author":"Walsh","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.lpm.2015.02.019_bib0380","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1002\/art.23800","article-title":"Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small vessel vasculitis: comparison of two independent cohorts","volume":"58","author":"Pagnoux","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.lpm.2015.02.019_bib0385","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1093\/rheumatology\/keq244","article-title":"Predictors at diagnosis of a first Wegener's granulomatosis relapse after obtaining complete remission","volume":"49","author":"Pierrot-Deseilligny Despujol","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.lpm.2015.02.019_bib0390","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1002\/art.34547","article-title":"Brief Report: long-term outcome of a randomized clinical trial comparing methotrexate to cyclophosphamide for remission induction in early systemic antineutrophil cytoplasmic antibody-associated vasculitis","volume":"64","author":"Faurschou","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.lpm.2015.02.019_bib0395","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/annrheumdis-2011-200477","article-title":"Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up","volume":"71","author":"Harper","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.lpm.2015.02.019_bib0400","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.2215\/CJN.00100114","article-title":"Long-term follow-up of cyclophosphamide compared with azathioprine for initial maintenance therapy in ANCA-associated vasculitis","volume":"9","author":"Walsh","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.lpm.2015.02.019_bib0405","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1056\/NEJMoa0909905","article-title":"Rituximab versus cyclophosphamide for ANCA-associated vasculitis","volume":"363","author":"Stone","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lpm.2015.02.019_bib0410","doi-asserted-by":"crossref","first-page":"488","DOI":"10.7326\/0003-4819-116-6-488","article-title":"Wegener granulomatosis: an analysis of 158 patients","volume":"116","author":"Hoffman","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.lpm.2015.02.019_bib0415","first-page":"100","article-title":"Malignancies in Wegener's granulomatosis: incidence and relation to cyclophosphamide therapy in a cohort of 293 patients","volume":"35","author":"Faurschou","year":"2008","journal-title":"J Rheumatol"},{"key":"10.1016\/j.lpm.2015.02.019_bib0420","article-title":"Prolonged risk of specific malignancies following cyclophosphamide therapy among patients with granulomatosis with polyangiitis","author":"Faurschou","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.lpm.2015.02.019_bib0425","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1136\/ard.2010.145250","article-title":"Incidence of malignancy in patients treated for antineutrophil cytoplasm antibody-associated vasculitis: follow-up data from European Vasculitis Study Group clinical trials","volume":"70","author":"Heijl","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.lpm.2015.02.019_bib0430","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/art.24386","article-title":"Increased morbidity from ischemic heart disease in patients with Wegener's granulomatosis","volume":"60","author":"Faurschou","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.lpm.2015.02.019_bib0435","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1002\/acr.22423","article-title":"High risk of pulmonary embolism and deep venous thrombosis but not of stroke in granulomatosis with polyangiitis (Wegener's)","volume":"66","author":"Faurschou","year":"2014","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.lpm.2015.02.019_bib0440","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/acr.20433","article-title":"A model to predict cardiovascular events in patients with newly diagnosed wegener's granulomatosis and microscopic polyangiitis","volume":"63","author":"Suppiah","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.lpm.2015.02.019_bib0445","first-page":"819","article-title":"Outcome of ANCA-associated vasculitis \u2013 long-term follow-up of four randomised controlled trials","volume":"18","author":"Flossmann","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.lpm.2015.02.019_bib0450","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2215\/CJN.07300712","article-title":"Lymphopenia and treatment-related infectious complications in ANCA-associated vasculitis","volume":"8","author":"Goupil","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.lpm.2015.02.019_bib0455","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa0909169","article-title":"Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis","volume":"363","author":"Jones","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lpm.2015.02.019_bib0460","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1056\/NEJMoa1404231","article-title":"Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis","volume":"371","author":"Guillevin","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lpm.2015.02.019_bib0465","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/annrheumdis-2013-203927","article-title":"Damage in the anca-associated vasculitides: long-term data from the European Vasculitis Study Group (EUVAS) therapeutic trials","volume":"74","author":"Robson","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.lpm.2015.02.019_bib0470","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/rheumatology\/keu366","article-title":"Glucocorticoid treatment and damage in the anti-neutrophil cytoplasm antibody-associated vasculitides: long-term data from the European Vasculitis Study Group trials","volume":"54","author":"Robson","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.lpm.2015.02.019_bib0475","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/acr.20649","article-title":"Assessment of health-related quality of life as an outcome measure in granulomatosis with polyangiitis (Wegener's)","volume":"64","author":"Tomasson","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.lpm.2015.02.019_bib0480","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.3899\/jrheum.100167","article-title":"Impaired health-related quality of life in patients treated for Wegener's granulomatosis","volume":"37","author":"Faurschou","year":"2010","journal-title":"J Rheumatol"},{"key":"10.1016\/j.lpm.2015.02.019_bib0485","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/annrheumdis-2012-202750","article-title":"The characterisation and determinants of quality of life in ANCA-associated vasculitis","volume":"73","author":"Basu","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.lpm.2015.02.019_bib0490","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/rheumatology\/ket483","article-title":"Markers for work disability in anti-neutrophil cytoplasmic antibody-associated vasculitis","volume":"53","author":"Basu","year":"2014","journal-title":"Rheumatology (Oxford)"}],"container-title":["La Presse M\u00e9dicale"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0755498215001980?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0755498215001980?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T06:32:30Z","timestamp":1537597950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0755498215001980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0755498215001980"],"URL":"https:\/\/doi.org\/10.1016\/j.lpm.2015.02.019","relation":{},"ISSN":["0755-4982"],"issn-type":[{"value":"0755-4982","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risks of treatments and long-term outcomes of systemic ANCA-associated vasculitis","name":"articletitle","label":"Article Title"},{"value":"La Presse M\u00e9dicale","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lpm.2015.02.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}