{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:50:27Z","timestamp":1790297427799,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"7-8","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["La Presse M\u00e9dicale"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.lpm.2018.07.006","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T10:02:41Z","timestamp":1532944961000},"page":"e151-e158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"P2","title":["Molecular genetics of Conn adenomas in the era of exome analysis"],"prefix":"10.1016","volume":"47","author":[{"given":"Rami M.","family":"El Zein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheerazed","family":"Boulkroun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Luiz","family":"Fernandes-Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Christina","family":"Zennaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lpm.2018.07.006_bib0295","first-page":"37","article-title":"Worldwide trends in blood pressure from 1975\u00a0to 2015: a pooled analysis of 1479\u00a0population-based measurement studies with 19.1\u00a0million participants","volume":"389","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.lpm.2018.07.006_bib0300","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1055\/s-0031-1295438","article-title":"Prevalence of primary aldosteronism in patient's cohorts and in population-based studies--a review of the current literature","volume":"44","author":"Hannemann","year":"2012","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.lpm.2018.07.006_bib0305","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1161\/01.HYP.0000040261.30455.B6","article-title":"Hyperaldosteronism among black and white subjects with resistant hypertension","volume":"40","author":"Calhoun","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.lpm.2018.07.006_bib0310","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0140-6736(08)60834-X","article-title":"Prevalence of primary hyperaldosteronism in resistant hypertension: a retrospective observational study","volume":"371","author":"Douma","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.lpm.2018.07.006_bib0315","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lpm.2018.07.006_bib0320","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1210\/jc.2008-0104","article-title":"Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline","volume":"93","author":"Funder","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lpm.2018.07.006_bib0325","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S2213-8587(17)30135-3","article-title":"Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort","volume":"5","author":"Williams","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.lpm.2018.07.006_bib0330","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1210\/jc.2013-2805","article-title":"Long-term cardio- and cerebrovascular events in patients with primary aldosteronism","volume":"98","author":"Mulatero","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lpm.2018.07.006_bib0335","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fendo.2016.00017","article-title":"Signaling interactions in the adrenal cortex","volume":"7","author":"Spat","year":"2016","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.lpm.2018.07.006_bib0340","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/HYPERTENSIONAHA.114.03419","article-title":"Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma","volume":"64","author":"Fernandes-Rosa","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.lpm.2018.07.006_bib0345","doi-asserted-by":"crossref","first-page":"e0147590","DOI":"10.1371\/journal.pone.0147590","article-title":"Genetics of aldosterone-producing adenoma in Korean patients","volume":"11","author":"Hong","year":"2016","journal-title":"Plos One"},{"key":"10.1016\/j.lpm.2018.07.006_bib0350","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1210\/jc.2011-2885","article-title":"Expression and mutations of KCNJ5\u00a0mRNA in Japanese patients with aldosterone-producing adenomas","volume":"97","author":"Taguchi","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lpm.2018.07.006_bib0355","doi-asserted-by":"crossref","first-page":"e708","DOI":"10.1097\/MD.0000000000000708","article-title":"Prevalence and characterization of somatic mutations in Chinese aldosterone-producing adenoma patients","volume":"94","author":"Wang","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.lpm.2018.07.006_bib0360","doi-asserted-by":"crossref","first-page":"11396","DOI":"10.1038\/srep11396","article-title":"Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population","volume":"5","author":"Wu","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.lpm.2018.07.006_bib0365","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1161\/HYPERTENSIONAHA.114.03346","article-title":"Clinical characteristics of somatic mutations in Chinese patients with aldosterone-producing adenoma","volume":"65","author":"Zheng","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.lpm.2018.07.006_bib0370","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2015-2149","article-title":"A meta-analysis of somatic KCNJ5\u00a0K(+) channel mutations in 1636\u00a0patients with an aldosterone-producing adenoma","volume":"100","author":"Lenzini","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lpm.2018.07.006_bib0375","doi-asserted-by":"crossref","first-page":"19546","DOI":"10.1038\/srep19546","article-title":"Activating mutations in CTNNB1\u00a0in aldosterone producing adenomas","volume":"6","author":"Akerstrom","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.lpm.2018.07.006_bib0380","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1210\/jc.2016-1700","article-title":"PRKACA somatic mutations are rare findings in aldosterone-producing adenomas","volume":"101","author":"Rhayem","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lpm.2018.07.006_bib0385","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/cen.12873","article-title":"Novel somatic mutations in primary hyperaldosteronism are related to the clinical, radiological and pathological phenotype","volume":"83","author":"Scholl","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.lpm.2018.07.006_bib0390","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.mce.2013.01.018","article-title":"KCNJ5\u00a0mutations in aldosterone producing adenoma and relationship with adrenal cortex remodeling","volume":"371","author":"Boulkroun","year":"2013","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.lpm.2018.07.006_bib0395","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/374135a0","article-title":"The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins","volume":"374","author":"Krapivinsky","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.lpm.2018.07.006_bib0400","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.1198785","article-title":"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension","volume":"331","author":"Choi","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.lpm.2018.07.006_bib0405","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1210\/en.2011-1733","article-title":"Potassium channel mutant KCNJ5\u00a0T158A expression in HAC-15\u00a0cells increases aldosterone synthesis","volume":"153","author":"Oki","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.lpm.2018.07.006_bib0410","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1073\/pnas.1121407109","article-title":"Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5","volume":"109","author":"Scholl","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.lpm.2018.07.006_bib0415","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.mce.2015.01.020","article-title":"Functional histopathological markers of aldosterone producing adenoma and somatic KCNJ5\u00a0mutations","volume":"408","author":"Fernandes-Rosa","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.lpm.2018.07.006_bib0420","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1210\/er.2017-00189","article-title":"Genetic causes of functional adrenocortical adenomas","volume":"38","author":"Zennaro","year":"2017","journal-title":"Endocr Rev"},{"key":"10.1016\/j.lpm.2018.07.006_bib0425","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.neulet.2010.08.085","article-title":"Signaling complexes of voltage-gated sodium and calcium channels","volume":"486","author":"Catterall","year":"2010","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.lpm.2018.07.006_bib0430","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ng.2716","article-title":"Somatic mutations in ATP1A1\u00a0and CACNA1D underlie a common subtype of adrenal hypertension","volume":"45","author":"Azizan","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.lpm.2018.07.006_bib0435","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/ng.2695","article-title":"Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism","volume":"45","author":"Scholl","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.lpm.2018.07.006_bib0440","doi-asserted-by":"crossref","DOI":"10.1038\/ng.2550","article-title":"Somatic mutations in ATP1A1\u00a0and ATP2B3\u00a0lead to aldosterone-producing adenomas and secondary hypertension","volume":"45","author":"Beuschlein","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.lpm.2018.07.006_bib0445","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.1210\/en.2015-1466","article-title":"Pathogenesis of adrenal aldosterone-producing adenomas carrying mutations of the Na(+)\/K(+)-ATPase","volume":"156","author":"Stindl","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.lpm.2018.07.006_bib0450","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1210\/en.2015-2029","article-title":"Cellular pathophysiology of an adrenal adenoma-associated mutant of the plasma membrane Ca(2+)-ATPase ATP2B3","volume":"157","author":"Tauber","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.lpm.2018.07.006_bib0455","doi-asserted-by":"crossref","first-page":"e06315","DOI":"10.7554\/eLife.06315","article-title":"Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism","volume":"4","author":"Scholl","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.lpm.2018.07.006_bib0460","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ebiom.2016.10.002","article-title":"CACNA1H mutations are associated with different forms of primary aldosteronism","volume":"13","author":"Daniil","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.lpm.2018.07.006_bib0465","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mce.2010.11.014","article-title":"The Wnt\/beta-catenin pathway in adrenocortical development and cancer","volume":"332","author":"El Wakil","year":"2011","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.lpm.2018.07.006_bib0470","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/hmg\/ddt484","article-title":"WNT\/beta-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production","volume":"23","author":"Berthon","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.lpm.2018.07.006_bib0475","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1056\/NEJMoa1504869","article-title":"Pregnancy, primary aldosteronism, and adrenal CTNNB1\u00a0mutations","volume":"373","author":"Teo","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lpm.2018.07.006_bib0480","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mce.2014.01.016","article-title":"Aberrant gonadotropin-releasing hormone receptor (GnRHR) expression and its regulation of CYP11B2\u00a0expression and aldosterone production in adrenal aldosterone-producing adenoma (APA)","volume":"384","author":"Nakamura","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.lpm.2018.07.006_bib0485","first-page":"318","article-title":"LH, progesterone, and TSH can stimulate aldosterone in vitro: a study on normal adrenal cortex and aldosterone producing adenoma","volume":"46","author":"Nicolini","year":"2014","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.lpm.2018.07.006_bib0490","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/ng.2956","article-title":"Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors","volume":"46","author":"Goh","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.lpm.2018.07.006_bib0495","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1126\/science.1249480","article-title":"Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome","volume":"344","author":"Cao","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.lpm.2018.07.006_bib0500","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1056\/NEJMoa1310359","article-title":"Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome","volume":"370","author":"Beuschlein","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lpm.2018.07.006_bib0505","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93136","article-title":"Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism","volume":"2","author":"Arlt","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.lpm.2018.07.006_bib0510","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1161\/HYPERTENSIONAHA.111.186478","article-title":"Prevalence, clinical, and molecular correlates of kcnj5\u00a0mutations in primary aldosteronism","volume":"59","author":"Boulkroun","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.lpm.2018.07.006_bib0515","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1097\/HJH.0000000000000186","article-title":"KCNJ5\u00a0gene somatic mutations affect cardiac remodelling but do not preclude cure of high blood pressure and regression of left ventricular hypertrophy in primary aldosteronism","volume":"32","author":"Rossi","year":"2014","journal-title":"J Hypertens"},{"key":"10.1016\/j.lpm.2018.07.006_bib0520","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/HJH.0000000000001578","article-title":"KCNJ5\u00a0mutation as a predictor for resolution of hypertension after surgical treatment of aldosterone-producing adenoma","volume":"36","author":"Kitamoto","year":"2018","journal-title":"J Hypertens"},{"key":"10.1016\/j.lpm.2018.07.006_bib0525","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/HYPERTENSIONAHA.115.06186","article-title":"Genotype-specific steroid profiles associated with aldosterone-producing adenomas","volume":"67","author":"Williams","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.lpm.2018.07.006_bib0530","doi-asserted-by":"crossref","first-page":"E1341","DOI":"10.1210\/jc.2013-4255","article-title":"Adrenal nodularity and somatic mutations in primary aldosteronism: one node is the culprit?","volume":"99","author":"Dekkers","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lpm.2018.07.006_bib0535","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/HYPERTENSIONAHA.115.05993","article-title":"Different somatic mutations in multinodular adrenals with aldosterone-producing adenoma","volume":"66","author":"Fernandes-Rosa","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.lpm.2018.07.006_bib0540","doi-asserted-by":"crossref","first-page":"K1","DOI":"10.1530\/EJE-16-0262","article-title":"Double adrenocortical adenomas harboring independent KCNJ5\u00a0and PRKACA somatic mutations","volume":"175","author":"Nanba","year":"2016","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.lpm.2018.07.006_bib0545","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1210\/jc.2015-3239","article-title":"Molecular heterogeneity in aldosterone-producing adenomas","volume":"101","author":"Nanba","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lpm.2018.07.006_bib0550","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1210\/jc.2016-1874","article-title":"Aldosterone-producing adenoma with a somatic KCNJ5\u00a0mutation revealing APC-dependent familial adenomatous polyposis","volume":"101","author":"Vouillarmet","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lpm.2018.07.006_bib0555","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1210\/jc.2009-2010","article-title":"Adrenocortical zonation in humans under normal and pathological conditions","volume":"95","author":"Nishimoto","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lpm.2018.07.006_bib0560","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1161\/HYPERTENSIONAHA.110.158543","article-title":"Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism","volume":"56","author":"Boulkroun","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.lpm.2018.07.006_bib0565","doi-asserted-by":"crossref","first-page":"E4591","DOI":"10.1073\/pnas.1505529112","article-title":"Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands","volume":"112","author":"Nishimoto","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.lpm.2018.07.006_bib0570","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1210\/jc.2015-3285","article-title":"Case report: nodule development from subcapsular aldosterone-producing cell clusters causes hyperaldosteronism","volume":"101","author":"Nishimoto","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lpm.2018.07.006_bib0575","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1172\/JCI91733","article-title":"Macrolides selectively inhibit mutant KCNJ5\u00a0potassium channels that cause aldosterone-producing adenoma","volume":"127","author":"Scholl","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.lpm.2018.07.006_bib0580","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1161\/HYPERTENSIONAHA.117.10226","article-title":"Macrolides blunt aldosterone biosynthesis: a proof-of-concept study in KCNJ5\u00a0mutated adenoma cells ex vivo","volume":"70","author":"Caroccia","year":"2017","journal-title":"Hypertension"}],"container-title":["La Presse M\u00e9dicale"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0755498218302896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0755498218302896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T02:05:32Z","timestamp":1535594732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0755498218302896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":58,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0755498218302896"],"URL":"https:\/\/doi.org\/10.1016\/j.lpm.2018.07.006","relation":{},"ISSN":["0755-4982"],"issn-type":[{"value":"0755-4982","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular genetics of Conn adenomas in the era of exome analysis","name":"articletitle","label":"Article Title"},{"value":"La Presse M\u00e9dicale","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lpm.2018.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}