{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:10:31Z","timestamp":1790539831073,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["La Presse M\u00e9dicale"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.lpm.2018.10.006","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T23:33:25Z","timestamp":1540510405000},"page":"892-898","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Faut-il limiter la dur\u00e9e des traitements par benzodiaz\u00e9pines\u00a0?"],"prefix":"10.1016","volume":"47","author":[{"given":"Florence","family":"Vorspan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Barr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Pariente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Montastruc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Tournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 6","key":"10.1016\/j.lpm.2018.10.006_bib0250","doi-asserted-by":"crossref","first-page":"S399","DOI":"10.1016\/S0924-977X(99)00051-6","article-title":"Limitations on the use of benzodiazepines in anxiety and insomnia: are they justified?","volume":"9","author":"Lader","year":"1999","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.lpm.2018.10.006_bib0255","series-title":"Acide gamma amino butyrique ou GABA, inhibiteur 2016","author":"Alain","year":"2016"},{"key":"10.1016\/j.lpm.2018.10.006_bib0260","series-title":"Benzodiaz\u00e9pines","author":"College National de Pharmacologie Medicale","year":"2018"},{"key":"10.1016\/j.lpm.2018.10.006_bib0265","series-title":"Rang & Dale's Pharmacology","author":"Ritter","year":"2015"},{"key":"10.1016\/j.lpm.2018.10.006_bib0270","series-title":"Guide interactions m\u00e9dicamenteuses","author":"Revue, Prescrire. Substance(s): benzodiaz\u00e9pines ou apparent\u00e9s","year":"2018"},{"key":"10.1016\/j.lpm.2018.10.006_bib0275","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1046\/j.1532-5415.2001.49161.x","article-title":"The role of benzodiazepines in the treatment of insomnia: meta-analysis of benzodiazepine use in the treatment of insomnia","volume":"49","author":"Holbrook","year":"2001","journal-title":"J Am Geriatri Soc"},{"key":"10.1016\/j.lpm.2018.10.006_bib0280","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1136\/bmj.38623.768588.47","article-title":"Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits","volume":"331","author":"Glass","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.lpm.2018.10.006_bib0285","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1532-5415.2012.03923.x","article-title":"American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults","volume":"60","author":"American Geriatrics Society Beers Criteria Update Expert P","year":"2012","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.lpm.2018.10.006_bib0290","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/JCP.0b013e31823fe4bd","article-title":"A randomized, naturalistic, parallel-group study for the long-term treatment of panic disorder with clonazepam or paroxetine","volume":"32","author":"Nardi","year":"2012","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.lpm.2018.10.006_bib0295","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1016\/j.clinthera.2016.09.010","article-title":"Review of safety and efficacy of sleep medicines in older adults","volume":"38","author":"Schroeck","year":"2016","journal-title":"Clinical therapeutics"},{"key":"10.1016\/j.lpm.2018.10.006_bib0300","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1365-2125.2012.04418.x","article-title":"Benzodiazepine harm: how can it be reduced?","volume":"77","author":"Lader","year":"2014","journal-title":"Br J Clinical Pharmacol"},{"key":"10.1016\/j.lpm.2018.10.006_bib0305","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1055\/s-0043-112755","article-title":"Influence of long-term benzodiazepine use on neurocognitive skills related to driving performance in patient populations: a review","volume":"50","author":"van der Sluiszen","year":"2017","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.lpm.2018.10.006_bib0310","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2165\/00023210-200418010-00004","article-title":"Cognitive effects of long-term benzodiazepine use: a meta-analysis","volume":"18","author":"Barker","year":"2004","journal-title":"CNS drugs"},{"key":"10.1016\/j.lpm.2018.10.006_bib0315","first-page":"733","volume":"14","author":"Billioti de Gage","year":"2015","journal-title":"Is there really a link between benzodiazepine use and the risk of dementia? Expert opinion on drug safety"},{"key":"10.1016\/j.lpm.2018.10.006_bib0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40263-015-0305-4","article-title":"The benzodiazepine-dementia disorders link: current state of knowledge","volume":"30","author":"Pariente","year":"2016","journal-title":"CNS drugs"},{"key":"10.1016\/j.lpm.2018.10.006_bib0325","doi-asserted-by":"crossref","first-page":"g5205","DOI":"10.1136\/bmj.g5205","article-title":"Benzodiazepine use and risk of Alzheimer's disease: case-control study","volume":"349","author":"Billioti de Gage","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.lpm.2018.10.006_bib0330","doi-asserted-by":"crossref","first-page":"825","DOI":"10.7150\/ijms.16185","article-title":"Association between benzodiazepine use and dementia: data mining of different medical databases","volume":"13","author":"Takada","year":"2016","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.lpm.2018.10.006_bib0335","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jpsychires.2014.07.003","article-title":"Zolpidem and the risk of Parkinson's disease: a nationwide population-based study","volume":"58","author":"Yang","year":"2014","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.lpm.2018.10.006_bib0340","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1001\/archinternmed.2009.357","article-title":"Meta-analysis of the impact of 9\u00a0medication classes on falls in elderly persons","volume":"169","author":"Woolcott","year":"2009","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.lpm.2018.10.006_bib0345","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2165\/00002512-200825010-00007","article-title":"Benzodiazepines and injurious falls in community dwelling elders","volume":"25","author":"Pariente","year":"2008","journal-title":"Drugs Aging"},{"key":"10.1016\/j.lpm.2018.10.006_bib0350","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1111\/j.1532-5415.2011.03591.x","article-title":"Risk of fractures requiring hospitalization after an initial prescription for zolpidem, alprazolam, lorazepam, or diazepam in older adults","volume":"59","author":"Finkle","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.lpm.2018.10.006_bib0355","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/pds.2031","article-title":"Impact of drug interactions, dosage, and duration of therapy on the risk of hip fracture associated with benzodiazepine use in older adults","volume":"19","author":"Zint","year":"2010","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.lpm.2018.10.006_bib0360","doi-asserted-by":"crossref","first-page":"1002347","DOI":"10.1371\/journal.pmed.1002347","article-title":"Prescription medicine use by pedestrians and the risk of injurious road traffic crashes: A case-crossover study","volume":"14","author":"Nee","year":"2017","journal-title":"PLoS Med"},{"key":"10.1016\/j.lpm.2018.10.006_bib0365","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1111\/bcp.13075","article-title":"Road traffic crash risk associated with benzodiazepine and z-hypnotic use after implementation of a colour-graded pictogram: a responsibility study","volume":"82","author":"Orriols","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.lpm.2018.10.006_bib0370","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/1047-2797(94)00112-7","article-title":"Risk of traffic accident injury after a prescription for a benzodiazepine","volume":"5","author":"Neutel","year":"1995","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.lpm.2018.10.006_bib0375","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.sleep.2007.11.011","article-title":"Road traffic accident risk related to prescriptions of the hypnotics zopiclone, zolpidem, flunitrazepam and nitrazepam","volume":"9","author":"Gustavsen","year":"2008","journal-title":"Sleep Med"},{"key":"10.1016\/j.lpm.2018.10.006_bib0380","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1517\/14740338.2014.925444","article-title":"Risk versus risk: a review of benzodiazepine reduction in older adults","volume":"13","author":"Paquin","year":"2014","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.lpm.2018.10.006_bib0385","doi-asserted-by":"crossref","first-page":"e113753","DOI":"10.1371\/journal.pone.0113753","article-title":"Factors associated with long-term use of hypnotics among patients with chronic insomnia","volume":"9","author":"Takaesu","year":"2014","journal-title":"PloS one"},{"key":"10.1016\/j.lpm.2018.10.006_bib0390","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12877-017-0432-5","article-title":"Use of the EMPOWER brochure to deprescribe sedative-hypnotic drugs in older adults with mild cognitive impairment","volume":"17","author":"Martin","year":"2017","journal-title":"BMC geriatrics"},{"key":"10.1016\/j.lpm.2018.10.006_bib0395","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1001\/jamainternmed.2014.949","article-title":"Reduction of inappropriate benzodiazepine prescriptions among older adults through direct patient education: the EMPOWER cluster randomized trial","volume":"174","author":"Tannenbaum","year":"2014","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.lpm.2018.10.006_bib0400","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1192\/bjp.bp.113.126003","article-title":"Interventions for reducing benzodiazepine use in older people: meta-analysis of randomised controlled trials","volume":"204","author":"Gould","year":"2014","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.lpm.2018.10.006_bib0405","first-page":"CD009652","article-title":"Psychosocial interventions for benzodiazepine harmful use, abuse or dependence","volume":"2015","author":"Darker","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.lpm.2018.10.006_bib0410","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1471-2296-13-111","article-title":"Discontinuation of reimbursement of benzodiazepines in the Netherlands: does it make a difference?","volume":"13","author":"Kollen","year":"2012","journal-title":"BMC Fam Pract"},{"key":"10.1016\/j.lpm.2018.10.006_bib0415","doi-asserted-by":"crossref","first-page":"e016229","DOI":"10.1136\/bmjopen-2017-016229","article-title":"Financial incentives to discontinue long-term benzodiazepine use: a discrete choice experiment investigating patient preferences and willingness to participate","volume":"7","author":"Marti","year":"2017","journal-title":"BMJ open"},{"key":"10.1016\/j.lpm.2018.10.006_bib0420","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.eurpsy.2011.11.003","article-title":"Do benzodiazepines still deserve a major role in the treatment of psychiatric disorders?. A critical reappraisal","volume":"28","author":"Dell\u2019osso","year":"2013","journal-title":"Eur Psychiatry"},{"key":"10.1016\/j.lpm.2018.10.006_bib0425","series-title":"M\u00e9dicaments psychotropes: Consommations et pharmacod\u00e9pendances. Rapport (Expertise collective)","first-page":"XII","author":"Inserm (dir.)","year":"2012"},{"key":"10.1016\/j.lpm.2018.10.006_bib0430","series-title":"The CBHSQ Report [Internet]. Rockville (MD): Substance Abuse and Mental Health Services Administration (US)","article-title":"Trends in Heroin Use in the United States: 2002\u00a0to 2013","author":"Lipari","year":"2013"},{"key":"10.1016\/j.lpm.2018.10.006_bib0435","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.drugalcdep.2017.11.035","article-title":"Factors associated with sedative use and misuse among heroin users","volume":"185","author":"Moses","year":"2018","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.lpm.2018.10.006_bib0440","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.drugalcdep.2012.07.004","article-title":"Polydrug abuse: a review of opioid and benzodiazepine combination use","volume":"125","author":"Jones","year":"2012","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.lpm.2018.10.006_bib0445","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jsat.2009.03.006","article-title":"Self-perceived motivation for benzodiazepine use and behavior related to benzodiazepine use among opiate-dependent patients","volume":"37","author":"Fats\u00e9as","year":"2009","journal-title":"J Subst Abuse Treat"},{"key":"10.1016\/j.lpm.2018.10.006_bib0450","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jsat.2016.06.008","article-title":"Reasons for benzodiazepine use among persons seeking opioid detoxification","volume":"68","author":"Stein","year":"2016","journal-title":"J Subst Abuse Treat"},{"key":"10.1016\/j.lpm.2018.10.006_bib0455","first-page":"16","article-title":"Drug interactions of clinical importance among the opioids, methadone and buprenorphine, and other frequently prescribed medications: a review","volume":"19","author":"McCance-Katz","year":"2010","journal-title":"Am J Addict"},{"key":"10.1016\/j.lpm.2018.10.006_bib0460","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1521-0391.2009.00007.x","article-title":"Benzodiazepines, methadone and buprenorphine: interactions and clinical management","volume":"19","author":"Lintzeris","year":"2009","journal-title":"Am J Addict"},{"key":"10.1016\/j.lpm.2018.10.006_bib0465","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.drugpo.2017.07.012","article-title":"I love having benzos after my coke shot: the use of psychotropic medication among cocaine users in downtown Montreal","volume":"49","author":"Motta-Ochoa","year":"2017","journal-title":"Int J Drug Policy"},{"key":"10.1016\/j.lpm.2018.10.006_bib0470","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.drugalcdep.2017.08.037","article-title":"Serious suicide attempts in outpatients with multiple substance use disorders","volume":"181","author":"Icick","year":"2017","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.lpm.2018.10.006_bib0475","doi-asserted-by":"crossref","first-page":"686","DOI":"10.2105\/AJPH.2016.303061","article-title":"Increasing benzodiazepine prescriptions and overdose mortality in the united states, 1996-2013","volume":"106","author":"Bachhuber","year":"2016","journal-title":"Am J Public Health"},{"key":"10.1016\/j.lpm.2018.10.006_bib0480","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1197\/j.aem.2005.12.011","article-title":"Testing positive for methadone and either a tricyclic antidepressant or a benzodiazepine is associated with an accidental overdose death: analysis of medical examiner data","volume":"13","author":"Chan","year":"2006","journal-title":"Acad Emerg Med"},{"issue":"3","key":"10.1016\/j.lpm.2018.10.006_bib0485","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.euroneuro.2007.10.001","article-title":"Tricyclic antidepressants abuse, with or without benzodiazepines abuse, in former heroin addicts currently in methadone maintenance treatment (MMT)","volume":"18","author":"Peles","year":"2008","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.lpm.2018.10.006_bib0245","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/JCP.0b013e3182670648","article-title":"Characteristics of quetiapine misuse among clients of a community-based methadone maintenance program","volume":"32","author":"McLarnon","year":"2012","journal-title":"J Clin Psychopharmacol"}],"container-title":["La Presse M\u00e9dicale"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0755498218303841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0755498218303841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T21:09:37Z","timestamp":1543439377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0755498218303841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0755498218303841"],"URL":"https:\/\/doi.org\/10.1016\/j.lpm.2018.10.006","relation":{},"ISSN":["0755-4982"],"issn-type":[{"value":"0755-4982","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Faut-il limiter la dur\u00e9e des traitements par benzodiaz\u00e9pines\u00a0?","name":"articletitle","label":"Article Title"},{"value":"La Presse M\u00e9dicale","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lpm.2018.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}