{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T01:13:17Z","timestamp":1761959597740,"version":"build-2065373602"},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":239,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research Reports"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/j.lrr.2023.100390","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T20:37:42Z","timestamp":1693255062000},"page":"100390","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Aggressive chronic lymphocytic leukemia masked by extensive marrow fibrosis"],"prefix":"10.1016","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6364-5848","authenticated-orcid":false,"given":"Hareem","family":"Farooq","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1548-918X","authenticated-orcid":false,"given":"Talha","family":"Badar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lrr.2023.100390_bib0001","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1586\/17474086.2014.977862","article-title":"Ibrutinib: a paradigm shift in management of CLL","volume":"7","author":"Badar","year":"2014","journal-title":"Expert Rev. Hematol."},{"key":"10.1016\/j.lrr.2023.100390_bib0002","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12938-021-00973-6","article-title":"The global burden and attributable risk factors of chronic lymphocytic leukemia in 204 countries and territories from 1990 to 2019: analysis based on the global burden of disease study 2019","volume":"21","author":"Yao","year":"2022","journal-title":"Biomed. Eng. Online"},{"key":"10.1016\/j.lrr.2023.100390_bib0003","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41375-022-01620-2","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms","volume":"36","author":"Alaggio","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.lrr.2023.100390_bib0004","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1002\/cncr.27930","article-title":"Significance of bone marrow reticulin fibrosis in chronic lymphocytic leukemia at diagnosis: a study of 176 patients with prognostic implications","volume":"119","author":"Tadmor","year":"2013","journal-title":"Cancer"},{"key":"10.1016\/j.lrr.2023.100390_bib0005","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ajh.2830430111","article-title":"Chronic lymphocytic leukemia associated with bone marrow fibrosis: possible role of interleukin 1 alpha in the pathogenesis","volume":"43","author":"Kimura","year":"1993","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.lrr.2023.100390_bib0006","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.leukres.2015.06.001","article-title":"Therapeutic benefit of decitabine, a hypomethylating agent, in patients with high-risk primary myelofibrosis and myeloproliferative neoplasm in accelerated or blastic\/acute myeloid leukemia phase","volume":"39","author":"Badar","year":"2015","journal-title":"Leuk. Res."},{"key":"10.1016\/j.lrr.2023.100390_bib0007","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1038\/sj.leu.2403172","article-title":"Marrow fibrosis, indicator of therapy failure in chronic myeloid leukemia \u2013 prospective long-term results from a randomized-controlled trial","volume":"17","author":"Buesche","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.lrr.2023.100390_bib0008","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1038\/bcj.2011.18","article-title":"Coexistence of primary myelofibrosis and chronic lymphocytic leukaemia: treatment of two different diseases with one agent","volume":"1","author":"Burgstaller","year":"2011","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.lrr.2023.100390_bib0009","first-page":"480","article-title":"[Coincidence of chronic idiopathic myelofibrosis and chronic lymphocytic leukaemia. A rare phenomenon?]","volume":"23","author":"B\u00f6hm","year":"2002","journal-title":"Pathologe"},{"key":"10.1016\/j.lrr.2023.100390_bib0010","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1136\/jcp.17.5.541","article-title":"Stromal changes in leukaemic and related bone marrow proliferations","volume":"17","author":"Sanerkin","year":"1964","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.lrr.2023.100390_bib0011","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12288-010-0020-8","article-title":"Simultaneous presence of two hematological malignancies: chronic lymphocytic leukemia and myelofibrosis in a patient","volume":"27","author":"Palta","year":"2011","journal-title":"Indian J. Hematol. Blood Transfus"},{"key":"10.1016\/j.lrr.2023.100390_bib0012","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1182\/blood-2013-11-536169","article-title":"Correlation between FDG\/PET, histology, characteristics, and survival in 332 patients with chronic lymphoid leukemia","volume":"123","author":"Falchi","year":"2014","journal-title":"Blood"}],"container-title":["Leukemia Research Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213048923000304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213048923000304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T01:09:00Z","timestamp":1761959340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213048923000304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":12,"alternative-id":["S2213048923000304"],"URL":"https:\/\/doi.org\/10.1016\/j.lrr.2023.100390","relation":{},"ISSN":["2213-0489"],"issn-type":[{"type":"print","value":"2213-0489"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aggressive chronic lymphocytic leukemia masked by extensive marrow fibrosis","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lrr.2023.100390","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100390"}}